| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Y Chang, J M Paris, S F Sawyer, A B Kirillov, D J Woodwar. Neuronal spike activity in rat nucleus accumbens during cocaine self-administration under different fixed-ratio schedules. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865199. |
moreover, the neuronal responses in the nucleus accumbens to cocaine self-administration may play an essential role in maintaining cocaine reinforcement. |
1997-01-06 |
2023-08-12 |
rat |
| S M Nicola, S B Kombian, R C Malenk. Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 5. 1997-01-03. PMID:8774428. |
the effects of dopamine (da) and the psychostimulants cocaine and amphetamine on excitatory transmission in the nucleus accumbens (nac) were examined in rat nac slices using both extracellular-field and whole-cell patch-clamp recording. |
1997-01-03 |
2023-08-12 |
mouse |
| J Ortiz, L W Fitzgerald, M Charlton, S Lane, L Trevisan, X Guitart, W Shoemaker, R S Duman, E J Nestle. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869159. |
in previous studies, we have demonstrated that chronic administration of morphine or cocaine produces some common biochemical adaptations in the ventral tegmental area (vta) and nucleus accumbens (nac), components of the mesolimbic dopamine system implicated in the reinforcing actions of these and other drugs of abuse. |
1997-01-03 |
2023-08-12 |
Not clear |
| J K Staley, J W Boja, F I Carroll, H H Seltzman, C D Wyrick, A H Lewin, P Abraham, D C Mas. Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869167. |
autoradiographic mapping of [125i]rti-121 revealed very high densities of cocaine recognition sites over areas known to be rich in dopaminergic innervation, including the caudate, putamen, and nucleus accumbens. |
1997-01-03 |
2023-08-12 |
human |
| A Dalia, L J Wallac. Amphetamine induction of c-fos in the nucleus accumbens is not inhibited by glutamate antagonists. Brain research. vol 694. issue 1-2. 1996-12-27. PMID:8974658. |
systemic administration of relatively high doses of amphetamine or cocaine induces expression of c-fos in the rat striatum and nucleus accumbens. |
1996-12-27 |
2023-08-12 |
rat |
| M S Reid, S P Berge. Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release. Neuroreport. vol 7. issue 7. 1996-12-10. PMID:8817559. |
cocaine-stimulated glutamate release in the nucleus accumbens was studied following chronic cocaine or saline pretreatment in order to determine whether this effect was sensitized in rats showing augmented dopamine release, locomotor and stereotypy responses. |
1996-12-10 |
2023-08-12 |
rat |
| M S Reid, S P Berge. Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release. Neuroreport. vol 7. issue 7. 1996-12-10. PMID:8817559. |
these results show that cocaine-stimulated glutamate release in the nucleus accumbens is sensitized following chronic cocaine pretreatment. |
1996-12-10 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. |
1996-12-05 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
to investigate the functional consequences of such opioid receptor changes, adenylyl cyclase activity was measured in rat nucleus accumbens and caudate putamen following continuous cocaine administration (50 mg/kg/day, 7 days). |
1996-12-05 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
in the nucleus accumbens chronic cocaine led to an increase in both the number of mu-opioid receptors and the maximal inhibition of adenylyl cyclase activity by damgo ([d-ala2,n-methyl-phe4,glyol]enkephalin). |
1996-12-05 |
2023-08-12 |
rat |
| S Izenwasser, B Heller, B M Co. Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. European journal of pharmacology. vol 297. issue 1-2. 1996-12-05. PMID:8851182. |
thus, continuous cocaine administration for 7 days results in a selective increase in mu-opioid receptor-mediated effector function in the nucleus accumbens. |
1996-12-05 |
2023-08-12 |
rat |
| L H Parsons, G F Koob, F Weis. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788507. |
extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. |
1996-12-04 |
2023-08-12 |
human |
| L H Parsons, G F Koob, F Weis. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788507. |
to explore the neurochemical basis for this hypothesis, we used in vivo microdialysis to monitor extracellular serotonin (5-ht) in the nucleus accumbens of the rat both during and for several hours after unlimited-access intravenous cocaine self-administration. |
1996-12-04 |
2023-08-12 |
human |
| L H Parsons, G F Koob, F Weis. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788507. |
together these results indicate that extracellular 5-ht is significantly decreased in the nucleus accumbens during withdrawal from cocaine self-administration. |
1996-12-04 |
2023-08-12 |
human |
| R Martin-Fardon, M Arnaud, E Rousseau, J M Kamenka, A Privat, J Vigno. N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine induce similar effects on striatal dopamine: a microdialysis study in freely moving rats. Neuroscience letters. vol 211. issue 3. 1996-12-04. PMID:8817570. |
for doses inducing similar behavioral effects (cocaine, 20mg/kg; btcp, 10 mg/kg) similar da increases were observed in the striatum and the nucleus accumbens. |
1996-12-04 |
2023-08-12 |
rat |
| M A Gerrits, J M Van Re. Effect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats. Brain research. vol 713. issue 1-2. 1996-12-03. PMID:8724982. |
effect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats. |
1996-12-03 |
2023-08-12 |
rat |
| S D Glick, S M Pearl, J Cai, I M Maisonneuv. Ibogaine-like effects of noribogaine in rats. Brain research. vol 713. issue 1-2. 1996-12-03. PMID:8725004. |
noribogaine (40 mg/kg) was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum. |
1996-12-03 |
2023-08-12 |
rat |
| G C Harris, M A Hedaya, W J Pan, P Kaliva. beta-adrenergic antagonism alters the behavioral and neurochemical responses to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866703. |
in experiment 2, propranolol was shown to augment significantly the increase in extracellular dopamine content in the nucleus accumbens that accompanies a cocaine challenge. |
1996-12-03 |
2023-08-12 |
rat |
| J Ortiz, L W Fitzgerald, S Lane, R Terwilliger, E J Nestle. Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 6. 1996-11-27. PMID:8726755. |
we have demonstrated previously that chronic administration of morphine, cocaine, or ethanol produces some common biochemical adaptations in the ventral tegmental area (vta) and nucleus accumbens (nac), components of the mesolimbic dopamine system implicated in the reinforcing and locomotor activating properties of these drugs of abuse. |
1996-11-27 |
2023-08-12 |
rat |
| N S Pilotte, L G Sharpe, S D Rountree, M J Kuha. Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822482. |
cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. |
1996-11-08 |
2023-08-12 |
rat |