| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura J Sim-Selley, Michael P Cassidy, Antonino Sparta, Venetia Zachariou, Eric J Nestler, Dana E Selle. Effect of ΔFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21907220. |
the stable transcription factor Δfosb is induced in the nucleus accumbens (nac) by chronic exposure to several drugs of abuse, and transgenic expression of Δfosb in the striatum enhances the rewarding properties of morphine and cocaine. |
2012-08-01 |
2023-08-12 |
mouse |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Jeffrey A Zidichouski, Tarek M Sale. Cocaine sensitization does not alter SP effects on locomotion or excitatory synaptic transmission in the NAc of rats. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21930135. |
substance p (sp) and cocaine employ similar mechanisms to modify excitatory synaptic transmission in the nucleus accumbens (nac), a region implicated in substance abuse. |
2012-07-27 |
2023-08-12 |
rat |
| Thorfinn T Riday, Barry E Kosofsky, C J Malang. The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22197517. |
expression of ampa receptor subunits (glur1 and glur2) and cre binding protein (creb) was measured in the ventral tegmental area (vta), dorsolateral striatum (str) and nucleus accumbens (nac) before and after a sensitizing regimen of cocaine, with and without icss. |
2012-07-27 |
2023-08-12 |
mouse |
| Dani Dumitriu, Quincey Laplant, Yael S Grossman, Caroline Dias, William G Janssen, Scott J Russo, John H Morrison, Eric J Nestle. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593064. |
subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. |
2012-07-27 |
2023-08-12 |
mouse |
| Dani Dumitriu, Quincey Laplant, Yael S Grossman, Caroline Dias, William G Janssen, Scott J Russo, John H Morrison, Eric J Nestle. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593064. |
numerous studies have found that chronic cocaine increases dendritic spine density of medium spiny neurons in the nucleus accumbens (nac). |
2012-07-27 |
2023-08-12 |
mouse |
| Casey E O'Neill, McKenzie L LeTendre, Ryan K Bachtel. Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22169945. |
adenosine a2a receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. |
2012-07-20 |
2023-08-12 |
rat |
| Courtney M Cameron, Regina M Carell. Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. The European journal of neuroscience. vol 35. issue 6. 2012-07-18. PMID:22356698. |
cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. |
2012-07-18 |
2023-08-12 |
rat |
| Lisa Wells, Jolanta Opacka-Juffry, Donald Fisher, Catherine Ledent, Susanna Hourani, Ian Kitche. In vivo dopaminergic and behavioral responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice. Synapse (New York, N.Y.). vol 66. issue 5. 2012-07-09. PMID:22213208. |
changes in the extracellular levels of dopamine (da) in the nucleus accumbens (nac) of mice lacking a(2a) adenosine receptors and wild type (wt) littermates after an acute cocaine (20 mg/kg) administration were evaluated by in vivo microdialysis studies. |
2012-07-09 |
2023-08-12 |
mouse |
| Amir Levine, Yanyou Huang, Bettina Drisaldi, Edmund A Griffin, Daniela D Pollak, Shiqin Xu, Deqi Yin, Christine Schaffran, Denise B Kandel, Eric R Kande. Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Science translational medicine. vol 3. issue 107. 2012-05-17. PMID:22049069. |
we tested this conclusion further and found that a histone deacetylase inhibitor simulated the actions of nicotine by priming the response to cocaine and enhancing fosb gene expression and ltp depression in the nucleus accumbens. |
2012-05-17 |
2023-08-12 |
mouse |
| Anne Marie Wissman, Andrew F McCollum, Guang-Zhe Huang, Amisra A Nikrodhanond, Catherine S Woolle. Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21510962. |
sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. |
2012-04-17 |
2023-08-12 |
human |
| Maartje M J Veeneman, Mark H Broekhoven, Ruth Damsteegt, Louk J M J Vanderschure. Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21918505. |
infusion of α-flupenthixol into the ventral nucleus accumbens (nacc) shell inhibited the acquisition of cocaine self-administration, reduced responding for the drug under fr-1 and pr schedules of reinforcement, and caused a downward shift of the dose-response curve of cocaine self-administration under an fr-1 schedule of reinforcement. |
2012-04-17 |
2023-08-12 |
Not clear |
| Bart J Naughton, Keerthi Thirtamara-Rajamani, Chuansong Wang, Matthew J During, Howard H G. Specific knockdown of the D2 long dopamine receptor variant. Neuroreport. vol 23. issue 1. 2012-03-27. PMID:22082989. |
dopamine signaling in the nucleus accumbens is critical in mediating the effects of cocaine. |
2012-03-27 |
2023-08-12 |
Not clear |
| Michael Fritz, Rana El Rawas, Sabine Klement, Kai Kummer, Michael J Mayr, Vincent Eggart, Ahmad Salti, Michael T Bardo, Alois Saria, Gerald Zerni. Differential effects of accumbens core vs. shell lesions in a rat concurrent conditioned place preference paradigm for cocaine vs. social interaction. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046347. |
in the present study, we investigated if the two subregions of the nucleus accumbens (acb), i.e., the core (acbc) and the shell (acbsh), would differentially affect cpp for cocaine vs social interaction. |
2012-03-26 |
2023-08-12 |
rat |
| Bradley J Martin, Bartholomew J Naughton, Keerthi Thirtamara-Rajamani, Daniel J Yoon, Dawn D Han, A Courtney Devries, Howard H G. Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens. Synapse (New York, N.Y.). vol 65. issue 6. 2012-03-12. PMID:20936687. |
cocaine is hypothesized to induce locomotor sensitization by neural changes, including an increase in the density of spines on the dendrites of neurons in the nucleus accumbens (nac). |
2012-03-12 |
2023-08-12 |
mouse |
| N D Volkow, G-J Wang, J H Newcorn, S H Kollins, T L Wigal, F Telang, J S Fowler, R Z Goldstein, N Klein, J Logan, C Wong, J M Swanso. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20856250. |
to evaluate this hypothesis, we performed secondary analyses to assess the correlation between the pet measures of dopamine d2/d3 receptor and dopamine transporter availability (obtained with [(11)c]raclopride and [(11)c]cocaine, respectively) in the dopamine reward pathway (midbrain and nucleus accumbens) and a surrogate measure of trait motivation (assessed using the achievement scale on the multidimensional personality questionnaire or mpq) in 45 adhd participants and 41 controls. |
2012-03-05 |
2023-08-12 |
human |
| Makoto Taniguchi, Maria B Carreira, Laura N Smith, Benjamin C Zirlin, Rachael L Neve, Christopher W Cowa. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron. vol 73. issue 1. 2012-03-05. PMID:22243750. |
importantly, we show that dephosphorylation of hdac5 s279 in the nucleus accumbens suppresses the development, but not expression, of cocaine reward behavior in vivo. |
2012-03-05 |
2023-08-12 |
Not clear |
| Brian R Lee, Yan Don. Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21232547. |
we recently demonstrated that repeated exposure to cocaine generated a large portion of "silent" glutamatergic synapses within the nucleus accumbens (nac). |
2012-01-27 |
2023-08-12 |
Not clear |
| Carrie R Ferrario, Jessica A Loweth, Mike Milovanovic, Kerstin A Ford, Gregorio L Galiñanes, Li-Jun Heng, Kuei Y Tseng, Marina E Wol. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²⁺-permeable AMPA receptors during the incubation of cocaine craving. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21276808. |
alterations in ampa receptor subunits and tarps in the rat nucleus accumbens related to the formation of ca²⁺-permeable ampa receptors during the incubation of cocaine craving. |
2012-01-27 |
2023-08-12 |
rat |
| Ilan Sondheimer, Lori A Knacksted. Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behavioural brain research. vol 225. issue 1. 2012-01-18. PMID:21824497. |
it has previously been shown that glt-1 expression is decreased in the nucleus accumbens following cocaine self-administration and extinction training; ceftriaxone given in the days immediately prior to reinstatement testing attenuates both cue- and cocaine-primed reinstatement. |
2012-01-18 |
2023-08-12 |
Not clear |
| Xuan Li, Marina E Wol. Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. The European journal of neuroscience. vol 34. issue 2. 2012-01-05. PMID:21692887. |
in the rodent nucleus accumbens (nac), cocaine elevates levels of brain-derived neurotrophic factor (bdnf). |
2012-01-05 |
2023-08-12 |
rat |