| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmen del Castillo, Lidia Morales, Luis F Alguacil, Elisabet Salas, Elisa Garrido, Elba Alonso, Carmen Pérez-Garcí. Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. Neuropharmacology. vol 57. issue 1. 2009-10-01. PMID:19393250. |
proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. |
2009-10-01 |
2023-08-12 |
rat |
| Carmen del Castillo, Lidia Morales, Luis F Alguacil, Elisabet Salas, Elisa Garrido, Elba Alonso, Carmen Pérez-Garcí. Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. Neuropharmacology. vol 57. issue 1. 2009-10-01. PMID:19393250. |
once the phenotype was established, we compared the protein expression in the nucleus accumbens (nac) of these animals after a single injection of either saline (sal) or cocaine (coc, 15 mg/kg). |
2009-10-01 |
2023-08-12 |
rat |
| John E Kelsey, Ellen J Willmor. Electrolytic lesions of the nucleus accumbens enhance locomotor sensitization to nicotine in rats. Behavioral neuroscience. vol 120. issue 3. 2009-09-30. PMID:16768612. |
electrolytic lesions of the medial core of the nucleus accumbens (nac) in male long-evans rats increased spontaneous locomotion, enhanced the locomotor stimulating effect of acute 5.0 mg/kg cocaine, enhanced the development and subsequent expression of locomotor sensitization produced by repeated injections of 0.4 mg/kg nicotine but not 7.5 mg/kg cocaine, and enhanced the expression of conditioned locomotion. |
2009-09-30 |
2023-08-12 |
rat |
| Gianluigi Tanda, Amy Hauck Newman, Aaron L Ebbs, Valeria Tronci, Jennifer L Green, Ronald J Tallarida, Jonathan L Kat. Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity. The Journal of pharmacology and experimental therapeutics. vol 330. issue 3. 2009-09-21. PMID:19483071. |
effects of combinations of cocaine with a cocaine analog, 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (win 35,428), were compared quantitatively with the combinations of cocaine with the n-butyl,4',4''-dif benztropine analog, 3-(bis(4-fluorophenyl)methoxy)-8-butyl-8-azabicyclo[3.2.1]octane (jhw 007), to determine whether their effects on da levels in the shell of the nucleus accumbens (nac) in mice differed. |
2009-09-21 |
2023-08-12 |
mouse |
| Catharine A Winstanley, Thomas A Green, David E H Theobald, William Renthal, Quincey LaPlant, Ralph J DiLeone, Sumana Chakravarty, Eric J Nestle. DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. Pharmacology, biochemistry, and behavior. vol 93. issue 3. 2009-09-16. PMID:19135469. |
analysis of nucleus accumbens tissue taken from rats over-expressing deltafosb in the ofc and treated chronically with saline or cocaine does not provide support for the hypothesis that increasing ofc deltafosb potentiates sensitization via the nucleus accumbens. |
2009-09-16 |
2023-08-12 |
rat |
| Manuel Mameli, Briac Halbout, Cyril Creton, David Engblom, Jan Rodriguez Parkitna, Rainer Spanagel, Christian Lüsche. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nature neuroscience. vol 12. issue 8. 2009-09-09. PMID:19597494. |
in the ventral tegmental area (vta), a single exposure to cocaine efficiently triggers nmda receptor-dependent synaptic plasticity in da neurons, whereas plasticity in the nucleus accumbens (nac) occurs only after repeated injections. |
2009-09-09 |
2023-08-12 |
mouse |
| Darlene H Brunzell, Yann S Mineur, Rachael L Neve, Marina R Picciott. Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 8. 2009-09-02. PMID:19212318. |
previous studies have implicated nucleus accumbens (nac) creb activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (cpp) is associated with nac creb activation. |
2009-09-02 |
2023-08-12 |
mouse |
| Guo-Chi Zhang, Li-Min Mao, John Q Wang, Xiang-Ping Ch. Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo. Neuroscience letters. vol 459. issue 3. 2009-08-24. PMID:19427358. |
we found that chronic systemic injection of cocaine (20mg/kg, once daily for 5 consecutive days; 14 days of withdrawal) increased asic1, but not asic2, protein levels in the striatum, including the dorsal (caudate putamen) and the ventral (nucleus accumbens) striatum. |
2009-08-24 |
2023-08-12 |
mouse |
| Z-X Xi, H K Kleitz, X Deng, B Ladenheim, X-Q Peng, X Li, E L Gardner, E A Stein, J L Cade. A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats. Neuroscience. vol 161. issue 2. 2009-08-19. PMID:19336247. |
the increased cocaine self-administration appeared to be a compensatory response to reduced cocaine reward after meth, because the same doses of meth caused a dose-dependent reduction both in "break-point" levels for cocaine self-administration under progressive-ratio reinforcement and in nucleus accumbens da response to acute cocaine. |
2009-08-19 |
2023-08-12 |
rat |
| Yanhua H Huang, Ying Lin, Ping Mu, Brian R Lee, Travis E Brown, Gary Wayman, Helene Marie, Wenhua Liu, Zhen Yan, Barbara A Sorg, Oliver M Schlüter, R Suzanne Zukin, Yan Don. In vivo cocaine experience generates silent synapses. Neuron. vol 63. issue 1. 2009-08-11. PMID:19607791. |
here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (nac) shell, a key brain region mediating addiction-related learning and memory. |
2009-08-11 |
2023-08-12 |
Not clear |
| Clifford M Knapp, Lisa Tozier, Arlene Pak, Domenic A Ciraulo, Conan Kornetsk. Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19463262. |
recent studies have shown that deep brain stimulation (dbs) of the nucleus accumbens (nacc) has an inhibitory effect on drug-seeking behaviors including reinstatement responding for cocaine. |
2009-08-05 |
2023-08-12 |
rat |
| Xia Li, Jie Li, Xiao-Qing Peng, Krista Spiller, Eliot L Gardner, Zheng-Xiong X. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19158667. |
microinjections of amn082 (1-5 microg/microl per side) into the nucleus accumbens (nac) or ventral pallidum (vp), but not dorsal striatum, also inhibited cocaine self-administration in a dose-dependent manner. |
2009-08-03 |
2023-08-12 |
rat |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Jeffrey A Zidichouski, Tarek M Sale. Substance P and cocaine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. The European journal of neuroscience. vol 29. issue 8. 2009-07-13. PMID:19385993. |
substance p and cocaine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. |
2009-07-13 |
2023-08-12 |
rat |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Jeffrey A Zidichouski, Tarek M Sale. Substance P and cocaine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. The European journal of neuroscience. vol 29. issue 8. 2009-07-13. PMID:19385993. |
substance p (sp) has been reported to produce effects on excitatory synaptic transmission in the nucleus accumbens (nac) that are similar to those induced by cocaine. |
2009-07-13 |
2023-08-12 |
rat |
| Gian Marco Leggio, Adeline Cathala, Delphine Moison, Kathryn A Cunningham, Pier Vincenzo Piazza, Umberto Spampinat. Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:18977370. |
a functional balance between excitatory and inhibitory control over dopamine (da)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin(2c) receptor (5-ht(2c)r) located within the ventral tegmental area and the nucleus accumbens (nac). |
2009-07-01 |
2023-08-12 |
rat |
| A R Soderman, E M Unterwal. Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18550291. |
adult male sprague-dawley rats received injections of ctap into the caudate putamen, the rostral or caudal ventral tegmental area (vta) or the medial shell or core of the nucleus accumbens prior to cocaine to determine the role of mu opioid receptors in cocaine-induced reward and hyperactivity. |
2009-06-29 |
2023-08-12 |
rat |
| A R Soderman, E M Unterwal. Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18550291. |
these results demonstrate the importance of mu opioid receptors in the nucleus accumbens and vta in cocaine-induced reward and hyperactivity and suggest that some aspects of the behavioral effects of cocaine are mediated by endogenous activation of mu opioid receptors in these brain regions. |
2009-06-29 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher Mueller, Chad Seubert, John R Mantsc. Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration. Neuroscience letters. vol 452. issue 2. 2009-06-29. PMID:19118598. |
cocaine self-administration followed by home cage exposure reduced the mglur5 protein in nucleus accumbens (na) shell and dorsolateral striatum. |
2009-06-29 |
2023-08-12 |
rat |
| William Renthal, Arvind Kumar, Guanghua Xiao, Matthew Wilkinson, Herbert E Covington, Ian Maze, Devanjan Sikder, Alfred J Robison, Quincey LaPlant, David M Dietz, Scott J Russo, Vincent Vialou, Sumana Chakravarty, Thomas J Kodadek, Ashley Stack, Mohamed Kabbaj, Eric J Nestle. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron. vol 62. issue 3. 2009-06-23. PMID:19447090. |
the findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins (sirt1 and sirt2)-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug. |
2009-06-23 |
2023-08-12 |
mouse |
| Johanna Schumann, Rami Yak. Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474322. |
prolonged withdrawal from repeated noncontingent cocaine exposure increases nmda receptor expression and erk activity in the nucleus accumbens. |
2009-06-23 |
2023-08-12 |
Not clear |