| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E M Unterwald, M J Kreek, M Cuntapa. The frequency of cocaine administration impacts cocaine-induced receptor alterations. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325352. |
using receptor autoradiography, twice daily injections of cocaine produced an upregulation of mu opioid receptors in the rostral nucleus accumbens, rostral caudate putamen, and layer i of the rostral cingulate cortex, whereas single daily injections resulted in a significant increase in the nucleus accumbens only. |
2001-07-26 |
2023-08-12 |
rat |
| E M Unterwald, M J Kreek, M Cuntapa. The frequency of cocaine administration impacts cocaine-induced receptor alterations. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325352. |
increased dopamine d1 receptor binding was found in the nucleus accumbens and olfactory tubercle following twice daily cocaine injections, but not after single daily injections of the same total daily dose. |
2001-07-26 |
2023-08-12 |
rat |
| H L Kimmel, A R Joyce, F I Carroll, M J Kuha. Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408534. |
cocaine increased the half-life of dat in both the striatum and the nucleus accumbens. |
2001-07-19 |
2023-08-12 |
rat |
| M Barrot, D N Abrous, M Marinelli, F Rougé-Pont, M Le Moal, P V Piazz. Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum. The European journal of neuroscience. vol 13. issue 4. 2001-06-28. PMID:11207816. |
the increased dopaminergic response to cocaine also contrasts with the decreased response previously observed in the shell of the nucleus accumbens [barrot et al. |
2001-06-28 |
2023-08-12 |
rat |
| E F Schmidt, M A Sutton, C A Schad, D A Karanian, E S Brodkin, D W Sel. Extinction training regulates tyrosine hydroxylase during withdrawal from cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 7. 2001-06-28. PMID:11264329. |
in this study, 12 d of cocaine self-administration in rats (4 hr/d) reduced th immunoreactivity by 29% in the nucleus accumbens (nac) shell, but not core, after a 1 week withdrawal period. |
2001-06-28 |
2023-08-12 |
rat |
| M R Gerasimov, W K Schiffer, E L Gardner, D A Marsteller, I C Lennon, S J Taylor, J D Brodie, C R Ashby, S L Dewe. GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine. European journal of pharmacology. vol 414. issue 2-3. 2001-06-21. PMID:11239920. |
to better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously paired with cocaine administration. |
2001-06-21 |
2023-08-12 |
Not clear |
| K Lutfy, T Do, N T Maidmen. Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. Psychopharmacology. vol 154. issue 1. 2001-06-21. PMID:11291998. |
orphanin fq/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. |
2001-06-21 |
2023-08-12 |
rat |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
here we report that, in dat-ko mice, cocaine and amphetamine increase dialysate dopamine in the medial part of the nucleus accumbens. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
these observations provide an explanation for the persistence of cocaine reinforcement in dat-ko mice and support the hypothesis of a primary role of nucleus accumbens dopamine in drug reinforcement. |
2001-06-07 |
2023-08-12 |
mouse |
| D Alvarez Fischer, M K Schäfer, B Ferger, S Gross, R Westermann, E Weihe, K Kuschinsk. Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284443. |
microdialysis in the nucleus accumbens which was performed after administration of cocaine (10 mg/kg i.p.) |
2001-05-24 |
2023-08-12 |
rat |
| W M Freeman, M A Nader, S H Nader, D J Robertson, L Gioia, S M Mitchell, J B Daunais, L J Porrino, D P Friedman, K E Vran. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299316. |
cdna hybridization arrays were used to illuminate cocaine-regulated genes in the nucleus accumbens (nacc) of non-human primates (macaca fascicularis; cynomolgus macaque), treated daily with escalating doses of cocaine over one year. |
2001-05-17 |
2023-08-12 |
monkey |
| T E Robinson, G Gorny, E Mitton, B Kol. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse (New York, N.Y.). vol 39. issue 3. 2001-05-10. PMID:11169774. |
cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. |
2001-05-10 |
2023-08-12 |
rat |
| T E Robinson, G Gorny, E Mitton, B Kol. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse (New York, N.Y.). vol 39. issue 3. 2001-05-10. PMID:11169774. |
in rats that self-administered cocaine, but not rats that worked for food, there was a significant increase in dendritic branching and in the density of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens and on pyramidal cells in the prefrontal and parietal (but not occipital) cortex. |
2001-05-10 |
2023-08-12 |
rat |
| M S Brenz Verca, D A Widmer, G C Wagner, J Dreye. Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function. Molecular and cellular neurosciences. vol 17. issue 2. 2001-05-10. PMID:11178868. |
cd81, a tetraspanin transmembrane protein involved in cell adhesion, was found by differential display to be upregulated in the nucleus accumbens of rat brain following acute cocaine treatment (four injections of 30 mg/kg every 2 h followed by 24 h withdrawal). |
2001-05-10 |
2023-08-12 |
rat |
| T Yamamoto, K Yabuuchi, T Yamaguchi, M Nakamich. [Animal models of drug dependence using the drug self-administration method]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 117. issue 1. 2001-05-10. PMID:11233296. |
given that an ampa receptor antagonist, but not dopamine antagonist, prevented cocaine-seeking behavior induced by cocaine, glutamate transmission in the nucleus accumbens is thought to be important for expression of craving or drug-seeking behavior. |
2001-05-10 |
2023-08-12 |
Not clear |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
modulation of striatal dopamine (da) release by acute or repeated cocaine treatment was studied in the nucleus accumbens and caudate-putamen of alcohol-preferring (aa, alko alcohol) and alcohol-avoiding (ana, alko non-alcohol) rats. |
2001-05-03 |
2023-08-12 |
rat |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
the first administration of cocaine increased da concentration similarly in rats of both lines in both the nucleus accumbens and caudate-putamen. |
2001-05-03 |
2023-08-12 |
rat |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
on the 4th day, the effect of cocaine was significantly larger in the nucleus accumbens of aa than in that of ana rats, whereas no such enhanced effect of cocaine was found in the caudate-putamen of either line. |
2001-05-03 |
2023-08-12 |
rat |
| V David, L H Gold, G F Koob, P Cazal. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 3. 2001-04-19. PMID:11166520. |
to test the hypothesis that injections directly into a reward-relevant brain region might support consistent cocaine-seeking behavior, balb/cbyj mice implanted in the nucleus accumbens (nac) or the caudate-putamen nucleus (cpu) were trained to discriminate between the arm enabling a microinjection of cocaine (30 pmol/50 nl or 150 pmol/50 nl) and the neutral arm of a y-maze. |
2001-04-19 |
2023-08-12 |
mouse |