| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina E Wolf, Kuei Y Tsen. Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22754497. |
in animal models of drug addiction, cocaine exposure has been shown to increase levels of calcium-permeable ampa receptors (cp-ampars) in two brain regions that are critical for motivation and reward-the ventral tegmental area (vta) and the nucleus accumbens (nac). |
2012-10-02 |
2023-08-12 |
Not clear |
| Rana El Rawas, Sabine Klement, Kai K Kummer, Michael Fritz, Georg Dechant, Alois Saria, Gerald Zerni. Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction. Frontiers in behavioral neuroscience. vol 6. 2012-10-02. PMID:23015784. |
however, the granular insular cortex and the dorsal part of the agranular insular cortex were more activated after cocaine cpp, whereas the prelimbic cortex and the core subregion of the nucleus accumbens were more activated after social interaction cpp. |
2012-10-02 |
2023-08-12 |
rat |
| David M Dietz, Haosheng Sun, Mary Kay Lobo, Michael E Cahill, Benjamin Chadwick, Virginia Gao, Ja Wook Koo, Michelle S Mazei-Robison, Caroline Dias, Ian Maze, Diane Damez-Werno, Karen C Dietz, Kimberly N Scobie, Deveroux Ferguson, Daniel Christoffel, Yoko Ohnishi, Georgia E Hodes, Yi Zheng, Rachael L Neve, Klaus M Hahn, Scott J Russo, Eric J Nestle. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature neuroscience. vol 15. issue 6. 2012-09-17. PMID:22522400. |
repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. |
2012-09-17 |
2023-08-12 |
Not clear |
| David M Dietz, Haosheng Sun, Mary Kay Lobo, Michael E Cahill, Benjamin Chadwick, Virginia Gao, Ja Wook Koo, Michelle S Mazei-Robison, Caroline Dias, Ian Maze, Diane Damez-Werno, Karen C Dietz, Kimberly N Scobie, Deveroux Ferguson, Daniel Christoffel, Yoko Ohnishi, Georgia E Hodes, Yi Zheng, Rachael L Neve, Klaus M Hahn, Scott J Russo, Eric J Nestle. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature neuroscience. vol 15. issue 6. 2012-09-17. PMID:22522400. |
further, we show, using viral-mediated gene transfer, that overexpression of a dominant negative mutant of rac1 or local knockout of rac1 is sufficient to increase the density of immature dendritic spines on nucleus accumbens neurons, whereas overexpression of a constitutively active rac1 or light activation of a photoactivatable form of rac1 blocks the ability of repeated cocaine exposure to produce this effect. |
2012-09-17 |
2023-08-12 |
Not clear |
| Juan Li, Nuyun Liu, Kangrong Lu, Lei Zhang, Jingjing Gu, Fukun Guo, Shengli An, Lin Zhang, Lu Zhan. Cocaine-induced dendritic remodeling occurs in both D1 and D2 dopamine receptor-expressing neurons in the nucleus accumbens. Neuroscience letters. vol 517. issue 2. 2012-09-14. PMID:22561554. |
repeated exposure to cocaine can induce persistent alterations in the brain's reward system, including increases in the number of dendrites and spine density on medium-sized spiny neurons (msns) in the nucleus accumbens (nac). |
2012-09-14 |
2023-08-12 |
mouse |
| Lindsey P Pattison, Scot McIntosh, Evgeny A Budygin, Scott E Hemb. Differential regulation of accumbal dopamine transmission in rats following cocaine, heroin and speedball self-administration. Journal of neurochemistry. vol 122. issue 1. 2012-08-27. PMID:22443145. |
in vivo fast-scan cyclic voltammetry was used to examine the effects of chronic intravenous self-administration (25 consecutive sessions) of cocaine (250 μg/inf), heroin (4.95 μg/inf) and speedball (250/4.95 μg/inf cocaine/heroin) on changes in electrically evoked dopamine (da) efflux, maximal rate of da uptake (v(max)) and the apparent affinity (k(m)) of the da transporter in the nucleus accumbens. |
2012-08-27 |
2023-08-12 |
rat |
| Joachim D Uys, Lori Knackstedt, Phelipe Hurt, Kenneth D Tew, Yefim Manevich, Steven Hutchens, Danyelle M Townsend, Peter W Kaliva. Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 12. 2012-08-08. PMID:21796101. |
impaired glutamate homeostasis in the nucleus accumbens has been linked to cocaine relapse in animal models, and results in part from cocaine-induced downregulation of the cystine-glutamate exchanger. |
2012-08-08 |
2023-08-12 |
mouse |
| Hanne M Hoffmann, Roser Nadal, Michel Vignes, Jordi Orti. Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. Addiction biology. vol 17. issue 3. 2012-08-06. PMID:21812869. |
brains from sham controls and cocaine rats were extracted 1 day after the last session, and slices obtained from the striatum and nucleus accumbens (nac) were incubated in vitro with or without the d1r agonist skf38393 or the d2r agonist quinpirole. |
2012-08-06 |
2023-08-12 |
rat |
| Laura J Sim-Selley, Michael P Cassidy, Antonino Sparta, Venetia Zachariou, Eric J Nestler, Dana E Selle. Effect of ΔFosB overexpression on opioid and cannabinoid receptor-mediated signaling in the nucleus accumbens. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21907220. |
the stable transcription factor Δfosb is induced in the nucleus accumbens (nac) by chronic exposure to several drugs of abuse, and transgenic expression of Δfosb in the striatum enhances the rewarding properties of morphine and cocaine. |
2012-08-01 |
2023-08-12 |
mouse |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Jeffrey A Zidichouski, Tarek M Sale. Cocaine sensitization does not alter SP effects on locomotion or excitatory synaptic transmission in the NAc of rats. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21930135. |
substance p (sp) and cocaine employ similar mechanisms to modify excitatory synaptic transmission in the nucleus accumbens (nac), a region implicated in substance abuse. |
2012-07-27 |
2023-08-12 |
rat |
| Thorfinn T Riday, Barry E Kosofsky, C J Malang. The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22197517. |
expression of ampa receptor subunits (glur1 and glur2) and cre binding protein (creb) was measured in the ventral tegmental area (vta), dorsolateral striatum (str) and nucleus accumbens (nac) before and after a sensitizing regimen of cocaine, with and without icss. |
2012-07-27 |
2023-08-12 |
mouse |
| Dani Dumitriu, Quincey Laplant, Yael S Grossman, Caroline Dias, William G Janssen, Scott J Russo, John H Morrison, Eric J Nestle. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593064. |
subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. |
2012-07-27 |
2023-08-12 |
mouse |
| Dani Dumitriu, Quincey Laplant, Yael S Grossman, Caroline Dias, William G Janssen, Scott J Russo, John H Morrison, Eric J Nestle. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593064. |
numerous studies have found that chronic cocaine increases dendritic spine density of medium spiny neurons in the nucleus accumbens (nac). |
2012-07-27 |
2023-08-12 |
mouse |
| Casey E O'Neill, McKenzie L LeTendre, Ryan K Bachtel. Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22169945. |
adenosine a2a receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. |
2012-07-20 |
2023-08-12 |
rat |
| Courtney M Cameron, Regina M Carell. Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. The European journal of neuroscience. vol 35. issue 6. 2012-07-18. PMID:22356698. |
cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose. |
2012-07-18 |
2023-08-12 |
rat |
| Lisa Wells, Jolanta Opacka-Juffry, Donald Fisher, Catherine Ledent, Susanna Hourani, Ian Kitche. In vivo dopaminergic and behavioral responses to acute cocaine are altered in adenosine A(2A) receptor knockout mice. Synapse (New York, N.Y.). vol 66. issue 5. 2012-07-09. PMID:22213208. |
changes in the extracellular levels of dopamine (da) in the nucleus accumbens (nac) of mice lacking a(2a) adenosine receptors and wild type (wt) littermates after an acute cocaine (20 mg/kg) administration were evaluated by in vivo microdialysis studies. |
2012-07-09 |
2023-08-12 |
mouse |
| Amir Levine, Yanyou Huang, Bettina Drisaldi, Edmund A Griffin, Daniela D Pollak, Shiqin Xu, Deqi Yin, Christine Schaffran, Denise B Kandel, Eric R Kande. Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. Science translational medicine. vol 3. issue 107. 2012-05-17. PMID:22049069. |
we tested this conclusion further and found that a histone deacetylase inhibitor simulated the actions of nicotine by priming the response to cocaine and enhancing fosb gene expression and ltp depression in the nucleus accumbens. |
2012-05-17 |
2023-08-12 |
mouse |
| Anne Marie Wissman, Andrew F McCollum, Guang-Zhe Huang, Amisra A Nikrodhanond, Catherine S Woolle. Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21510962. |
sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. |
2012-04-17 |
2023-08-12 |
human |
| Maartje M J Veeneman, Mark H Broekhoven, Ruth Damsteegt, Louk J M J Vanderschure. Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21918505. |
infusion of α-flupenthixol into the ventral nucleus accumbens (nacc) shell inhibited the acquisition of cocaine self-administration, reduced responding for the drug under fr-1 and pr schedules of reinforcement, and caused a downward shift of the dose-response curve of cocaine self-administration under an fr-1 schedule of reinforcement. |
2012-04-17 |
2023-08-12 |
Not clear |
| Bart J Naughton, Keerthi Thirtamara-Rajamani, Chuansong Wang, Matthew J During, Howard H G. Specific knockdown of the D2 long dopamine receptor variant. Neuroreport. vol 23. issue 1. 2012-03-27. PMID:22082989. |
dopamine signaling in the nucleus accumbens is critical in mediating the effects of cocaine. |
2012-03-27 |
2023-08-12 |
Not clear |