| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Heilig, J A Engel, B Söderpal. C-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine. European journal of pharmacology. vol 236. issue 2. 1993-08-05. PMID:8319761. |
c-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine. |
1993-08-05 |
2023-08-12 |
rat |
| M Heilig, J A Engel, B Söderpal. C-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine. European journal of pharmacology. vol 236. issue 2. 1993-08-05. PMID:8319761. |
here, we report that bilateral administration of an antisense oligo against c-fos in the nucleus accumbens blocks cocaine induced locomotor stimulation, without affecting spontaneous exploratory activity. |
1993-08-05 |
2023-08-12 |
rat |
| D D Wheeler, A M Edwards, J G Ond. Dopamine uptake in five structures of the brain: comparison of rate, sodium dependence and sensitivity to cocaine. Neuropharmacology. vol 32. issue 5. 1993-08-03. PMID:8321431. |
neither the rate of uptake nor the na-dependence correlated precisely with the sensitivity to cocaine but the two structures which showed the greatest rate of uptake (nucleus accumbens and striatum) also showed the greatest sensitivity to [na]o. |
1993-08-03 |
2023-08-12 |
rat |
| T Baptista, S R Weiss, R M Pos. Carbamazepine attenuates cocaine-induced increases in dopamine in the nucleus accumbens: an in vivo dialysis study. European journal of pharmacology. vol 236. issue 1. 1993-07-30. PMID:8319744. |
the basal levels of dopamine in the nucleus accumbens did not differ between groups; however, the increases in dopamine following cocaine administration (4 mg/kg i.v.) |
1993-07-30 |
2023-08-12 |
rat |
| X Guitart, J H Kogan, M Berhow, R Z Terwilliger, G K Aghajanian, E J Nestle. Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals. Brain research. vol 611. issue 1. 1993-07-29. PMID:8518951. |
in the current study, we compared lewis and fischer rats with respect to levels of adenylate cyclase, cyclic amp-dependent protein kinase and g-proteins in the nucleus accumbens (nac) and locus coeruleus (lc), brain regions in sprague-dawley rats where these proteins are regulated by chronic exposure to morphine or to cocaine. |
1993-07-29 |
2023-08-12 |
rat |
| W A Cass, G A Gerhardt, K Gillespie, P Curella, R D Mayfield, N R Zahnise. Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515274. |
the decrease in dopamine clearance rate observed in the nucleus accumbens of the cocaine-treated rats after a challenge injection of cocaine is consistent with increased dopaminergic transmission, but does not appear to be sufficient in itself for producing behavioral sensitization. |
1993-07-22 |
2023-08-12 |
rat |
| W A Cass, N R Zahnise. Cocaine levels in striatum and nucleus accumbens: augmentation following challenge injection in rats withdrawn from repeated cocaine administration. Neuroscience letters. vol 152. issue 1-2. 1993-07-19. PMID:8515873. |
cocaine levels in striatum and nucleus accumbens: augmentation following challenge injection in rats withdrawn from repeated cocaine administration. |
1993-07-19 |
2023-08-12 |
rat |
| W A Cass, N R Zahnise. Cocaine levels in striatum and nucleus accumbens: augmentation following challenge injection in rats withdrawn from repeated cocaine administration. Neuroscience letters. vol 152. issue 1-2. 1993-07-19. PMID:8515873. |
), and levels of cocaine were measured in dorsal striatum and nucleus accumbens 20 min after the last injection. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
d1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
sch23390, a selective d1 dopamine antagonist, significantly increased the self-administration of cocaine when injected into the nucleus accumbens. |
1993-07-19 |
2023-08-12 |
rat |
| R Maldonado, P Robledo, A J Chover, S B Caine, G F Koo. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8516365. |
these data suggest that d1 receptors in the nucleus accumbens are important for the reinforcing properties of cocaine. |
1993-07-19 |
2023-08-12 |
rat |
| C D Striplin, P W Kaliva. Robustness of G protein changes in cocaine sensitization shown with immunoblotting. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511715. |
a significant decline in gi1 alpha was seen in the nucleus accumbens at 14 days following daily cocaine administration regardless of whether they received an acute challenge with cocaine or saline 1 hr prior to decapitation. |
1993-07-15 |
2023-08-12 |
rat |
| C D Striplin, P W Kaliva. Robustness of G protein changes in cocaine sensitization shown with immunoblotting. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8511715. |
no change in g protein immunoreactivity was measured in the nucleus accumbens or ventral tegmental area of rats decapitated 1 hr after discontinuing daily cocaine. |
1993-07-15 |
2023-08-12 |
rat |
| S T Cain, D Griff, C M Joyner, E H Ellinwood, C B Nemerof. Chronic continuous or intermittent infusion of cocaine differentially alter the concentration of neurotensin-like immunoreactivity in specific rat brain regions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 8. issue 3. 1993-07-12. PMID:8507352. |
twenty-four hours following a single acute injection of 40 mg/kg of cocaine, nt-li was increased in the sn and nucleus accumbens. |
1993-07-12 |
2023-08-12 |
rat |
| J I Javaid, J M Davi. Cocaine disposition in discrete regions of rat brain. Biopharmaceutics & drug disposition. vol 14. issue 4. 1993-06-30. PMID:8499585. |
in rat brain, cocaine effects on striatal and nucleus accumbens dopaminergic systems show quantitative differences. |
1993-06-30 |
2023-08-12 |
rat |
| N E Goeders, J E Smit. Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 265. issue 2. 1993-06-22. PMID:8496810. |
intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens. |
1993-06-22 |
2023-08-12 |
rat |
| Y L Hurd, M Herkenha. Molecular alterations in the neostriatum of human cocaine addicts. Synapse (New York, N.Y.). vol 13. issue 4. 1993-05-25. PMID:7683144. |
the greater magnitude of changes in the dorsolateral striatum (caudate and putamen) as opposed to the ventromedial striatum (nucleus accumbens) suggests that cocaine abuse preferentially alters the biosynthetic activity of striatal systems associated with sensorimotor functioning. |
1993-05-25 |
2023-08-12 |
human |
| C W Bradberry, J B Nobiletti, J D Elsworth, B Murphy, P Jatlow, R H Rot. Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8455033. |
extracellular levels of dopamine in the nucleus accumbens were increased to approximately 400% of preinjection value by both cocaine and cocaethylene when administered intravenously. |
1993-04-19 |
2023-08-12 |
rat |
| C W Bradberry, J B Nobiletti, J D Elsworth, B Murphy, P Jatlow, R H Rot. Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin. Journal of neurochemistry. vol 60. issue 4. 1993-04-19. PMID:8455033. |
after intraperitoneal administration, extracellular levels of dopamine in the nucleus accumbens were increased to 400% of preinjection levels by cocaine, but were only increased to 200% of preinjection levels by cocaethylene, the difference being statistically significant. |
1993-04-19 |
2023-08-12 |
rat |
| F Rougé-Pont, P V Piazza, M Kharouby, M Le Moal, H Simo. Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study. Brain research. vol 602. issue 1. 1993-04-12. PMID:8448654. |
furthermore, previous studies have shown that hr animals have a higher basal dopac/da ratio in the nucleus accumbens and higher extracellular concentrations of dopamine in this structure in response to cocaine. |
1993-04-12 |
2023-08-12 |
rat |