| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad-Reza Khajevand-Khazaei, Pouria Ziaee, Seyyed-Alireza Motevalizadeh, Mahdi Rohani, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge in the rat. European journal of pharmacology. vol 826. 2018-09-10. PMID:29518393. |
additionally, naringenin was able to lower hippocampal nuclear factor-kappab (nf-κb), toll-like receptor 4 (tlr4), tumor necrosis factor α (tnfα), cyclooxygenase-2 (cox2), inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) level and its immunoreactivity, and to elevate nuclear factor (erythroid-derived 2)-like 2 (nrf2). |
2018-09-10 |
2023-08-13 |
rat |
| Shan Wang, Xiaowei Zhang, Liuyu Zhai, Xiaona Sheng, Weina Zheng, Hongshan Chu, Guohua Zhan. Atorvastatin Attenuates Cognitive Deficits and Neuroinflammation Induced by Aβ Journal of molecular neuroscience : MN. vol 64. issue 3. 2018-09-05. PMID:29417448. |
however, changes in tlr4 signaling pathway induced by beta-amyloid (aβ) have not been well characterized in brain, especially in the hippocampus. |
2018-09-05 |
2023-08-13 |
rat |
| Shan Wang, Xiaowei Zhang, Liuyu Zhai, Xiaona Sheng, Weina Zheng, Hongshan Chu, Guohua Zhan. Atorvastatin Attenuates Cognitive Deficits and Neuroinflammation Induced by Aβ Journal of molecular neuroscience : MN. vol 64. issue 3. 2018-09-05. PMID:29417448. |
in the present study, we explored the changes of tlr4 signaling pathway induced by aβ in the hippocampus and the role of atorvastatin in modulating this signal pathway and neurotoxicity induced by aβ. |
2018-09-05 |
2023-08-13 |
rat |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
here, we examined the relationship between toll-like receptor (tlr4; inflammatory), insulin-like growth factor receptor 1 (igf-1r; neurotropic) and camkiiα expression in the hippocampus of behaviorally deficient schizophrenic mice after we induced schizophrenia through nmdar inhibition. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
additionally, wt schizophrenic mice show an increased percentage of phosphorylated camkiiα in addition to upregulated tlr4 signaling (tlr4, nf-κb, and mapk/erk) in the hippocampus. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
interestingly, igf-1r and camkiiα expressions were preserved in the tlr4 kd hippocampus after attenuation of nmdar function. |
2018-08-31 |
2023-08-13 |
mouse |
| O M Ogundele, C C Le. CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4. Brain research bulletin. vol 137. 2018-08-31. PMID:29137928. |
our results show that a sustained igf-1r expression may preserve the synaptic activity of camkiiα while tlr4 signaling ablates hippocampal camkiiα expression in nmdar hypofunction schizophrenia. |
2018-08-31 |
2023-08-13 |
mouse |
| Rebecca J Henry, Daniel M Kerr, Lisa E Flannery, Marykate Killilea, Edel M Hughes, Louise Corcoran, David P Finn, Michelle Roch. Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1. Brain, behavior, and immunity. vol 62. 2018-08-29. PMID:28237711. |
systemic administration of the faah inhibitor pf3845 increased levels of aea, and related faah substrates n-oleoylethanolamide (oea) and n-palmitoylethanolamide (pea), in the frontal cortex and hippocampus of rats, an effect associated with an attenuation in the expression of pro- and anti-inflammatory cytokines and mediators measured 2hrs following systemic administration of the tlr4 agonist, lipopolysaccharide (lps). |
2018-08-29 |
2023-08-13 |
rat |
| Mudan Cai, Jun Hwan Lee, Eun Jin Yan. Bee Venom Ameliorates Cognitive Dysfunction Caused by Neuroinflammation in an Animal Model of Vascular Dementia. Molecular neurobiology. vol 54. issue 8. 2018-08-06. PMID:27686075. |
animals that had been treated with bv showed an improved cognitive function and a reduced expression of neuroinflammatory proteins in the hippocampus, including iba-1, tlr4, cd14, and tnf-α. |
2018-08-06 |
2023-08-13 |
bee |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
the present study aimed to investigate the effect of α7 nicotinic acetylcholine receptor (α7nachr) agonist on the damage of hippocampal neurons and the expression of toll like receptor 4 (tlr4)/myeloid differentiation primary response 88 (myd88)/nuclear factor (nf)‑κb signal pathway‑associated factors in cardiopulmonary bypass (cpb). |
2018-05-21 |
2023-08-13 |
rat |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
quantitative polymerase chain reaction and western blot assays were used to determine the expression of tlr4, myd88 and nf‑κb mrna, and protein in the hippocampus. |
2018-05-21 |
2023-08-13 |
rat |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
the expression of tlr4, myd88 and nf‑κb mrna, and protein in the hippocampus of cpb, mla and cpt groups were significantly higher compared with that in the sham group, and the pha group expression was significantly lower compared with the cpb group (p<0.05). |
2018-05-21 |
2023-08-13 |
rat |
| Sijie Tan, Yan Wang, Ke Chen, Zhifeng Long, Ju Zo. Ketamine Alleviates Depressive-Like Behaviors via Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice. Biological & pharmaceutical bulletin. vol 40. issue 8. 2018-05-02. PMID:28769008. |
subsequently, brain tissue was harvested to investigate inflammatory response in the hippocampus via investigating reactive microglia numbers, serum cytokines levels and the toll-like receptor type 4 (tlr4)/p38 mitogen-activated protein kinase (mapk) pathway. |
2018-05-02 |
2023-08-13 |
mouse |
| Ana Rubio-Araiz, Francesca Porcu, Mercedes Pérez-Hernández, Mª Salud García-Gutiérrez, María Auxiliadora Aracil-Fernández, María Dolores Gutierrez-López, Consuelo Guerri, Jorge Manzanares, Esther O'Shea, María Isabel Colad. Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model. Addiction biology. vol 22. issue 4. 2018-04-24. PMID:26949123. |
the etoh-induced effects on bbb impairment are not evident in the hippocampus of tlr4-knockout mice, suggesting the involvement of tlr4 signaling in the underlying mechanism leading to bbb disruption in mice. |
2018-04-24 |
2023-08-13 |
mouse |
| Olalekan M Ogundele, Philip J Ebenezer, Charles C Lee, Joseph Franci. Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy. Neuroscience. vol 353. 2018-03-14. PMID:28438613. |
furthermore, this was linked with a significant increase in hmgb1 (hippocampus: p<0.001, pfc: p<0.05) and tlr4 expression (hippocampus: p<0.01; pfc: ns) in the neurons. |
2018-03-14 |
2023-08-13 |
rat |
| Min-Xuan Xu, Rong Yu, Li-Fei Shao, Yan-Xiu Zhang, Chen-Xu Ge, Xin-Meng Liu, Wen-Yuan Wu, Jian-Mei Li, Ling-Dong Kon. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain, behavior, and immunity. vol 58. 2018-01-17. PMID:26765996. |
fructose feeding was found to induce hippocampal microglia activation with neuroinflammation through the activation of the toll-like receptor 4 (tlr4)/nuclear transcription factor κb (nf-κb) signaling, resulting in the reduction of neurogenesis in the dentate gyrus (dg) of mice. |
2018-01-17 |
2023-08-13 |
mouse |
| Ting Chen, Chang Chen, Zongze Zhang, Yufeng Zou, Mian Peng, Yanlin Wan. Toll-like receptor 4 knockout ameliorates neuroinflammation due to lung-brain interaction in mechanically ventilated mice. Brain, behavior, and immunity. vol 56. 2018-01-04. PMID:27067748. |
microgliosis, astrocytosis, and the tlr4 immunoreactivity in the hippocampus were measured by double immunofluorescence. |
2018-01-04 |
2023-08-13 |
mouse |
| Sudeshna Das, K P Mishra, Lilly Ganju, S B Sing. Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment. Journal of neuroimmunology. vol 313. 2017-11-29. PMID:29146293. |
real time pcr, western bloting, flow cytometric and immunofluorescence studies demonstrated that andrographolide inhibited lipopolysaccharide (lps)-induced overexpression of hmgb1, tlr4, nfκb, cox-2, inos, and release of inflammatory mediators in primary mix glial culture, adult mice prefrontal cortex and hippocampus region. |
2017-11-29 |
2023-08-13 |
mouse |
| Jingyi Yan, Jianing Bai, Chen Gao, Yanling Liang, Baohua Zhao, Yanqing Bia. Chronic unpredictable stress abrogates the endotoxin tolerance induced by repeated peripheral LPS challenge via the TLR4 signaling pathway. Neuroscience letters. vol 645. 2017-10-10. PMID:28254553. |
the mrna expression of tlr4 and myd88 and the protein levels of tlr4 and nf-κbp65 were significantly increased, but the protein levels of pi3k and p-akt were significantly decreased in the hippocampus of the mice. |
2017-10-10 |
2023-08-13 |
mouse |
| Qing-Peng Hu, Ding-An Ma. Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation. BMC neuroscience. vol 17. issue 1. 2017-08-21. PMID:27193049. |
histone deacetylase inhibitor saha attenuates post-seizure hippocampal microglia tlr4/myd88 signaling and inhibits tlr4 gene expression via histone acetylation. |
2017-08-21 |
2023-08-13 |
rat |