| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha L White, Pavel I Ortinski, Shayna H Friedman, Lei Zhang, Rachael L Neve, Robert G Kalb, Heath D Schmidt, R Christopher Pierc. A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 3. 2016-10-06. PMID:26149358. |
these results indicate that activation of glua1-containing ampars in subregions of the nucleus accumbens reinstates cocaine seeking. |
2016-10-06 |
2023-08-13 |
Not clear |
| Jacqueline F McGinty, Agnieska Zelek-Molik, Wei-Lun Su. Cocaine self-administration causes signaling deficits in corticostriatal circuitry that are reversed by BDNF in early withdrawal. Brain research. vol 1628. issue Pt A. 2016-09-27. PMID:25268928. |
cocaine self-administration disturbs intracellular signaling in prefrontal cortical neurons that regulate neurotransmission in the nucleus accumbens. |
2016-09-27 |
2023-08-13 |
Not clear |
| Yi Zhang, Xiongzhao Zhu, Can Huang, Xiuwu Zhan. Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine. Scientific reports. vol 5. 2016-09-23. PMID:26538265. |
molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine. |
2016-09-23 |
2023-08-13 |
rat |
| Jakub Jedynak, Matthew Hearing, Anna Ingebretson, Stephanie R Ebner, Matthew Kelly, Rachel A Fischer, Saïd Kourrich, Mark J Thoma. Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 2. 2016-09-20. PMID:26068728. |
cocaine and amphetamine induce overlapping but distinct patterns of ampar plasticity in nucleus accumbens medium spiny neurons. |
2016-09-20 |
2023-08-13 |
mouse |
| Ahmad Salti, Kai K Kummer, Chinmaya Sadangi, Georg Dechant, Alois Saria, Rana El Rawa. Social interaction reward decreases p38 activation in the nucleus accumbens shell of rats. Neuropharmacology. vol 99. 2016-08-30. PMID:26300300. |
we hypothesized that cocaine cpp will increase pp38 in the nucleus accumbens shell/core as compared to social interaction cpp. |
2016-08-30 |
2023-08-13 |
rat |
| Ahmad Salti, Kai K Kummer, Chinmaya Sadangi, Georg Dechant, Alois Saria, Rana El Rawa. Social interaction reward decreases p38 activation in the nucleus accumbens shell of rats. Neuropharmacology. vol 99. 2016-08-30. PMID:26300300. |
given the emerging role of p38 in stress/anxiety behaviors, these results suggest that (1) social interaction reward has anti-stress effects; (2) cocaine conditioning per se does not affect p38 activation and that (3) marginal stress is sufficient to induce p38 activation in the shell of the nucleus accumbens. |
2016-08-30 |
2023-08-13 |
rat |
| Laurie P Sutton, Marc G Caro. Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine. Neuropharmacology. vol 99. 2016-08-30. PMID:26314207. |
specifically, cocaine treatment increased the phosphorylation on residues thr2446 and ser2481 but not on ser2448 in the nucleus accumbens (nac) and that this increase in phosphorylated mtor levels was also apparent when complexed with its binding partner raptor. |
2016-08-30 |
2023-08-13 |
mouse |
| A L Northcutt, M R Hutchinson, X Wang, M V Baratta, T Hiranita, T A Cochran, M B Pomrenze, E L Galer, T A Kopajtic, C M Li, J Amat, G Larson, D C Cooper, Y Huang, C E O'Neill, H Yin, N R Zahniser, J L Katz, K C Rice, S F Maier, R K Bachtell, L R Watkin. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular psychiatry. vol 20. issue 12. 2016-08-29. PMID:25644383. |
resulting increases in extracellular dopamine in the nucleus accumbens (nac) are traditionally thought to result from cocaine's ability to block dopamine transporters (dats). |
2016-08-29 |
2023-08-13 |
Not clear |
| Yanhua H Huang, Oliver M Schlüter, Yan Don. Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 5. 2016-08-19. PMID:25829364. |
a transient but prominent increase in the level of "silent synapses"--a signature of immature glutamatergic synapses that contain only nmda receptors without stably expressed ampa receptors--has been identified in the nucleus accumbens (nac) following exposure to cocaine. |
2016-08-19 |
2023-08-13 |
Not clear |
| Erin S Calipari, Rosemary C Bagot, Immanuel Purushothaman, Thomas J Davidson, Jordan T Yorgason, Catherine J Peña, Deena M Walker, Stephen T Pirpinias, Kevin G Guise, Charu Ramakrishnan, Karl Deisseroth, Eric J Nestle. In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 10. 2016-08-09. PMID:26831103. |
the reinforcing and rewarding properties of cocaine are attributed to its ability to increase dopaminergic transmission in nucleus accumbens (nac). |
2016-08-09 |
2023-08-13 |
Not clear |
| Chiung-Chun Huang, Ying-Ching Liang, Cheng-Che Lee, Kuei-Sen Hs. Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25319571. |
we previously reported that animals withdrawn from repeated cocaine exposure exhibited a selective deficit in the ability to elicit metabotropic glutamate receptor 5 (mglur5)-dependent long-term depression (ltd) in the nucleus accumbens (nac) shell. |
2016-08-08 |
2023-08-13 |
mouse |
| H D Schmidt, K N McFarland, S B Darnell, M N Huizenga, G R Sangrey, J-H J Cha, R C Pierce, G Sadri-Vakil. ADAR2-dependent GluA2 editing regulates cocaine seeking. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25349168. |
emerging evidence suggests that the reinstatement of cocaine seeking is associated with increased synaptic expression of cp-ampars in the nucleus accumbens. |
2016-08-02 |
2023-08-13 |
rat |
| H D Schmidt, K N McFarland, S B Darnell, M N Huizenga, G R Sangrey, J-H J Cha, R C Pierce, G Sadri-Vakil. ADAR2-dependent GluA2 editing regulates cocaine seeking. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25349168. |
in the present study, we investigated the effects of forced cocaine abstinence on glua2 q/r site editing and adar2 expression in the nucleus accumbens. |
2016-08-02 |
2023-08-13 |
rat |
| D Y Sakae, F Marti, S Lecca, F Vorspan, E Martín-García, L J Morel, A Henrion, J Gutiérrez-Cuesta, A Besnard, N Heck, E Herzog, S Bolte, V F Prado, M A M Prado, F Bellivier, C B Eap, S Crettol, P Vanhoutte, J Caboche, A Gratton, L Moquin, B Giros, R Maldonado, S Daumas, M Mameli, S Jamain, S El Mestikaw. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:26239290. |
the absence of vglut3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. |
2016-08-02 |
2023-08-13 |
mouse |
| Shane A Perrine, Farhad Ghoddoussi, Kirtan Desai, Robert J Kohler, Ajay T Eapen, Michael J Lisieski, Mariana Angoa-Perez, Donald M Kuhn, Kelly E Bosse, Alana C Conti, David Bissig, Bruce A Berkowit. Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI. NMR in biomedicine. vol 28. issue 11. 2016-08-01. PMID:26411897. |
here, we tested the hypothesis that cocaine produces locomotor (behavioral) sensitization that correlates with increased calcium channel-mediated neuroactivity in brain regions linked with drug addiction, such as the nucleus accumbens (nac), anterior striatum (ast) and hippocampus, as measured using manganese-enhanced mri (memri). |
2016-08-01 |
2023-08-13 |
rat |
| Alois Saria, Janine Prast, Aurelia Schardl, Kai Kumme. Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction: Neurochemical and electrophysiological correlates in the nucleus accumbens corridor. SpringerPlus. vol 4. issue Suppl 1. 2016-07-07. PMID:27386182. |
reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction: neurochemical and electrophysiological correlates in the nucleus accumbens corridor. |
2016-07-07 |
2023-08-13 |
Not clear |
| Huikun Wang, Tyler Treadway, Daniel P Covey, Joseph F Cheer, Carl R Lupic. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. Cell reports. vol 12. issue 12. 2016-07-06. PMID:26365195. |
cocaine mobilizes 2-ag via inhibition of norepinephrine uptake and promotion of a cooperative interaction between gq/11-coupled type-1 metabotropic glutamate and α1-adrenergic receptors to stimulate internal calcium stores and activate phospholipase c. the disinhibition of da neurons by cocaine-mobilized 2-ag is also functionally relevant because it augments da release in the nucleus accumbens in vivo. |
2016-07-06 |
2023-08-13 |
rat |
| Taku Nagai, Shinichi Nakamuta, Keisuke Kuroda, Sakura Nakauchi, Tomoki Nishioka, Tetsuya Takano, Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Takashi Nakano, Junichiro Yoshimoto, Kenta Kobayashi, Motokazu Uchigashima, Masahiko Watanabe, Masami Miura, Akinori Nishi, Kazuto Kobayashi, Kiyofumi Yamada, Mutsuki Amano, Kozo Kaibuch. Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo. Neuron. vol 89. issue 3. 2016-06-28. PMID:26804993. |
cocaine exposure activated rap1 in the nucleus accumbens in mice. |
2016-06-28 |
2023-08-13 |
mouse |
| Michael E Cahill, Rosemary C Bagot, Amy M Gancarz, Deena M Walker, HaoSheng Sun, Zi-Jun Wang, Elizabeth A Heller, Jian Feng, Pamela J Kennedy, Ja Wook Koo, Hannah M Cates, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling. Neuron. vol 89. issue 3. 2016-06-28. PMID:26844834. |
dendritic spines are the sites of most excitatory synapses in the cns, and opposing alterations in the synaptic structure of medium spiny neurons (msns) of the nucleus accumbens (nac), a primary brain reward region, are seen at early versus late time points after cocaine administration. |
2016-06-28 |
2023-08-13 |
Not clear |
| Olivia Engmann, Albert Giralt, Nicolas Gervasi, Lucile Marion-Poll, Laila Gasmi, Odile Filhol, Marina R Picciotto, Diana Gilligan, Paul Greengard, Angus C Nairn, Denis Hervé, Jean-Antoine Giraul. DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nature communications. vol 6. 2016-05-12. PMID:26639316. |
this cascade is implicated in the effects of brief exposure to novel enriched environment on dendritic spines in nucleus accumbens and cocaine locomotor response. |
2016-05-12 |
2023-08-13 |
mouse |