| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Lindholm, Rosin A, I Dahlin, J Georgieva, J Franc. Ethanol administration potentiates cocaine-induced dopamine levels in the rat nucleus accumbens. Brain research. vol 915. issue 2. 2001-12-12. PMID:11595207. |
acute administration of ethanol or cocaine increases the extracellular dopamine (da) concentration in the nucleus accumbens (nacc), a terminal region of the mesolimbic dopaminergic pathway. |
2001-12-12 |
2023-08-12 |
rat |
| K Yoshimoto, B Kato, S Ueda, K Noritake, K Sakai, M Shibata, M Hori, H Kawano, Y Takeuchi, Y Wakabayashi, M Yasuhar. Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young and aged rats. Mechanisms of ageing and development. vol 122. issue 15. 2001-12-07. PMID:11557275. |
nucleus accumbens (acc) of young (4 months old) and aged (24 months old) wistar rats were perfused with dopamine (da) uptake blocker, cocaine, or the serotonin (5-ht) selective reuptake inhibitor, fluoxetine, through the microdialysis probe membrane, used to assess the dopamine transporter (dat) or serotonin transporter (sert) modulation. |
2001-12-07 |
2023-08-12 |
rat |
| T Hikida, S Kaneko, T Isobe, Y Kitabatake, D Watanabe, I Pastan, S Nakanish. Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11606786. |
increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens. |
2001-12-07 |
2023-08-12 |
mouse |
| T Hikida, S Kaneko, T Isobe, Y Kitabatake, D Watanabe, I Pastan, S Nakanish. Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11606786. |
an important neural substrate for cocaine addiction is the nucleus accumbens (nac), which receives dopaminergic input from the ventral tegmental area. |
2001-12-07 |
2023-08-12 |
mouse |
| G C Harris, K Altomare, G Aston-Jone. Preference for a cocaine-associated environment is attenuated by augmented accumbal serotonin in cocaine withdrawn rats. Psychopharmacology. vol 156. issue 1. 2001-12-05. PMID:11465629. |
recent studies have found decreased serotonin (5-ht) transmission within the nucleus accumbens following withdrawal from chronic cocaine. |
2001-12-05 |
2023-08-12 |
rat |
| C M Andrews, I Luck. Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens. Psychopharmacology. vol 155. issue 3. 2001-12-04. PMID:11432683. |
effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens. |
2001-12-04 |
2023-08-12 |
Not clear |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
there was a decrease in such labeling in the nucleus accumbens in the group receiving acute cocaine. |
2001-12-04 |
2023-08-12 |
rat |
| L B Kozell, C K Meshu. The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564413. |
this study indicates that acute cocaine administration significantly decreases nerve terminal glutamate immunoreactivity in the nucleus accumbens. |
2001-12-04 |
2023-08-12 |
rat |
| N M Richtand, S C Woods, S P Berger, S M Strakowsk. D3 dopamine receptor, behavioral sensitization, and psychosis. Neuroscience and biobehavioral reviews. vol 25. issue 5. 2001-12-04. PMID:11566480. |
the requirement for differential tolerance at d3 vs d1 and d2 receptors may explain the observed development of sensitization following application of cocaine, but not amphetamine, directly into nucleus accumbens. |
2001-12-04 |
2023-08-12 |
Not clear |
| C N Haile, T A Koste. Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats. The Journal of pharmacology and experimental therapeutics. vol 299. issue 2. 2001-12-04. PMID:11602661. |
these data show that manipulating d1- and d2-like receptor availability has strain-selective effects on the reinforcing, but not discriminative stimulus, effects of cocaine that are predicted by inherent differences in nucleus accumbens receptor populations. |
2001-12-04 |
2023-08-12 |
rat |
| P E Molina, N Ahmed, J Gatley, N D Volkow, N N Abumra. L-tryptophan attenuation of the dopaminergic and behavioral responses to cocaine. Life sciences. vol 69. issue 16. 2001-12-04. PMID:11693270. |
cocaine increased nucleus accumbens microdialysate dopamine levels (500% at 30 min). |
2001-12-04 |
2023-08-12 |
rat |
| C J Swanson, D A Baker, D Carson, P F Worley, P W Kaliva. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 22. 2001-12-04. PMID:11698615. |
the present study aimed to characterize a functional role for group i metabotropic glutamate receptors (mglurs) in the nucleus accumbens and the capacity of repeated cocaine to elicit long-term changes in group i mglur function. |
2001-12-04 |
2023-08-12 |
Not clear |
| C J Swanson, D A Baker, D Carson, P F Worley, P W Kaliva. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 22. 2001-12-04. PMID:11698615. |
similarly, dhpg induced an mglur1-dependent increase in locomotor activity after microinjection into the nucleus accumbens that was significantly blunted 3 weeks after repeated cocaine administration. |
2001-12-04 |
2023-08-12 |
Not clear |
| C M Knapp, K Lee, M Foye, D A Ciraulo, C Kornetsk. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life sciences. vol 69. issue 14. 2001-10-25. PMID:11589507. |
evidence from cocaine self-administration studies suggests that increasing the activity of cyclic amp (camp) pathways within the nucleus accumbens may produce a reduction in cocaine's reinforcing effects. |
2001-10-25 |
2023-08-12 |
rat |
| C M Knapp, K Lee, M Foye, D A Ciraulo, C Kornetsk. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life sciences. vol 69. issue 14. 2001-10-25. PMID:11589507. |
bsr thresholds were determined in rats after the systemic administration of cocaine (4 mg/kg ip) and the infusion of rolipram (0.2 microg/side) into the nucleus accumbens both alone and in combination. |
2001-10-25 |
2023-08-12 |
rat |
| C M Knapp, K Lee, M Foye, D A Ciraulo, C Kornetsk. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life sciences. vol 69. issue 14. 2001-10-25. PMID:11589507. |
compared to values for saline alone, thresholds were lower after the injection of cocaine (4 mg/kg ip) or the infusion of rolipram (0.2 microg/side) into the nucleus accumbens. |
2001-10-25 |
2023-08-12 |
rat |
| C M Knapp, K Lee, M Foye, D A Ciraulo, C Kornetsk. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life sciences. vol 69. issue 14. 2001-10-25. PMID:11589507. |
these results suggest that infusion into the nucleus accumbens of rolipram, an agent that putatively elevates camp levels in this structure, can enhance the sensitivity of reward pathways to bsr and can augment cocaine's actions on these pathways. |
2001-10-25 |
2023-08-12 |
rat |
| E Ang, J Chen, P Zagouras, H Magna, J Holland, E Schaeffer, E J Nestle. Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration. Journal of neurochemistry. vol 79. issue 1. 2001-10-25. PMID:11595774. |
induction of nuclear factor-kappab in nucleus accumbens by chronic cocaine administration. |
2001-10-25 |
2023-08-12 |
mouse |
| E Ang, J Chen, P Zagouras, H Magna, J Holland, E Schaeffer, E J Nestle. Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration. Journal of neurochemistry. vol 79. issue 1. 2001-10-25. PMID:11595774. |
deltafosb is a fos family transcription factor that is induced by chronic exposure to cocaine and other drugs of abuse in the nucleus accumbens and related striatal regions, brain regions that are important for the behavioral effects of these drugs. |
2001-10-25 |
2023-08-12 |
mouse |
| E Ang, J Chen, P Zagouras, H Magna, J Holland, E Schaeffer, E J Nestle. Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration. Journal of neurochemistry. vol 79. issue 1. 2001-10-25. PMID:11595774. |
subsequent experiments confirmed the induction of nf-kappab in the nucleus accumbens of mice overexpressing deltafosb as well as in wild-type mice treated chronically, but not acutely, with cocaine. |
2001-10-25 |
2023-08-12 |
mouse |