| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Kozell, K Meshu. Alterations in nerve terminal glutamate immunoreactivity in the nucleus accumbens and ventral tegmental area following single and repeated doses of cocaine. Psychopharmacology. vol 165. issue 4. 2003-03-20. PMID:12459930. |
our laboratory has previously reported that a single dose of cocaine, but not repeated cocaine, decreased the density of presynaptic nerve terminal glutamate immunolabeling in the nucleus accumbens when measured 3 days later. |
2003-03-20 |
2023-08-12 |
Not clear |
| I Roth-Deri, A Zangen, M Aleli, R G Goelman, G Pelled, R Nakash, I Gispan-Herman, T Green, Y Shaham, G Yadi. Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603818. |
effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. |
2003-03-19 |
2023-08-12 |
Not clear |
| I Roth-Deri, A Zangen, M Aleli, R G Goelman, G Pelled, R Nakash, I Gispan-Herman, T Green, Y Shaham, G Yadi. Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603818. |
the effect of cocaine on beta-endorphin release in the nucleus accumbens was mimicked by a local perfusion of dopamine (5 microm) and was blocked by coadministration of sch-23390 (10 microm). |
2003-03-19 |
2023-08-12 |
Not clear |
| I Roth-Deri, A Zangen, M Aleli, R G Goelman, G Pelled, R Nakash, I Gispan-Herman, T Green, Y Shaham, G Yadi. Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603818. |
we demonstrate an increase in beta-endorphin release in the nucleus accumbens following experimenter-delivered and self-administered cocaine mediated by the local dopaminergic system. |
2003-03-19 |
2023-08-12 |
Not clear |
| K Steven LaForge, Vadim Yuferov, Yan Zhou, Ann Ho, Fred Nyberg, Mary Jeanne Kree. "Binge" cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain. Brain research bulletin. vol 59. issue 5. 2003-03-17. PMID:12507685. |
following 7 days of cocaine administration, however, lower levels of preproenkephalin mrna were observed in the nucleus accumbens and hypothalamus of cocaine-treated animals and higher levels in the frontal cortex and amygdala. |
2003-03-17 |
2023-08-12 |
rat |
| Niki Sharan, Victor Z Chong, Venugopalan D Nair, Ram K Mishra, Robert J Hayes, Eliot L Gardne. Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regions. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422371. |
acute treatment with cocaine increased crp40 expression in the nucleus accumbens and striatum, whereas chronic treatment with cocaine increased crp40 expression in the nucleus accumbens only. |
2003-03-07 |
2023-08-12 |
Not clear |
| Lin Lu, Ben Zhang, Zhiyuan Liu, Zhanyin Zhan. Reactivation of cocaine conditioned place preference induced by stress is reversed by cholecystokinin-B receptors antagonist in rats. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393241. |
in another experiment, cck-a or b receptor antagonists were infused into nucleus accumbens or amygdala to determine which brain area are involved in the role of different cck receptors in stress or drug-induced relapse to cocaine seeking. |
2003-01-24 |
2023-08-12 |
rat |
| N Suto, J D Austin, L M Tanabe, M K Kramer, D A Wright, P Vezin. Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 6. 2003-01-24. PMID:12464454. |
thus, in a manner paralleling the sensitization of amph-induced locomotion and nucleus accumbens da overflow, previous exposure to amph in the vta leads to enhanced intravenous self-administration of cocaine and activation of d(1) da receptors in this site during pre-exposure is necessary for the production of this effect. |
2003-01-24 |
2023-08-12 |
rat |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
elevated expression of 5-ht1b receptors in nucleus accumbens efferents sensitizes animals to cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| John F Neumaier, Evelyn S Vincow, Andreas Arvanitogiannis, Roy A Wise, William A Carlezo. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486179. |
for example, serotonin actions at 5-ht1b receptors in the ventral tegmental area (vta) modulate cocaine-induced dopamine release in the nucleus accumbens (nacc) and alter the rewarding and stimulant properties of cocaine. |
2003-01-23 |
2023-08-12 |
Not clear |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
these initial studies showed that: 1) the half-life of the transporter was between 2 and 3 days in these two brain regions; 2) pretreatment with dopamine d1 and d2 receptor agonists and antagonists over several days differentially altered dat half-lives in the striatum and nucleus accumbens; and 3) pretreatment with cocaine for several days increased the half-life of dat by decreasing the degradation rate constant in both brain regions. |
2003-01-23 |
2023-08-12 |
rat |
| Heather L Kimmel, F Ivy Carroll, Michael J Kuha. Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490570. |
cocaine pretreatment and withdrawal reduced the half-life of the transporter protein from 2.1 days to 0.94 day in the striatum, but did not alter the half-life of 2.2 days in the nucleus accumbens. |
2003-01-23 |
2023-08-12 |
rat |
| M S Todtenkopf, A Mihalakopoulos, J R Stella. Withdrawal duration differentially affects c-fos expression in the medial prefrontal cortex and discrete subregions of the nucleus accumbens in cocaine-sensitized rats. Neuroscience. vol 114. issue 4. 2003-01-10. PMID:12379259. |
repeated cocaine administration resulted in robust sensitization that correlated with a significant decrease in the density of c-fos nuclei in all three subdivisions of the medial prefrontal cortex, and two subdivisions of the nucleus accumbens only in animals challenged after a 2-day withdrawal period. |
2003-01-10 |
2023-08-12 |
rat |
| Zachary A Rodd-Henricks, David L McKinzie, Ting-Kai Li, James M Murphy, William J McBrid. Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438546. |
cocaine is self-administered into the shell but not the core of the nucleus accumbens of wistar rats. |
2002-12-24 |
2023-08-12 |
human |
| S Ikemot. Ventral striatal anatomy of locomotor activity induced by cocaine, D-amphetamine, dopamine and D1/D2 agonists. Neuroscience. vol 113. issue 4. 2002-11-27. PMID:12182899. |
however, injections of mixtures of the d(1)- and d(2)-type agonists skf 38393 and quinpirole or cocaine into the medial olfactory tubercle or the medial shell of the nucleus accumbens induced marked locomotion and rearing, while these injections into the core induced little or no locomotion or rearing. |
2002-11-27 |
2023-08-12 |
Not clear |
| Michelle E Ehrlich, John Sommer, Edwin Canas, Ellen M Unterwal. Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417638. |
here we demonstrate that, after chronic administration of the psychostimulants cocaine and amphetamine, the transcription factor deltafosb is upregulated in the nucleus accumbens of periadolescent mice but not in post-weanling or adult mice. |
2002-11-25 |
2023-08-12 |
mouse |
| Edmund Przegaliński, Joanna Siwanowicz, Iwona Papla, Małgorzata Fili. Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 5. 2002-11-22. PMID:12208556. |
the present study was designed to find out whether 5-ht(1b) receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. |
2002-11-22 |
2023-08-12 |
rat |
| Zheng-Xiong Xi, Sammanda Ramamoorthy, David A Baker, Hui Shen, Devadoss J Samuvel, Peter W Kaliva. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388642. |
repeated cocaine produces enduring neuroadaptations in glutamate transmission in the nucleus accumbens that are thought to contribute to addiction. |
2002-11-22 |
2023-08-12 |
human |
| Zheng-Xiong Xi, Sammanda Ramamoorthy, David A Baker, Hui Shen, Devadoss J Samuvel, Peter W Kaliva. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388642. |
together, these data demonstrate that repeated cocaine produces an enduring reduction in mglur2/3 function in the nucleus accumbens. |
2002-11-22 |
2023-08-12 |
human |
| Antoinette Y Freeman, R Christopher Pierc. Neutralization of neutrophin-3 in the ventral tegmental area or nucleus accumbens differentially modulates cocaine-induced behavioral plasticity in rats. Synapse (New York, N.Y.). vol 46. issue 2. 2002-11-19. PMID:12211082. |
a neutralizing antibody for nt-3, bdnf or their vehicle was administered into the ventral tegmental area (vta) or nucleus accumbens prior to each of four daily injections of 15 mg/kg cocaine. |
2002-11-19 |
2023-08-12 |
rat |