| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Cornish, P Duffy, P W Kaliva. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501460. |
this study investigated the effect of ionotropic glutamate receptor agonist or antagonist administration into the nucleus accumbens on the maintenance of cocaine self-administration and the reinstatement of cocaine-seeking behavior. |
1999-12-09 |
2023-08-12 |
Not clear |
| J L Cornish, P Duffy, P W Kaliva. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501460. |
the stimulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or n-methyl-d-aspartate glutamate receptors in the nucleus accumbens with either alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or 1-aminocyclobutane-cis-1,3-dicarboxylic acid, respectively, decreased the number of cocaine-reinforced responses, suggesting an enhancement in the rewarding properties of cocaine. |
1999-12-09 |
2023-08-12 |
Not clear |
| J L Cornish, P Duffy, P W Kaliva. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501460. |
these results suggest that stimulation of glutamate receptors in the nucleus accumbens augments the reinforcing effect of cocaine, yet glutamate transmission is not required to maintain cocaine self-administration. |
1999-12-09 |
2023-08-12 |
Not clear |
| S A Bennett, J M Arnold, J Chen, J Stenger, D L Paul, D C Robert. Long-term changes in connexin32 gap junction protein and mRNA expression following cocaine self-administration in rats. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510198. |
using elisa, western analysis, immunohistochemistry, semi-quantitative reverse transcriptase polymerase chain reaction (rt-pcr), and non-radioactive in situ hybridization, we demonstrate that withdrawal from chronic cocaine self-administration causes lasting changes in connexin32 (cx32) expression in the nucleus accumbens and hippocampus at 2, 7 and 21 days after the last cocaine injection. |
1999-11-24 |
2023-08-12 |
rat |
| A Rosin, S Lindholm, J Franck, J Georgiev. Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neuroscience letters. vol 275. issue 1. 1999-11-15. PMID:10554970. |
downregulation of kappa opioid receptor mrna levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. |
1999-11-15 |
2023-08-12 |
human |
| A Rosin, S Lindholm, J Franck, J Georgiev. Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neuroscience letters. vol 275. issue 1. 1999-11-15. PMID:10554970. |
here, the effects of separately and concurrently administered ethanol and 'binge' cocaine on kappa opioid receptor (kor) mrna in the ventral tegmental area (vta) and nucleus accumbens (nac) of rats were studied. |
1999-11-15 |
2023-08-12 |
human |
| M B Kelz, J Chen, W A Carlezon, K Whisler, L Gilden, A M Beckmann, C Steffen, Y J Zhang, L Marotti, D W Self, T Tkatch, G Baranauskas, D J Surmeier, R L Neve, R S Duman, M R Picciotto, E J Nestle. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature. vol 401. issue 6750. 1999-10-14. PMID:10499584. |
using transgenic mice in which deltafosb can be induced in adults in the subset of nucleus accumbens neurons in which cocaine induces the protein, we show that deltafosb expression increases the responsiveness of an animal to the rewarding and locomotor-activating effects of cocaine. |
1999-10-14 |
2023-08-12 |
mouse |
| J Turchan, B Przewłocka, G Toth, W Lasoń, A Borsodi, R Przewłock. The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391475. |
the effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. |
1999-10-08 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, G Toth, W Lasoń, A Borsodi, R Przewłock. The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391475. |
the present study was carried out to evaluate the effect of morphine, cocaine and ethanol on the density of opioid receptors in the nucleus accumbens and striatum of rat brain. |
1999-10-08 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, G Toth, W Lasoń, A Borsodi, R Przewłock. The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391475. |
repeated morphine administration decreased the receptor density after both ligands of the delta receptor in the nucleus accumbens after 3, 24 and 48 h, and in the striatum after 24 and 48 h. the density of [3h]ile5,6deltorphin b binding remained unchanged in both structures following repeated cocaine administration. |
1999-10-08 |
2023-08-12 |
rat |
| J Turchan, B Przewłocka, G Toth, W Lasoń, A Borsodi, R Przewłock. The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391475. |
after repeated cocaine administration either no changes (3 h) or a decrease in the binding of [3h]h-tyr-tic psi[ch2-nh]phe-phe-oh in the nucleus accumbens and striatum were observed after 24 and 48 h. ethanol did not influence the binding density of [3h]h-tyr-tic psi[ch2-nh]phe-phe-oh and [3h]ile5,6deltorphin b in the nucleus accumbens and striatum at any time-point studied. |
1999-10-08 |
2023-08-12 |
rat |
| P W Kalivas, P Duffy, S A Mackle. Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400893. |
nac-1 is an mrna that is increased selectively in the nucleus accumbens after acute and repeated cocaine administration. |
1999-09-27 |
2023-08-12 |
rat |
| P W Kalivas, P Duffy, S A Mackle. Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400893. |
antisense or control oligonucleotides were microinjected into the nucleus accumbens of rats to define the role of nac-1 in the behavioral responses to acute systemic cocaine. |
1999-09-27 |
2023-08-12 |
rat |
| P W Kalivas, P Duffy, S A Mackle. Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400893. |
the augmentation in cocaine motor behavior produced by nac-1 antisense pretreatment in the nucleus accumbens was not associated with increased dopamine release as estimated by microdialysis. |
1999-09-27 |
2023-08-12 |
rat |
| P W Kalivas, P Duffy, S A Mackle. Interrupted expression of NAC-1 augments the behavioral responses to cocaine. Synapse (New York, N.Y.). vol 33. issue 2. 1999-09-27. PMID:10400893. |
these data suggest that the induction of nac-1 by cocaine may be a compensatory mechanism that minimizes the behavioral impact of cocaine administration by regulating postsynaptic dopamine transmission within the nucleus accumbens. |
1999-09-27 |
2023-08-12 |
rat |
| G Hedou, J Feldon, C A Heidbrede. Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens. European journal of pharmacology. vol 372. issue 2. 1999-08-17. PMID:10395094. |
effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens. |
1999-08-17 |
2023-08-12 |
rat |
| G Hedou, J Feldon, C A Heidbrede. Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens. European journal of pharmacology. vol 372. issue 2. 1999-08-17. PMID:10395094. |
the present study sought to investigate the contributions of the ventral prelimbic/infralimbic cortices and shell subterritory of the nucleus accumbens as well as the dorsal prelimbic/anterior cingulate cortices and core subregion of the nucleus accumbens to the acute systemic effects of cocaine (20 mg/kg i.p.) |
1999-08-17 |
2023-08-12 |
rat |
| G Hedou, J Feldon, C A Heidbrede. Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens. European journal of pharmacology. vol 372. issue 2. 1999-08-17. PMID:10395094. |
in contrast, cocaine significantly increased dialysate dopamine in the shell of the nucleus accumbens, whereas only a slight increase in dopamine was observed in the core subregion of the nucleus accumbens. |
1999-08-17 |
2023-08-12 |
rat |
| G Hedou, J Feldon, C A Heidbrede. Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens. European journal of pharmacology. vol 372. issue 2. 1999-08-17. PMID:10395094. |
in contrast, the magnitude of the locomotor response to cocaine became progressively larger as dopamine levels increased in the shell of the nucleus accumbens. |
1999-08-17 |
2023-08-12 |
rat |
| G Hedou, J Feldon, C A Heidbrede. Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens. European journal of pharmacology. vol 372. issue 2. 1999-08-17. PMID:10395094. |
these results show a dissociation in the pattern of dopamine release in subterritories of both the medial prefrontal cortex and nucleus accumbens in response to the acute systemic administration of cocaine. |
1999-08-17 |
2023-08-12 |
rat |