| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morgan H James, Gary Aston-Jone. The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse. Neuron. vol 92. issue 1. 2017-10-26. PMID:27710789. |
(2016) describe how cocaine produces divergent forms of plasticity at synapses between specific neurons in nucleus accumbens and ventral pallidum, and how these changes are associated with positive and negative reward behaviors. |
2017-10-26 |
2023-08-13 |
Not clear |
| Alexander Gomez-A, Amanda M Fiorenza, Suelen L Boschen, Adam H Sugi, Danielle Beckman, Sergio T Ferreira, Kendall Lee, Charles D Blaha, Claudio Da Cunh. Diazepam Inhibits Electrically Evoked and Tonic Dopamine Release in the Nucleus Accumbens and Reverses the Effect of Amphetamine. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:28038309. |
in addition, our findings challenge the classic view that all drugs of abuse cause dopamine release in the nucleus accumbens and suggest that benzodiazepines could be useful in the treatment of addiction to other drugs that increase the level of dopamine release, such as cocaine, amphetamines, and nicotine. |
2017-10-24 |
2023-08-13 |
mouse |
| Kala Venkiteswaran, Danielle N Alexander, Matthew D Puhl, Anand Rao, Amanda L Piquet, Jennifer E Nyland, Megha P Subramanian, Puja Iyer, Matthew M Boisvert, Erin Handly, Thyagarajan Subramanian, Patricia Sue Grigso. Transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. Brain research bulletin. vol 123. 2017-10-20. PMID:26562520. |
transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. |
2017-10-20 |
2023-08-13 |
human |
| Nitish Mittal, Ani Minasyan, Nicole Romaneschi, Joshua K Hakimian, Gabriel Gonzalez-Fernandez, Ralph Albert, Nina Desai, Ian A Mendez, Timothy Schallert, Sean B Ostlund, Wendy Walwy. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PloS one. vol 12. issue 10. 2017-10-19. PMID:28973019. |
we then examined glutamatergic synaptic strength in wt and ko medium spiny neurons (msns) of the nucleus accumbens (nac) shell in naïve animals, and from those that underwent cocaine self-administration. |
2017-10-19 |
2023-08-13 |
mouse |
| Makoto Taniguchi, Maria B Carreira, Yonatan A Cooper, Ana-Clara Bobadilla, Jasper A Heinsbroek, Nobuya Koike, Erin B Larson, Evan A Balmuth, Brandon W Hughes, Rachel D Penrod, Jaswinder Kumar, Laura N Smith, Daniel Guzman, Joseph S Takahashi, Tae-Kyung Kim, Peter W Kalivas, David W Self, Yingxi Lin, Christopher W Cowa. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. vol 96. issue 1. 2017-10-10. PMID:28957664. |
we found that dephosphorylated, nuclear histone deacetylase 5 (hdac5) in the nucleus accumbens (nac) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. |
2017-10-10 |
2023-08-13 |
Not clear |
| Justin C Strickland, Jean M Abel, Ryan T Lacy, Joshua S Beckmann, Maryam A Witte, Wendy J Lynch, Mark A Smit. The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens. Drug and alcohol dependence. vol 163. 2017-10-03. PMID:27137405. |
the effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and bdnf expression in the nucleus accumbens. |
2017-10-03 |
2023-08-13 |
Not clear |
| Gil M Lewitus, Sarah C Konefal, Andrew D Greenhalgh, Horia Pribiag, Keanan Augereau, David Stellwage. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. vol 90. issue 3. 2017-08-22. PMID:27112496. |
repeated administration of cocaine results in the development of behavioral sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (nac) through an unknown mechanism. |
2017-08-22 |
2023-08-13 |
Not clear |
| Nicholas M Graziane, Shichao Sun, William J Wright, Daniel Jang, Zheng Liu, Yanhua H Huang, Eric J Nestler, Yu Tian Wang, Oliver M Schlüter, Yan Don. Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses. Nature neuroscience. vol 19. issue 7. 2017-08-18. PMID:27239940. |
exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (nac)-based behaviors, yet produce very different adaptations at nac excitatory synapses. |
2017-08-18 |
2023-08-13 |
Not clear |
| Ramesh Chandra, Michel Engeln, T Chase Francis, Prasad Konkalmatt, Dipal Patel, Mary Kay Lob. A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action. Biological psychiatry. vol 81. issue 7. 2017-08-14. PMID:27939396. |
a role for peroxisome proliferator-activated receptor gamma coactivator-1α in nucleus accumbens neuron subtypes in cocaine action. |
2017-08-14 |
2023-08-13 |
Not clear |
| Ramesh Chandra, Michel Engeln, T Chase Francis, Prasad Konkalmatt, Dipal Patel, Mary Kay Lob. A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action. Biological psychiatry. vol 81. issue 7. 2017-08-14. PMID:27939396. |
in addition, the pgc-1α promoter has binding sites for early growth response 3 (egr3), which plays a dynamic role in cocaine action in nucleus accumbens (nac) medium spiny neuron (msn) subtypes, those enriched in dopamine receptor d |
2017-08-14 |
2023-08-13 |
Not clear |
| Andrew F Scheyer, Jessica A Loweth, Daniel T Christian, Jamie Uejima, Rana Rabei, Tuan Le, Hubert Dolubizno, Michael T Stefanik, Conor H Murray, Courtney Sakas, Marina E Wol. AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving. Biological psychiatry. vol 80. issue 9. 2017-08-09. PMID:27264310. |
after prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (nac) core synapses through incorporation of ca |
2017-08-09 |
2023-08-13 |
human |
| Ashlynn I Gerth, Amber L Alhadeff, Harvey J Grill, Mitchell F Roitma. Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. Brain research. vol 1655. 2017-08-08. PMID:27789280. |
cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (dat). |
2017-08-08 |
2023-08-13 |
Not clear |
| Ashlynn I Gerth, Amber L Alhadeff, Harvey J Grill, Mitchell F Roitma. Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem. Brain research. vol 1655. 2017-08-08. PMID:27789280. |
to explore regional contributions of cocaine to dopamine signaling, we administered cocaine to the lateral or fourth ventricles and compared the effects on dopamine release in the nucleus accumbens evoked by electrical stimulation of the ventral tegmental area to that of systemically-delivered cocaine. |
2017-08-08 |
2023-08-13 |
Not clear |
| Michael D Scofield, Hao Li, Benjamin M Siemsen, Kati L Healey, Phuong K Tran, Nicholas Woronoff, Heather A Boger, Peter W Kalivas, Kathryn J Reissne. Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biological psychiatry. vol 80. issue 3. 2017-08-07. PMID:26946381. |
while it has been shown that cocaine experience impairs astroglial glutamate uptake and release in the nucleus accumbens (nac), few studies have explored effects of self-administration on the structure and physiology of astrocytes. |
2017-08-07 |
2023-08-13 |
Not clear |
| Paula A Gajewski, Gustavo Turecki, Alfred J Robiso. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. PloS one. vol 11. issue 8. 2017-07-31. PMID:27494187. |
the transcription factor Δfosb is induced in the prefrontal cortex (pfc) and hippocampus (hpc) of rodents in response to stress or cocaine, and its expression in these regions is thought to regulate their "top down" control of reward circuitry, including the nucleus accumbens (nac). |
2017-07-31 |
2023-08-13 |
human |
| Dongmin Lee, Meaghan Creed, Kanghoon Jung, Thomas Stefanelli, Daniel J Wendler, Won Chan Oh, Neymi Layne Mignocchi, Christian Lüscher, Hyung-Bae Kwo. Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain. Nature methods. vol 14. issue 5. 2017-07-31. PMID:28369042. |
we applied the itango system to decipher the roles of two classes of dopaminergic neurons in the mouse nucleus accumbens in a sensitized locomotor response to cocaine. |
2017-07-31 |
2023-08-13 |
mouse |
| Tianyuan Wang, Janine H Santos, Jian Feng, David C Fargo, Li Shen, Gonzalo Riadi, Elizabeth Keeley, Zachary S Rosh, Eric J Nestler, Richard P Woychi. A Novel Analytical Strategy to Identify Fusion Transcripts between Repetitive Elements and Protein Coding-Exons Using RNA-Seq. PloS one. vol 11. issue 7. 2017-07-20. PMID:27415830. |
we applied it to an rna-seq dataset from the nucleus accumbens (nac) of mice repeatedly exposed to cocaine. |
2017-07-20 |
2023-08-13 |
mouse |
| Eric J Nestle. Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function". Brain research. vol 1645. 2017-07-13. PMID:26740398. |
moreover, in the same study we showed similar induction of adenylyl cyclase and pka activity in nucleus accumbens (nac) in response to chronic administration of cocaine, but not of several non-abused psychoactive drugs. |
2017-07-13 |
2023-08-13 |
rat |
| Santiago Cuesta, Jorgelina Batuecas, Maria J Severin, Alejandrina Funes, Silvana B Rosso, Alejandra M Pacchion. Role of Wnt/β-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity: a possible novel target for addiction treatment. Journal of neurochemistry. vol 140. issue 1. 2017-07-13. PMID:27718509. |
we found that a cocaine challenge, after a period of abstinence, induced an increase in the activity of the pathway which is revealed as an increase in the total and nuclear levels of β-catenin (final effector of the pathway) in the nucleus accumbens (nacc), together with a decrease in the activity of glycogen synthase kinase 3β (gsk3β). |
2017-07-13 |
2023-08-13 |
Not clear |
| Courtney M Cameron, R Mark Wightman, Regina M Carell. One month of cocaine abstinence potentiates rapid dopamine signaling in the nucleus accumbens core. Neuropharmacology. vol 111. 2017-07-11. PMID:27616012. |
given the importance of the mesolimbic dopamine (da) system in drug addiction, we sought to characterize cocaine abstinence induced changes in rapid da signaling in the nucleus accumbens (nac). |
2017-07-11 |
2023-08-13 |
rat |