| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lionel Host, Patrick Anglard, Pascal Romieu, Christelle Thibault, Doulaye Dembele, Dominique Aunis, Jean Zwille. Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20132486. |
in the present study, we investigated alterations in gene expression patterns in the anterior cingulate cortex and nucleus accumbens of rats self-administering cocaine and treated with tsa. |
2010-04-30 |
2023-08-12 |
rat |
| Lionel Host, Patrick Anglard, Pascal Romieu, Christelle Thibault, Doulaye Dembele, Dominique Aunis, Jean Zwille. Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20132486. |
using oligonucleotide microarrays, we identified 722 probe sets in the cortex and 136 probe sets in the nucleus accumbens that were differentially expressed between vehicle and tsa-treated rats that self-administered cocaine. |
2010-04-30 |
2023-08-12 |
rat |
| Lionel Host, Patrick Anglard, Pascal Romieu, Christelle Thibault, Doulaye Dembele, Dominique Aunis, Jean Zwille. Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20132486. |
tsa treatment was found to up-regulate both lis1 and reelin protein expression in the cortex and to down-regulate it in the nucleus accumbens of rats self-administering cocaine. |
2010-04-30 |
2023-08-12 |
rat |
| Ping Mu, Jason T Moyer, Masago Ishikawa, Yonghong Zhang, Jaak Panksepp, Barbara A Sorg, Oliver M Schlüter, Yan Don. Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 10. 2010-04-09. PMID:20220002. |
exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons. |
2010-04-09 |
2023-08-12 |
rat |
| Xiao-Qing Peng, Jie Li, Eliot L Gardner, Charles R Ashby, Ajit Thomas, Krystyna Wozniak, Barbara S Slusher, Zheng-Xiong X. Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19887067. |
we have recently reported that the endogenous mglu2/3 agonist n-acetylaspartylglutamate (naag) and the n-acetylated-alpha-linked-acidic dipeptidase (naaladase, a naag degradation enzyme) inhibitor 2-pmpa significantly inhibit cocaine self-administration and cocaine-induced reinstatement of drug-seeking behavior by attenuating cocaine-enhanced extracellular dopamine and glutamate in the nucleus accumbens. |
2010-04-05 |
2023-08-12 |
rat |
| Heath D Schmidt, R Christopher Pierc. Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Annals of the New York Academy of Sciences. vol 1187. 2010-04-02. PMID:20201846. |
a growing body of evidence indicates that repeated exposure to cocaine leads to profound changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. |
2010-04-02 |
2023-08-12 |
Not clear |
| N S Tannu, L L Howell, S E Hemb. Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration. Molecular psychiatry. vol 15. issue 2. 2010-03-30. PMID:18504425. |
integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration. |
2010-03-30 |
2023-08-12 |
human |
| N S Tannu, L L Howell, S E Hemb. Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration. Molecular psychiatry. vol 15. issue 2. 2010-03-30. PMID:18504425. |
the reinforcing effects and long-term consequences of cocaine self-administration have been associated with brain regions of the mesolimbic dopamine pathway, namely the nucleus accumbens (nac). |
2010-03-30 |
2023-08-12 |
human |
| G W Hubert, D F Manvich, M J Kuha. Cocaine and amphetamine-regulated transcript-containing neurons in the nucleus accumbens project to the ventral pallidum in the rat and may inhibit cocaine-induced locomotion. Neuroscience. vol 165. issue 1. 2010-03-11. PMID:19825396. |
cocaine and amphetamine-regulated transcript-containing neurons in the nucleus accumbens project to the ventral pallidum in the rat and may inhibit cocaine-induced locomotion. |
2010-03-11 |
2023-08-12 |
rat |
| Joachim D Uys, Angus C Grey, Armina Wiggins, John H Schwacke, Kevin L Schey, Peter W Kaliva. Matrix-assisted laser desorption/ionization tissue profiling of secretoneurin in the nucleus accumbens shell from cocaine-sensitized rats. Journal of mass spectrometry : JMS. vol 45. issue 1. 2010-03-10. PMID:19918966. |
in an effort to measure changes in nucleus accumbens protein expression as potential biomarkers for addiction, coronal tissue sections were obtained from rats that developed behavioral sensitization after daily administration of cocaine, or from daily saline-treated controls. |
2010-03-10 |
2023-08-12 |
rat |
| Deranda B Lester, Anthony D Miller, Charles D Blah. Muscarinic receptor blockade in the ventral tegmental area attenuates cocaine enhancement of laterodorsal tegmentum stimulation-evoked accumbens dopamine efflux in the mouse. Synapse (New York, N.Y.). vol 64. issue 3. 2010-03-02. PMID:19862686. |
the reinforcing properties of cocaine have been related to increased extracellular concentrations of dopamine in the nucleus accumbens (nac). |
2010-03-02 |
2023-08-12 |
mouse |
| Brandon J Aragona, Jeremy J Day, Mitchell F Roitman, Nathan A Cleaveland, R Mark Wightman, Regina M Carell. Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats. The European journal of neuroscience. vol 30. issue 10. 2010-02-26. PMID:19912327. |
drug seeking is significantly regulated by drug-associated cues and associative learning between environmental cues and cocaine reward is mediated by dopamine transmission within the nucleus accumbens (nac). |
2010-02-26 |
2023-08-12 |
rat |
| Marcelo T Marin, Alexander Berkow, Sam A Golden, Eisuke Koya, Cleopatra S Planeta, Bruce T Hop. Context-specific modulation of cocaine-induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens. The European journal of neuroscience. vol 30. issue 10. 2010-02-26. PMID:19912338. |
in contrast, creb and camkiv phosphorylation in nucleus accumbens homogenates were decreased by cocaine test injections. |
2010-02-26 |
2023-08-12 |
rat |
| E Rodríguez-Borrero, F Rivera-Escalera, F Candelas, J Montalvo, W J Muñoz-Miranda, J R Walker, C S Maldonado-Vlaa. Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats. Neuropharmacology. vol 58. issue 1. 2010-02-25. PMID:19596360. |
it is known that changes in gene expression within the nucleus accumbens (nac) occur during cocaine dependence development. |
2010-02-25 |
2023-08-12 |
human |
| Lori A Knackstedt, Roberto I Melendez, Peter W Kaliva. Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological psychiatry. vol 67. issue 1. 2010-02-25. PMID:19717140. |
the cystine-glutamate exchanger is downregulated after chronic cocaine, resulting in reduced extracellular levels of nucleus accumbens glutamate. |
2010-02-25 |
2023-08-12 |
Not clear |
| E E Velazquez, A Valdomero, O A Orsingher, G R Cuadr. Perinatal undernutrition facilitates morphine sensitization and cross-sensitization to cocaine in adult rats: a behavioral and neurochemical study. Neuroscience. vol 165. issue 2. 2010-02-24. PMID:19892003. |
a challenge with cocaine in morphine pre-exposed animals produced an increase in da release, but only in the nucleus accumbens "core" of d-rats. |
2010-02-24 |
2023-08-12 |
rat |
| Vijay Chandrasekar, Jean-Luc Dreye. The brain-specific Neural Zinc Finger transcription factor 2b (NZF-2b/7ZFMyt1) causes suppression of cocaine-induced locomotor activity. Neurobiology of disease. vol 37. issue 1. 2010-02-22. PMID:19786102. |
chronic cocaine induces high expression of the brain-specific neural-zinc-finger transcription factor-2b (nzf-2b/7zfmyt1), particularly in the mesolimbic dopaminergic pathway, resulting in a 11-fold increase in nzf-2b/7zfmyt1 expression in the nucleus accumbens (nac). |
2010-02-22 |
2023-08-12 |
Not clear |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Annamalai Balasubramaniam, Ronald E See, Lankupalle D Jayanth. Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Biochemical and biophysical research communications. vol 391. issue 3. 2010-02-22. PMID:20035724. |
here, we determined the changes in molecular mechanisms of dat regulation in the caudate-putamen (cpu) and nucleus accumbens (nacc) of rats with a history of cocaine self-administration, followed by 3weeks of withdrawal under extinction conditions (i.e., no cocaine available). |
2010-02-22 |
2023-08-12 |
rat |
| Ian Maze, Herbert E Covington, David M Dietz, Quincey LaPlant, William Renthal, Scott J Russo, Max Mechanic, Ezekiell Mouzon, Rachael L Neve, Stephen J Haggarty, Yanhua Ren, Srihari C Sampath, Yasmin L Hurd, Paul Greengard, Alexander Tarakhovsky, Anne Schaefer, Eric J Nestle. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (New York, N.Y.). vol 327. issue 5962. 2010-01-26. PMID:20056891. |
repeated cocaine administration reduced global levels of h3k9 dimethylation in the nucleus accumbens. |
2010-01-26 |
2023-08-12 |
mouse |
| Ian Maze, Herbert E Covington, David M Dietz, Quincey LaPlant, William Renthal, Scott J Russo, Max Mechanic, Ezekiell Mouzon, Rachael L Neve, Stephen J Haggarty, Yanhua Ren, Srihari C Sampath, Yasmin L Hurd, Paul Greengard, Alexander Tarakhovsky, Anne Schaefer, Eric J Nestle. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (New York, N.Y.). vol 327. issue 5962. 2010-01-26. PMID:20056891. |
using conditional mutagenesis and viral-mediated gene transfer, we found that g9a down-regulation increased the dendritic spine plasticity of nucleus accumbens neurons and enhanced the preference for cocaine, thereby establishing a crucial role for histone methylation in the long-term actions of cocaine. |
2010-01-26 |
2023-08-12 |
mouse |