| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B T Hope, H E Nye, M B Kelz, D W Self, M J Iadarola, Y Nakabeppu, R S Duman, E J Nestle. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. vol 13. issue 5. 1994-12-27. PMID:7946359. |
following chronic cocaine treatment, we have found a long-lasting increase in ap-1 binding in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of cocaine. |
1994-12-27 |
2023-08-12 |
rat |
| J R Nation, R T Burke. Attenuation of cocaine-induced elevation of nucleus accumbens dopamine in lead-exposed rats. Brain research bulletin. vol 35. issue 1. 1994-12-20. PMID:7953752. |
the results of this experiment showed that cocaine caused a significantly greater increase in extracellular nucleus accumbens dopamine in control animals relative to lead-treated animals. |
1994-12-20 |
2023-08-12 |
rat |
| D W Self, R Z Terwilliger, E J Nestler, L Stei. Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 10. 1994-11-14. PMID:7931576. |
inactivation of gi and g(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. |
1994-11-14 |
2023-08-12 |
rat |
| D W Self, R Z Terwilliger, E J Nestler, L Stei. Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 10. 1994-11-14. PMID:7931576. |
the pertussis toxin (ptx)-sensitive g proteins gi and g(o) may be implicated in drug reinforcement and addiction, since certain reward-related dopamine and opiate receptor subtypes are coupled to these g proteins, and since chronic exposure to cocaine or morphine alters levels of these g proteins in the nucleus accumbens (nac). |
1994-11-14 |
2023-08-12 |
rat |
| E M Unterwald, A Ho, J M Rubenfeld, M J Kree. Time course of the development of behavioral sensitization and dopamine receptor up-regulation during binge cocaine administration. The Journal of pharmacology and experimental therapeutics. vol 270. issue 3. 1994-11-07. PMID:7932193. |
transient increases in d2 receptor number were found in the olfactory tubercle, rostral nucleus accumbens and rostral caudate putamen after 7 days of cocaine injections which returned to baseline levels after 14 days of cocaine treatment. |
1994-11-07 |
2023-08-12 |
human |
| J Liu, J Nickolenko, F R Shar. Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 18. 1994-10-04. PMID:8078918. |
since the morphine induction of c-fos and junb in striatum and nucleus accumbens (na) was similar to that observed with cocaine and amphetamine, these data support current concepts that limbic striatum and na are among the brain regions that mediate drug abuse. |
1994-10-04 |
2023-08-12 |
Not clear |
| E A Kiyatkin, E A Stei. Biphasic changes in mesolimbic dopamine signal during cocaine self-administration. Neuroreport. vol 5. issue 8. 1994-09-19. PMID:8061279. |
high-speed chronoamperometry with nafion-coated carbon fiber microelectrodes was used to follow changes in extracellular dopamine (da) concentration in the nucleus accumbens of rats during intravenous cocaine self-administration (sa) behavior. |
1994-09-19 |
2023-08-12 |
rat |
| H Miyata, N Hironaka, K Ando, T Yanagit. [Rotational behavior induced by methamphetamine and cocaine in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine system]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 2. 1994-08-24. PMID:8042345. |
the present results suggest that methamphetamine produces longer duration of the facilitation of dopaminergic transmission both in the nucleus accumbens and in the striatum than does cocaine. |
1994-08-24 |
2023-08-12 |
rat |
| E A Kiyatki. Changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. Brain research. vol 642. issue 1-2. 1994-08-16. PMID:8032884. |
changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. |
1994-08-16 |
2023-08-12 |
rat |
| E A Kiyatki. Changes in dopamine-dependent electrochemical signal in the nucleus accumbens associated with repeated cocaine injections in rats. Brain research. vol 642. issue 1-2. 1994-08-16. PMID:8032884. |
high-speed chronoamperometry with nafion-coated monoamine-sensitive electrodes was used to evaluate changes in the extracellular dopamine (da) concentrations in the nucleus accumbens following each of a series of daily cocaine injections (15 mg/kg, i.p. |
1994-08-16 |
2023-08-12 |
rat |
| S P Gygi, J W Gibb, G R Hanso. Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:7913495. |
the effects of two antipsychotic (dopamine antagonist) drugs, haloperidol and clozapine, and of two psychotomimetic (dopamine-releasing) drugs, methamphetamine and cocaine, on neurotensin (nt) concentrations in discrete regions of the caudate nucleus, nucleus accumbens and globus pallidus were examined. |
1994-08-15 |
2023-08-12 |
Not clear |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
chronic cocaine administration produced a significant decrease in the uptake of [3h]dopamine into the frontal cortex (49%) with no significant differences in the nucleus accumbens or striatum. |
1994-08-15 |
2023-08-12 |
rat |
| J M Masserano, D Venable, R J Wyat. Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035309. |
in addition, the ic50 values for gbr 12909 and cocaine in the frontal cortex were significantly greater than values for either compound in the nucleus accumbens or striatum. |
1994-08-15 |
2023-08-12 |
rat |
| A Gratton, R A Wis. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027767. |
high-speed chronoamperometry was used to determine the moment-to-moment and day-to-day changes in dopamine-related electrochemical signals in the nucleus accumbens of rats allowed to self-administer cocaine (0.8 mg/kg/injection) intravenously. |
1994-08-11 |
2023-08-12 |
rat |
| A Gratton, R A Wis. Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027767. |
thus, the effects of cocaine on da-associated signals in nucleus accumbens (1) changed dramatically during the development of the self-administration habit and (2) depended on environmental and behavioral as well as pharmacological factors. |
1994-08-11 |
2023-08-12 |
rat |
| S E Hemby, G H Jones, G W Hubert, D B Neill, J B Justic. Assessment of the relative contribution of peripheral and central components in cocaine place conditioning. Pharmacology, biochemistry, and behavior. vol 47. issue 4. 1994-08-08. PMID:8029272. |
the first experiment was conducted to examine changes in locomotor activity and extracellular dopamine (da) concentrations in the nucleus accumbens (nacc) following intraperitoneal (ip) injections of cocaine hcl (15 mg/kg) or cocaine methiodide (19.6 mg/kg). |
1994-08-08 |
2023-08-12 |
Not clear |
| N S Pilotte, L G Sharpe, M J Kuha. Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:7912283. |
withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of lewis rats. |
1994-07-26 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, M J Kuha. Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:7912283. |
animals given only 1/10 of the cocaine dose had no changes in nucleus accumbens after 10 days of administration and 10 days of withdrawal. |
1994-07-26 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
the effects of 7 days repeated cocaine administration on the dynamics of dopamine release and metabolism in four rat brain regions (frontal cortex, hypothalamus, nucleus accumbens and striatum) were evaluated 1 week (long-term effects) after the final cocaine injection. |
1994-07-13 |
2023-08-12 |
rat |
| F Karoum, M F Egan, R J Wyat. Selective reduction in dopamine turnover in the rat frontal cortex and hypothalamus during withdrawal from repeated cocaine exposure. European journal of pharmacology. vol 254. issue 1-2. 1994-07-13. PMID:8206108. |
consistent with a previous report, cocaine withdrawal was associated with marked reductions in dopac rate of formation in the frontal cortex and hypothalamus but not in the nucleus accumbens or the striatum. |
1994-07-13 |
2023-08-12 |
rat |