| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erin B Larson, Danielle L Graham, Rose R Arzaga, Nicole Buzin, Joseph Webb, Thomas A Green, Caroline E Bass, Rachael L Neve, Ernest F Terwilliger, Eric J Nestler, David W Sel. Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 45. 2012-01-04. PMID:22072694. |
chronic exposure to addictive drugs enhances camp response element binding protein (creb)-regulated gene expression in nucleus accumbens (nac), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. |
2012-01-04 |
2023-08-12 |
rat |
| Adriana A Alcantara, Helen Y Lim, Christopher E Floyd, Juanita Garces, John M Mendenhall, Chelsea L Lyons, Monica L Berlang. Cocaine- and morphine-induced synaptic plasticity in the nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 4. 2011-12-20. PMID:20730804. |
this study examined behavioral changes and electron microscopic evidence of altered synaptic connectivity within the nucleus accumbens (nac) following repeated administration of cocaine or morphine. |
2011-12-20 |
2023-08-12 |
rat |
| Thomas F Tropea, Zeeba D Kabir, Gagandeep Kaur, Anjali M Rajadhyaksha, Barry E Kosofsk. Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry. vol 2. 2011-12-15. PMID:22162970. |
enhanced dopamine d1 and bdnf signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. |
2011-12-15 |
2023-08-12 |
mouse |
| Thomas F Tropea, Zeeba D Kabir, Gagandeep Kaur, Anjali M Rajadhyaksha, Barry E Kosofsk. Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry. vol 2. 2011-12-15. PMID:22162970. |
in this study we further examined basal as well as cocaine or d1-induced activation of a set of molecules known to be mediators of neuronal plasticity following psychostimulant treatment, with emphasis in the dorsal striatum (str) and nucleus accumbens (nac) of adult mice exposed to cocaine in utero. |
2011-12-15 |
2023-08-12 |
mouse |
| Kathryn Schierberl, Jin Hao, Thomas F Tropea, Stephen Ra, Thomas P Giordano, Qinghao Xu, Sandra M Garraway, Franz Hofmann, Sven Moosmang, Joerg Striessnig, Charles E Inturrisi, Anjali M Rajadhyaksh. Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 38. 2011-12-07. PMID:21940447. |
utilizing cocaine psychomotor sensitization, we have examined phosphorylation of glua1 at key residues serine 845 (s845) and s831, as well as glua1 cell surface levels in the nucleus accumbens (nac) of cocaine-preexposed mice and the role of brain-specific ca(v)1.2 and ca(v)1.3 l-type ca²⁺ channels (ltccs), therein. |
2011-12-07 |
2023-08-12 |
mouse |
| James E McCutcheon, Jessica A Loweth, Kerstin A Ford, Michela Marinelli, Marina E Wolf, Kuei Y Tsen. Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 41. 2011-12-06. PMID:21994370. |
following prolonged withdrawal from extended access cocaine self-administration in adult rats, high conductance ca2+ -ermeable ampa receptors (cp-ampars) accumulate in nucleus accumbens (nac) synapses and mediate the expression of "incubated" cue-induced cocaine craving. |
2011-12-06 |
2023-08-12 |
rat |
| Jia-Qian Ren, Yan Jiang, Zhihui Wang, Deirdre McCarthy, Anjali M Rajadhyaksha, Thomas F Tropea, Barry E Kosofsky, Pradeep G Bhid. Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:20854831. |
although dopamine release was induced in the nucleus accumbens of prenatally l-dopa exposed mice at p60 by cocaine, the dopamine release in the nucleus accumbens was not significantly different between the l-dopa and control groups. |
2011-11-22 |
2023-08-12 |
mouse |
| Amy W Lasek, Julie Gesch, Francesco Giorgetti, Viktor Kharazia, Ulrike Heberlei. Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 40. 2011-11-18. PMID:21976498. |
moreover, we show that erα knock-out mice exhibit enhanced cocaine sensitization and conditioned place preference and an increase in alk expression in the nucleus accumbens. |
2011-11-18 |
2023-08-12 |
mouse |
| Kun Liu, Jeffery D Stekete. Repeated exposure to cocaine alters medial prefrontal cortex dopamine D₂-like receptor modulation of glutamate and dopamine neurotransmission within the mesocorticolimbic system. Journal of neurochemistry. vol 119. issue 2. 2011-11-15. PMID:21692802. |
the present report tested the hypothesis that reduced medial prefrontal cortex d₂ receptor function as a result of repeated cocaine exposure results in augmented excitatory transmission to the nucleus accumbens and ventral tegmental area, possibly as a partial result of enhanced inhibition of local dopamine release. |
2011-11-15 |
2023-08-12 |
rat |
| M O Job, I M McNamara, M J Kuha. CART Peptides Regulate Psychostimulants and May be Endogenous Antidepressants. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886553. |
injection of cart 55-102 into the nucleus accumbens produces no effect, but when co-administered with cocaine, it reduces the locomotor and rewarding properties of cocaine. |
2011-11-10 |
2023-08-12 |
human |
| E Y Jang, M Hwang, S S Yoon, J R Lee, K J Kim, H-C Kim, C H Yan. Liquiritigenin decreases selective molecular and behavioral effects of cocaine in rodents. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886557. |
in addition, lq inhibited creb phosphorylation and c-fos expression in the striatum and the nucleus accumbens induced by acute cocaine. |
2011-11-10 |
2023-08-12 |
rat |
| Satoru M Sato, Anne Marie Wissman, Andrew F McCollum, Catherine S Woolle. Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats. PloS one. vol 6. issue 7. 2011-11-04. PMID:21747956. |
in the current study, we evaluated locomotor activity in male and female rats treated with saline or cocaine for 2 weeks and quantitatively mapped Δfosb expression in the dorsal striatum and nucleus accumbens of each animal by using an anti-fosb antibody that recognizes Δfosb isoforms preferentially. |
2011-11-04 |
2023-08-12 |
rat |
| Satoru M Sato, Anne Marie Wissman, Andrew F McCollum, Catherine S Woolle. Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats. PloS one. vol 6. issue 7. 2011-11-04. PMID:21747956. |
western blot and immunohistochemical analyses indicated that basal levels of Δfosb were higher in the nucleus accumbens than the dorsal striatum, but that the effect of cocaine on Δfosb was greater in the dorsal striatum. |
2011-11-04 |
2023-08-12 |
rat |
| Satoru M Sato, Anne Marie Wissman, Andrew F McCollum, Catherine S Woolle. Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats. PloS one. vol 6. issue 7. 2011-11-04. PMID:21747956. |
immunostaining showed that the effect of cocaine in both the dorsal striatum and nucleus accumbens was primarily to increase the intensity of Δfosb immunoreactivity in individual neurons, rather than to increase the number of cells that express Δfosb. |
2011-11-04 |
2023-08-12 |
rat |
| Herbert E Covington, Ian Maze, HaoSheng Sun, Howard M Bomze, Kristine D DeMaio, Emma Y Wu, David M Dietz, Mary Kay Lobo, Subroto Ghose, Ezekiel Mouzon, Rachael L Neve, Carol A Tamminga, Eric J Nestle. A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. vol 71. issue 4. 2011-10-25. PMID:21867882. |
here, we identify repressive histone methylation in nucleus accumbens (nac), an important brain reward region, as a key mechanism linking cocaine exposure to increased stress vulnerability. |
2011-10-25 |
2023-08-12 |
mouse |
| Michael P Saddoris, Alice Stamatakis, Regina M Carell. Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration. The European journal of neuroscience. vol 33. issue 12. 2011-10-24. PMID:21507084. |
other groups, following pavlovian and instrumental conditioning, were subsequently trained to self-administer cocaine with nosepoke responses, or received yoked saline infusions and nosepoked for water rewards, and then performed pit while electrophysiological recordings were taken in the nucleus accumbens. |
2011-10-24 |
2023-08-12 |
rat |
| Kensuke Kimura, Takatoshi Hikida, Satoshi Yawata, Takashi Yamaguchi, Shigetada Nakanish. Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 24. 2011-09-29. PMID:21628570. |
the nucleus accumbens (nac) serves as a key neural substrate that controls acute and adaptive behavioral responses to cocaine administration. |
2011-09-29 |
2023-08-12 |
mouse |
| Marina E Wol. Regulation of AMPA receptor trafficking in the nucleus accumbens by dopamine and cocaine. Neurotoxicity research. vol 18. issue 3-4. 2011-09-15. PMID:20361291. |
regulation of ampa receptor trafficking in the nucleus accumbens by dopamine and cocaine. |
2011-09-15 |
2023-08-12 |
rat |
| Shigenobu Toda, Haowei Shen, Peter W Kaliva. Inhibition of actin polymerization prevents cocaine-induced changes in spine morphology in the nucleus accumbens. Neurotoxicity research. vol 18. issue 3-4. 2011-09-15. PMID:20401643. |
withdrawal from daily cocaine administration causes an increase in actin cycling and increases spine head diameter in medium spiny neurons from the core of the nucleus accumbens. |
2011-09-15 |
2023-08-12 |
human |
| Dustin K Van Dolah, Li-Min Mao, Christopher Shaffer, Ming-Lei Guo, Eugene E Fibuch, Xiang-Ping Chu, Shilpa Buch, John Q Wan. Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Biological psychiatry. vol 69. issue 11. 2011-09-12. PMID:21216391. |
reversible palmitoylation regulates surface stability of ampa receptors in the nucleus accumbens in response to cocaine in vivo. |
2011-09-12 |
2023-08-12 |
Not clear |