| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N S Pilotte, L G Sharpe, S D Rountree, M J Kuha. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822482. |
we have previously shown that withdrawal from repeated, intermittent infusions of cocaine in lewis rats results in a long-lasting reduction in dopamine transporter levels in the nucleus accumbens. |
1996-11-08 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, S D Rountree, M J Kuha. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822482. |
these results indicate that the limbic portions of the nucleus accumbens are involved in neurochemical adaptations during withdrawal from cocaine. |
1996-11-08 |
2023-08-12 |
rat |
| Y Egilmez, M E Jung, J D Lane, M W Emmett-Oglesb. Dopamine release during cocaine self-administration in rats: effect of SCH23390. Brain research. vol 701. issue 1-2. 1996-10-25. PMID:8925277. |
this experiment tested the hypotheses that: (1) self-administration of cocaine would produce an increase in dopamine (da) oxidation current in the nucleus accumbens (n. |
1996-10-25 |
2023-08-12 |
rat |
| G S Schuelke, R J Konkol, L C Terry, J A Madde. Effect of cocaine metabolites on behavior: possible neuroendocrine mechanisms. Brain research bulletin. vol 39. issue 1. 1996-10-24. PMID:8846107. |
direct injection of eme into the nucleus accumbens significantly suppressed systemic cocaine potentiation of intracranial electrical self-stimulation of the ventral tegmental area, whereas corticotropin releasing hormone injected icv selectively potentiated be-induced seizures and death. |
1996-10-24 |
2023-08-12 |
human |
| J B Daunais, J F McGint. The effects of D1 or D2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge. Brain research. Molecular brain research. vol 35. issue 1-2. 1996-10-11. PMID:8717360. |
quantitative image analysis of autoradiograms revealed that (1) sch 23390 completely suppressed basal and cocaine binge-induced zif/268 mrna in the striatal and cerebral cortical areas examined; (2) sulpiride enhanced basal levels of zif/268 mrna in the medial caudate and dorsomedial shell of the nucleus accumbens; (3) sulpiride partially blocked cocaine binge-induced levels of zif/268 mrna in the dorsal striatum but had no effect in sensory cortex; (4) sch 23390, but not sulpiride, significantly reduced the constitutive expression of preprodynorphin mrna; and (5) sch 23390 and sulpiride blocked cocaine binge-induced expression of preprodynorphin mrna in the dorsal striatum. |
1996-10-11 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
neurochemical evidence that postsynaptic nucleus accumbens d3 receptor stimulation enhances cocaine reinforcement. |
1996-10-02 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
the mechanism by which two d3 receptor-preferring agonists, 7-hydroxydipropylaminotetralin (7-oh-dpat) and quinelorane, modulate cocaine reinforcement was examined by monitoring nucleus accumbens dopamine levels with in vivo microdialysis while rats intravenously self-administered the following four different drug solutions consecutively: (1) cocaine; (2) a combination of cocaine plus a low dose of either agonist; (3) either agonist alone; and finally, (4) a physiological saline solution. |
1996-10-02 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
both 7-oh-dpat (4 micrograms/infusion) and quinelorane (0.25 microgram/infusion) decreased cocaine (0.25 mg/infusion) intake in a manner indicating an enhancement of cocaine reinforcement and simultaneously decreased the cocaine-induced elevations in nucleus accumbens dopamine levels by > 50%. |
1996-10-02 |
2023-08-12 |
rat |
| L H Parsons, S B Caine, P Sokoloff, J C Schwartz, G F Koob, F Weis. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752115. |
these findings indicate that postsynaptic d3 receptor stimulation in the nucleus accumbens enhances the reinforcing properties of cocaine. |
1996-10-02 |
2023-08-12 |
rat |
| D Boulay, D Duterte-Boucher, I Leroux-Nicollet, L Naudon, J Costenti. Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine. The Journal of pharmacology and experimental therapeutics. vol 278. issue 1. 1996-09-23. PMID:8764367. |
locomotor sensitization and decrease in [3h]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by gbr12783 or cocaine. |
1996-09-23 |
2023-08-12 |
rat |
| M S Reid, K Hsu, B K Tolliver, C A Crawford, S P Berge. Evidence for the involvement of phospholipase A2 mechanisms in the development of stimulant sensitization. The Journal of pharmacology and experimental therapeutics. vol 276. issue 3. 1996-09-20. PMID:8786557. |
local injections of melittin (0.1 microgram/0.4 microliter) into the ventral tegmental area sensitized the subsequent stimulation of locomotor activity, stereotypy and nucleus accumbens dopamine release by cocaine, when tested 72 hr later. |
1996-09-20 |
2023-08-12 |
rat |
| G F Koob, B Caine, A Markou, L Pulvirenti, F Weis. Role for the mesocortical dopamine system in the motivating effects of cocaine. NIDA research monograph. vol 145. 1996-09-18. PMID:8742805. |
this mesocorticolimbic da system innervates the region of the nucleus accumbens (nacc) (ventral striatum) in the anterior part of the basal forebrain and appears to play a critical role in mediating the acute reinforcing effects of cocaine and amphetamine. |
1996-09-18 |
2023-08-12 |
rat |
| C A Heidbreder, A C Thompson, T S Shippenber. Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768696. |
the present study sought to characterize basal dialysate dopamine (da) concentrations within the nucleus accumbens (nac), 2, 12 or 22 days after the cessation of either repeated cocaine (20 mg/kg/day x 5 days) or saline (1.0 ml/kg/day x 5 days) treatment. |
1996-09-18 |
2023-08-12 |
Not clear |
| J D Wagstaff, J W Gibb, G R Hanso. Microdialysis assessment of methamphetamine-induced changes in extracellular neurotensin in the striatum and nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768703. |
stimulants of abuse such as cocaine and methamphetamine (meth) have dramatic effects on tissue neurotensin (nt) levels in the striatum and nucleus accumbens. |
1996-09-18 |
2023-08-12 |
rat |
| R C Pierce, K Bell, P Duffy, P W Kaliva. Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 4. 1996-09-18. PMID:8778304. |
repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. |
1996-09-18 |
2023-08-12 |
rat |
| R C Pierce, K Bell, P Duffy, P W Kaliva. Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 4. 1996-09-18. PMID:8778304. |
at 2-3 weeks after the last daily injection, four experiments were performed to assess changes in excitatory amino acid (eaa) transmission in the nucleus accumbens produced by repeated cocaine administration. |
1996-09-18 |
2023-08-12 |
rat |
| R C Pierce, K Bell, P Duffy, P W Kaliva. Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 4. 1996-09-18. PMID:8778304. |
these results indicate that repeated cocaine administration increases eaa transmission in the nucleus accumbens only in rats that develop behavioral sensitization to cocaine. |
1996-09-18 |
2023-08-12 |
rat |
| B A Morrow, J R Taylor, R H Rot. Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: reversal by glycine/N-methyl-D-aspartate antagonist co-treatment. Neuroscience. vol 69. issue 1. 1996-07-08. PMID:8637621. |
additionally, the elevated metabolic activity of dopamine in the medial prefrontal cortex, nucleus accumbens and ventral tegmental area associated with aversive conditioning was diminished in rats pre-exposed to cocaine. |
1996-07-08 |
2023-08-12 |
rat |
| L L Peoples, M O Wes. Phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627379. |
phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration. |
1996-06-21 |
2023-08-12 |
rat |
| L L Peoples, M O Wes. Phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627379. |
to examine potential neural mechanisms involved in cocaine self-administration, the activity of single neurons in the nucleus accumbens of rats was recorded during intravenous cocaine self-administration. |
1996-06-21 |
2023-08-12 |
rat |