| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Fagergren, H R Smith, J B Daunais, M A Nader, L J Porrino, Y L Hur. Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. The European journal of neuroscience. vol 17. issue 10. 2003-07-28. PMID:12786988. |
moreover, cocaine self-administration failed to alter the pdyn mrna expression in high- or low-expressing pdyn cell populations in the nucleus accumbens during any condition studied. |
2003-07-28 |
2023-08-12 |
human |
| Stefan D Schlussman, Yong Zhang, Vadim Yuferov, K Steven LaForge, Ann Ho, Mary Jeanne Kree. Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742644. |
preprodynorphin mrna was measured in the nucleus accumbens (nac) and caudate putamen (cpu) after 3-day 'binge' pattern cocaine administration in c57bl/6j and 129/j mice, strains which differ in behavior and in dopamine increases in the cpu after 'binge' cocaine. |
2003-07-22 |
2023-08-12 |
mouse |
| Kazuaki Shimosato, Noriki Nagao, Satoru Watanabe, Shigeo Kitayam. Suppressive effects of trihexyphenidyl on methamphetamine-induced dopamine release as measured by in vivo microdialysis. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710014. |
the present study examined using in vivo microdialysis whether thp differentially affects the extracellular dopamine (da) levels in the nucleus accumbens and striatum of mice injected with map and cocaine in comparison with another antimuscarinic agent, scopolamine (scp). |
2003-07-17 |
2023-08-12 |
mouse |
| Kazuaki Shimosato, Noriki Nagao, Satoru Watanabe, Shigeo Kitayam. Suppressive effects of trihexyphenidyl on methamphetamine-induced dopamine release as measured by in vivo microdialysis. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710014. |
cocaine (10 mg/kg) increased da levels during the initial hour to 254% in the nucleus accumbens and 220% in the striatum as compared to the basal level. |
2003-07-17 |
2023-08-12 |
mouse |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
the mechanism of action of drugs of abuse like cocaine and amphetamines has been studied extensively in the dopamine terminal field areas of the caudate-putamen (cpu) and the nucleus accumbens (nac) of the rodent brain. |
2003-07-17 |
2023-08-12 |
mouse |
| M-C Peakman, C Colby, L I Perrotti, P Tekumalla, T Carle, P Ulery, J Chao, C Duman, C Steffen, L Monteggia, M R Allen, J L Stock, R S Duman, J D McNeish, M Barrot, D W Self, E J Nestler, E Schaeffe. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain research. vol 970. issue 1-2. 2003-07-08. PMID:12706249. |
administration of cocaine induces the fos family of transcription factors in the striatum, including the nucleus accumbens (nac), a brain region important for the rewarding effects of addictive drugs. |
2003-07-08 |
2023-08-12 |
mouse |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. |
2003-07-01 |
2023-08-12 |
Not clear |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
cocaine and morphine elevate dopamine levels in the nucleus accumbens (nac), and the overwhelming actions of dopamine are implicated in reinforcement and addiction of abusive drugs. |
2003-07-01 |
2023-08-12 |
Not clear |
| S D Norrholm, J A Bibb, E J Nestler, C C Ouimet, J R Taylor, P Greengar. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5. Neuroscience. vol 116. issue 1. 2003-06-24. PMID:12535933. |
repeated exposure to cocaine produces an enduring increase in dendritic spine density in adult rat nucleus accumbens. |
2003-06-24 |
2023-08-12 |
rat |
| Shinichi Naka. Is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats? Anesthesiology. vol 98. issue 6. 2003-06-24. PMID:12766673. |
is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats? |
2003-06-24 |
2023-08-12 |
rat |
| J V Trinh, D L Nehrenberg, J P R Jacobsen, M G Caron, W C Wetse. Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699766. |
amphetamine and cocaine produced similar changes to that for methylphenidate, except these psychostimulants also induced fos-li in the nucleus accumbens of the ko animals. |
2003-06-16 |
2023-08-12 |
mouse |
| Jadwiga Turchan, Marcin Maj, Barbara Przewłocka, Ryszard Przewłock. Effect of cocaine and amphetamine on biosynthesis of proenkephalin and prodynorphin in some regions of the rat limbic system. Polish journal of pharmacology. vol 54. issue 4. 2003-06-03. PMID:12523490. |
these studies also indicate that the changes in opioid gene expression in the central nucleus of the amygdala are not parallel to those observed in the nucleus accumbens after cocaine and amphetamine, which suggests that peptidergic systems in the structures of extended amygdala might be regulated by different neurochemical mechanisms after psychostymulant administration. |
2003-06-03 |
2023-08-12 |
rat |
| Vladimir I Chefer, Irina Zakharova, Toni S Shippenber. Enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 7. 2003-05-30. PMID:12684494. |
enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. |
2003-05-30 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Sammanda Ramamoorthy, Hui Shen, Russell Lake, Devadoss J Samuvel, Peter W Kaliva. GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716959. |
gaba transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine. |
2003-05-30 |
2023-08-12 |
human |
| Krista McFarland, Christopher C Lapish, Peter W Kaliva. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716962. |
when extinguished cocaine self-administration behavior was reinstated by a cocaine-priming injection, extracellular levels of both dopamine and glutamate were elevated in the nucleus accumbens. |
2003-05-30 |
2023-08-12 |
human |
| A Y Freeman, J-J Soghomonian, R C Pierc. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605901. |
tyrosine kinase b and c receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. |
2003-05-21 |
2023-08-12 |
rat |
| A Y Freeman, J-J Soghomonian, R C Pierc. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605901. |
we also examined the influence of acute or repeated injections of cocaine on the number of tyrosine kinase b and c receptors immunoreactive neuronal profiles in the rat neostriatum and nucleus accumbens. |
2003-05-21 |
2023-08-12 |
rat |
| A Y Freeman, J-J Soghomonian, R C Pierc. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605901. |
one or 14 days following the last of seven daily injections of 15 mg/kg cocaine or saline there were no differences in the numbers of tyrosine kinase b or c receptors immunoreactive neuronal profiles between these treatment groups.collectively, the present results indicate that tyrosine kinase b and c receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles, which suggests that the striatal medium spiny neurons expressing tyrosine kinase b and c receptors include those that project to the pallidum or the ventral mesencephalon. |
2003-05-21 |
2023-08-12 |
rat |
| A Y Freeman, J-J Soghomonian, R C Pierc. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605901. |
the current results also show that an acute injection of cocaine results in a decrease in the number of tyrosine kinase b and c receptors immunoreactive neuronal profiles in specific regions of the nucleus accumbens and neostriatum, indicating that cocaine-induced increases in extracellular dopamine in the striatal complex result in compensatory decreases in the expression of tyrosine kinase b and c receptors. |
2003-05-21 |
2023-08-12 |
rat |
| M J Bubar, L R McMahon, P De Deurwaerdère, U Spampinato, K A Cunningha. Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens. Neuropharmacology. vol 44. issue 3. 2003-05-02. PMID:12604093. |
in the present study, the ability of the selective serotonin reuptake inhibitors (ssris) fluoxetine (10 mg/kg, ip) and fluvoxamine (10 and 20 mg/kg, ip) to alter cocaine (10 mg/kg, ip)-induced hyperactivity and da release in the nucleus accumbens (nac) was analyzed in male sprague-dawley rats. |
2003-05-02 |
2023-08-12 |
rat |