| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' B Przew\\xc5\\x82ocka, W Laso\\xc5\\x8. Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5. issue 4. 1997-01-17. PMID:8998398.' |
the effects of single and repeated cocaine administration on proenkephalin (penk) and d2 dopamine receptor mrna expression in the nucleus accumbens and striatum of the rat were studied. |
1997-01-17 |
2023-08-12 |
rat |
| b' B Przew\\xc5\\x82ocka, W Laso\\xc5\\x8. Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5. issue 4. 1997-01-17. PMID:8998398.' |
the obtained results suggest that in the nucleus accumbens and striatum there is an opposite regulation between penk and d2 receptor gene expression a short time after single and chronic cocaine administration. |
1997-01-17 |
2023-08-12 |
rat |
| L M Teneud, T Baptista, E Murzi, B G Hoebel, L Hernande. Systemic and local cocaine increase extracellular serotonin in the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 53. issue 3. 1997-01-15. PMID:8866981. |
systemic and local cocaine increase extracellular serotonin in the nucleus accumbens. |
1997-01-15 |
2023-08-12 |
rat |
| L M Teneud, T Baptista, E Murzi, B G Hoebel, L Hernande. Systemic and local cocaine increase extracellular serotonin in the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 53. issue 3. 1997-01-15. PMID:8866981. |
the effect of systemic or intra-accumbens injections of cocaine on serotonin (5-ht) overflow was studied by nucleus accumbens microdialysis in freely moving rats. |
1997-01-15 |
2023-08-12 |
rat |
| L M Teneud, T Baptista, E Murzi, B G Hoebel, L Hernande. Systemic and local cocaine increase extracellular serotonin in the nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 53. issue 3. 1997-01-15. PMID:8866981. |
these experiments suggest that systemic cocaine acts on the nucleus accumbens to increase synaptic 5-ht. |
1997-01-15 |
2023-08-12 |
rat |
| M Xu, X T Hu, D C Cooper, F J White, S Tonegaw. A genetic approach to study mechanisms of cocaine action. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959023. |
extracellular single unit recording of dopamine sensitive nucleus accumbens neurons in the d1 receptor mutant mice and control mice revealed a marked reduction in the inhibitory effects of cocaine and dopamine on the generation of action potentials, suggesting that d1 receptors play a fundamental role in cocaine- and dopamine-mediated neurophysiological effects within the nucleus accumbens. |
1997-01-08 |
2023-08-12 |
mouse |
| K A Benson, S F Ali, M C Wilso. The effects of prenatal cocaine exposure on dopaminergic challenge and receptor binding in Wistar rats. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959041. |
alterations in the dopaminergic system at maturity were evaluated using pharmacological challenges with amphetamine and cocaine and by measuring d1 and d2 receptor binding in the nucleus accumbens and caudate nucleus. |
1997-01-08 |
2023-08-12 |
rat |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. |
1997-01-06 |
2023-08-12 |
rat |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
chronic ensemble recording techniques were used to investigate neuronal activity in the nucleus accumbens in freely moving rats during different cocaine self-administration schedules. |
1997-01-06 |
2023-08-12 |
rat |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
the issue of concern in this study was the role of nucleus accumbens in initiating and sustaining cocaine self-administration. |
1997-01-06 |
2023-08-12 |
rat |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
phasic alterations in neural spike activity were observed in 50% of nucleus accumbens neurons before (termed "anticipatory" responses) and after lever pressing for cocaine self-administration. |
1997-01-06 |
2023-08-12 |
rat |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
the results suggest that nucleus accumbens may be involved in initiating general reward-seeking behaviors and action which are not exclusively associated with cocaine self-administration. |
1997-01-06 |
2023-08-12 |
rat |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
moreover, the neuronal responses in the nucleus accumbens to cocaine self-administration may play an essential role in maintaining cocaine reinforcement. |
1997-01-06 |
2023-08-12 |
rat |
| S M Nicola, S B Kombian, R C Malenk. Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 5. 1997-01-03. PMID:8774428. |
the effects of dopamine (da) and the psychostimulants cocaine and amphetamine on excitatory transmission in the nucleus accumbens (nac) were examined in rat nac slices using both extracellular-field and whole-cell patch-clamp recording. |
1997-01-03 |
2023-08-12 |
mouse |
| J Ortiz, L W Fitzgerald, M Charlton, S Lane, L Trevisan, X Guitart, W Shoemaker, R S Duman, E J Nestle. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869159. |
in previous studies, we have demonstrated that chronic administration of morphine or cocaine produces some common biochemical adaptations in the ventral tegmental area (vta) and nucleus accumbens (nac), components of the mesolimbic dopamine system implicated in the reinforcing actions of these and other drugs of abuse. |
1997-01-03 |
2023-08-12 |
Not clear |
| J K Staley, J W Boja, F I Carroll, H H Seltzman, C D Wyrick, A H Lewin, P Abraham, D C Mas. Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869167. |
autoradiographic mapping of [125i]rti-121 revealed very high densities of cocaine recognition sites over areas known to be rich in dopaminergic innervation, including the caudate, putamen, and nucleus accumbens. |
1997-01-03 |
2023-08-12 |
human |
| A Dalia, L J Wallac. Amphetamine induction of c-fos in the nucleus accumbens is not inhibited by glutamate antagonists. Brain research. vol 694. issue 1-2. 1996-12-27. PMID:8974658. |
systemic administration of relatively high doses of amphetamine or cocaine induces expression of c-fos in the rat striatum and nucleus accumbens. |
1996-12-27 |
2023-08-12 |
rat |
| M S Reid, S P Berge. Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release. Neuroreport. vol 7. issue 7. 1996-12-10. PMID:8817559. |
cocaine-stimulated glutamate release in the nucleus accumbens was studied following chronic cocaine or saline pretreatment in order to determine whether this effect was sensitized in rats showing augmented dopamine release, locomotor and stereotypy responses. |
1996-12-10 |
2023-08-12 |
rat |
| M S Reid, S P Berge. Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release. Neuroreport. vol 7. issue 7. 1996-12-10. PMID:8817559. |
these results show that cocaine-stimulated glutamate release in the nucleus accumbens is sensitized following chronic cocaine pretreatment. |
1996-12-10 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. |
1996-12-05 |
2023-08-12 |
rat |