| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
to investigate the functional consequences of such opioid receptor changes, adenylyl cyclase activity was measured in rat nucleus accumbens and caudate putamen following continuous cocaine administration (50 mg/kg/day, 7 days). |
1996-12-05 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
in the nucleus accumbens chronic cocaine led to an increase in both the number of mu-opioid receptors and the maximal inhibition of adenylyl cyclase activity by damgo ([d-ala2,n-methyl-phe4,glyol]enkephalin). |
1996-12-05 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
thus, continuous cocaine administration for 7 days results in a selective increase in mu-opioid receptor-mediated effector function in the nucleus accumbens. |
1996-12-05 |
2023-08-12 |
rat |
| L H Parsons, G F Koob, F Weis. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788507. |
extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. |
1996-12-04 |
2023-08-12 |
human |
| L H Parsons, G F Koob, F Weis. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788507. |
to explore the neurochemical basis for this hypothesis, we used in vivo microdialysis to monitor extracellular serotonin (5-ht) in the nucleus accumbens of the rat both during and for several hours after unlimited-access intravenous cocaine self-administration. |
1996-12-04 |
2023-08-12 |
human |
| L H Parsons, G F Koob, F Weis. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788507. |
together these results indicate that extracellular 5-ht is significantly decreased in the nucleus accumbens during withdrawal from cocaine self-administration. |
1996-12-04 |
2023-08-12 |
human |
| R Martin-Fardon, M Arnaud, E Rousseau, J M Kamenka, A Privat, J Vigno. N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine induce similar effects on striatal dopamine: a microdialysis study in freely moving rats. Neuroscience letters. vol 211. issue 3. 1996-12-04. PMID:8817570. |
for doses inducing similar behavioral effects (cocaine, 20mg/kg; btcp, 10 mg/kg) similar da increases were observed in the striatum and the nucleus accumbens. |
1996-12-04 |
2023-08-12 |
rat |
| M A Gerrits, J M Van Re. Effect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats. Brain research. vol 713. issue 1-2. 1996-12-03. PMID:8724982. |
effect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats. |
1996-12-03 |
2023-08-12 |
rat |
| S D Glick, S M Pearl, J Cai, I M Maisonneuv. Ibogaine-like effects of noribogaine in rats. Brain research. vol 713. issue 1-2. 1996-12-03. PMID:8725004. |
noribogaine (40 mg/kg) was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum. |
1996-12-03 |
2023-08-12 |
rat |
| G C Harris, M A Hedaya, W J Pan, P Kaliva. beta-adrenergic antagonism alters the behavioral and neurochemical responses to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866703. |
in experiment 2, propranolol was shown to augment significantly the increase in extracellular dopamine content in the nucleus accumbens that accompanies a cocaine challenge. |
1996-12-03 |
2023-08-12 |
rat |
| J Ortiz, L W Fitzgerald, S Lane, R Terwilliger, E J Nestle. Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 6. 1996-11-27. PMID:8726755. |
we have demonstrated previously that chronic administration of morphine, cocaine, or ethanol produces some common biochemical adaptations in the ventral tegmental area (vta) and nucleus accumbens (nac), components of the mesolimbic dopamine system implicated in the reinforcing and locomotor activating properties of these drugs of abuse. |
1996-11-27 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, S D Rountree, M J Kuha. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822482. |
cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. |
1996-11-08 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, S D Rountree, M J Kuha. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822482. |
we have previously shown that withdrawal from repeated, intermittent infusions of cocaine in lewis rats results in a long-lasting reduction in dopamine transporter levels in the nucleus accumbens. |
1996-11-08 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, S D Rountree, M J Kuha. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822482. |
these results indicate that the limbic portions of the nucleus accumbens are involved in neurochemical adaptations during withdrawal from cocaine. |
1996-11-08 |
2023-08-12 |
rat |
| Y Egilmez, M E Jung, J D Lane, M W Emmett-Oglesb. Dopamine release during cocaine self-administration in rats: effect of SCH23390. Brain research. vol 701. issue 1-2. 1996-10-25. PMID:8925277. |
this experiment tested the hypotheses that: (1) self-administration of cocaine would produce an increase in dopamine (da) oxidation current in the nucleus accumbens (n. |
1996-10-25 |
2023-08-12 |
rat |
| G S Schuelke, R J Konkol, L C Terry, J A Madde. Effect of cocaine metabolites on behavior: possible neuroendocrine mechanisms. Brain research bulletin. vol 39. issue 1. 1996-10-24. PMID:8846107. |
direct injection of eme into the nucleus accumbens significantly suppressed systemic cocaine potentiation of intracranial electrical self-stimulation of the ventral tegmental area, whereas corticotropin releasing hormone injected icv selectively potentiated be-induced seizures and death. |
1996-10-24 |
2023-08-12 |
human |
| J B Daunais, J F McGint. The effects of D1 or D2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge. Brain research. Molecular brain research. vol 35. issue 1-2. 1996-10-11. PMID:8717360. |
quantitative image analysis of autoradiograms revealed that (1) sch 23390 completely suppressed basal and cocaine binge-induced zif/268 mrna in the striatal and cerebral cortical areas examined; (2) sulpiride enhanced basal levels of zif/268 mrna in the medial caudate and dorsomedial shell of the nucleus accumbens; (3) sulpiride partially blocked cocaine binge-induced levels of zif/268 mrna in the dorsal striatum but had no effect in sensory cortex; (4) sch 23390, but not sulpiride, significantly reduced the constitutive expression of preprodynorphin mrna; and (5) sch 23390 and sulpiride blocked cocaine binge-induced expression of preprodynorphin mrna in the dorsal striatum. |
1996-10-11 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
neurochemical evidence that postsynaptic nucleus accumbens d3 receptor stimulation enhances cocaine reinforcement. |
1996-10-02 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
the mechanism by which two d3 receptor-preferring agonists, 7-hydroxydipropylaminotetralin (7-oh-dpat) and quinelorane, modulate cocaine reinforcement was examined by monitoring nucleus accumbens dopamine levels with in vivo microdialysis while rats intravenously self-administered the following four different drug solutions consecutively: (1) cocaine; (2) a combination of cocaine plus a low dose of either agonist; (3) either agonist alone; and finally, (4) a physiological saline solution. |
1996-10-02 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
both 7-oh-dpat (4 micrograms/infusion) and quinelorane (0.25 microgram/infusion) decreased cocaine (0.25 mg/infusion) intake in a manner indicating an enhancement of cocaine reinforcement and simultaneously decreased the cocaine-induced elevations in nucleus accumbens dopamine levels by > 50%. |
1996-10-02 |
2023-08-12 |
rat |