| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Derek A Costello, Melanie B Watson, Thelma R Cowley, Niamh Murphy, Ciarán Murphy Royal, Cecilia Garlanda, Marina A Lync. Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 10. 2011-05-11. PMID:21389242. |
we propose that il-1ri is activated by il-1α and tlr4 is activated by the endogenous agonist, high mobility group box 1 (hmgb1), as we identified enhanced expression of both cytokines in the hippocampus of sigirr(-/-) mice. |
2011-05-11 |
2023-08-12 |
mouse |
| Melanie B Watson, Derek A Costello, Dónal G Carney, Keith McQuillan, Marina A Lync. SIGIRR modulates the inflammatory response in the brain. Brain, behavior, and immunity. vol 24. issue 6. 2010-10-08. PMID:20394816. |
the evidence suggests that these changes are a likely consequence of increased hippocampal expression of cd14 and tlr4, and nfkappab activation in sigirr(-/-) mice. |
2010-10-08 |
2023-08-12 |
mouse |
| Dae Won Chung, Ki-Yeon Yoo, In Koo Hwang, Dae Won Kim, Jin Young Chung, Choong Hyun Lee, Jung Hoon Choi, Soo Young Choi, Hwa Young Youn, In Se Lee, Moo-Ho Wo. Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cellular and molecular neurobiology. vol 30. issue 4. 2010-09-07. PMID:19908141. |
for this, we investigated the optimal concentration of lps influencing the icr mouse hippocampus to measure the lps receptor, e.g., toll-like receptor 4 (tlr4), expression in mouse hippocampal homogenates. |
2010-09-07 |
2023-08-12 |
mouse |
| Dae Won Chung, Ki-Yeon Yoo, In Koo Hwang, Dae Won Kim, Jin Young Chung, Choong Hyun Lee, Jung Hoon Choi, Soo Young Choi, Hwa Young Youn, In Se Lee, Moo-Ho Wo. Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cellular and molecular neurobiology. vol 30. issue 4. 2010-09-07. PMID:19908141. |
tlr4 expression was significantly and prominently increased in the hippocampal homogenates of the lps (1 mg/kg)-treated group. |
2010-09-07 |
2023-08-12 |
mouse |
| Dae Won Chung, Ki-Yeon Yoo, In Koo Hwang, Dae Won Kim, Jin Young Chung, Choong Hyun Lee, Jung Hoon Choi, Soo Young Choi, Hwa Young Youn, In Se Lee, Moo-Ho Wo. Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cellular and molecular neurobiology. vol 30. issue 4. 2010-09-07. PMID:19908141. |
in brief, our results indicate that intraperitoneal administration of 1 mg/kg lps effectively induces lps receptor (tlr4) expression in the hippocampus, and the treatment increases corticosterone levels, inflammation in the blood vessels, and microglial activation in the hippocampus without any neuronal damage. |
2010-09-07 |
2023-08-12 |
mouse |
| Yin Gao, Xiubin Fang, He Sun, Yu Wang, Li Jie Yao, Jing Ping Li, Yue Tong, Baohui Zhang, Yuli Li. Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice. Biological & pharmaceutical bulletin. vol 32. issue 10. 2010-01-28. PMID:19801825. |
we determined the result of tlr4 antibodies-blocking and mice cerebral ischemia-reperfusion injuries by western blot, and evaluated neuronal damage in the hippocampus. |
2010-01-28 |
2023-08-12 |
mouse |
| Fang Hua, Jing Ma, Tuanzhu Ha, Yeling Xia, Jim Kelley, David L Williams, Race L Kao, I William Browder, John B Schweitzer, John H Kalbfleisch, Chuanfu L. Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. Journal of neuroimmunology. vol 190. issue 1-2. 2007-12-21. PMID:17884182. |
the present study investigated the role and mechanisms-of-action of tlr4 signaling in ischemia-induced hippocampal neuronal death. |
2007-12-21 |
2023-08-12 |
mouse |
| Fang Hua, Jing Ma, Tuanzhu Ha, Yeling Xia, Jim Kelley, David L Williams, Race L Kao, I William Browder, John B Schweitzer, John H Kalbfleisch, Chuanfu L. Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. Journal of neuroimmunology. vol 190. issue 1-2. 2007-12-21. PMID:17884182. |
these data suggest that activation of tlr4 signaling contributes to ischemia-induced hippocampal neuronal death. |
2007-12-21 |
2023-08-12 |
mouse |
| Fang Hua, Jing Ma, Tuanzhu Ha, Yeling Xia, Jim Kelley, David L Williams, Race L Kao, I William Browder, John B Schweitzer, John H Kalbfleisch, Chuanfu L. Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. Journal of neuroimmunology. vol 190. issue 1-2. 2007-12-21. PMID:17884182. |
in addition, these data suggest that modulation of tlr4 signaling may attenuate ischemic injury in hippocampal neurons. |
2007-12-21 |
2023-08-12 |
mouse |
| Asya Rolls, Ravid Shechter, Anat London, Yaniv Ziv, Ayal Ronen, Rinat Levy, Michal Schwart. Toll-like receptors modulate adult hippocampal neurogenesis. Nature cell biology. vol 9. issue 9. 2007-12-17. PMID:17704767. |
tlr2 deficiency in mice impaired hippocampal neurogenesis, whereas the absence of tlr4 resulted in enhanced proliferation and neuronal differentiation. |
2007-12-17 |
2023-08-12 |
mouse |