| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Philpot, C L Kirstei. Repeated cocaine exposure: effects on catecholamines in the nucleus accumbens septi of periadolescent animals. Pharmacology, biochemistry, and behavior. vol 62. issue 3. 1999-05-17. PMID:10080238. |
for this reason, the present study examined the effects of repeated cocaine administration on the responsiveness of the nucleus accumbens septi (nacc) to either cocaine or saline challenge. |
1999-05-17 |
2023-08-12 |
Not clear |
| G A Gerhardt, C Ksir, C Pivik, S D Dickinson, J Sabeti, N R Zahnise. Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely-moving rats. Journal of neuroscience methods. vol 87. issue 1. 1999-05-07. PMID:10065995. |
finally, the concurrent effects of systemic cocaine injection on da uptake in nucleus accumbens and locomotor activity were examined. |
1999-05-07 |
2023-08-12 |
rat |
| W J Pan, M A Heday. Cocaine and alcohol interactions in the rat: effect on cocaine pharmacokinetics and pharmacodynamics. Journal of pharmaceutical sciences. vol 88. issue 4. 1999-05-07. PMID:10187758. |
the neurochemical response to cocaine administration, measured as the change in dopamine concentration in the nucleus accumbens (n acc) and the change in the mean arterial blood pressure were monitored simultaneously. |
1999-05-07 |
2023-08-12 |
rat |
| L L Peoples, A J Uzwiak, F Gee, M O Wes. Tonic firing of rat nucleus accumbens neurons: changes during the first 2 weeks of daily cocaine self-administration sessions. Brain research. vol 822. issue 1-2. 1999-04-21. PMID:10082901. |
tonic firing of rat nucleus accumbens neurons: changes during the first 2 weeks of daily cocaine self-administration sessions. |
1999-04-21 |
2023-08-12 |
rat |
| L L Peoples, A J Uzwiak, F Gee, M O Wes. Tonic firing of rat nucleus accumbens neurons: changes during the first 2 weeks of daily cocaine self-administration sessions. Brain research. vol 822. issue 1-2. 1999-04-21. PMID:10082901. |
activity of single neurons in the nucleus accumbens (nacc) of rats was recorded extracellularly on the 2nd and 15th days of intravenous cocaine self-administration. |
1999-04-21 |
2023-08-12 |
rat |
| B K Tolliver, A H Newman, J L Katz, L B Ho, L M Fox, K Hsu, S P Berge. Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10086994. |
the current studies evaluated the novel diphenylmethoxytropane analog 4-chlorobenztropine (4-cl-bzt), cocaine, and combinations of the two drugs for their abilities to stimulate locomotor activity, produce cocaine-like discriminative stimulus effects, and elevate extracellular dopamine (da) in the nucleus accumbens (nac) as measured by in vivo microdialysis. |
1999-04-21 |
2023-08-12 |
rat |
| P A Broderick, M F Pierce. Neurochemical and behavioral evidence supporting (+)-AJ 76 as a potential pharmacotherapy for cocaine abuse. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 10-12. 1999-04-15. PMID:9928899. |
in vivo microvoltammetry was used to detect synaptic concentrations of dopamine (da) and serotonin (5-ht) from nucleus accumbens (nacc) in awake, freely moving, male, sprague dawley laboratory rats, while their locomotor behavior was monitored, simultaneously, in an open-field paradigm; the purpose was to evaluate the pharmacology of the d3-preferring, dopamine (da) autoreceptor antagonist, (+)-aj 76 [cis-(+)-1s, 2r-5-methoxy-1-methyl-2-(n-propylamino)-tetralin hcl] and its potential use as a pharmacotherapy for cocaine abuse. |
1999-04-15 |
2023-08-12 |
rat |
| I Sziráki, H Sershen, M Benuck, A Hashim, A Lajth. Receptor systems participating in nicotine-specific effects. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874095. |
in the present paper we compare the effects of receptor-specific antagonists on the increase of dopamine induced by nicotine with that induced by cocaine in the nucleus accumbens in conscious rats. |
1999-03-18 |
2023-08-12 |
rat |
| K Grasing, S Ghos. Selegiline prevents long-term changes in dopamine efflux and stress immobility during the second and third weeks of abstinence following opiate withdrawal. Neuropharmacology. vol 37. issue 8. 1999-02-26. PMID:9833630. |
brain slices obtained from the nucleus accumbens of opiate-withdrawn animals immediately following swim stress testing displayed diminished efflux of tritiated dopamine after two in vitro exposures to cocaine or amphetamine. |
1999-02-26 |
2023-08-12 |
human |
| A Y Deutch, M Bubser, C D Youn. Psychostimulant-induced Fos protein expression in the thalamic paraventricular nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 24. 1999-02-25. PMID:9852603. |
we examined the effects of acute amphetamine and cocaine administration on expression of fos protein in the thalamic paraventricular nucleus (pvt), which provides glutamatergic inputs to the nucleus accumbens and also receives dopaminergic afferents. |
1999-02-25 |
2023-08-12 |
Not clear |
| D J Henry, X T Hu, F J Whit. Adaptations in the mesoaccumbens dopamine system resulting from repeated administration of dopamine D1 and D2 receptor-selective agonists: relevance to cocaine sensitization. Psychopharmacology. vol 140. issue 2. 1999-02-25. PMID:9860115. |
among the adaptations implicated in cocaine sensitization are transient subsensitivity of impulse-regulating da d2 autoreceptors on ventral tegmental area (vta) da neurons leading to hyperactivity of the mesoaccumbens da pathway, and persistently enhanced da d1 receptor responses of nucleus accumbens (nac) neurons. |
1999-02-25 |
2023-08-12 |
rat |
| N Thiriet, N Humblot, C Burgun, D Aunis, J Zwille. Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase. Brain research. Molecular brain research. vol 62. issue 2. 1999-02-18. PMID:9813294. |
injection of cocaine, amphetamine and caffeine induced hvh-5 mrna expression within 40 min in the nucleus accumbens (nac), caudate putamen, frontal cortex and hippocampus, with a maximal effect in the nac. |
1999-02-18 |
2023-08-12 |
rat |
| A S Keys, G P Mark, N Emre, C K Meshu. Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse (New York, N.Y.). vol 30. issue 4. 1999-01-22. PMID:9826231. |
reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. |
1999-01-22 |
2023-08-12 |
rat |
| A S Keys, G P Mark, N Emre, C K Meshu. Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse (New York, N.Y.). vol 30. issue 4. 1999-01-22. PMID:9826231. |
alterations in the density of gaba and glutamate immunolabeling within nerve terminals in the shell region of the nucleus accumbens were assessed in rats withdrawn from intravenous cocaine exposure. |
1999-01-22 |
2023-08-12 |
rat |
| A S Keys, G P Mark, N Emre, C K Meshu. Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse (New York, N.Y.). vol 30. issue 4. 1999-01-22. PMID:9826231. |
these results demonstrate that glutamate density is suppressed in the shell region of the nucleus accumbens following withdrawal from 2 weeks of cocaine exposure. |
1999-01-22 |
2023-08-12 |
rat |
| J D Stekete. Injection of SCH 23390 into the ventral tegmental area blocks the development of neurochemical but not behavioral sensitization to cocaine. Behavioural pharmacology. vol 9. issue 1. 1998-12-29. PMID:9832950. |
motor activity and extracellular dopamine concentrations in the nucleus accumbens were monitored on the day the animals received the first of their four daily treatments and/or on the day animals received their cocaine challenge injection. |
1998-12-29 |
2023-08-12 |
Not clear |
| D J David, N R Zahniser, B J Hoffer, G A Gerhard. In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell. Experimental neurology. vol 153. issue 2. 1998-11-25. PMID:9784287. |
in addition, these data indicate that dats are more sensitive to the effects of psychomotor stimulants, such as cocaine, in the shell of the nucleus accumbens. |
1998-11-25 |
2023-08-12 |
rat |
| J L Neisewander, R A Fuchs, L E O'Dell, T V Khroya. Effects of SCH-23390 on dopamine D1 receptor occupancy and locomotion produced by intraaccumbens cocaine infusion. Synapse (New York, N.Y.). vol 30. issue 2. 1998-11-16. PMID:9723789. |
in experiment 2, rats received coinfusion of sch-23390 (0-1 microg/side) and cocaine (0 or 100 microg/side) into the nucleus accumbens (nac). |
1998-11-16 |
2023-08-12 |
rat |
| T H Lee, K R Gee, E H Ellinwood, F J Seidle. Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat. Psychopharmacology. vol 137. issue 3. 1998-10-28. PMID:9683008. |
altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat. |
1998-10-28 |
2023-08-12 |
rat |
| A V Azaryan, B J Clock, J G Rosenberger, B M Co. Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration. Canadian journal of physiology and pharmacology. vol 76. issue 3. 1998-10-22. PMID:9673791. |
transient upregulation of mu opioid receptor mrna levels in nucleus accumbens during chronic cocaine administration. |
1998-10-22 |
2023-08-12 |
rat |