| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T N Ferraro, G T Golden, W H Berrettini, E Gottheil, C H Yang, G R Cuppels, W H Voge. Cocaine intake by rats correlates with cocaine-induced dopamine changes in the nucleus accumbens shell. Pharmacology, biochemistry, and behavior. vol 66. issue 2. 2000-08-28. PMID:10880696. |
a significant negative correlation was found between cocaine-induced increases in extracellular dopamine in the shell of the nucleus accumbens and the voluntary intake of cocaine (r = -0.73, p < 0.01). |
2000-08-28 |
2023-08-12 |
rat |
| R M Carelli, S G Ijame. Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825479. |
nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats. |
2000-08-07 |
2023-08-12 |
rat |
| R M Carelli, S G Ijame. Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825479. |
electrophysiological recording procedures were used to examine nucleus accumbens (acb) cell firing in rats (n=13) during cocaine self-administration sessions consisting of three phases. |
2000-08-07 |
2023-08-12 |
rat |
| S M Nicola, S A Deadwyle. Firing rate of nucleus accumbens neurons is dopamine-dependent and reflects the timing of cocaine-seeking behavior in rats on a progressive ratio schedule of reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 14. 2000-08-03. PMID:10884336. |
we recorded neuronal spike activity from cells in the nucleus accumbens (nac) of rats responding on a pr schedule for cocaine reinforcement. |
2000-08-03 |
2023-08-12 |
rat |
| Q Yan, M E Reith, S Ya. Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773215. |
this study was conducted to determine whether dopamine (da) release in the nucleus accumbens (nacc) following 5-ht(2a) receptor stimulation is potentiated by intermittent cocaine. |
2000-07-14 |
2023-08-12 |
rat |
| R M Carelli, S G Ijames, A J Crumlin. Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818162. |
evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward. |
2000-06-15 |
2023-08-12 |
rat |
| R M Carelli, S G Ijames, A J Crumlin. Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818162. |
electrophysiological recording procedures were used to examine nucleus accumbens (acb) cell firing in rats trained to press a lever on a multiple schedule [ fixed ratio (fr)1, fr1] for either two "natural" reinforcers (food and water), or a natural reinforcer and intravenous self-administration of cocaine. |
2000-06-15 |
2023-08-12 |
rat |
| R M Carelli, S G Ijames, A J Crumlin. Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818162. |
these findings indicate that in the well-trained animal, cocaine activates a neural circuit in the acb that is largely separate from the circuit that processes information about food and water reward. |
2000-06-15 |
2023-08-12 |
rat |
| E R McLeman, J J Warsh, L Ang, P P Li, K S Kalasinsky, B M Ross, J Tong, G Schmunk, V Adams, S J Kis. The human nucleus accumbens is highly susceptible to G protein down-regulation by methamphetamine and heroin. Journal of neurochemistry. vol 74. issue 5. 2000-05-25. PMID:10800957. |
as animal data suggest that a unique feature of this small brain area is its high sensitivity to down-regulation of an inhibitory g protein by drugs of abuse, we compared g protein levels in postmortem nucleus accumbens with those in seven other brain regions of chronic users of cocaine, methamphetamine, and heroin, and of matched controls. |
2000-05-25 |
2023-08-12 |
human |
| F Weiss, C S Maldonado-Vlaar, L H Parsons, T M Kerr, D L Smith, O Ben-Shaha. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 8. 2000-05-17. PMID:10760299. |
cocaine-related stimuli may increase the likelihood of relapse by evoking drug craving, and brain-imaging studies have identified the amygdala and nucleus accumbens (nacc) as putative neuroanatomical substrates for these effects of cocaine cues. |
2000-05-17 |
2023-08-12 |
rat |
| M E Alburges, B P Ramos, L Bush, G R Hanso. Responses of the extrapyramidal and limbic substance P systems to ibogaine and cocaine treatments. European journal of pharmacology. vol 390. issue 1-2. 2000-05-11. PMID:10708715. |
since previous studies demonstrated differential effects of stimulants of abuse (amphetamines) on neuropeptide systems such as substance p, we examined the impact of ibogaine and cocaine on extrapyramidal (striatum and substantia nigra) and limbic (nucleus accumbens and frontal cortex) substance p-like immunoreactivity. |
2000-05-11 |
2023-08-12 |
Not clear |
| D W Johnson, P Eodice, H Winterbottom, D J Mokle. Decreased accumbens dopamine release after cocaine challenge in behaviorally sensitized female rats. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764919. |
the effects of the competitive nmda receptor antagonist cpp on the initiation of behavioral sensitization to acute cocaine and basal and acute cocaine-induced dopamine (da) release in the nucleus accumbens (nac) were assessed in female sprague-dawley rats. |
2000-05-10 |
2023-08-12 |
rat |
| J W Grimm, R E Se. Dissociation of primary and secondary reward-relevant limbic nuclei in an animal model of relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 5. 2000-05-09. PMID:10731622. |
in contrast, ttx inactivation of the nucleus accumbens produced the exact opposite effects, with significant blockade of primary reward (cocaine alone), but not secondary reward (tone + light). |
2000-05-09 |
2023-08-12 |
rat |
| R M Carell. Activation of accumbens cell firing by stimuli associated with cocaine delivery during self-administration. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657032. |
electrophysiological recording procedures were used in behaving rats (n = 11) to examine the responsiveness of nucleus accumbens (acb) neurons to stimuli associated with intravenous cocaine delivery during self-administration sessions. |
2000-04-11 |
2023-08-12 |
rat |
| R M Carell. Activation of accumbens cell firing by stimuli associated with cocaine delivery during self-administration. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657032. |
of 208 acb neurons recorded during cocaine (0.33 mg/inf) self-administration sessions, 78 cells exhibited one of four types of patterned discharges (increases and/or decreases in firing rate) immediately before and/or following the cocaine-reinforced response. |
2000-04-11 |
2023-08-12 |
rat |
| R M Carell. Activation of accumbens cell firing by stimuli associated with cocaine delivery during self-administration. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657032. |
all phasically active acb cells were examined in test sessions consisting of "probe" trials (18-20 per session) during which either the drug only was delivered (0.33 mg/inf cocaine, 6 sec) or the stimulus only (tone-houselight, 20 sec) was randomly presented by the computer, interspersed between reinforced lever press responses. |
2000-04-11 |
2023-08-12 |
rat |
| R M Carell. Activation of accumbens cell firing by stimuli associated with cocaine delivery during self-administration. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657032. |
results show that acb cells that exhibit postresponse changes in firing rate within seconds of the reinforced response appear to be controlled, at least in part, by the stimulus paired with cocaine delivery during the self-administration session and not via a direct pharmacological action of cocaine. |
2000-04-11 |
2023-08-12 |
rat |
| S Ikemoto, N E Goeder. Intra-medial prefrontal cortex injections of scopolamine increase instrumental responses for cocaine: an intravenous self-administration study in rats. Brain research bulletin. vol 51. issue 2. 2000-03-30. PMID:10709961. |
the present experiments examined the effects of muscarinic cholinergic receptor blockade in the nucleus accumbens (nac) and medial prefrontal cortex (mpc) on intravenous cocaine self-administration. |
2000-03-30 |
2023-08-12 |
rat |
| F Karoum, M E Wolf, A D Mosnai. Effects of the administration of amphetamine, either alone or in combination with reserpine or cocaine, on regional brain beta-phenylethylamine and dopamine release. American journal of therapeutics. vol 4. issue 9-10. 2000-01-24. PMID:10423628. |
on the other hand, the increase in brain pea produced by amph (5 mg/kg) was not influenced by either increased cytoplasmic da (as deduced from the effects of 1 mg/kg reserpine pretreatment) or da uptake inhibition (as deduced from the effect of cocaine pretreatment) in the frontal cortex or the nucleus accumbens. |
2000-01-24 |
2023-08-12 |
rat |
| M Erdtmann-Vourliotis, P Mayer, U Riechert, V Höll. Acute injection of drugs with low addictive potential (delta(9)-tetrahydrocannabinol, 3,4-methylenedioxymethamphetamine, lysergic acid diamide) causes a much higher c-fos expression in limbic brain areas than highly addicting drugs (cocaine and morphine). Brain research. Molecular brain research. vol 71. issue 2. 1999-12-23. PMID:10521585. |
taken together, our study revealed that the drugs with the highest addictive potential, cocaine and morphine, yielded a very low c-fos synthesis throughout the brain whereas the brain regions closely linked to pleasure (especially the nucleus accumbens) responded strongly to drugs with an apparently lower addictive potential (thc, lsd, mdma). |
1999-12-23 |
2023-08-12 |
rat |