| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Kiyatki. Changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. Brain research. vol 642. issue 1-2. 1994-08-16. PMID:8032884. |
changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. |
1994-08-16 |
2023-08-12 |
rat |
| E A Kiyatki. Changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. Brain research. vol 642. issue 1-2. 1994-08-16. PMID:8032884. |
high-speed chronoamperometry with nafion-coated monoamine-sensitive electrodes was used to evaluate changes in the extracellular dopamine (da) concentrations in the nucleus accumbens following each of a series of daily cocaine injections (15 mg/kg, i.p. |
1994-08-16 |
2023-08-12 |
rat |
| S P Gygi, J W Gibb, G R Hanso. Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:7913495. |
the effects of two antipsychotic (dopamine antagonist) drugs, haloperidol and clozapine, and of two psychotomimetic (dopamine-releasing) drugs, methamphetamine and cocaine, on neurotensin (nt) concentrations in discrete regions of the caudate nucleus, nucleus accumbens and globus pallidus were examined. |
1994-08-15 |
2023-08-12 |
Not clear |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
chronic cocaine administration produced a significant decrease in the uptake of [3h]dopamine into the frontal cortex (49%) with no significant differences in the nucleus accumbens or striatum. |
1994-08-15 |
2023-08-12 |
rat |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
in addition, the ic50 values for gbr 12909 and cocaine in the frontal cortex were significantly greater than values for either compound in the nucleus accumbens or striatum. |
1994-08-15 |
2023-08-12 |
rat |
| A Gratton, R A Wis. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027767. |
high-speed chronoamperometry was used to determine the moment-to-moment and day-to-day changes in dopamine-related electrochemical signals in the nucleus accumbens of rats allowed to self-administer cocaine (0.8 mg/kg/injection) intravenously. |
1994-08-11 |
2023-08-12 |
rat |
| A Gratton, R A Wis. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027767. |
thus, the effects of cocaine on da-associated signals in nucleus accumbens (1) changed dramatically during the development of the self-administration habit and (2) depended on environmental and behavioral as well as pharmacological factors. |
1994-08-11 |
2023-08-12 |
rat |
| S E Hemby, G H Jones, G W Hubert, D B Neill, J B Justic. Assessment of the relative contribution of peripheral and central components in cocaine place conditioning. Pharmacology, biochemistry, and behavior. vol 47. issue 4. 1994-08-08. PMID:8029272. |
the first experiment was conducted to examine changes in locomotor activity and extracellular dopamine (da) concentrations in the nucleus accumbens (nacc) following intraperitoneal (ip) injections of cocaine hcl (15 mg/kg) or cocaine methiodide (19.6 mg/kg). |
1994-08-08 |
2023-08-12 |
Not clear |
| N S Pilotte, L G Sharpe, M J Kuha. Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:7912283. |
withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of lewis rats. |
1994-07-26 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, M J Kuha. Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:7912283. |
animals given only 1/10 of the cocaine dose had no changes in nucleus accumbens after 10 days of administration and 10 days of withdrawal. |
1994-07-26 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
the effects of 7 days repeated cocaine administration on the dynamics of dopamine release and metabolism in four rat brain regions (frontal cortex, hypothalamus, nucleus accumbens and striatum) were evaluated 1 week (long-term effects) after the final cocaine injection. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
consistent with a previous report, cocaine withdrawal was associated with marked reductions in dopac rate of formation in the frontal cortex and hypothalamus but not in the nucleus accumbens or the striatum. |
1994-07-13 |
2023-08-12 |
rat |
| G Di Chiara, E Acquas, G Tanda, C Cadon. Drugs of abuse: biochemical surrogates of specific aspects of natural reward? Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910742. |
both natural rewards and drugs of abuse, including amphetamine, cocaine and other psychostimulants, preferentially stimulate dopamine transmission in the mesolimbic nucleus accumbens compared with the dorsal caudate, an area related to the extrapyramidal motor system. |
1994-06-23 |
2023-08-12 |
Not clear |
| K E Asin, A L Nikkel, D Wirtshafte. Repeated D1 receptor agonist treatment blocks cocaine-induced locomotor activity and c-fos expression. Brain research. vol 637. issue 1-2. 1994-06-16. PMID:7910104. |
pretreatment of rats for 4 days with the selective dopamine d1 receptor agonist a-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. |
1994-06-16 |
2023-08-12 |
rat |
| M Marinelli, P V Piazza, V Deroche, S Maccari, M Le Moal, H Simo. Corticosterone circadian secretion differentially facilitates dopamine-mediated psychomotor effect of cocaine and morphine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 1. 1994-06-14. PMID:8182438. |
locomotor response to cocaine and morphine was studied after both systemic and central injections, into the nucleus accumbens for cocaine and into the ventral tegmental area for morphine. |
1994-06-14 |
2023-08-12 |
Not clear |
| J M Wilson, J N Nobrega, M E Carroll, H B Niznik, K Shannak, S T Lac, Z B Pristupa, L M Dixon, S J Kis. Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182452. |
following chronic, unlimited access cocaine self-administration, binding of 3h-win 35,428 was significantly elevated in whole nucleus accumbens (+69%, p < 0.001) and striatum (+65%, p < 0.001) on the last day of cocaine exposure ("on-cocaine group"); whereas in the 3 week withdrawn animals ("cocaine-withdrawn group"), levels were either normal (striatum) or reduced (-30%, p < 0.05, nucleus accumbens). |
1994-06-14 |
2023-08-12 |
rat |
| J M Wilson, J N Nobrega, M E Carroll, H B Niznik, K Shannak, S T Lac, Z B Pristupa, L M Dixon, S J Kis. Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182452. |
these data provide additional support to the hypothesis that some of the long-term effects of cocaine exposure (drug craving, depression) could be consequent to reduced nucleus accumbens dopamine function. |
1994-06-14 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. Journal of the experimental analysis of behavior. vol 61. issue 2. 1994-06-02. PMID:8169570. |
infusion of the catecholaminergic neurotoxin 6-hydroxydopamine, but not the vehicle solution, into the region of the nucleus accumbens and olfactory tubercle produced selective reductions in cocaine self-administration without significantly altering responding maintained by food within the same sessions. |
1994-06-02 |
2023-08-12 |
rat |
| S B Kombian, R C Malenk. Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens. Nature. vol 368. issue 6468. 1994-05-05. PMID:7908412. |
the nucleus accumbens (na), a ventral extension of the striatum, plays a role in several complex behaviour patterns and also is a major site of action of drugs of abuse such as cocaine. |
1994-05-05 |
2023-08-12 |
Not clear |
| J Y Chang, S F Sawyer, R S Lee, D J Woodwar. Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:8120621. |
electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. |
1994-04-07 |
2023-08-12 |
rat |