| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuqin Ye, Hongyu Xu, Xin Zhang, Ze Li, Yanfeng Jia, Xiaosheng He, Jason H Huan. Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice. International journal of molecular sciences. vol 15. issue 7. 2015-04-10. PMID:25036030. |
these results indicate that hippocampal proliferating cells (suggestive of nscs) expressed tlr4, and that there was a potential association between increased expression of tlr4 and the proliferation of nscs post tbi. |
2015-04-10 |
2023-08-13 |
mouse |
| Yuqin Ye, Hongyu Xu, Xin Zhang, Ze Li, Yanfeng Jia, Xiaosheng He, Jason H Huan. Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice. International journal of molecular sciences. vol 15. issue 7. 2015-04-10. PMID:25036030. |
it is concluded that hippocampal tlr4 may play a potential role in endogenous neurogenesis after tbi. |
2015-04-10 |
2023-08-13 |
mouse |
| Ryan P Vetreno, Fulton T Crew. Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning. Frontiers in neuroscience. vol 9. 2015-03-02. PMID:25729346. |
in the hippocampus, aie treatment induced a long-term upregulation of neuroimmune genes, including toll-like receptor 4 (tlr4) and its endogenous agonist high-mobility group box 1 as well as several proinflammatory signaling molecules. |
2015-03-02 |
2023-08-13 |
rat |
| M Zhao, A Zhou, L Xu, X Zhan. The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons. Neuroscience. vol 269. 2015-02-12. PMID:24680857. |
this study investigated a possible role for a toll-like receptor 4 (tlr4)-mediated pten/pi3k/akt/nf-κb signaling pathway in neuroinflammation in rat hippocampal neurons. |
2015-02-12 |
2023-08-12 |
rat |
| Mohsen Zhaleh, Marzieh Panahi, Mehri Ghafurian Broujerdnia, Rostam Ghorbani, Kambiz Ahmadi Angali, Ghasem Sak. Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury. Journal of injury & violence research. vol 6. issue 2. 2015-01-26. PMID:24121451. |
in this study we investigated the neurodegenerative effects of morphine through its effects on toll-like receptor 4 (tlr4) in the male rat hippocampus and evaluated the level of interleukin-1 beta (il-1β). |
2015-01-26 |
2023-08-12 |
rat |
| Yue He, Ailing Zhou, Wei Jian. Toll-like receptor 4-mediated signaling participates in apoptosis of hippocampal neurons. Neural regeneration research. vol 8. issue 29. 2014-09-10. PMID:25206585. |
this study explored the role of the toll-like receptor 4 (tlr4)-mediated pi3k/akt-glycogen syn-thase kinase 3β (gsk-3β) signaling pathways in lipopolysaccharide-induced apoptosis in a primary culture of hippocampal neurons. |
2014-09-10 |
2023-08-13 |
Not clear |
| Yue He, Ailing Zhou, Wei Jian. Toll-like receptor 4-mediated signaling participates in apoptosis of hippocampal neurons. Neural regeneration research. vol 8. issue 29. 2014-09-10. PMID:25206585. |
the level of active caspase-3 and the ratio of bax/bcl-2 in hippocampal neurons treated with tlr4 antibody or the gsk-3β inhibitor, licl, creased before intervention with lipopolysaccharide, but increased after treatment with the akt hibitor, ly294002. |
2014-09-10 |
2023-08-13 |
Not clear |
| Yi Wang, Huijuan He, Dan Li, Wenjing Zhu, Kaiming Duan, Yuan Le, Yan Liao, Yangwen O. The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats. Molecular medicine reports. vol 7. issue 4. 2014-07-25. PMID:23426570. |
shortly after surgery, aged rats demonstrated significant deficits in memory and learning, accompanied by the activation of microglia, marked upregulation of tlr4 on microglia in the hippocampus, as well as an increased expression of two downstream factors [myeloid differentiation factor 88 (myd88) and tir-domain-containing adapter-inducing interferon-β (trif)] and pro-inflammatory cytokines [including tumor necrosis factor α (tnf-α) and interleukin 1β (il-1β)]. |
2014-07-25 |
2023-08-12 |
rat |
| Guo-Xia Zhang, Ai-Ling Zhou, Gui-Ping Zhang, Ya-E Hu, Jia-Hui Ma. [The role of TLR4-mediated MyD88-dependent pathway in neuroinflammation in hippocampal neurons of rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 29. issue 1. 2014-01-23. PMID:23662405. |
to investigate weather there is a toll-like receptor 4 (tlr4)-mediated myeloid differentiation factor 88 (myd88)-dependent pathway in hippocampal neurons of rats and the probable role of the pathway in neuroinflammation. |
2014-01-23 |
2023-08-12 |
rat |
| Shan-Shan Mao, Rong Hua, Xiao-Ping Zhao, Xia Qin, Zhen-Quan Sun, Yang Zhang, Yu-Qing Wu, Meng-Xing Jia, Jun-Li Cao, Yong-Mei Zhan. Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-κB pathway. Journal of neurotrauma. vol 29. issue 10. 2013-05-22. PMID:22583372. |
pretreatment with pacap inhibited upregulation of tlr4 and its downstream signaling molecules myd88, p-iκb, and nf-κb, and suppressed increases in the levels of the downstream inflammatory agents interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α), in the brain tissue around the injured cortex and in the hippocampus. |
2013-05-22 |
2023-08-12 |
rat |
| Eitan Okun, Boaz Barak, Ravit Saada-Madar, Sarah M Rothman, Kathleen J Griffioen, Nicholas Roberts, Kamilah Castro, Mohamed R Mughal, Mario A Pita, Alexis M Stranahan, Thiruma V Arumugam, Mark P Mattso. Evidence for a developmental role for TLR4 in learning and memory. PloS one. vol 7. issue 10. 2013-02-22. PMID:23071817. |
we found that developmental tlr4 deficiency enhances spatial reference memory acquisition and memory retention, impairs contextual fear-learning and enhances motor functions, traits that were correlated with creb up-regulation in the hippocampus. |
2013-02-22 |
2023-08-12 |
mouse |
| Yong Li, Jian Gong, Sheng-Min Shao, Jian-Qiong Ke, Xiao-Tong Wang, Guo-Qing Zhen. [The effects of chronic hypoxic hypercapnia on the TLR4 and NFkappaB in hippocampus neuron in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 25. issue 1. 2012-10-01. PMID:21186609. |
[the effects of chronic hypoxic hypercapnia on the tlr4 and nfkappab in hippocampus neuron in rats]. |
2012-10-01 |
2023-08-12 |
rat |
| Yong Li, Jian Gong, Sheng-Min Shao, Jian-Qiong Ke, Xiao-Tong Wang, Guo-Qing Zhen. [The effects of chronic hypoxic hypercapnia on the TLR4 and NFkappaB in hippocampus neuron in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 25. issue 1. 2012-10-01. PMID:21186609. |
to study the expression and effect of tlr4 and nfkappab protein in hippocampus neuron in rats exposed to chronic hypoxic hypercapnia. |
2012-10-01 |
2023-08-12 |
rat |
| Subhash C Pande. TLR4-MyD88 signalling: a molecular target for alcohol actions. British journal of pharmacology. vol 165. issue 5. 2012-09-07. PMID:21955082. |
the deletions of tlr4 or myd88 gene or pharmacological inhibition of tlr4 by (+)-naloxone were able to attenuate alcohol-induced sedation, motor impairment and acute alcohol-induced increases in ikbα protein levels in the hippocampus of mice. |
2012-09-07 |
2023-08-12 |
mouse |
| Tin-Tin Win-Shwe, Daisuke Nakajima, Hidekazu Fujimak. Involvement of TLR4 in diazinon-induced neurotoxicity in mice. Journal of UOEH. vol 34. issue 1. 2012-05-15. PMID:22428454. |
to investigate the role of tlr4 in hippocampal neurotrophin expression, c3h/hen (tlr4 intact) and c3h/hej (tlr4 defective) male adult mice were administered diazinon (0, 0.05, 0.5 or 5 mg/kg) intraperitoneally once a week for three weeks. |
2012-05-15 |
2023-08-12 |
mouse |
| Tin-Tin Win-Shwe, Daisuke Nakajima, Hidekazu Fujimak. Involvement of TLR4 in diazinon-induced neurotoxicity in mice. Journal of UOEH. vol 34. issue 1. 2012-05-15. PMID:22428454. |
our findings indicate that diazinon injection affects neurotrophin expression in the hippocampus in tlr4-defective mice but not in tlr4 intact mice. |
2012-05-15 |
2023-08-12 |
mouse |
| Tin-Tin Win-Shwe, Daisuke Nakajima, Hidekazu Fujimak. Involvement of TLR4 in diazinon-induced neurotoxicity in mice. Journal of UOEH. vol 34. issue 1. 2012-05-15. PMID:22428454. |
these results suggest that a defective tlr4 signaling pathway in the mouse hippocampus can be easily affected by diazinon administration. |
2012-05-15 |
2023-08-12 |
mouse |
| Tin-Tin Win-Shwe, Naoki Kunugita, Yasuhiro Yoshida, Hidekazu Fujimak. Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure. Neurotoxicology and teratology. vol 33. issue 5. 2012-01-31. PMID:21802510. |
role of hippocampal tlr4 in neurotoxicity in mice following toluene exposure. |
2012-01-31 |
2023-08-12 |
mouse |
| Tin-Tin Win-Shwe, Naoki Kunugita, Yasuhiro Yoshida, Hidekazu Fujimak. Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure. Neurotoxicology and teratology. vol 33. issue 5. 2012-01-31. PMID:21802510. |
the present study was designed to investigate the possible involvement of tlr4 pathway in the mouse hippocampus following toluene exposure. |
2012-01-31 |
2023-08-12 |
mouse |
| Rui Feng, Shuqing Li, Fan L. Toll-like receptor 4 is involved in ischemic tolerance of postconditioning in hippocampus of tree shrews to thrombotic cerebral ischemia. Brain research. vol 1384. 2011-07-19. PMID:21315690. |
it is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whether tlr4 expression plays a role. |
2011-07-19 |
2023-08-12 |
Not clear |