| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Reith, M Y Li, Q S Ya. Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers. Psychopharmacology. vol 134. issue 3. 1998-02-26. PMID:9438681. |
extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers. |
1998-02-26 |
2023-08-12 |
rat |
| M T Bard. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Critical reviews in neurobiology. vol 12. issue 1-2. 1998-02-24. PMID:9444481. |
with amphetamine and cocaine, initiation of reward is controlled within the nucleus accumbens and prefrontal cortex, respectively. |
1998-02-24 |
2023-08-12 |
Not clear |
| P M Kunko, R J Loeloff, S Izenwasse. Chronic administration of the selective dopamine uptake inhibitor GBR 12,909, but not cocaine, produces marked decreases in dopamine transporter density. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 5. 1998-02-19. PMID:9402035. |
gbr 12,909 produced both tolerance to the inhibition of [3h]dopamine uptake by cocaine, and a decrease in total uptake of dopamine, in the caudate putamen, with no change in the nucleus accumbens. |
1998-02-19 |
2023-08-12 |
rat |
| G Tanda, F E Pontieri, R Frau, G Di Chiar. Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. The European journal of neuroscience. vol 9. issue 10. 1998-02-04. PMID:9421168. |
to this end, changes of extracellular da and na in the pfcx and of extracellular da in the nucleus accumbens (nac) were measured following the administration of amphetamine and cocaine, which are known to bind to both da and na carriers, or gbr 12909, a selective da carrier blocker. |
1998-02-04 |
2023-08-12 |
rat |
| F J White, A Joshi, T E Koeltzow, X T H. Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 1. 1998-01-30. PMID:9408916. |
high doses of sch 23390 alone produced supersensitivity to the behavioral effects of cocaine and to the inhibitory effects of d1 receptor agonists on nucleus accumbens neurons. |
1998-01-30 |
2023-08-12 |
Not clear |
| G Zernig, I A O'Laughlin, H C Fibige. Nicotine and heroin augment cocaine-induced dopamine overflow in nucleus accumbens. European journal of pharmacology. vol 337. issue 1. 1998-01-26. PMID:9389374. |
both nicotine + cocaine as well as heroin + cocaine stimulated nucleus accumbens dopamine overflow in an additive manner. |
1998-01-26 |
2023-08-12 |
rat |
| R J Moore, S L Vinsant, M A Nader, L J Porrino, D P Friedma. Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys. Synapse (New York, N.Y.). vol 28. issue 1. 1998-01-20. PMID:9414012. |
because the release of dopamine in the nucleus accumbens (nac) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound effects on drug-seeking and drug-taking behavior. |
1998-01-20 |
2023-08-12 |
monkey |
| R J Moore, S L Vinsant, M A Nader, L J Porrino, D P Friedma. Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys. Synapse (New York, N.Y.). vol 28. issue 1. 1998-01-20. PMID:9414012. |
in animals that self-administered cocaine, the density of d1 binding was significantly lower in the regions of the striatum at the level where the nucleus accumbens is most fully developed. |
1998-01-20 |
2023-08-12 |
monkey |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
the nucleus accumbens is a forebrain region that mediates cocaine self-administration and withdrawal effects in animal models of cocaine dependence. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
using a combination of current-clamp recordings in brain slices and whole-cell patch-clamp recordings from freshly dissociated neurons, we found that nucleus accumbens neurons are less excitable in cocaine withdrawn rats because of a novel form of plasticity: reduced whole-cell sodium currents. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
three days after discontinuation of repeated cocaine injections, nucleus accumbens neurons recorded in brain slices were less responsive to depolarizing current injections, had higher action potential thresholds, and had lower spike amplitudes. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
because nucleus accumbens neurons are normally recruited to coordinate response patterns of movement and affect, the decreased excitability during cocaine withdrawal may be related to symptoms such as anergia, anhedonia, and depression. |
1998-01-16 |
2023-08-12 |
rat |
| A J Uzwiak, F X Guyette, M O West, L L People. Neurons in accumbens subterritories of the rat: phasic firing time-locked within seconds of intravenous cocaine self-infusion. Brain research. vol 767. issue 2. 1998-01-15. PMID:9367270. |
individual neurons were recorded extracellularly in the nucleus accumbens (nacc) of rats during cocaine self-administration sessions. |
1998-01-15 |
2023-08-12 |
rat |
| F J White, X T Hu, X F Zhan. Neuroadaptations in nucleus accumbens neurons resulting from repeated cocaine administration. Advances in pharmacology (San Diego, Calif.). vol 42. 1997-11-25. PMID:9328068. |
neuroadaptations in nucleus accumbens neurons resulting from repeated cocaine administration. |
1997-11-25 |
2023-08-12 |
Not clear |
| J K Staley, R B Rothman, K C Rice, J Partilla, D C Mas. Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 21. 1997-11-20. PMID:9334398. |
the number of kappa2 receptors in the nucleus accumbens and other limbic brain regions from cocaine fatalities was increased twofold as compared with age-matched and drug-free control subjects. |
1997-11-20 |
2023-08-12 |
human |
| S E Hemby, C Co, T R Koves, J E Smith, S I Dworki. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology. vol 133. issue 1. 1997-11-14. PMID:9335075. |
differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. |
1997-11-14 |
2023-08-12 |
human |
| S E Hemby, C Co, T R Koves, J E Smith, S I Dworki. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology. vol 133. issue 1. 1997-11-14. PMID:9335075. |
studies indicate that nucleus accumbens (nacc) dopamine neurotransmission is involved in the reinforcing and direct effects of cocaine. |
1997-11-14 |
2023-08-12 |
human |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
only infusion of cocaine into the nucleus accumbens has been demonstrated to substitute fully for the systemic effects of this psychostimulant. |
1997-10-23 |
2023-08-12 |
rat |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
6-hydroxydopamine lesions of da terminals in the nucleus accumbens also attenuated the dose-effect curve for systemic administration of cocaine. |
1997-10-23 |
2023-08-12 |
rat |