| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johanna Schumann, Rami Yak. Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474322. |
cocaine-induced changes in glutamatergic synaptic transmission in the ventral tegmental area (vta) and the nucleus accumbens (nac) play a key role in cocaine behavioral effects. |
2009-06-23 |
2023-08-12 |
Not clear |
| C J Malanga, Jia-Qian Ren, Réjean M Guerriero, Barry E Kosofsk. Augmentation of cocaine-sensitized dopamine release in the nucleus accumbens of adult mice following prenatal cocaine exposure. Developmental neuroscience. vol 31. issue 1-2. 2009-06-16. PMID:19372689. |
augmentation of cocaine-sensitized dopamine release in the nucleus accumbens of adult mice following prenatal cocaine exposure. |
2009-06-16 |
2023-08-12 |
mouse |
| Evan P Sleipness, Heiko T Jansen, James O Schenk, Barbara A Sor. Time-of-day differences in dopamine clearance in the rat medial prefrontal cortex and nucleus accumbens. Synapse (New York, N.Y.). vol 62. issue 12. 2009-05-26. PMID:18792987. |
we used rotating disk electrode voltammetry to examine dopamine clearance and inhibition of clearance by cocaine in the rat medial prefrontal cortex (mpfc) and nucleus accumbens (nac). |
2009-05-26 |
2023-08-12 |
rat |
| S Pendyam, A Mohan, P W Kalivas, S S Nai. Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19084053. |
computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. |
2009-05-20 |
2023-08-12 |
rat |
| S Pendyam, A Mohan, P W Kalivas, S S Nai. Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19084053. |
chronic cocaine administration causes instability in extracellular glutamate in the nucleus accumbens that is thought to contribute to the vulnerability to relapse. |
2009-05-20 |
2023-08-12 |
rat |
| Danielle L Graham, Vaishnav Krishnan, Erin B Larson, Ami Graham, Scott Edwards, Ryan K Bachtell, Diana Simmons, Lana M Gent, Olivier Berton, Carlos A Bolanos, Ralph J DiLeone, Luis F Parada, Eric J Nestler, David W Sel. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biological psychiatry. vol 65. issue 8. 2009-05-19. PMID:18990365. |
previous studies found that brain-derived neurotrophic factor (bdnf) derived from nucleus accumbens (nac) neurons can mediate persistent behavioral changes that contribute to cocaine addiction. |
2009-05-19 |
2023-08-12 |
Not clear |
| Laura Orio, Scott Edwards, Olivier George, Loren H Parsons, George F Koo. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 15. 2009-05-12. PMID:19369553. |
anandamide levels in the nucleus accumbens (nac) shell were decreased in sha rats but unchanged in lga rats during cocaine self-administration. |
2009-05-12 |
2023-08-12 |
human |
| Erik B Oleson, Sanjay Talluri, Steven R Childers, James E Smith, David C S Roberts, Keith D Bonin, Evgeny A Budygi. Dopamine uptake changes associated with cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18923398. |
cocaine was intravenously infused into anesthetized rats, according to inter-infusion intervals obtained from self-administering animals, and dopamine uptake changes (apparent k(m)) were assessed in the nucleus accumbens using voltammetry. |
2009-05-07 |
2023-08-12 |
rat |
| Małgorzata Frankowska, Karolina Wydra, Agata Faron-Górecka, Magdalena Zaniewska, Maciej Kuśmider, Marta Dziedzicka-Wasylewska, Małgorzata Fili. Alterations in gamma-aminobutyric acid(B) receptor binding in the rat brain after reinstatement of cocaine-seeking behavior. Pharmacological reports : PR. vol 60. issue 6. 2009-04-23. PMID:19211975. |
the binding of [(3)h]cgp 54626 in the nucleus accumbens and the amygdaloid complex was decreased by about 20% in rats that actively administered cocaine. |
2009-04-23 |
2023-08-12 |
rat |
| George A Rogge, Douglas C Jones, Thomas Green, Eric Nestler, Michael J Kuha. Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain research. vol 1251. 2009-04-20. PMID:19046951. |
production of mrna from the cocaine- and amphetamine-regulated transcript (cart) gene is regulated by cocaine and other drugs of abuse in the nucleus accumbens (nac), a brain reward region. |
2009-04-20 |
2023-08-12 |
rat |
| Armina T Wiggins, Alejandra M Pacchioni, Peter W Kaliva. Integrin expression is altered after acute and chronic cocaine. Neuroscience letters. vol 450. issue 3. 2009-04-20. PMID:19073234. |
cocaine addiction is associated with an increase in actin cycling and alterations in dendritic spines in the nucleus accumbens. |
2009-04-20 |
2023-08-12 |
mouse |
| Armina T Wiggins, Alejandra M Pacchioni, Peter W Kaliva. Integrin expression is altered after acute and chronic cocaine. Neuroscience letters. vol 450. issue 3. 2009-04-20. PMID:19073234. |
after 3 weeks of withdrawal, the level of beta-integrins in the postsynaptic density enriched subfraction from nucleus accumbens tissue was quantified by immunoblotting at 0, 30 or 120min following an a cocaine challenge injection. |
2009-04-20 |
2023-08-12 |
mouse |
| Tao Li, Chun-Xia Yan, Ying Hou, Wei Cao, Teng Chen, Bo-Feng Zhu, Sheng-Bing L. Cue-elicited drug craving represses ERK activation in mice prefrontal association cortex. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18940233. |
in the accumbens nucleus (acb) and caudate putamen (cpu) that are associated with cocaine addiction, the activities of erk1 and erk2 among four groups showed no difference. |
2009-04-16 |
2023-08-12 |
mouse |
| Giovanni Hernandez, Eric Haines, Peter Shizga. Potentiation of intracranial self-stimulation during prolonged subcutaneous infusion of cocaine. Journal of neuroscience methods. vol 175. issue 1. 2009-04-09. PMID:18765253. |
in the first, changes in dopamine tone in the nucleus accumbens were measured by means of microdialysis during prolonged subcutaneous infusions of cocaine. |
2009-04-09 |
2023-08-12 |
Not clear |
| Olga D Taraschenko, Heather Y Rubbinaccio, Isabelle M Maisonneuve, Stanley D Glic. 18-methoxycoronaridine: a potential new treatment for obesity in rats? Psychopharmacology. vol 201. issue 3. 2009-04-07. PMID:18751969. |
since 18-methoxycoronaridine (18-mc), a selective antagonist of alpha3beta4 nicotinic receptors, was previously shown to alter dopamine release in the nucleus accumbens in response to chronic injections of cocaine and morphine, this drug could be a promising therapy for abnormal eating behavior. |
2009-04-07 |
2023-08-12 |
rat |
| Rajani Maiya, Yan Zhou, Erin H Norris, Mary Jeanne Kreek, Sidney Stricklan. Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 6. 2009-03-10. PMID:19181855. |
compared with wt mice, tpa-/- mice injected with cocaine displayed attenuated phosphorylation of erk, camp response element binding protein (creb), and dopamine and camp-regulated phosphoprotein 32 kda (darpp-32) and blunted induction of immediate early genes (iegs) c-fos, egr-1, and homer 1a in the amygdala and the nucleus accumbens (nac). |
2009-03-10 |
2023-08-12 |
mouse |
| Lars V Kristiansen, Michael J Bannon, James H Meador-Woodruf. Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18357522. |
chronic abuse of cocaine is known to cause neuroadaptive changes in the nucleus accumbens (nac) and ventral tegmental area (vta). |
2009-02-23 |
2023-08-12 |
human |
| Ahmed A Othman, Amy H Newman, Natalie D Eddingto. The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. Journal of pharmaceutical sciences. vol 97. issue 12. 2009-02-10. PMID:18425847. |
effect of ga2-50 on the extracelluar nucleus accumbens (nac) dopamine levels and on cocaine's induced dopamine elevation was evaluated using intracerebral microdialysis. |
2009-02-10 |
2023-08-12 |
human |
| Seong-Yeol Nah, Kamal S Bhatia, Johnnie Lyles, Everett H Ellinwood, Tong H Le. Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens. Brain research. vol 1248. 2009-02-03. PMID:19026615. |
we previously used the real-time fast-scan cyclic voltammetry in rat nucleus accumbens slices to demonstrate that cocaine not only enhances da release evoked by single-pulse electrical stimulation and inhibits da uptake during application but also further increases the release upon washout (termed a "rebound" release enhancement). |
2009-02-03 |
2023-08-12 |
rat |
| Rita A Fuchs, Donna R Ramirez, Guinevere H Bel. Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats. Psychopharmacology. vol 200. issue 4. 2009-01-29. PMID:18597075. |
the nucleus accumbens (nac) is a functionally heterogeneous brain region with respect to its involvement in cocaine-seeking behavior triggered by drug-associated explicit conditioned stimuli, foot shock stress, or cocaine itself in the reinstatement animal model of drug relapse. |
2009-01-29 |
2023-08-12 |
rat |