| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa A Briand, Andre U Deutschmann, Alexandra S Ellis, Anne Q Fosnoch. Disrupting GluA2 phosphorylation potentiates reinstatement of cocaine seeking. Neuropharmacology. vol 111. 2017-07-11. PMID:27622930. |
taken together these results indicate that disrupting glua2 phosphorylation and increasing glua2-mediated transmission in the nucleus accumbens leads to increased vulnerability to cocaine relapse. |
2017-07-11 |
2023-08-13 |
mouse |
| Michel M M Verheij, Leandro F Vendruscolo, Lucia Caffino, Giuseppe Giannotti, Maxime Cazorla, Fabio Fumagalli, Marco A Riva, Judith R Homberg, George F Koob, Candice Conte. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 31. 2017-07-10. PMID:27488635. |
systemic delivery of a brain-penetrant trkb antagonist reduces cocaine self-administration and normalizes trkb signaling in the nucleus accumbens and prefrontal cortex. |
2017-07-10 |
2023-08-13 |
human |
| Avani Shukla, Anna Beroun, Myrto Panopoulou, Peter A Neumann, Seth Gn Grant, M Foster Olive, Yan Dong, Oliver M Schlüte. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference. The EMBO journal. vol 36. issue 4. 2017-07-10. PMID:28077487. |
exposure to cocaine generates silent synapses in the nucleus accumbens (nac), whose eventual unsilencing/maturation by recruitment of calcium-permeable ampa-type glutamate receptors (cp-ampars) after drug withdrawal results in profound remodeling of nac neuro-circuits. |
2017-07-10 |
2023-08-13 |
mouse |
| Marta Valenza, Roberto Picetti, Vadim Yuferov, Eduardo R Butelman, Mary Jeanne Kree. Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration. Neuropharmacology. vol 105. 2017-06-21. PMID:26777278. |
we performed a correlation analysis between the mrna level, found in the dorsal striatum (ds), nucleus accumbens (nacc) shell and core respectively, and individual cocaine intake. |
2017-06-21 |
2023-08-13 |
human |
| Anthony Purgianto, Jessica A Loweth, Julia J Miao, Mike Milovanovic, Marina E Wol. Surface expression of GABAA receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration. Brain research. vol 1642. 2017-05-23. PMID:27060767. |
surface expression of gabaa receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration. |
2017-05-23 |
2023-08-13 |
rat |
| Anthony Purgianto, Jessica A Loweth, Julia J Miao, Mike Milovanovic, Marina E Wol. Surface expression of GABAA receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration. Brain research. vol 1642. 2017-05-23. PMID:27060767. |
it is well established that cocaine-induced changes in glutamate receptor expression in the nucleus accumbens (nac) play a significant role in animal models of cocaine addiction. |
2017-05-23 |
2023-08-13 |
rat |
| Lena A Khibnik, Michael Beaumont, Marie Doyle, Mitra Heshmati, Paul A Slesinger, Eric J Nestler, Scott J Russ. Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens. Biological psychiatry. vol 79. issue 11. 2017-05-01. PMID:26164802. |
stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens. |
2017-05-01 |
2023-08-13 |
Not clear |
| Lena A Khibnik, Michael Beaumont, Marie Doyle, Mitra Heshmati, Paul A Slesinger, Eric J Nestler, Scott J Russ. Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens. Biological psychiatry. vol 79. issue 11. 2017-05-01. PMID:26164802. |
repeated exposure to cocaine or social stress leads to lasting structural and functional synaptic alterations in medium spiny neurons (msns) of nucleus accumbens (nac). |
2017-05-01 |
2023-08-13 |
Not clear |
| Amy Gancarz, Yan Jouroukhin, Atsushi Saito, Alexey Shevelkin, Lauren E Mueller, Atsushi Kamiya, David M Dietz, Mikhail V Pletniko. DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity. Neuroscience research. vol 105. 2016-12-30. PMID:26385055. |
cocaine sa significantly increased expression of disc1 in the nucleus accumbens (nac); while knockdown of disc1 in nac significantly increased cocaine sa and decreased phosphorylation of gsk-3β at ser9 compared to scrambled shrna. |
2016-12-30 |
2023-08-13 |
Not clear |
| Chung-Lung Chan, Daniel S Wheeler, Robert A Wheele. The neural encoding of cocaine-induced devaluation in the ventral pallidum. Neurobiology of learning and memory. vol 130. 2016-12-30. PMID:26948120. |
cocaine experience affects motivation structures such as the nucleus accumbens (nac) and its major output target, the ventral pallidum (vp). |
2016-12-30 |
2023-08-13 |
rat |
| Bethania Mongi-Bragato, Emiliano Zamponi, Constanza García-Keller, María Amparo Assis, Miriam B Virgolini, Daniel H Mascó, Andreas Zimmer, Liliana M Cancel. Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. Addiction biology. vol 21. issue 2. 2016-12-20. PMID:25431310. |
we found that ko mice do not develop sensitization to the stimulating properties of cocaine on locomotor activity and on dopamine release in the nucleus accumbens (nac). |
2016-12-20 |
2023-08-13 |
mouse |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
in addition, using designer receptors exclusively activated by designer drugs (dreadds) technology, we found that stimulation of the serotonergic dorsal raphe nucleus (drn) afferents to the nucleus accumbens (nac) abolishes cocaine reward and promotes antidepressive-like behaviors. |
2016-12-14 |
2023-08-13 |
mouse |
| Luisa Lo Iacono, Alessandro Valzania, Federica Visco-Comandini, Maria Teresa Viscomi, Armando Felsani, Stefano Puglisi-Allegra, Valeria Carol. Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine. Neuropharmacology. vol 103. 2016-12-13. PMID:26706499. |
regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine. |
2016-12-13 |
2023-08-13 |
mouse |
| Amber L LaCrosse, Kristine Hill, Lori A Knacksted. Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26706696. |
ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens ampa subunit expression. |
2016-12-13 |
2023-08-13 |
Not clear |
| Lori A Knackstedt, Marek Schwend. mGlu5 Receptors and Relapse to Cocaine-Seeking: The Role of Receptor Trafficking in Postrelapse Extinction Learning Deficits. Neural plasticity. vol 2016. 2016-12-13. PMID:26881139. |
we have previously demonstrated that mtep, an allosteric antagonist of mglu5, infused into the nucleus accumbens attenuates relapse after abstinence from cocaine self-administration. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yao-Ying Ma, Xiusong Wang, Yanhua Huang, Helene Marie, Eric J Nestler, Oliver M Schlüter, Yan Don. Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 18. 2016-12-13. PMID:27091967. |
specifically, our previous results show that cocaine self-administration generates ampa receptor (ampar)-silent excitatory synapses within the basolateral amygdala (bla) to nucleus accumbens (nac) projection, and maturation of these silent synapses via recruiting calcium-permeable (cp) ampars contributes to incubation of cocaine craving. |
2016-12-13 |
2023-08-13 |
rat |
| Elena H Chartoff, Shayla R Ebner, Angela Sparrow, David Potter, Phillip M Baker, Michael E Ragozzino, Mitchell F Roitma. Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 4. 2016-11-08. PMID:26239494. |
chronic cocaine exposure increases levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (kor) that suppresses dopamine release in the nucleus accumbens (nac) and elicits negative affective states upon drug withdrawal. |
2016-11-08 |
2023-08-13 |
rat |
| Meriem Gaval-Cruz, Richard B Goertz, Daniel J Puttick, Dawn E Bowles, Rebecca C Meyer, Randy A Hall, Daijin Ko, Carlos A Paladini, David Weinshenke. Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. Addiction biology. vol 21. issue 1. 2016-11-01. PMID:25123018. |
chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular d2 responses in the nucleus accumbens. |
2016-11-01 |
2023-08-13 |
mouse |
| Samantha L White, Pavel I Ortinski, Shayna H Friedman, Lei Zhang, Rachael L Neve, Robert G Kalb, Heath D Schmidt, R Christopher Pierc. A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 3. 2016-10-06. PMID:26149358. |
a growing body of evidence indicates that the transport of glua1 subunit-containing calcium-permeable ampa receptors (cp-ampars) to synapses in subregions of the nucleus accumbens promotes cocaine seeking. |
2016-10-06 |
2023-08-13 |
Not clear |
| Samantha L White, Pavel I Ortinski, Shayna H Friedman, Lei Zhang, Rachael L Neve, Robert G Kalb, Heath D Schmidt, R Christopher Pierc. A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 3. 2016-10-06. PMID:26149358. |
consistent with these findings, the present results show that administration of the cp-ampar antagonist, naspm, into the caudal lateral core or caudal medial shell of the nucleus accumbens attenuated cocaine priming-induced reinstatement of drug seeking. |
2016-10-06 |
2023-08-13 |
Not clear |