| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
on the next day, rats were challenged with an acute dose of cocaine administered by one of two routes (systemic or intracranial), and extra-cellular dopamine (da) in the nucleus accumbens (acb) was measured by in vivo microdialysis. |
1996-04-10 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
rats acutely challenged systemically with 20 mg/kg cocaine showed enhanced acb extracellular da levels (compared to control rats that had not previously received chronic cocaine). |
1996-04-10 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
however, rats acutely challenged with intracranial cocaine by perfusion of 10(-5) m cocaine directly into the acb did not. |
1996-04-10 |
2023-08-12 |
rat |
| J Chen, R Marmur, W Paredes, A Pulles, E L Gardne. Systemic cocaine challenge after chronic cocaine treatment reveals sensitization of extracellular dopamine levels in nucleus accumbens but direct cocaine perfusion into nucleus accumbens does not: implications for the neural locus of cocaine sensitization. Life sciences. vol 58. issue 8. 1996-04-10. PMID:8594313. |
it is suggested that both the development and triggering of cocaine sensitization, as manifested by enhanced acb da content to subsequent acute cocaine challenge, may involve more than just neural mechanisms occurring locally within the acb. |
1996-04-10 |
2023-08-12 |
rat |
| A V Azaryan, L J Coughlin, B Búzás, B J Clock, B M Co. Effect of chronic cocaine treatment on mu- and delta-opioid receptor mRNA levels in dopaminergically innervated brain regions. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592112. |
a significant increase in the level of mor mrna was detected in nucleus accumbens after 3 days of cocaine treatment. |
1996-04-03 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. |
1996-04-03 |
2023-08-12 |
rat |
| M Y Li, Q S Yan, L L Coffey, M E Reit. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592125. |
the present results suggest a contribution of the increase in norepinephrine, but not serotonin, to the enhancement of dopamine after cocaine applied focally in the nucleus accumbens. |
1996-04-03 |
2023-08-12 |
rat |
| S B Caine, S C Heinrichs, V L Coffin, G F Koo. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain research. vol 692. issue 1-2. 1996-02-20. PMID:8548319. |
these results support a role for d-1 dopamine receptors in the nucleus accumbens and amygdala in the effects of self-administered cocaine, and suggest that d-1 receptors in certain portions of the 'extended amygdala' may be an important substrate for the reinforcing actions of cocaine. |
1996-02-20 |
2023-08-12 |
rat |
| H E Nye, B T Hope, M B Kelz, M Iadarola, E J Nestle. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531143. |
pharmacological studies of the regulation of chronic fos-related antigen induction by cocaine in the striatum and nucleus accumbens. |
1996-02-01 |
2023-08-12 |
rat |
| H E Nye, B T Hope, M B Kelz, M Iadarola, E J Nestle. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531143. |
previous work has demonstrated that chronic administration of cocaine induces apparently novel fos-like transcription factors, termed chronic fras (fos-related antigens), in the rat striatum and nucleus accumbens. |
1996-02-01 |
2023-08-12 |
rat |
| H E Nye, B T Hope, M B Kelz, M Iadarola, E J Nestle. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531143. |
pretreatment with a d1 receptor antagonist, which did not affect chronic fra levels by itself, attenuated cocaine induction of the chronic fras in striatum and nucleus accumbens. |
1996-02-01 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. |
1995-12-07 |
2023-08-12 |
rat |
| R A Wise, P Newton, K Leeb, B Burnette, D Pocock, J B Justic. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology. vol 120. issue 1. 1995-12-07. PMID:7480530. |
fluctuations in extracellular dopamine and dopac levels in nucleus accumbens septi (nas) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. |
1995-12-07 |
2023-08-12 |
rat |
| J A Smith, Q Mo, H Guo, P M Kunko, S E Robinso. Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens. Brain research. vol 683. issue 2. 1995-11-21. PMID:7552364. |
cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens. |
1995-11-21 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
inhibitory effects of dopamine and methylenedioxymethamphetamine (mdma) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
one to 11 days after the last cocaine exposure, rats were anesthetized with urethane and effects of microiontophoretically-applied dopamine on glutamate-evoked firing of neurons in the nucleus accumbens and in the caudate/putamen were tested. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
dopamine produced a dose-dependent inhibition of glutamate-evoked firing in both the nucleus accumbens and the caudate/putamen of rats that had been repeatedly exposed to self-administered cocaine and in control rats. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
following cessation of repeated cocaine self-administration sessions, nucleus accumbens cells were also sensitized to the inhibitory effects of methylenedioxymethamphetamine (mdma), a drug that increases extracellular levels of da and serotonin in the nucleus accumbens. |
1995-11-06 |
2023-08-12 |
rat |
| S R White, G C Harris, K M Imel, M J Wheato. Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are enhanced following cocaine self-administration. Brain research. vol 681. issue 1-2. 1995-11-06. PMID:7552276. |
this sensitization to da- and mdma-induced inhibition in the nucleus accumbens and in the striatum indicates that long-term neuroadaptations occur in these regions of the nervous system following repeated exposure to self-administered cocaine. |
1995-11-06 |
2023-08-12 |
rat |
| L H Parsons, G F Koob, F Weis. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562486. |
serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. |
1995-10-25 |
2023-08-12 |
rat |