| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Zhang, Guoqiang Cheng, Longxia Chen, Wenhao Zhou, Jinqiao Su. Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats. Brain & development. vol 37. issue 8. 2016-06-02. PMID:25530127. |
in this study, we investigated the expression of tlr2 and tlr4 in the hippocampus of the neonatal rats. |
2016-06-02 |
2023-08-13 |
rat |
| Ki Mo Lee, JiHye Bang, Bu Yeo Kim, In Sun Lee, Jung-Soo Han, Bang Yeon Hwang, Won Kyung Jeo. Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling. BMC complementary and alternative medicine. vol 15. 2016-02-11. PMID:25898017. |
fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of tlr4 and p38 mapk signaling. |
2016-02-11 |
2023-08-13 |
Not clear |
| Shun-Mei Lu, Bo Gui, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Hai-Ling Liu, Jie Sun, Yian-Ning Qia. Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. Brain research bulletin. vol 114. 2016-01-26. PMID:25839444. |
prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal tlr4 activation in aged rats. |
2016-01-26 |
2023-08-13 |
rat |
| Shun-Mei Lu, Bo Gui, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Hai-Ling Liu, Jie Sun, Yian-Ning Qia. Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. Brain research bulletin. vol 114. 2016-01-26. PMID:25839444. |
so we hypothesized that inhibition of tlr4 signaling in the hippocampus maybe involved in the protective effects of prophylactic lithium on the occurrence of inflammation and pocd. |
2016-01-26 |
2023-08-13 |
rat |
| Shun-Mei Lu, Bo Gui, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Hai-Ling Liu, Jie Sun, Yian-Ning Qia. Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats. Brain research bulletin. vol 114. 2016-01-26. PMID:25839444. |
then, we also found that splenectomy merely increased hippocampal tlr2 and tlr4 mrna levels in aged rats. |
2016-01-26 |
2023-08-13 |
rat |
| Jin-Tao Liu, Bei-Yu Chen, Jie-Qiong Zhang, Fang Kuang, Liang-Wei Che. Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering TLR4-MyD88-NFκB signaling cascades. Toxicology letters. vol 239. issue 2. 2016-01-25. PMID:26386401. |
it revealed that (1) significant microglial activation occurred in hippocampus soon following pb exposure; (2) increased levels of tlr4, myd88, nfκb expression were concomitantly detected; (3) brdu-incorporated progenitor cells were observed in dentate gyrus with significantly-increased numbers at d28 in pb insult group; (4) obvious astrogliogenesis was observed while these doublecortin-labeled differentiated neurons were not significantly changed in hippocampus; (5) administration of myd88 inhibitory peptide attenuated or relieved above effects; (6) enhanced expression levels of il-1β, tnfα, p38mapk and erk1/2 were also detected in hippocampus, indicating potential implication of inflammatory response and mapk signaling activation in lead-induced microgliosis and astrogliosis. |
2016-01-25 |
2023-08-13 |
mouse |
| Ying Li, Akshata A Korgaonkar, Bogumila Swietek, Jianfeng Wang, Fatima S Elgammal, Stella Elkabes, Vijayalakshmi Santhakuma. Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury. Neurobiology of disease. vol 74. 2016-01-06. PMID:25497689. |
concussive brain injury caused a transient increase in hippocampal tlr4 expression within 4h, which peaked at 24h. |
2016-01-06 |
2023-08-13 |
rat |
| Dan Wu, Xian Zhang, Min Zhao, Ai-Ling Zho. The role of the TLR4/NF-κB signaling pathway in Aβ accumulation in primary hippocampal neurons. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 3. 2015-09-10. PMID:26109305. |
the present study aimed to investigate the role of the toll-like receptor 4 (tlr4)/nuclear factor κb (nf-κb) signaling pathway in the accumulation of amyloid β protein (aβ) in primary hippocampal neurons of rats. |
2015-09-10 |
2023-08-13 |
rat |
| Dan Wu, Xian Zhang, Min Zhao, Ai-Ling Zho. The role of the TLR4/NF-κB signaling pathway in Aβ accumulation in primary hippocampal neurons. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 3. 2015-09-10. PMID:26109305. |
meanwhile, the levels of tlr4 mrna and protein in hippocampal neurons were tested by rt-qpcr and western blotting, respectively, after stimulation with aβ1-42 at different concentrations. |
2015-09-10 |
2023-08-13 |
rat |
| Shun-Mei Lu, Chan-Juan Yu, Ya-Hua Liu, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Feng Zhang, Yan-Ning Qian, Bo Gu. S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway. Brain, behavior, and immunity. vol 44. 2015-08-13. PMID:25449673. |
on the one hand, s100a8 could induce tlr4 activation of cd11b(+) cells in the blood and hippocampus via intraperitoneal or intracerebroventricular injection. |
2015-08-13 |
2023-08-13 |
mouse |
| Shun-Mei Lu, Chan-Juan Yu, Ya-Hua Liu, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Feng Zhang, Yan-Ning Qian, Bo Gu. S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway. Brain, behavior, and immunity. vol 44. 2015-08-13. PMID:25449673. |
on the other hand, tlr4 deficiency conversely alleviated s100a8 protein-induced hippocampal microgliosis. |
2015-08-13 |
2023-08-13 |
mouse |
| Shun-Mei Lu, Chan-Juan Yu, Ya-Hua Liu, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Feng Zhang, Yan-Ning Qian, Bo Gu. S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway. Brain, behavior, and immunity. vol 44. 2015-08-13. PMID:25449673. |
furthermore, the increased expression of s100a8 protein in the hippocampus induced by surgery sharply decreased in both tlr4 and myd88 genetically deficient mice. |
2015-08-13 |
2023-08-13 |
mouse |
| Yanling Liang, Zhigang Lei, Hui Zhang, Zhiqiang Xu, Qiliang Cui, Zao C X. Toll-like receptor 4 is associated with seizures following ischemia with hyperglycemia. Brain research. vol 1590. 2015-07-09. PMID:25223904. |
tlr4 was mildly expressed in a few cells in the control hippocampus, primarily in interneurons, and was localized in the cytoplasm. |
2015-07-09 |
2023-08-13 |
rat |
| Yanling Liang, Zhigang Lei, Hui Zhang, Zhiqiang Xu, Qiliang Cui, Zao C X. Toll-like receptor 4 is associated with seizures following ischemia with hyperglycemia. Brain research. vol 1590. 2015-07-09. PMID:25223904. |
high mobility group box 1 (hmgb1) (an endogenous ligand of tlr4) was localized in the nucleus of neuronal cells throughout the hippocampus in the control animals. |
2015-07-09 |
2023-08-13 |
rat |
| Ling Xu, Ai-Ling Zhou, Min Zha. [Involvement of Toll-like receptor 4 in apoptosis of hippocampal neurons through Akt/FoxO3a/Bim signaling pathways]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 3. 2015-05-16. PMID:24964849. |
the present study was to investigate whether toll-like receptor 4 (tlr4)-mediated akt/foxo3a/bim signaling pathway participated in lipopolysaccharide (lps)-induced apoptosis in hippocampal neurons. |
2015-05-16 |
2023-08-13 |
rat |
| Ling Xu, Ai-Ling Zhou, Min Zha. [Involvement of Toll-like receptor 4 in apoptosis of hippocampal neurons through Akt/FoxO3a/Bim signaling pathways]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 3. 2015-05-16. PMID:24964849. |
the primarily cultured rat hippocampal neurons were treated with lps, tlr4 antibody+lps, and ly294002+lps, respectively. |
2015-05-16 |
2023-08-13 |
rat |
| Ling Xu, Ai-Ling Zhou, Min Zha. [Involvement of Toll-like receptor 4 in apoptosis of hippocampal neurons through Akt/FoxO3a/Bim signaling pathways]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 3. 2015-05-16. PMID:24964849. |
in conclusion, the present study suggests that akt/foxo3a/bim signaling pathways mediated by tlr4 participate in the apoptotic processes of primarily cultured hippocampal neurons treated with lps, and the activation of tlr4 causes neuronal apoptosis. |
2015-05-16 |
2023-08-13 |
rat |
| Yuqin Ye, Hongyu Xu, Xin Zhang, Ze Li, Yanfeng Jia, Xiaosheng He, Jason H Huan. Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice. International journal of molecular sciences. vol 15. issue 7. 2015-04-10. PMID:25036030. |
in the present study, association between tlr4 expression and nscs proliferation in the hippocampus was investigated in a mouse model of tbi using controlled cortical impact (cci). |
2015-04-10 |
2023-08-13 |
mouse |
| Yuqin Ye, Hongyu Xu, Xin Zhang, Ze Li, Yanfeng Jia, Xiaosheng He, Jason H Huan. Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice. International journal of molecular sciences. vol 15. issue 7. 2015-04-10. PMID:25036030. |
morphological observation on the expression of brdu, sox2, and tlr4 in the hippocampus was performed by inmmunofluorescence (if). |
2015-04-10 |
2023-08-13 |
mouse |
| Yuqin Ye, Hongyu Xu, Xin Zhang, Ze Li, Yanfeng Jia, Xiaosheng He, Jason H Huan. Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice. International journal of molecular sciences. vol 15. issue 7. 2015-04-10. PMID:25036030. |
it was observed that brdu+/sox2+cells accounted for 95.80%±7.91% among brdu+ cells; several brdu+ cells and sox2+ cells in the hippocampus were also tlr4-positive post injury, and that brdu+ cell numbers, together with tlr4 expression at either protein or mrna level, increased significantly in tbi mice over 1, 3, 7, 14, and 21 days survivals and changed in a similar temporal pattern with a peak at 3 day post-injury. |
2015-04-10 |
2023-08-13 |
mouse |