| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
elevated expression of 5-ht1b receptors in nucleus accumbens efferents sensitizes animals to cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
for example, serotonin actions at 5-ht1b receptors in the ventral tegmental area (vta) modulate cocaine-induced dopamine release in the nucleus accumbens (nacc) and alter the rewarding and stimulant properties of cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
these initial studies showed that: 1) the half-life of the transporter was between 2 and 3 days in these two brain regions; 2) pretreatment with dopamine d1 and d2 receptor agonists and antagonists over several days differentially altered dat half-lives in the striatum and nucleus accumbens; and 3) pretreatment with cocaine for several days increased the half-life of dat by decreasing the degradation rate constant in both brain regions. |
2003-01-23 |
2023-08-12 |
rat |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
cocaine pretreatment and withdrawal reduced the half-life of the transporter protein from 2.1 days to 0.94 day in the striatum, but did not alter the half-life of 2.2 days in the nucleus accumbens. |
2003-01-23 |
2023-08-12 |
rat |
| M S Todtenkopf, A Mihalakopoulos, J R Stella. Withdrawal duration differentially affects c-fos expression in the medial prefrontal cortex and discrete subregions of the nucleus accumbens in cocaine-sensitized rats. Neuroscience. vol 114. issue 4. 2003-01-10. PMID:12379259. |
repeated cocaine administration resulted in robust sensitization that correlated with a significant decrease in the density of c-fos nuclei in all three subdivisions of the medial prefrontal cortex, and two subdivisions of the nucleus accumbens only in animals challenged after a 2-day withdrawal period. |
2003-01-10 |
2023-08-12 |
rat |
| Zachary A Rodd-Henricks, David L McKinzie, Ting-Kai Li, James M Murphy, William J McBrid. Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438546. |
cocaine is self-administered into the shell but not the core of the nucleus accumbens of wistar rats. |
2002-12-24 |
2023-08-12 |
human |
| S Ikemot. Ventral striatal anatomy of locomotor activity induced by cocaine, D-amphetamine, dopamine and D1/D2 agonists. Neuroscience. vol 113. issue 4. 2002-11-27. PMID:12182899. |
however, injections of mixtures of the d(1)- and d(2)-type agonists skf 38393 and quinpirole or cocaine into the medial olfactory tubercle or the medial shell of the nucleus accumbens induced marked locomotion and rearing, while these injections into the core induced little or no locomotion or rearing. |
2002-11-27 |
2023-08-12 |
Not clear |
| Michelle E Ehrlich, John Sommer, Edwin Canas, Ellen M Unterwal. Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417638. |
here we demonstrate that, after chronic administration of the psychostimulants cocaine and amphetamine, the transcription factor deltafosb is upregulated in the nucleus accumbens of periadolescent mice but not in post-weanling or adult mice. |
2002-11-25 |
2023-08-12 |
mouse |
| Edmund Przegaliński, Joanna Siwanowicz, Iwona Papla, Małgorzata Fili. Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 5. 2002-11-22. PMID:12208556. |
the present study was designed to find out whether 5-ht(1b) receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. |
2002-11-22 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Sammanda Ramamoorthy, David A Baker, Hui Shen, Devadoss J Samuvel, Peter W Kaliva. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388642. |
repeated cocaine produces enduring neuroadaptations in glutamate transmission in the nucleus accumbens that are thought to contribute to addiction. |
2002-11-22 |
2023-08-12 |
human |
| Zheng-Xiong Xi, Sammanda Ramamoorthy, David A Baker, Hui Shen, Devadoss J Samuvel, Peter W Kaliva. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388642. |
together, these data demonstrate that repeated cocaine produces an enduring reduction in mglur2/3 function in the nucleus accumbens. |
2002-11-22 |
2023-08-12 |
human |
| Antoinette Y Freeman, R Christopher Pierc. Neutralization of neutrophin-3 in the ventral tegmental area or nucleus accumbens differentially modulates cocaine-induced behavioral plasticity in rats. Synapse (New York, N.Y.). vol 46. issue 2. 2002-11-19. PMID:12211082. |
a neutralizing antibody for nt-3, bdnf or their vehicle was administered into the ventral tegmental area (vta) or nucleus accumbens prior to each of four daily injections of 15 mg/kg cocaine. |
2002-11-19 |
2023-08-12 |
rat |
| Antoinette Y Freeman, R Christopher Pierc. Neutralization of neutrophin-3 in the ventral tegmental area or nucleus accumbens differentially modulates cocaine-induced behavioral plasticity in rats. Synapse (New York, N.Y.). vol 46. issue 2. 2002-11-19. PMID:12211082. |
administration of anti-nt-3 into the nucleus accumbens increased the behavioral response to cocaine over all 4 days of cocaine administration, with no sensitization of this behavioral response. |
2002-11-19 |
2023-08-12 |
rat |
| Antoinette Y Freeman, R Christopher Pierc. Neutralization of neutrophin-3 in the ventral tegmental area or nucleus accumbens differentially modulates cocaine-induced behavioral plasticity in rats. Synapse (New York, N.Y.). vol 46. issue 2. 2002-11-19. PMID:12211082. |
in contrast, pretreatment with anti-bdnf into the vta or nucleus accumbens had no influence on the initiation of behavioral sensitization to cocaine. |
2002-11-19 |
2023-08-12 |
rat |
| Antoinette Y Freeman, R Christopher Pierc. Neutralization of neutrophin-3 in the ventral tegmental area or nucleus accumbens differentially modulates cocaine-induced behavioral plasticity in rats. Synapse (New York, N.Y.). vol 46. issue 2. 2002-11-19. PMID:12211082. |
taken together, these data indicate that neutralization of nt-3 in the vta enhances cocaine-induced behavioral sensitization, while administration of the nt-3 antibody into the nucleus accumbens increases the hyperactive behavioral response induced by cocaine but impairs the further development of behavioral sensitization. |
2002-11-19 |
2023-08-12 |
rat |
| A Eugene Pekary, Shayani Senanayake, Albert Satti. Cocaine regulates TRH-related peptides in rat brain. Neurochemistry international. vol 41. issue 6. 2002-11-12. PMID:12213229. |
trh and leu(2)-trh, decreased 47 and 93%, respectively in the nucleus accumbens (am) while other eep-ir peaks decreased 50-100% consistent with the significant decrease in total eep-ir in the ams following acute cocaine treatment. |
2002-11-12 |
2023-08-12 |
rat |
| Dongsheng Zhang, Lu Zhang, Dan Wen Lou, Yusaku Nakabeppu, Jianhua Zhang, Ming X. The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. Journal of neurochemistry. vol 82. issue 6. 2002-10-22. PMID:12354293. |
to test this possibility, we systematically compared the expression of the fos and jun family immediate early genes in the nucleus accumbens and caudoputamen in d1 receptor mutant and wild-type control mice after acute and repeated cocaine exposure. |
2002-10-22 |
2023-08-12 |
mouse |
| Regina M Carell. Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. Physiology & behavior. vol 76. issue 3. 2002-10-08. PMID:12117574. |
nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. |
2002-10-08 |
2023-08-12 |
rat |
| Regina M Carell. Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. Physiology & behavior. vol 76. issue 3. 2002-10-08. PMID:12117574. |
here, our electrophysiological studies that examined acb cell firing within seconds of lever press responding for intravenous cocaine vs. water or food reinforcement in rats are reviewed. |
2002-10-08 |
2023-08-12 |
rat |
| Regina M Carell. Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. 'natural' reinforcement. Physiology & behavior. vol 76. issue 3. 2002-10-08. PMID:12117574. |
initial investigations revealed that a subset of acb neurons exhibits four types of firing patterns within seconds of the reinforced response for intravenous cocaine during self-administration sessions. |
2002-10-08 |
2023-08-12 |
rat |