Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Michael Fritz, Rana El Rawas, Sabine Klement, Kai Kummer, Michael J Mayr, Vincent Eggart, Ahmad Salti, Michael T Bardo, Alois Saria, Gerald Zerni. Differential effects of accumbens core vs. shell lesions in a rat concurrent conditioned place preference paradigm for cocaine vs. social interaction. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046347. |
in the present study, we investigated if the two subregions of the nucleus accumbens (acb), i.e., the core (acbc) and the shell (acbsh), would differentially affect cpp for cocaine vs social interaction. |
2012-03-26 |
2023-08-12 |
rat |
Bradley J Martin, Bartholomew J Naughton, Keerthi Thirtamara-Rajamani, Daniel J Yoon, Dawn D Han, A Courtney Devries, Howard H G. Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 6. 2012-03-12. PMID:20936687. |
cocaine is hypothesized to induce locomotor sensitization by neural changes, including an increase in the density of spines on the dendrites of neurons in the nucleus accumbens (nac). |
2012-03-12 |
2023-08-12 |
mouse |
N D Volkow, G-J Wang, J H Newcorn, S H Kollins, T L Wigal, F Telang, J S Fowler, R Z Goldstein, N Klein, J Logan, C Wong, J M Swanso. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20856250. |
to evaluate this hypothesis, we performed secondary analyses to assess the correlation between the pet measures of dopamine d2/d3 receptor and dopamine transporter availability (obtained with [(11)c]raclopride and [(11)c]cocaine, respectively) in the dopamine reward pathway (midbrain and nucleus accumbens) and a surrogate measure of trait motivation (assessed using the achievement scale on the multidimensional personality questionnaire or mpq) in 45 adhd participants and 41 controls. |
2012-03-05 |
2023-08-12 |
human |
Makoto Taniguchi, Maria B Carreira, Laura N Smith, Benjamin C Zirlin, Rachael L Neve, Christopher W Cowa. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron. vol 73. issue 1. 2012-03-05. PMID:22243750. |
importantly, we show that dephosphorylation of hdac5 s279 in the nucleus accumbens suppresses the development, but not expression, of cocaine reward behavior in vivo. |
2012-03-05 |
2023-08-12 |
Not clear |
Brian R Lee, Yan Don. Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21232547. |
we recently demonstrated that repeated exposure to cocaine generated a large portion of "silent" glutamatergic synapses within the nucleus accumbens (nac). |
2012-01-27 |
2023-08-12 |
Not clear |
Carrie R Ferrario, Jessica A Loweth, Mike Milovanovic, Kerstin A Ford, Gregorio L Galiñanes, Li-Jun Heng, Kuei Y Tseng, Marina E Wol. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21276808. |
alterations in ampa receptor subunits and tarps in the rat nucleus accumbens related to the formation of ca²⁺-permeable ampa receptors during the incubation of cocaine craving. |
2012-01-27 |
2023-08-12 |
rat |
Ilan Sondheimer, Lori A Knacksted. Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behavioural brain research. vol 225. issue 1. 2012-01-18. PMID:21824497. |
it has previously been shown that glt-1 expression is decreased in the nucleus accumbens following cocaine self-administration and extinction training; ceftriaxone given in the days immediately prior to reinstatement testing attenuates both cue- and cocaine-primed reinstatement. |
2012-01-18 |
2023-08-12 |
Not clear |
Xuan Li, Marina E Wol. Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. The European journal of neuroscience. vol 34. issue 2. 2012-01-05. PMID:21692887. |
in the rodent nucleus accumbens (nac), cocaine elevates levels of brain-derived neurotrophic factor (bdnf). |
2012-01-05 |
2023-08-12 |
rat |
Erin B Larson, Danielle L Graham, Rose R Arzaga, Nicole Buzin, Joseph Webb, Thomas A Green, Caroline E Bass, Rachael L Neve, Ernest F Terwilliger, Eric J Nestler, David W Sel. Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 45. 2012-01-04. PMID:22072694. |
chronic exposure to addictive drugs enhances camp response element binding protein (creb)-regulated gene expression in nucleus accumbens (nac), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. |
2012-01-04 |
2023-08-12 |
rat |
Adriana A Alcantara, Helen Y Lim, Christopher E Floyd, Juanita Garces, John M Mendenhall, Chelsea L Lyons, Monica L Berlang. Cocaine- and morphine-induced synaptic plasticity in the nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 4. 2011-12-20. PMID:20730804. |
this study examined behavioral changes and electron microscopic evidence of altered synaptic connectivity within the nucleus accumbens (nac) following repeated administration of cocaine or morphine. |
2011-12-20 |
2023-08-12 |
rat |
Thomas F Tropea, Zeeba D Kabir, Gagandeep Kaur, Anjali M Rajadhyaksha, Barry E Kosofsk. Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry. vol 2. 2011-12-15. PMID:22162970. |
enhanced dopamine d1 and bdnf signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. |
2011-12-15 |
2023-08-12 |
mouse |
Thomas F Tropea, Zeeba D Kabir, Gagandeep Kaur, Anjali M Rajadhyaksha, Barry E Kosofsk. Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry. vol 2. 2011-12-15. PMID:22162970. |
in this study we further examined basal as well as cocaine or d1-induced activation of a set of molecules known to be mediators of neuronal plasticity following psychostimulant treatment, with emphasis in the dorsal striatum (str) and nucleus accumbens (nac) of adult mice exposed to cocaine in utero. |
2011-12-15 |
2023-08-12 |
mouse |
Kathryn Schierberl, Jin Hao, Thomas F Tropea, Stephen Ra, Thomas P Giordano, Qinghao Xu, Sandra M Garraway, Franz Hofmann, Sven Moosmang, Joerg Striessnig, Charles E Inturrisi, Anjali M Rajadhyaksh. Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 38. 2011-12-07. PMID:21940447. |
utilizing cocaine psychomotor sensitization, we have examined phosphorylation of glua1 at key residues serine 845 (s845) and s831, as well as glua1 cell surface levels in the nucleus accumbens (nac) of cocaine-preexposed mice and the role of brain-specific ca(v)1.2 and ca(v)1.3 l-type ca²⁺ channels (ltccs), therein. |
2011-12-07 |
2023-08-12 |
mouse |
James E McCutcheon, Jessica A Loweth, Kerstin A Ford, Michela Marinelli, Marina E Wolf, Kuei Y Tsen. Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 41. 2011-12-06. PMID:21994370. |
following prolonged withdrawal from extended access cocaine self-administration in adult rats, high conductance ca2+ -ermeable ampa receptors (cp-ampars) accumulate in nucleus accumbens (nac) synapses and mediate the expression of "incubated" cue-induced cocaine craving. |
2011-12-06 |
2023-08-12 |
rat |
Jia-Qian Ren, Yan Jiang, Zhihui Wang, Deirdre McCarthy, Anjali M Rajadhyaksha, Thomas F Tropea, Barry E Kosofsky, Pradeep G Bhid. Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:20854831. |
although dopamine release was induced in the nucleus accumbens of prenatally l-dopa exposed mice at p60 by cocaine, the dopamine release in the nucleus accumbens was not significantly different between the l-dopa and control groups. |
2011-11-22 |
2023-08-12 |
mouse |
Amy W Lasek, Julie Gesch, Francesco Giorgetti, Viktor Kharazia, Ulrike Heberlei. Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 40. 2011-11-18. PMID:21976498. |
moreover, we show that erα knock-out mice exhibit enhanced cocaine sensitization and conditioned place preference and an increase in alk expression in the nucleus accumbens. |
2011-11-18 |
2023-08-12 |
mouse |
Kun Liu, Jeffery D Stekete. Repeated exposure to cocaine alters medial prefrontal cortex dopamine D₂-like receptor modulation of glutamate and dopamine neurotransmission within the mesocorticolimbic system. Journal of neurochemistry. vol 119. issue 2. 2011-11-15. PMID:21692802. |
the present report tested the hypothesis that reduced medial prefrontal cortex d₂ receptor function as a result of repeated cocaine exposure results in augmented excitatory transmission to the nucleus accumbens and ventral tegmental area, possibly as a partial result of enhanced inhibition of local dopamine release. |
2011-11-15 |
2023-08-12 |
rat |
M O Job, I M McNamara, M J Kuha. CART Peptides Regulate Psychostimulants and May be Endogenous Antidepressants. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886553. |
injection of cart 55-102 into the nucleus accumbens produces no effect, but when co-administered with cocaine, it reduces the locomotor and rewarding properties of cocaine. |
2011-11-10 |
2023-08-12 |
human |
E Y Jang, M Hwang, S S Yoon, J R Lee, K J Kim, H-C Kim, C H Yan. Liquiritigenin decreases selective molecular and behavioral effects of cocaine in rodents. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886557. |
in addition, lq inhibited creb phosphorylation and c-fos expression in the striatum and the nucleus accumbens induced by acute cocaine. |
2011-11-10 |
2023-08-12 |
rat |
Satoru M Sato, Anne Marie Wissman, Andrew F McCollum, Catherine S Woolle. Quantitative mapping of cocaine-induced ΔFosB expression in the striatum of male and female rats. PloS one. vol 6. issue 7. 2011-11-04. PMID:21747956. |
in the current study, we evaluated locomotor activity in male and female rats treated with saline or cocaine for 2 weeks and quantitatively mapped Δfosb expression in the dorsal striatum and nucleus accumbens of each animal by using an anti-fosb antibody that recognizes Δfosb isoforms preferentially. |
2011-11-04 |
2023-08-12 |
rat |