| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bryan F Singer, Myranda A Bryan, Pavlo Popov, Terry E Robinson, Brandon J Aragon. Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine. Behavioural brain research. vol 324. 2017-12-13. PMID:28223145. |
repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (da) transmission within the nucleus accumbens (nac). |
2017-12-13 |
2023-08-13 |
rat |
| Caroline Jung, Ariana Rabinowitsch, Wei Ting Lee, Danielle Zheng, Soledad Cabeza de Vaca, Kenneth D Car. Effects of food restriction on expression of place conditioning and biochemical correlates in rat nucleus accumbens. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27376947. |
when ad libitum-fed rats undergo cocaine place preference conditioning (cpp) but are switched to food restriction for testing, cpp becomes resistant to extinction and correlates with phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor glua1 at ser845 in nucleus accumbens (nac) core. |
2017-12-12 |
2023-08-13 |
rat |
| M Shen, C Jiang, P Liu, F Wang, L M. Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward. Translational psychiatry. vol 6. issue 12. 2017-12-07. PMID:27922639. |
our results showed that inhibition of leptin signaling by intracerebroventricular infusion of the leptin receptor (lepr) antagonist smla during cocaine conditioning increased the cocaine-cpp and upregulated the level of dopamine and its metabolites in the nucleus accumbens (nac). |
2017-12-07 |
2023-08-13 |
Not clear |
| Courtney M Keller, Kelly N Breaux, Nicholas E Goeder. Effects of the combination of metyrapone and oxazepam on cocaine-induced increases in corticosterone in the medial prefrontal cortex and nucleus accumbens. Psychoneuroendocrinology. vol 77. 2017-12-07. PMID:28024272. |
the administration of cocaine resulted in an increase in corticosterone in the medial prefrontal cortex following vehicle pretreatment, which was not observed in the nucleus accumbens. |
2017-12-07 |
2023-08-13 |
rat |
| Stephanie K Nygard, Anthony Klambatsen, Bailey Balouch, Vanya Quinones-Jenab, Shirzad Jena. NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior. Behavioural brain research. vol 317. 2017-11-29. PMID:27664298. |
n-methyl-d-aspartate receptor (nmdar) antagonism prior to cocaine administration during conditioning blocked the acquisition of cocaine cpp and reduced nucleus accumbens (nac) phosphorylated-erk (perk) and phosphorylated creb (pcreb) levels following the cpp test (drug-free). |
2017-11-29 |
2023-08-13 |
Not clear |
| Caitlin A Orsini, Marci R Mitchell, Sara C Heshmati, Kristy G Shimp, Megan S Spurrell, Jennifer L Bizon, Barry Setlo. Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task. Behavioural brain research. vol 321. 2017-11-29. PMID:28057530. |
chronic cocaine can also result in enhanced dopamine (da) release in the nucleus accumbens (nac) in response to reward-related cues. |
2017-11-29 |
2023-08-13 |
rat |
| Wen-Yu Tzeng, Chian-Fang G Cherng, Shyi-Wu Wang, Lung Y. Familiar companions diminish cocaine conditioning and attenuate cocaine-stimulated dopamine release in the nucleus accumbens. Behavioural brain research. vol 306. 2017-11-17. PMID:27001454. |
familiar companions diminish cocaine conditioning and attenuate cocaine-stimulated dopamine release in the nucleus accumbens. |
2017-11-17 |
2023-08-13 |
mouse |
| Wen-Yu Tzeng, Chian-Fang G Cherng, Shyi-Wu Wang, Lung Y. Familiar companions diminish cocaine conditioning and attenuate cocaine-stimulated dopamine release in the nucleus accumbens. Behavioural brain research. vol 306. 2017-11-17. PMID:27001454. |
at 20mg/kg, cocaine stimulated dopamine (da) release in the nucleus accumbens as evidenced by a significant decrease in total (spontaneous and electrical stimulation-provoked) da release in accumbal superfusate samples. |
2017-11-17 |
2023-08-13 |
mouse |
| Wen-Yu Tzeng, Chian-Fang G Cherng, Shyi-Wu Wang, Lung Y. Familiar companions diminish cocaine conditioning and attenuate cocaine-stimulated dopamine release in the nucleus accumbens. Behavioural brain research. vol 306. 2017-11-17. PMID:27001454. |
taken together, these results indicate that familiar companions, regardless of their pharmacological status, may exert dampening effects on cpp induced by moderate to high conditioning doses of cocaine, at least in part, by preventing cocaine-stimulated da release in the nucleus accumbens. |
2017-11-17 |
2023-08-13 |
mouse |
| Eduardo A V Marinho, Alexandre J Oliveira-Lima, Thais S Yokoyama, Renan Santos-Baldaia, Luciana T C Ribeiro, Marilia A Baldaia, Raphael Wuo da Silva, Andre Willian Hollais, Fernanda Talhati, Beatriz Monteiro Longo, Lais Fernanda Berro, Roberto Frussa-Filh. Post-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in mice. Pharmacology, biochemistry, and behavior. vol 156. 2017-11-09. PMID:28366798. |
c-fos protein expression was evaluated in the nucleus accumbens (nacc), ventral tegmental area (vta), basolateral amygdala (bla), medial prefrontal cortex (mpfc) and caudate-putamen (cpu) after the last (cocaine) challenge. |
2017-11-09 |
2023-08-13 |
mouse |
| Yafang Zhang, Elizabeth J Crofton, Xiuzhen Fan, Dingge Li, Fanping Kong, Mala Sinha, Bruce A Luxon, Heidi M Spratt, Cheryl F Lichti, Thomas A Gree. Convergent transcriptomics and proteomics of environmental enrichment and cocaine identifies novel therapeutic strategies for addiction. Neuroscience. vol 339. 2017-11-06. PMID:27717806. |
the current study is a secondary analysis of the convergence of recently published separate transcriptomic and proteomic analyses of nucleus accumbens (nac) tissue from rats subjected to environmental enrichment vs. isolation and cocaine self-administration vs. saline. |
2017-11-06 |
2023-08-13 |
rat |
| Michael P Saddori. Terminal Dopamine Release Kinetics in the Accumbens Core and Shell Are Distinctly Altered after Withdrawal from Cocaine Self-Administration. eNeuro. vol 3. issue 5. 2017-10-31. PMID:27752541. |
repeated self-administration of cocaine is associated with impairments in motivated behaviors as well as alterations in both dopamine (da) release and neural signaling within the nucleus accumbens (nac). |
2017-10-31 |
2023-08-13 |
rat |
| Morgan H James, Gary Aston-Jone. The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse. Neuron. vol 92. issue 1. 2017-10-26. PMID:27710789. |
(2016) describe how cocaine produces divergent forms of plasticity at synapses between specific neurons in nucleus accumbens and ventral pallidum, and how these changes are associated with positive and negative reward behaviors. |
2017-10-26 |
2023-08-13 |
Not clear |
| Alexander Gomez-A, Amanda M Fiorenza, Suelen L Boschen, Adam H Sugi, Danielle Beckman, Sergio T Ferreira, Kendall Lee, Charles D Blaha, Claudio Da Cunh. Diazepam Inhibits Electrically Evoked and Tonic Dopamine Release in the Nucleus Accumbens and Reverses the Effect of Amphetamine. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:28038309. |
in addition, our findings challenge the classic view that all drugs of abuse cause dopamine release in the nucleus accumbens and suggest that benzodiazepines could be useful in the treatment of addiction to other drugs that increase the level of dopamine release, such as cocaine, amphetamines, and nicotine. |
2017-10-24 |
2023-08-13 |
mouse |
| Kala Venkiteswaran, Danielle N Alexander, Matthew D Puhl, Anand Rao, Amanda L Piquet, Jennifer E Nyland, Megha P Subramanian, Puja Iyer, Matthew M Boisvert, Erin Handly, Thyagarajan Subramanian, Patricia Sue Grigso. Transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. Brain research bulletin. vol 123. 2017-10-20. PMID:26562520. |
transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. |
2017-10-20 |
2023-08-13 |
human |
| Nitish Mittal, Ani Minasyan, Nicole Romaneschi, Joshua K Hakimian, Gabriel Gonzalez-Fernandez, Ralph Albert, Nina Desai, Ian A Mendez, Timothy Schallert, Sean B Ostlund, Wendy Walwy. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PloS one. vol 12. issue 10. 2017-10-19. PMID:28973019. |
we then examined glutamatergic synaptic strength in wt and ko medium spiny neurons (msns) of the nucleus accumbens (nac) shell in naïve animals, and from those that underwent cocaine self-administration. |
2017-10-19 |
2023-08-13 |
mouse |
| Makoto Taniguchi, Maria B Carreira, Yonatan A Cooper, Ana-Clara Bobadilla, Jasper A Heinsbroek, Nobuya Koike, Erin B Larson, Evan A Balmuth, Brandon W Hughes, Rachel D Penrod, Jaswinder Kumar, Laura N Smith, Daniel Guzman, Joseph S Takahashi, Tae-Kyung Kim, Peter W Kalivas, David W Self, Yingxi Lin, Christopher W Cowa. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. vol 96. issue 1. 2017-10-10. PMID:28957664. |
we found that dephosphorylated, nuclear histone deacetylase 5 (hdac5) in the nucleus accumbens (nac) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. |
2017-10-10 |
2023-08-13 |
Not clear |
| Justin C Strickland, Jean M Abel, Ryan T Lacy, Joshua S Beckmann, Maryam A Witte, Wendy J Lynch, Mark A Smit. The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens. Drug and alcohol dependence. vol 163. 2017-10-03. PMID:27137405. |
the effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and bdnf expression in the nucleus accumbens. |
2017-10-03 |
2023-08-13 |
Not clear |
| Gil M Lewitus, Sarah C Konefal, Andrew D Greenhalgh, Horia Pribiag, Keanan Augereau, David Stellwage. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. vol 90. issue 3. 2017-08-22. PMID:27112496. |
repeated administration of cocaine results in the development of behavioral sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (nac) through an unknown mechanism. |
2017-08-22 |
2023-08-13 |
Not clear |
| Nicholas M Graziane, Shichao Sun, William J Wright, Daniel Jang, Zheng Liu, Yanhua H Huang, Eric J Nestler, Yu Tian Wang, Oliver M Schlüter, Yan Don. Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses. Nature neuroscience. vol 19. issue 7. 2017-08-18. PMID:27239940. |
exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (nac)-based behaviors, yet produce very different adaptations at nac excitatory synapses. |
2017-08-18 |
2023-08-13 |
Not clear |