| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
here we report that, in dat-ko mice, cocaine and amphetamine increase dialysate dopamine in the medial part of the nucleus accumbens. |
2001-06-07 |
2023-08-12 |
mouse |
| E Carboni, C Spielewoy, C Vacca, M Nosten-Bertrand, B Giros, G Di Chiar. Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 9. 2001-06-07. PMID:11312315. |
these observations provide an explanation for the persistence of cocaine reinforcement in dat-ko mice and support the hypothesis of a primary role of nucleus accumbens dopamine in drug reinforcement. |
2001-06-07 |
2023-08-12 |
mouse |
| D Alvarez Fischer, M K Schäfer, B Ferger, S Gross, R Westermann, E Weihe, K Kuschinsk. Sensitization to the behavioural effects of cocaine: alterations in tyrosine hydroxylase or endogenous opioid mRNAs are not necessarily involved. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 3. 2001-05-24. PMID:11284443. |
microdialysis in the nucleus accumbens which was performed after administration of cocaine (10 mg/kg i.p.) |
2001-05-24 |
2023-08-12 |
rat |
| W M Freeman, M A Nader, S H Nader, D J Robertson, L Gioia, S M Mitchell, J B Daunais, L J Porrino, D P Friedman, K E Vran. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299316. |
cdna hybridization arrays were used to illuminate cocaine-regulated genes in the nucleus accumbens (nacc) of non-human primates (macaca fascicularis; cynomolgus macaque), treated daily with escalating doses of cocaine over one year. |
2001-05-17 |
2023-08-12 |
monkey |
| T E Robinson, G Gorny, E Mitton, B Kol. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse (New York, N.Y.). vol 39. issue 3. 2001-05-10. PMID:11169774. |
cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. |
2001-05-10 |
2023-08-12 |
rat |
| T E Robinson, G Gorny, E Mitton, B Kol. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse (New York, N.Y.). vol 39. issue 3. 2001-05-10. PMID:11169774. |
in rats that self-administered cocaine, but not rats that worked for food, there was a significant increase in dendritic branching and in the density of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens and on pyramidal cells in the prefrontal and parietal (but not occipital) cortex. |
2001-05-10 |
2023-08-12 |
rat |
| M S Brenz Verca, D A Widmer, G C Wagner, J Dreye. Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function. Molecular and cellular neurosciences. vol 17. issue 2. 2001-05-10. PMID:11178868. |
cd81, a tetraspanin transmembrane protein involved in cell adhesion, was found by differential display to be upregulated in the nucleus accumbens of rat brain following acute cocaine treatment (four injections of 30 mg/kg every 2 h followed by 24 h withdrawal). |
2001-05-10 |
2023-08-12 |
rat |
| T Yamamoto, K Yabuuchi, T Yamaguchi, M Nakamich. [Animal models of drug dependence using the drug self-administration method]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 117. issue 1. 2001-05-10. PMID:11233296. |
given that an ampa receptor antagonist, but not dopamine antagonist, prevented cocaine-seeking behavior induced by cocaine, glutamate transmission in the nucleus accumbens is thought to be important for expression of craving or drug-seeking behavior. |
2001-05-10 |
2023-08-12 |
Not clear |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
modulation of striatal dopamine (da) release by acute or repeated cocaine treatment was studied in the nucleus accumbens and caudate-putamen of alcohol-preferring (aa, alko alcohol) and alcohol-avoiding (ana, alko non-alcohol) rats. |
2001-05-03 |
2023-08-12 |
rat |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
the first administration of cocaine increased da concentration similarly in rats of both lines in both the nucleus accumbens and caudate-putamen. |
2001-05-03 |
2023-08-12 |
rat |
| J A Mikkola, A Honkanen, T P Piepponen, K Kiianmaa, L Ahte. Effects of repeated cocaine treatment on striatal dopamine release in alcohol-preferring AA and alcohol-avoiding ANA rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 2. 2001-05-03. PMID:11218073. |
on the 4th day, the effect of cocaine was significantly larger in the nucleus accumbens of aa than in that of ana rats, whereas no such enhanced effect of cocaine was found in the caudate-putamen of either line. |
2001-05-03 |
2023-08-12 |
rat |
| V David, L H Gold, G F Koob, P Cazal. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 3. 2001-04-19. PMID:11166520. |
to test the hypothesis that injections directly into a reward-relevant brain region might support consistent cocaine-seeking behavior, balb/cbyj mice implanted in the nucleus accumbens (nac) or the caudate-putamen nucleus (cpu) were trained to discriminate between the arm enabling a microinjection of cocaine (30 pmol/50 nl or 150 pmol/50 nl) and the neutral arm of a y-maze. |
2001-04-19 |
2023-08-12 |
mouse |
| M Filip, M L Thomas, K A Cunningha. Dopamine D5 receptors in nucleus accumbens contribute to the detection of cocaine in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11000198. |
dopamine d5 receptors in nucleus accumbens contribute to the detection of cocaine in rats. |
2001-02-22 |
2023-08-12 |
rat |
| R Ito, J W Dalley, S R Howes, T W Robbins, B J Everit. Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11007908. |
results showed the following: (1) nucleus accumbens da increased in both the core and shell during intravenous cocaine self-administration; (2) noncontingent presentations of a cocaine-associated cs+ led to increased da release selectively in the nucleus accumbens core; and (3) extracellular da levels were unaltered in both core and shell during a protracted period of drug-seeking behavior under the control of the same cocaine-associated cue. |
2001-02-22 |
2023-08-12 |
rat |
| A C Thompson, A Zapata, J B Justice, R A Vaughan, L G Sharpe, T S Shippenber. Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11125013. |
kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. |
2001-02-22 |
2023-08-12 |
rat |
| A C Thompson, A Zapata, J B Justice, R A Vaughan, L G Sharpe, T S Shippenber. Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11125013. |
coadministration of kappa-opioid receptor agonists (kappa-agonists) with cocaine prevents alterations in dialysate dopamine (da) concentration in the nucleus accumbens (acb) that occur during abstinence from repeated cocaine treatment. |
2001-02-22 |
2023-08-12 |
rat |
| A C Thompson, A Zapata, J B Justice, R A Vaughan, L G Sharpe, T S Shippenber. Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 24. 2001-02-22. PMID:11125013. |
these results demonstrate that kappa-opioid receptor activation modulates da uptake in the acb in a manner opposite to that of cocaine: repeated u-69593 administration decreases the basal rate of da uptake, and acute u-69593 administration transiently increases da uptake. |
2001-02-22 |
2023-08-12 |
rat |
| M Arroyo, W A Baker, B J Everit. Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides. Brain research. Molecular brain research. vol 83. issue 1-2. 2001-02-15. PMID:11072100. |
in addition, the expression of the striatal neuropeptides was also differentially altered; substance p mrna levels were transiently increased in the shell of the nucleus accumbens by prolonged cocaine self-administration, but enkephalin mrna levels in the dorsal and ventral striatum remained unaltered under all conditions. |
2001-02-15 |
2023-08-12 |
rat |
| M Barrot, M C Rettori, B Guardiola-Lemaître, C Jarry, M Le Moal, P V Piazz. Interactions between imidazoline binding sites and dopamine levels in the rat nucleus accumbens. The European journal of neuroscience. vol 12. issue 12. 2001-02-15. PMID:11122366. |
s23229 had a stronger efficacy than s23230 and increased dopamine levels in the nucleus accumbens at an extent similar to the one of cocaine. |
2001-02-15 |
2023-08-12 |
rat |
| K K Szumlinski, I M Maisonneuve, S D Glic. Iboga interactions with psychomotor stimulants: panacea in the paradox? Toxicon : official journal of the International Society on Toxinology. vol 39. issue 1. 2001-02-02. PMID:10936624. |
however, this interpretation is contradicted by very recent observations that 18-mc is without effect on the dopamine response to acute cocaine and that both ibogaine and 18-mc block the expression of sensitized levels of dopamine in the nucleus accumbens produced by chronic cocaine administration. |
2001-02-02 |
2023-08-12 |
Not clear |