| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary Kay Lobo, Herbert E Covington, Dipesh Chaudhury, Allyson K Friedman, HaoSheng Sun, Diane Damez-Werno, David M Dietz, Samir Zaman, Ja Wook Koo, Pamela J Kennedy, Ezekiell Mouzon, Murtaza Mogri, Rachael L Neve, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (New York, N.Y.). vol 330. issue 6002. 2010-11-10. PMID:20947769. |
because loss of trkb in d2+ neurons increases their neuronal excitability, we next used optogenetic tools to control selectively the firing rate of d1+ and d2+ nucleus accumbens neurons and studied consequent effects on cocaine reward. |
2010-11-10 |
2023-08-12 |
Not clear |
| Adam Podet, Min J Lee, Alan C Swann, Nachum Dafn. Nucleus accumbens lesions modulate the effects of methylphenidate. Brain research bulletin. vol 82. issue 5-6. 2010-11-01. PMID:20470871. |
in studies on cocaine and amphetamine, this effect has been reported to involve the nucleus accumbens (nac), one of the nuclei belonging to the motive circuit. |
2010-11-01 |
2023-08-12 |
rat |
| Anthony T Fabbricatore, Udi E Ghitza, Volodymyr F Prokopenko, Mark O Wes. Electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration II: phasic firing patterns. The European journal of neuroscience. vol 31. issue 9. 2010-10-14. PMID:20525080. |
electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration ii: phasic firing patterns. |
2010-10-14 |
2023-08-12 |
rat |
| Anthony T Fabbricatore, Udi E Ghitza, Volodymyr F Prokopenko, Mark O Wes. Electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration II: phasic firing patterns. The European journal of neuroscience. vol 31. issue 9. 2010-10-14. PMID:20525080. |
in the cocaine self-administering rat, individual nucleus accumbens (nacc) neurons exhibit phasic changes in firing rate within minutes and/or seconds of lever presses (i.e. |
2010-10-14 |
2023-08-12 |
rat |
| Erin B Larson, Fatih Akkentli, Scott Edwards, Danielle L Graham, Diana L Simmons, Imran N Alibhai, Eric J Nestler, David W Sel. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. Journal of neurochemistry. vol 115. issue 1. 2010-10-13. PMID:20633205. |
we found that cfos, fosb, and Δfosb exhibit regionally and temporally distinct expression patterns, with greater accumulation of Δfosb protein in the nucleus accumbens (nac) shell and core after chronic cocaine administration, whereas Δfosb increases in the caudate-putamen (cpu) remained similar with either acute or chronic administration. |
2010-10-13 |
2023-08-12 |
rat |
| Xi Wang, Yi-xiao Luo, Ying-ying He, Fang-qiong Li, Hai-shui Shi, Li-fen Xue, Yan-xue Xue, Lin L. Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 38. 2010-10-08. PMID:20861369. |
we found that exposure to a cocaine-related cue induced reinstatement to cocaine seeking and increased phosphorylation of p70s6 kinase (p70s6k) and ribosomal protein s6 (rps6), measures of mtor activity, in the nucleus accumbens (nac) core but not shell. |
2010-10-08 |
2023-08-12 |
rat |
| Quincey LaPlant, Vincent Vialou, Herbert E Covington, Dani Dumitriu, Jian Feng, Brandon L Warren, Ian Maze, David M Dietz, Emily L Watts, Sergio D Iñiguez, Ja Wook Koo, Ezekiell Mouzon, William Renthal, Fiona Hollis, Hui Wang, Michele A Noonan, Yanhua Ren, Amelia J Eisch, Carlos A Bolaños, Mohamed Kabbaj, Guanghua Xiao, Rachael L Neve, Yasmin L Hurd, Ronald S Oosting, Gouping Fan, John H Morrison, Eric J Nestle. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature neuroscience. vol 13. issue 9. 2010-10-04. PMID:20729844. |
we found that dnmt3a expression was regulated in mouse nucleus accumbens (nac) by chronic cocaine use and chronic social defeat stress. |
2010-10-04 |
2023-08-12 |
mouse |
| Carrie R Ferrario, Xuan Li, Xiaoting Wang, Jeremy M Reimers, Jamie L Uejima, Marina E Wol. The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19924109. |
alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor (ampar) surface expression in the nucleus accumbens (nac) is enhanced after withdrawal from repeated cocaine exposure. |
2010-09-07 |
2023-08-12 |
rat |
| Annelyn Torres-Reveron, Jeremy Weedon, Diana L Dow-Edward. Methylphenidate response in prenatal cocaine-exposed rats: a behavioral and brain functional study. Brain research. vol 1337. 2010-08-25. PMID:20382132. |
prenatal cocaine produced insignificant effects on the rates of brain glucose metabolism overall but produced a reduced response to mpd in the nucleus accumbens in a rostral/caudal gradient compared to control. |
2010-08-25 |
2023-08-12 |
rat |
| Lori A Knackstedt, Khaled Moussawi, Ryan Lalumiere, Marek Schwendt, Matthias Klugmann, Peter W Kaliva. Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 23. 2010-08-24. PMID:20534846. |
rats were either extinguished or withdrawn without extinction training (abstinence) from cocaine self-administration, and measurements of postsynaptic density proteins in the core and shell subcompartments of the nucleus accumbens were compared with yoked-saline controls. |
2010-08-24 |
2023-08-12 |
rat |
| Mary M Torregrossa, Hayde Sanchez, Jane R Taylo. D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 31. 2010-08-24. PMID:20685995. |
d-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens. |
2010-08-24 |
2023-08-12 |
human |
| Michel M M Verheij, Eric L W de Mulder, Elvira De Leonibus, Karen M J van Loo, Alexander R Cool. Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18315567. |
rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens. |
2010-08-13 |
2023-08-12 |
rat |
| Angelica Rocha, Peter W Kaliva. Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking. The European journal of neuroscience. vol 31. issue 5. 2010-07-12. PMID:20180839. |
although the involvement of the medial prefrontal cortex projection to the nucleus accumbens in the reinstatement of cocaine seeking has been well studied, it is not known if this projection plays a similar role in the reinstatement of cue- and methamphetamine-induced drug seeking in animals extinguished from methamphetamine self-administration. |
2010-07-12 |
2023-08-12 |
rat |
| Fernando Kasanetz, Véronique Deroche-Gamonet, Nadège Berson, Eric Balado, Mathieu Lafourcade, Olivier Manzoni, Pier Vincenzo Piazz. Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science (New York, N.Y.). vol 328. issue 5986. 2010-07-08. PMID:20576893. |
cocaine self-administration rapidly suppresses long-term depression (ltd), an important form of synaptic plasticity in the nucleus accumbens. |
2010-07-08 |
2023-08-12 |
rat |
| Jacqueline F McGinty, Timothy W Whitfield, William J Berglin. Brain-derived neurotrophic factor and cocaine addiction. Brain research. vol 1314. 2010-06-07. PMID:19732758. |
conversely, repeated administration of bdnf antiserum into the nucleus accumbens during chronic cocaine self-administration attenuates cocaine-induced reinstatement. |
2010-06-07 |
2023-08-12 |
Not clear |
| Jacqueline F McGinty, Timothy W Whitfield, William J Berglin. Brain-derived neurotrophic factor and cocaine addiction. Brain research. vol 1314. 2010-06-07. PMID:19732758. |
furthermore, 3 weeks after bdnf infusion in animals with a cocaine self-administration history, suppressed basal levels of glutamate are normalized and a cocaine prime-induced increase in extracellular glutamate levels in the nucleus accumbens is prevented. |
2010-06-07 |
2023-08-12 |
Not clear |
| Analía Valdomero, Cristian Hansen, Nelia Gerez de Burgos, Gabriel R Cuadra, Otto A Orsinghe. GM1 ganglioside enhances the rewarding properties of cocaine in rats. European journal of pharmacology. vol 630. issue 1-3. 2010-05-24. PMID:20044989. |
in addition, gm1 (100microm) did not alter the dopamine transporter inhibition induced by cocaine (10(-7)-10(-5)m), as determined by the uptake of [(3-)h]-dopamine in the microsacs of nucleus accumbens. |
2010-05-24 |
2023-08-12 |
rat |
| Daniel Marcellino, Gemma Navarro, Kristoffer Sahlholm, Johanna Nilsson, Luigi F Agnati, Enric I Canela, Carme Lluís, Peter Århem, Rafael Franco, Kjell Fux. Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. Biochemical and biophysical research communications. vol 394. issue 4. 2010-05-13. PMID:20307491. |
recent findings give neurochemical evidence that extended cocaine self-administration in the rat give rise to an up-regulation of functional a(2a)rs in the nucleus accumbens that return to baseline expression levels during cocaine withdrawal. |
2010-05-13 |
2023-08-12 |
human |
| Qiang Chen, Xiongzhao Zhu, Yu Zhang, William C Wetsel, Tong H Lee, Xiuwu Zhan. Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:19629758. |
our recent studies have demonstrated that integrin-linked kinase (ilk) is involved in the induction and maintenance of cocaine behavioral sensitization and chronic cocaine-induced neural plasticity in the nucleus accumbens (nac) core. |
2010-05-07 |
2023-08-12 |
rat |
| Willard M Freeman, Melinda E Lull, Kruti M Patel, Robert M Brucklacher, Drake Morgan, David C S Roberts, Kent E Vran. Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. BMC neuroscience. vol 11. 2010-05-06. PMID:20187946. |
gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. |
2010-05-06 |
2023-08-12 |
Not clear |