| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
nucleus accumbens dopamine is often hypothesized as the critical factor for modulating cocaine self-administration. |
1998-04-24 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
in the current study we examined the extent to which dopamine in the amygdala could contribute to cocaine intake behaviour and modify nucleus accumbens dopamine levels. |
1998-04-24 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
although cocaine induced similar profiles of dopamine overflow in the two mesolimbic areas, in the nucleus accumbens the latency of the dopaminergic response was shorter (three- to four-fold) during both initiation and termination of the cocaine self-administration session than in the amygdala. |
1998-04-24 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
this behavioural effect was accompanied by a dose-dependent increase in nucleus accumbens dopamine levels; at the highest sch 23390 concentration cocaine intake was increased by 400% and dopamine levels were potentiated by an additional 400%. |
1998-04-24 |
2023-08-12 |
rat |
| J Y Chang, P H Janak, D J Woodwar. Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 8. 1998-04-20. PMID:9526026. |
to compare neuronal activity within the mesocorticolimbic circuit during the self-administration of cocaine and heroin, multiple-channel single-unit recordings of spike activity within the rat medial prefrontal cortex (mpfc) and nucleus accumbens (nac) were obtained during the consecutive self-administration of cocaine and heroin within the same session. |
1998-04-20 |
2023-08-12 |
rat |
| B E Hildebrand, G G Nomikos, P Hertel, B Schilström, T H Svensso. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain research. vol 779. issue 1-2. 1998-04-02. PMID:9473676. |
withdrawal from chronic treatment with various types of addictive drugs, including amphetamine, cocaine, ethanol and morphine is associated with a decrease in dopaminergic output in the nucleus accumbens (nac), whereas the effects of withdrawal from these drugs on dopaminergic output in the medial prefrontal cortex (pfc), as yet, remain largely unknown. |
1998-04-02 |
2023-08-12 |
rat |
| D W Self, L M Genova, B T Hope, W J Barnhart, J J Spencer, E J Nestle. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 5. 1998-03-04. PMID:9465009. |
involvement of camp-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. |
1998-03-04 |
2023-08-12 |
human |
| D W Self, L M Genova, B T Hope, W J Barnhart, J J Spencer, E J Nestle. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 5. 1998-03-04. PMID:9465009. |
camp-dependent protein kinase (pka) in the nucleus accumbens (nac) has been implicated in cocaine addiction because (1) cocaine reinforcement is mediated by dopamine receptors that modulate camp formation, and (2) repeated exposure to cocaine upregulates the camp system in nac neurons. |
1998-03-04 |
2023-08-12 |
human |
| M E Reith, M Y Li, Q S Ya. Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers. Psychopharmacology. vol 134. issue 3. 1998-02-26. PMID:9438681. |
extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers. |
1998-02-26 |
2023-08-12 |
rat |
| M T Bard. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Critical reviews in neurobiology. vol 12. issue 1-2. 1998-02-24. PMID:9444481. |
with amphetamine and cocaine, initiation of reward is controlled within the nucleus accumbens and prefrontal cortex, respectively. |
1998-02-24 |
2023-08-12 |
Not clear |
| P M Kunko, R J Loeloff, S Izenwasse. Chronic administration of the selective dopamine uptake inhibitor GBR 12,909, but not cocaine, produces marked decreases in dopamine transporter density. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 5. 1998-02-19. PMID:9402035. |
gbr 12,909 produced both tolerance to the inhibition of [3h]dopamine uptake by cocaine, and a decrease in total uptake of dopamine, in the caudate putamen, with no change in the nucleus accumbens. |
1998-02-19 |
2023-08-12 |
rat |
| G Tanda, F E Pontieri, R Frau, G Di Chiar. Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. The European journal of neuroscience. vol 9. issue 10. 1998-02-04. PMID:9421168. |
to this end, changes of extracellular da and na in the pfcx and of extracellular da in the nucleus accumbens (nac) were measured following the administration of amphetamine and cocaine, which are known to bind to both da and na carriers, or gbr 12909, a selective da carrier blocker. |
1998-02-04 |
2023-08-12 |
rat |
| F J White, A Joshi, T E Koeltzow, X T H. Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 1. 1998-01-30. PMID:9408916. |
high doses of sch 23390 alone produced supersensitivity to the behavioral effects of cocaine and to the inhibitory effects of d1 receptor agonists on nucleus accumbens neurons. |
1998-01-30 |
2023-08-12 |
Not clear |
| G Zernig, I A O'Laughlin, H C Fibige. Nicotine and heroin augment cocaine-induced dopamine overflow in nucleus accumbens. European journal of pharmacology. vol 337. issue 1. 1998-01-26. PMID:9389374. |
both nicotine + cocaine as well as heroin + cocaine stimulated nucleus accumbens dopamine overflow in an additive manner. |
1998-01-26 |
2023-08-12 |
rat |
| R J Moore, S L Vinsant, M A Nader, L J Porrino, D P Friedma. Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys. Synapse (New York, N.Y.). vol 28. issue 1. 1998-01-20. PMID:9414012. |
because the release of dopamine in the nucleus accumbens (nac) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound effects on drug-seeking and drug-taking behavior. |
1998-01-20 |
2023-08-12 |
monkey |
| R J Moore, S L Vinsant, M A Nader, L J Porrino, D P Friedma. Effect of cocaine self-administration on striatal dopamine D1 receptors in rhesus monkeys. Synapse (New York, N.Y.). vol 28. issue 1. 1998-01-20. PMID:9414012. |
in animals that self-administered cocaine, the density of d1 binding was significantly lower in the regions of the striatum at the level where the nucleus accumbens is most fully developed. |
1998-01-20 |
2023-08-12 |
monkey |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
the nucleus accumbens is a forebrain region that mediates cocaine self-administration and withdrawal effects in animal models of cocaine dependence. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
using a combination of current-clamp recordings in brain slices and whole-cell patch-clamp recordings from freshly dissociated neurons, we found that nucleus accumbens neurons are less excitable in cocaine withdrawn rats because of a novel form of plasticity: reduced whole-cell sodium currents. |
1998-01-16 |
2023-08-12 |
rat |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
three days after discontinuation of repeated cocaine injections, nucleus accumbens neurons recorded in brain slices were less responsive to depolarizing current injections, had higher action potential thresholds, and had lower spike amplitudes. |
1998-01-16 |
2023-08-12 |
rat |