| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L L Peoples, F Gee, R Bibi, M O Wes. Phasic firing time locked to cocaine self-infusion and locomotion: dissociable firing patterns of single nucleus accumbens neurons in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 18. 1998-10-02. PMID:9736676. |
the activity of single nucleus accumbens (nacc) neurons of rats was extracellularly recorded during intravenous cocaine self-administration sessions (0.7 mg/kg per infusion, fixed ratio 1). |
1998-10-02 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, W Lasoń, R Przewłock. Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681945. |
to elucidate the activity of the endogenous prodynorphin system upon treatment with psychostimulants, we investigated the effect of single and repeated cocaine and amphetamine on the prodynorphin messenger rna level, the prodynorphin-derived peptide alpha-neoendorphin tissue level, and its in vitro release in the nucleus accumbens and striatum of rats. |
1998-10-01 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, W Lasoń, R Przewłock. Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681945. |
as shown by an in situ hybridization study, the prodynorphin messenger rna levels in the nucleus accumbens and striatum were raised following single (at 3 h) and chronic (at 3 and 24 h) cocaine administration. |
1998-10-01 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, W Lasoń, R Przewłock. Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681945. |
acute cocaine and amphetamine administration had no effect on the alpha-neoendorphin tissue level, whereas chronic administration of those drugs elevated the alpha-neoendorphin level in the nucleus accumbens and striatum at the late time-points studied. |
1998-10-01 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, W Lasoń, R Przewłock. Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681945. |
acute and repeated cocaine administration had no effect on alpha-neoendorphin release in both the nucleus accumbens and striatum at 3 and 48 h after drug injection. |
1998-10-01 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, W Lasoń, R Przewłock. Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. Neuroscience. vol 85. issue 4. 1998-10-01. PMID:9681945. |
addition of cocaine or amphetamine to the incubation medium (10(-5)-10(-6) m) decreased the basal release of alpha-neoendorphin in the nucleus accumbens slices of naive rats, but it did not change the stimulated release (k+, 57 mm). |
1998-10-01 |
2023-08-12 |
rat |
| S M Antelman, A R Caggiula, B J Kucinski, H Fowler, S Gershon, D J Edwards, M C Austin, R Stiller, S Kiss, D Koca. The effects of lithium on a potential cycling model of bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 3. 1998-08-31. PMID:9612846. |
in order to test whether such cycling might be of potential relevance to bipolar disorder, the authors examined whether cocaine-induced cyclicity of amphetamine-evoked efflux of dopamine from slices of rat nucleus accumbens and striatum and/or cocaine induced oscillation of a behavior, stress-induced hypoalgesia, could be prevented by lithium, the agent of choice in treating this disease. |
1998-08-31 |
2023-08-12 |
rat |
| T J De Vries, A R Cools, T S Shippenber. Infusion of a D-1 receptor agonist into the nucleus accumbens enhances cocaine-induced behavioural sensitization. Neuroreport. vol 9. issue 8. 1998-08-13. PMID:9665597. |
the present study was designed to evaluate the effect of dopamine (da) d-1 receptor activation in the nucleus accumbens (nac) on the locomotor sensitizing effects of repeated intra-accumbens (intra-nac) infusions of cocaine. |
1998-08-13 |
2023-08-12 |
Not clear |
| K Mills, T A Arsah, S F Ali, D C Shockle. Calcium channel antagonist isradipine attenuates cocaine-induced motor activity in rats: correlation with brain monoamine levels. Annals of the New York Academy of Sciences. vol 844. 1998-08-13. PMID:9668678. |
in the nucleus accumbens cocaine (20 mg/kg, i.p.) |
1998-08-13 |
2023-08-12 |
rat |
| S D Glick, I S Maisonneuv. Mechanisms of antiaddictive actions of ibogaine. Annals of the New York Academy of Sciences. vol 844. 1998-08-13. PMID:9668680. |
some effects of ibogaine (e.g., on morphine and cocaine self-administration, morphine-induced hyperactivity, cocaine-induced increases in nucleus accumbens dopamine) are mimicked by kappa agonist (u50,488) and/or a nmda antagonist (mk-801). |
1998-08-13 |
2023-08-12 |
rat |
| L H Clay, E A Mazzio, M G Kolta, K F Solima. Repeated administration of cocaine alters dopamine uptake and release in the striatum nucleus accumbens. Annals of the New York Academy of Sciences. vol 844. 1998-08-13. PMID:9668692. |
repeated administration of cocaine alters dopamine uptake and release in the striatum nucleus accumbens. |
1998-08-13 |
2023-08-12 |
rat |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
in vivo microdialysis has shown that maternal cocaine exposure significantly decreases basal extracellular concentrations of dopamine in the nucleus accumbens of young-adult offspring (4 weeks after cessation of cocaine treatment). |
1998-07-27 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
nucleus accumbens dopamine is often hypothesized as the critical factor for modulating cocaine self-administration. |
1998-04-24 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
in the current study we examined the extent to which dopamine in the amygdala could contribute to cocaine intake behaviour and modify nucleus accumbens dopamine levels. |
1998-04-24 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
although cocaine induced similar profiles of dopamine overflow in the two mesolimbic areas, in the nucleus accumbens the latency of the dopaminergic response was shorter (three- to four-fold) during both initiation and termination of the cocaine self-administration session than in the amygdala. |
1998-04-24 |
2023-08-12 |
rat |
| Y L Hurd, A McGregor, M Ponté. In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517459. |
this behavioural effect was accompanied by a dose-dependent increase in nucleus accumbens dopamine levels; at the highest sch 23390 concentration cocaine intake was increased by 400% and dopamine levels were potentiated by an additional 400%. |
1998-04-24 |
2023-08-12 |
rat |
| J Y Chang, P H Janak, D J Woodwar. Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 8. 1998-04-20. PMID:9526026. |
to compare neuronal activity within the mesocorticolimbic circuit during the self-administration of cocaine and heroin, multiple-channel single-unit recordings of spike activity within the rat medial prefrontal cortex (mpfc) and nucleus accumbens (nac) were obtained during the consecutive self-administration of cocaine and heroin within the same session. |
1998-04-20 |
2023-08-12 |
rat |
| B E Hildebrand, G G Nomikos, P Hertel, B Schilström, T H Svensso. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain research. vol 779. issue 1-2. 1998-04-02. PMID:9473676. |
withdrawal from chronic treatment with various types of addictive drugs, including amphetamine, cocaine, ethanol and morphine is associated with a decrease in dopaminergic output in the nucleus accumbens (nac), whereas the effects of withdrawal from these drugs on dopaminergic output in the medial prefrontal cortex (pfc), as yet, remain largely unknown. |
1998-04-02 |
2023-08-12 |
rat |
| D W Self, L M Genova, B T Hope, W J Barnhart, J J Spencer, E J Nestle. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 5. 1998-03-04. PMID:9465009. |
involvement of camp-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. |
1998-03-04 |
2023-08-12 |
human |
| D W Self, L M Genova, B T Hope, W J Barnhart, J J Spencer, E J Nestle. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 5. 1998-03-04. PMID:9465009. |
camp-dependent protein kinase (pka) in the nucleus accumbens (nac) has been implicated in cocaine addiction because (1) cocaine reinforcement is mediated by dopamine receptors that modulate camp formation, and (2) repeated exposure to cocaine upregulates the camp system in nac neurons. |
1998-03-04 |
2023-08-12 |
human |