| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carrie R Ferrario, Xuan Li, Marina E Wol. Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the rat nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 1. 2011-02-04. PMID:20506566. |
changes in α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor (ampar) surface expression in the rodent nucleus accumbens (nac) are produced by cocaine exposure and implicated in addiction-related behaviors. |
2011-02-04 |
2023-08-12 |
rat |
| Paul F Kramer, Christine H Christensen, Lisa A Hazelwood, Alice Dobi, Roland Bock, David R Sibley, Yolanda Mateo, Veronica A Alvare. Dopamine D2 receptor overexpression alters behavior and physiology in Drd2-EGFP mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209197. |
dopamine (da) transients evoked by stimulation in the nucleus accumbens showed slower clearance in drd2-egfp mice, and cocaine actions on da clearance were impaired in these mice. |
2011-02-04 |
2023-08-12 |
mouse |
| Garret D Stuber, F Woodward Hopf, Kay M Tye, Billy T Chen, Antonello Bonc. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Current topics in behavioral neurosciences. vol 3. 2011-01-20. PMID:21161748. |
both the dopaminergic neurons of the ventral tegmental area as well medium spiny neurons in nucleus accumbens show enhanced excitatory synaptic strength following passive or active exposure to drugs such as cocaine and alcohol. |
2011-01-20 |
2023-08-12 |
Not clear |
| Marcel M van Gaalen, Dustin Schetters, Anton N M Schoffelmeer, Taco J De Vrie. 5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcement. The international journal of neuropsychopharmacology. vol 13. issue 7. 2011-01-10. PMID:20426879. |
5-ht6 receptors (5-ht6rs) are abundantly expressed in brain areas such as the nucleus accumbens and prefrontal cortex, which are critically involved in cocaine reinforcement and relapse. |
2011-01-10 |
2023-08-12 |
rat |
| George A Rogge, Li-Ling Shen, Michael J Kuha. Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter. Brain research. vol 1344. 2011-01-10. PMID:20451507. |
both over expression of cyclic amp response element binding protein (creb) in the nucleus accumbens (nac), and intra-accumbal injection of cocaine- and amphetamine-regulated transcript (cart) peptides, have been shown to decrease cocaine reward. |
2011-01-10 |
2023-08-12 |
rat |
| K Y Salas-Ramirez, M Frankfurt, A Alexander, V N Luine, E Friedma. Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats: influence of sex. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20553818. |
in addition, gestational cocaine increased dendritic spine density in the prefrontal cortex and nucleus accumbens in both genders, but only females had increased spine density in the ca1 region of the hippocampus. |
2010-12-16 |
2023-08-12 |
human |
| Chinwe A Nwaneshiudu, Ellen M Unterwal. NK-3 receptor antagonism prevents behavioral sensitization to cocaine: a role of glycogen synthase kinase-3 in the nucleus accumbens. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20807318. |
nk-3 receptor antagonism prevents behavioral sensitization to cocaine: a role of glycogen synthase kinase-3 in the nucleus accumbens. |
2010-12-02 |
2023-08-12 |
mouse |
| Chinwe A Nwaneshiudu, Ellen M Unterwal. NK-3 receptor antagonism prevents behavioral sensitization to cocaine: a role of glycogen synthase kinase-3 in the nucleus accumbens. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20807318. |
collectively, these findings demonstrate the involvement of nk-3 receptors in development and expression of behavioral sensitization and in regulation of gsk3 activity in the nucleus accumbens after repeated cocaine. |
2010-12-02 |
2023-08-12 |
mouse |
| Nii A Addy, David P Daberkow, Jeremy N Ford, Paul A Garris, R Mark Wightma. Sensitization of rapid dopamine signaling in the nucleus accumbens core and shell after repeated cocaine in rats. Journal of neurophysiology. vol 104. issue 2. 2010-12-01. PMID:20554845. |
to study dopamine neurotransmission after 1-day withdrawal, we used fast-scan cyclic voltammetry (fscv) to determine whether repeated cocaine alters rapid dopamine release and uptake in the nucleus accumbens (nac) core and shell. |
2010-12-01 |
2023-08-12 |
human |
| Marina E Wol. The Bermuda Triangle of cocaine-induced neuroadaptations. Trends in neurosciences. vol 33. issue 9. 2010-11-26. PMID:20655604. |
activation of medium spiny neurons (msns) of the nucleus accumbens is critical for goal-directed behaviors including cocaine seeking. |
2010-11-26 |
2023-08-12 |
Not clear |
| Drew D Kiraly, Xin-Ming Ma, Christopher M Mazzone, Xiaonan Xin, Richard E Mains, Betty A Eippe. Behavioral and morphological responses to cocaine require kalirin7. Biological psychiatry. vol 68. issue 3. 2010-11-22. PMID:20452575. |
long-lasting increases in dendritic spine density and gene expression in the nucleus accumbens and in the ambulatory response to cocaine occur following chronic cocaine treatment. |
2010-11-22 |
2023-08-12 |
Not clear |
| Mary Kay Lobo, Herbert E Covington, Dipesh Chaudhury, Allyson K Friedman, HaoSheng Sun, Diane Damez-Werno, David M Dietz, Samir Zaman, Ja Wook Koo, Pamela J Kennedy, Ezekiell Mouzon, Murtaza Mogri, Rachael L Neve, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (New York, N.Y.). vol 330. issue 6002. 2010-11-10. PMID:20947769. |
the nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two subpopulations of nucleus accumbens projection neurons, those expressing dopamine d1 versus d2 receptors, are poorly understood. |
2010-11-10 |
2023-08-12 |
Not clear |
| Mary Kay Lobo, Herbert E Covington, Dipesh Chaudhury, Allyson K Friedman, HaoSheng Sun, Diane Damez-Werno, David M Dietz, Samir Zaman, Ja Wook Koo, Pamela J Kennedy, Ezekiell Mouzon, Murtaza Mogri, Rachael L Neve, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (New York, N.Y.). vol 330. issue 6002. 2010-11-10. PMID:20947769. |
because loss of trkb in d2+ neurons increases their neuronal excitability, we next used optogenetic tools to control selectively the firing rate of d1+ and d2+ nucleus accumbens neurons and studied consequent effects on cocaine reward. |
2010-11-10 |
2023-08-12 |
Not clear |
| Adam Podet, Min J Lee, Alan C Swann, Nachum Dafn. Nucleus accumbens lesions modulate the effects of methylphenidate. Brain research bulletin. vol 82. issue 5-6. 2010-11-01. PMID:20470871. |
in studies on cocaine and amphetamine, this effect has been reported to involve the nucleus accumbens (nac), one of the nuclei belonging to the motive circuit. |
2010-11-01 |
2023-08-12 |
rat |
| Anthony T Fabbricatore, Udi E Ghitza, Volodymyr F Prokopenko, Mark O Wes. Electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration II: phasic firing patterns. The European journal of neuroscience. vol 31. issue 9. 2010-10-14. PMID:20525080. |
electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration ii: phasic firing patterns. |
2010-10-14 |
2023-08-12 |
rat |
| Anthony T Fabbricatore, Udi E Ghitza, Volodymyr F Prokopenko, Mark O Wes. Electrophysiological evidence of mediolateral functional dichotomy in the rat nucleus accumbens during cocaine self-administration II: phasic firing patterns. The European journal of neuroscience. vol 31. issue 9. 2010-10-14. PMID:20525080. |
in the cocaine self-administering rat, individual nucleus accumbens (nacc) neurons exhibit phasic changes in firing rate within minutes and/or seconds of lever presses (i.e. |
2010-10-14 |
2023-08-12 |
rat |
| Erin B Larson, Fatih Akkentli, Scott Edwards, Danielle L Graham, Diana L Simmons, Imran N Alibhai, Eric J Nestler, David W Sel. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. Journal of neurochemistry. vol 115. issue 1. 2010-10-13. PMID:20633205. |
we found that cfos, fosb, and Δfosb exhibit regionally and temporally distinct expression patterns, with greater accumulation of Δfosb protein in the nucleus accumbens (nac) shell and core after chronic cocaine administration, whereas Δfosb increases in the caudate-putamen (cpu) remained similar with either acute or chronic administration. |
2010-10-13 |
2023-08-12 |
rat |
| Xi Wang, Yi-xiao Luo, Ying-ying He, Fang-qiong Li, Hai-shui Shi, Li-fen Xue, Yan-xue Xue, Lin L. Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 38. 2010-10-08. PMID:20861369. |
we found that exposure to a cocaine-related cue induced reinstatement to cocaine seeking and increased phosphorylation of p70s6 kinase (p70s6k) and ribosomal protein s6 (rps6), measures of mtor activity, in the nucleus accumbens (nac) core but not shell. |
2010-10-08 |
2023-08-12 |
rat |
| Quincey LaPlant, Vincent Vialou, Herbert E Covington, Dani Dumitriu, Jian Feng, Brandon L Warren, Ian Maze, David M Dietz, Emily L Watts, Sergio D Iñiguez, Ja Wook Koo, Ezekiell Mouzon, William Renthal, Fiona Hollis, Hui Wang, Michele A Noonan, Yanhua Ren, Amelia J Eisch, Carlos A Bolaños, Mohamed Kabbaj, Guanghua Xiao, Rachael L Neve, Yasmin L Hurd, Ronald S Oosting, Gouping Fan, John H Morrison, Eric J Nestle. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature neuroscience. vol 13. issue 9. 2010-10-04. PMID:20729844. |
we found that dnmt3a expression was regulated in mouse nucleus accumbens (nac) by chronic cocaine use and chronic social defeat stress. |
2010-10-04 |
2023-08-12 |
mouse |
| Carrie R Ferrario, Xuan Li, Xiaoting Wang, Jeremy M Reimers, Jamie L Uejima, Marina E Wol. The role of glutamate receptor redistribution in locomotor sensitization to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19924109. |
alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor (ampar) surface expression in the nucleus accumbens (nac) is enhanced after withdrawal from repeated cocaine exposure. |
2010-09-07 |
2023-08-12 |
rat |