| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yamin Zhang, Yi Zhang, Ruipeng Wu, Fulin Gao, Peixi Zang, Xiaojuan Hu, Cheng G. Effect of cerebral small vessel disease on cognitive function and TLR4 expression in hippocampus. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 67. 2019-11-29. PMID:31288981. |
effect of cerebral small vessel disease on cognitive function and tlr4 expression in hippocampus. |
2019-11-29 |
2023-08-13 |
rat |
| Yamin Zhang, Yi Zhang, Ruipeng Wu, Fulin Gao, Peixi Zang, Xiaojuan Hu, Cheng G. Effect of cerebral small vessel disease on cognitive function and TLR4 expression in hippocampus. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 67. 2019-11-29. PMID:31288981. |
the aim of this study was to explore the differences in cognitive and neurological functions between cerebral small vessel disease (csvd) rats and normal rats, as well as to study the toll- like receptor 4 (tlr4) expression in the hippocampus of csvd rats to understand its role in this brain structure. |
2019-11-29 |
2023-08-13 |
rat |
| Yamin Zhang, Yi Zhang, Ruipeng Wu, Fulin Gao, Peixi Zang, Xiaojuan Hu, Cheng G. Effect of cerebral small vessel disease on cognitive function and TLR4 expression in hippocampus. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 67. 2019-11-29. PMID:31288981. |
after each measurement, 10 rats in the observation group and 5 in the control group were decapitated to collect samples for determining the expression of tlr4 in the hippocampus. |
2019-11-29 |
2023-08-13 |
rat |
| Yamin Zhang, Yi Zhang, Ruipeng Wu, Fulin Gao, Peixi Zang, Xiaojuan Hu, Cheng G. Effect of cerebral small vessel disease on cognitive function and TLR4 expression in hippocampus. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 67. 2019-11-29. PMID:31288981. |
csvd rats exhibited poor cognitive and neurological functions compared to normal rats and high expression of tlr4 in the hippocampus. |
2019-11-29 |
2023-08-13 |
rat |
| Y Liu, M G. Participation of TLR4 and neuroinflammation in the hippocampus in vascular cognitive impairment of hypertensive stroke-prone rats. Journal of biological regulators and homeostatic agents. vol 33. issue 5. 2019-11-21. PMID:31507142. |
participation of tlr4 and neuroinflammation in the hippocampus in vascular cognitive impairment of hypertensive stroke-prone rats. |
2019-11-21 |
2023-08-13 |
rat |
| Songnian Fu, Jiangtao Wang, Chenguang Hao, Haihong Dang, Sheng Jian. Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice. Psychopharmacology. vol 236. issue 7. 2019-11-04. PMID:30847567. |
additionally, we also found that cums induced the upregulation of proinflammatory cytokines; tlr4 and nlrp3-associated proteins were significantly suppressed by tmp in the prefrontal cortex and hippocampus. |
2019-11-04 |
2023-08-13 |
mouse |
| Shafiq Ur Rehman, Tahir Ali, Sayed Ibrar Alam, Rahat Ullah, Amir Zeb, Keun Woo Lee, Bart P F Rutten, Myeong Ok Ki. Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058023. |
ferulic acid rescues lps-induced neurotoxicity via modulation of the tlr4 receptor in the mouse hippocampus. |
2019-08-06 |
2023-08-13 |
mouse |
| Shafiq Ur Rehman, Tahir Ali, Sayed Ibrar Alam, Rahat Ullah, Amir Zeb, Keun Woo Lee, Bart P F Rutten, Myeong Ok Ki. Ferulic Acid Rescues LPS-Induced Neurotoxicity via Modulation of the TLR4 Receptor in the Mouse Hippocampus. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058023. |
first, we provide evidence that fa interferes with tlr4 interaction sites, which are required for the activation of microglia-induced neuroinflammation, and further examined the potential mechanism of its neuroprotective effects in the mouse hippocampus using molecular docking simulation and immunoblot analysis. |
2019-08-06 |
2023-08-13 |
mouse |
| Patricia Rivera, María Del Mar Fernández-Arjona, Daniel Silva-Peña, Eduardo Blanco, Antonio Vargas, María Dolores López-Ávalos, Jesús M Grondona, Antonia Serrano, Francisco Javier Pavón, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30098312. |
regarding innate immune activity, urb597 specifically increased mrna levels of toll-like receptor 4 (tlr4), glial fibrillary acidic protein (gfap) and the chemokine stromal cell-derived factor 1 (sdf-1α/cxcl12), and elevated the cell population expressing the chemokine receptors cx3cr1, ccr2 and ccr4 in the ethanol-exposed rat hippocampus. |
2019-07-08 |
2023-08-13 |
rat |
| Justin Miron, Cynthia Picard, Josée Frappier, Doris Dea, Louise Théroux, Judes Poirie. TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer's Disease and in Response to Hippocampal Deafferentation in Rodents. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29782315. |
tlr4 gene expression and pro-inflammatory cytokines in alzheimer's disease and in response to hippocampal deafferentation in rodents. |
2019-06-10 |
2023-08-13 |
mouse |
| Justin Miron, Cynthia Picard, Josée Frappier, Doris Dea, Louise Théroux, Judes Poirie. TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer's Disease and in Response to Hippocampal Deafferentation in Rodents. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29782315. |
similarly, using a mouse model of hippocampal deafferentation without amyloidosis, (i.e., the entorhinal cortex lesioned mouse), we observed significant increases in the expression of both the tlr4 (p = 0.0367 and p = 0.0193 compared to sham-lesioned mice or to the contralateral side, respectively) and il1b (p = 0.0055 and p = 0.0066 compared to sham-lesioned mice or to the contralateral side, respectively) genes in the deafferentation phase, but not during the ensuing reinnervation process. |
2019-06-10 |
2023-08-13 |
mouse |
| Zhenzhen Qu, Lijing Jia, Tao Xie, Junli Zhen, Peipei Si, Zhiqiang Cui, Yan Xue, Can Sun, Weiping Wan. (-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-05-22. PMID:30843525. |
the morris water maze test and hippocampal late-phase long-term potentiation (l-ltp) recordings were used to evaluate cognitive impairment, and tlr4, nf-kappab, and il-1ß levels were determined using western blot analysis. |
2019-05-22 |
2023-08-13 |
rat |
| Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Ali-Mohammad Rousta, Mohammad-Reza Azadi, Javad Fahanik-Babaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects. Cytokine. vol 104. 2019-04-29. PMID:29102164. |
furthermore, genistein administration to lps-injected group lowered hippocampal level of interleukin 6 (il-6), nuclear factor-kappab (nf-κb) p65, toll-like receptor 4 (tlr4), tumor necrosis factor α (tnfα), cyclooxygenase-2 (cox2), inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap), and increased hippocampal level of antioxidant element nuclear factor (erythroid-derived 2)-like 2 (nrf2). |
2019-04-29 |
2023-08-13 |
rat |
| Yongxiang Yang, Yuqin Ye, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng H. MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway. Neurochemical research. vol 44. issue 4. 2019-04-26. PMID:30628018. |
mir-124 enriched exosomes promoted the m2 polarization of microglia and enhanced hippocampus neurogenesis after traumatic brain injury by inhibiting tlr4 pathway. |
2019-04-26 |
2023-08-13 |
rat |
| Federica Frigerio, Corey Flynn, Ye Han, Kyle Lyman, Joaquin N Lugo, Teresa Ravizza, Antoine Ghestem, Julika Pitsch, Albert Becker, Anne E Anderson, Annamaria Vezzani, Dane Chetkovich, Christophe Bernar. Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29427087. |
here, we report that intracerebroventricular injection of the prototypical inflammatory molecule lipopolysaccharide (lps) in rats triggered a strong and long-lasting inflammatory response in hippocampal microglia associated with a concomitant upregulation of toll-like receptor (tlr4) in pyramidal and hilar neurons. |
2019-02-04 |
2023-08-13 |
rat |
| Mohsen Khalili, Mitra Alavi, Elham Esmaeil-Jamaat, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Trigonelline mitigates lipopolysaccharide-induced learning and memory impairment in the rat due to its anti-oxidative and anti-inflammatory effect. International immunopharmacology. vol 61. 2018-11-08. PMID:29935483. |
furthermore, trigonelline depressed hippocampal nuclear factor-kappab (nf-κb), toll-like receptor 4 (tlr4), and tumor necrosis factor α (tnf α) in lps-challenged rats. |
2018-11-08 |
2023-08-13 |
rat |
| Wei Jiang, Xian Zhang, Ai-Ling Zho. [The role of TLR Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 32. issue 6. 2018-10-18. PMID:29926630. |
[the role of tlr to investigate the effects of the toll like receptor 4 (tlr4) -p38-jnk signaling pathway in the apoptosis of hippocampal neurons in rats and its mechanisms. |
2018-10-18 |
2023-08-13 |
rat |
| Hongsheng Jiang, Yanzhou Wang, Xin Liang, Xiaofeng Xing, Xiuzhen Xu, Caifeng Zho. Toll-Like Receptor 4 Knockdown Attenuates Brain Damage and Neuroinflammation After Traumatic Brain Injury via Inhibiting Neuronal Autophagy and Astrocyte Activation. Cellular and molecular neurobiology. vol 38. issue 5. 2018-10-05. PMID:29222622. |
elevated tlr4 was specifically observed in the hippocampal astrocytes and neurons posttrauma. |
2018-10-05 |
2023-08-13 |
rat |
| Hongsheng Jiang, Yanzhou Wang, Xin Liang, Xiaofeng Xing, Xiuzhen Xu, Caifeng Zho. Toll-Like Receptor 4 Knockdown Attenuates Brain Damage and Neuroinflammation After Traumatic Brain Injury via Inhibiting Neuronal Autophagy and Astrocyte Activation. Cellular and molecular neurobiology. vol 38. issue 5. 2018-10-05. PMID:29222622. |
interestingly, tlr4 shrna decreased the concentrations of interleukin (il)-1β, il-6, and tissue necrosis factor-α; alleviated hippocampal neuronal damage; reduced brain edema formation; and improved neurological deficits after tbi. |
2018-10-05 |
2023-08-13 |
rat |
| En-Tzu Liao, Yi-Wen Lin, Chun-Ping Huang, Nou-Ying Tang, Ching-Liang Hsie. Electric Stimulation of Ear Reduces the Effect of Toll-Like Receptor 4 Signaling Pathway on Kainic Acid-Induced Epileptic Seizures in Rats. BioMed research international. vol 2018. 2018-09-20. PMID:29682548. |
experimental ka injection successfully initiated an epileptic seizure accompanied by increased expression of tlr4 in the prefrontal cortex, hippocampus, and somatosensory cortex. |
2018-09-20 |
2023-08-13 |
rat |