| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Di Chiara, E Acquas, G Tanda, C Cadon. Drugs of abuse: biochemical surrogates of specific aspects of natural reward? Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910742. |
both natural rewards and drugs of abuse, including amphetamine, cocaine and other psychostimulants, preferentially stimulate dopamine transmission in the mesolimbic nucleus accumbens compared with the dorsal caudate, an area related to the extrapyramidal motor system. |
1994-06-23 |
2023-08-12 |
Not clear |
| K E Asin, A L Nikkel, D Wirtshafte. Repeated D1 receptor agonist treatment blocks cocaine-induced locomotor activity and c-fos expression. Brain research. vol 637. issue 1-2. 1994-06-16. PMID:7910104. |
pretreatment of rats for 4 days with the selective dopamine d1 receptor agonist a-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. |
1994-06-16 |
2023-08-12 |
rat |
| M Marinelli, P V Piazza, V Deroche, S Maccari, M Le Moal, H Simo. Corticosterone circadian secretion differentially facilitates dopamine-mediated psychomotor effect of cocaine and morphine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 1. 1994-06-14. PMID:8182438. |
locomotor response to cocaine and morphine was studied after both systemic and central injections, into the nucleus accumbens for cocaine and into the ventral tegmental area for morphine. |
1994-06-14 |
2023-08-12 |
Not clear |
| J M Wilson, J N Nobrega, M E Carroll, H B Niznik, K Shannak, S T Lac, Z B Pristupa, L M Dixon, S J Kis. Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182452. |
following chronic, unlimited access cocaine self-administration, binding of 3h-win 35,428 was significantly elevated in whole nucleus accumbens (+69%, p < 0.001) and striatum (+65%, p < 0.001) on the last day of cocaine exposure ("on-cocaine group"); whereas in the 3 week withdrawn animals ("cocaine-withdrawn group"), levels were either normal (striatum) or reduced (-30%, p < 0.05, nucleus accumbens). |
1994-06-14 |
2023-08-12 |
rat |
| J M Wilson, J N Nobrega, M E Carroll, H B Niznik, K Shannak, S T Lac, Z B Pristupa, L M Dixon, S J Kis. Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182452. |
these data provide additional support to the hypothesis that some of the long-term effects of cocaine exposure (drug craving, depression) could be consequent to reduced nucleus accumbens dopamine function. |
1994-06-14 |
2023-08-12 |
rat |
| S B Caine, G F Koo. Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. Journal of the experimental analysis of behavior. vol 61. issue 2. 1994-06-02. PMID:8169570. |
infusion of the catecholaminergic neurotoxin 6-hydroxydopamine, but not the vehicle solution, into the region of the nucleus accumbens and olfactory tubercle produced selective reductions in cocaine self-administration without significantly altering responding maintained by food within the same sessions. |
1994-06-02 |
2023-08-12 |
rat |
| S B Kombian, R C Malenk. Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens. Nature. vol 368. issue 6468. 1994-05-05. PMID:7908412. |
the nucleus accumbens (na), a ventral extension of the striatum, plays a role in several complex behaviour patterns and also is a major site of action of drugs of abuse such as cocaine. |
1994-05-05 |
2023-08-12 |
Not clear |
| J Y Chang, S F Sawyer, R S Lee, D J Woodwar. Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:8120621. |
electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. |
1994-04-07 |
2023-08-12 |
rat |
| J Y Chang, S F Sawyer, R S Lee, D J Woodwar. Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 1. 1994-04-07. PMID:8120621. |
the goal of this study was to clarify the role of the nucleus accumbens septi (nas) in the expression of cocaine self-administration behaviors. |
1994-04-07 |
2023-08-12 |
rat |
| E M Unterwald, B M Cox, M J Kreek, T E Cote, S Izenwasse. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310423. |
repeated daily cocaine injections have been shown to alter mu-opioid receptor densities in the caudate putamen and nucleus accumbens of rat brain (unterwald et al., 1991, 1992). |
1994-03-17 |
2023-08-12 |
rat |
| E M Unterwald, B M Cox, M J Kreek, T E Cote, S Izenwasse. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310423. |
adenylyl cyclase activity was measured in rat rostral caudate putamen and nucleus accumbens following repeated cocaine administration to determine the functional consequences of cocaine-induced opioid receptor changes. |
1994-03-17 |
2023-08-12 |
rat |
| E M Unterwald, B M Cox, M J Kreek, T E Cote, S Izenwasse. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310423. |
basal adenylyl cyclase activity was unchanged in the nucleus accumbens following cocaine treatment. |
1994-03-17 |
2023-08-12 |
rat |
| E M Unterwald, B M Cox, M J Kreek, T E Cote, S Izenwasse. Chronic repeated cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310423. |
these results suggest that chronic, repeated cocaine administration results in a selective impairment of delta-opioid receptor-mediated effector function in the caudate putamen and nucleus accumbens. |
1994-03-17 |
2023-08-12 |
rat |
| J K Staley, M Basile, D D Flynn, D C Mas. Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55: in vitro binding and autoradiographic characterization. Journal of neurochemistry. vol 62. issue 2. 1994-03-02. PMID:8294917. |
autoradiographic mapping of [125i]rti-55 revealed very high densities of cocaine recognition sites over areas known to be rich in dopaminergic innervation, including the caudate, putamen, and nucleus accumbens. |
1994-03-02 |
2023-08-12 |
human |
| D J Fontana, R M Post, A Per. Conditioned increases in mesolimbic dopamine overflow by stimuli associated with cocaine. Brain research. vol 629. issue 1. 1994-02-23. PMID:8287278. |
environmental stimuli paired with a large dose of cocaine for one training session elicited significant increases in locomotor activity and in extracellular dopamine in the nucleus accumbens of rats during a second test session with a low dose of cocaine. |
1994-02-23 |
2023-08-12 |
rat |
| R M Carelli, V C King, R E Hampson, S A Deadwyle. Firing patterns of nucleus accumbens neurons during cocaine self-administration in rats. Brain research. vol 626. issue 1-2. 1994-02-14. PMID:8281424. |
firing patterns of nucleus accumbens neurons during cocaine self-administration in rats. |
1994-02-14 |
2023-08-12 |
rat |
| R M Carelli, V C King, R E Hampson, S A Deadwyle. Firing patterns of nucleus accumbens neurons during cocaine self-administration in rats. Brain research. vol 626. issue 1-2. 1994-02-14. PMID:8281424. |
the firing patterns of neurons in the nucleus accumbens (na) were recorded in rats trained to self-administer cocaine via response contingent intravenous drug infusions. |
1994-02-14 |
2023-08-12 |
rat |
| F G Kaddis, L J Wallace, N J Uretsk. AMPA/kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists. Pharmacology, biochemistry, and behavior. vol 46. issue 3. 1994-02-09. PMID:7506423. |
ampa/kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists. |
1994-02-09 |
2023-08-12 |
Not clear |
| F G Kaddis, L J Wallace, N J Uretsk. AMPA/kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists. Pharmacology, biochemistry, and behavior. vol 46. issue 3. 1994-02-09. PMID:7506423. |
the purpose of this study was to determine whether ampa/kainate excitatory amino acid receptors in the nucleus accumbens (nac) play a role in the locomotor stimulation produced by cocaine and dopamine receptor agonists. |
1994-02-09 |
2023-08-12 |
Not clear |
| P A Broderick, E P Kornak, F Eng, R Wechsle. Real time detection of acute (IP) cocaine-enhanced dopamine and serotonin release in ventrolateral nucleus accumbens of the behaving Norway rat. Pharmacology, biochemistry, and behavior. vol 46. issue 3. 1994-02-09. PMID:8278450. |
cocaine (10 mg/kg), administered intraperitoneal (ip), was studied for its effects on dopamine (da) and serotonin (5-ht) release in ventrolateral nucleus accumbens (vlnacc) of conscious and behaving male, virus-free, sprague-dawley rats with in vivo electrochemistry (voltammetry). |
1994-02-09 |
2023-08-12 |
rat |