| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mónica Tramullas, Beate C Finger, Timothy G Dinan, John F Crya. Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity. PloS one. vol 11. issue 5. 2017-07-26. PMID:27159520. |
in the present study we investigated the impact of long-term exposure to high-fat diet on visceral pain perception and on the levels of tlr4 and cd11b (a microglial cell marker) protein expression in the prefrontal cortex (pfc) and hippocampus. |
2017-07-26 |
2023-08-13 |
mouse |
| Mónica Tramullas, Beate C Finger, Timothy G Dinan, John F Crya. Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity. PloS one. vol 11. issue 5. 2017-07-26. PMID:27159520. |
in parallel, enhanced tlr4 expression and microglia activation were found in brain areas related to visceral pain, the pfc and the hippocampus. |
2017-07-26 |
2023-08-13 |
mouse |
| Xiaoni Shao, Wenjie Lu, Fabao Gao, Dandan Li, Jing Hu, Yan Li, Zeping Zuo, Hui Jie, Yinglan Zhao, Xiaobo Ce. Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 43. 2017-07-14. PMID:27798180. |
here, we show that a high-ua diet triggers the expression of proinflammatory cytokines, activates the toll-like receptor 4 (tlr4)/nuclear factor (nf)-κb pathway, and increases gliosis in the hippocampus of wistar rats. |
2017-07-14 |
2023-08-13 |
mouse |
| Xiaoni Shao, Wenjie Lu, Fabao Gao, Dandan Li, Jing Hu, Yan Li, Zeping Zuo, Hui Jie, Yinglan Zhao, Xiaobo Ce. Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 43. 2017-07-14. PMID:27798180. |
additionally, c57bl/6 mice that lack tlr4 are substantially protected against ua-induced cognitive dysfunction, possibly due to a decrease in inflammatory gene expression in the hippocampus. |
2017-07-14 |
2023-08-13 |
mouse |
| Jorge Montesinos, Silvia Alfonso-Loeches, Consuelo Guerr. Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System. Alcoholism, clinical and experimental research. vol 40. issue 11. 2017-06-21. PMID:27650785. |
the research data suggest that overactivation of tlr4 or nlrs increases pro-inflammatory cytokines and mediators to cause neural damage in the cerebral cortex and hippocampus, while modest tlr4 activation, along with the generation of certain cytokines and chemokines in specific brain areas (e.g., amygdala, ventral tegmental area), modulate neurotransmission, alcohol drinking, and alcohol rewards. |
2017-06-21 |
2023-08-13 |
human |
| Yi Shen, Huaping Qin, Juan Chen, Lingyan Mou, Yang He, Yixiu Yan, Hang Zhou, Ya Lv, Zhong Chen, Junlu Wang, Yu-Dong Zho. Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons. The Journal of cell biology. vol 215. issue 5. 2017-05-29. PMID:27920126. |
postnatal activation of tlr4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons. |
2017-05-29 |
2023-08-13 |
mouse |
| Mahboubeh Zarezadeh, Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Mehrdad Roghan. Garlic active constituent s-allyl cysteine protects against lipopolysaccharide-induced cognitive deficits in the rat: Possible involved mechanisms. European journal of pharmacology. vol 795. 2017-05-08. PMID:27915041. |
meanwhile, sac down-regulated hippocampal nuclear factor-b, toll-like receptor 4 (tlr4), glial fibrillary acidic protein (gfap), and interleukin 1β (il-1β) and up-regulated nuclear factor (erythroid-derived 2)-like 2 (nrf2) in addition to lowering iba1-immunoreactive intensity in the hippocampus of lps-injected group. |
2017-05-08 |
2023-08-13 |
rat |
| Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Zahra Ghasemi, Mehrdad Roghan. S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. European journal of pharmacology. vol 794. 2017-04-05. PMID:27887948. |
meanwhile, sac lowered hippocampal nf-kb, tlr4, and tnfα and prevented reduction of nrf2 and heme oxygenase-1 (ho-1) in diabetic rats. |
2017-04-05 |
2023-08-13 |
rat |
| Reza Sedaghat, Yosra Taab, Zahra Kiasalari, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 87. 2017-02-21. PMID:28061403. |
it also significantly restored hippocampal level of reactive oxygen species (ros), glutathione (gsh), nuclear factor (erythroid-derived 2)-like 2 (nrf2), activity of catalase and caspase 3, nuclear factor-b (nf-κb), toll-like receptor 4 (tlr4), tumor necrosis factor α (tnfα), interleukin-1β (il-1β), neural cell adhesion molecule (ncam), glial fibrillary acidic protein (gfap), cathepsin d, and heme oxygenase 1 (ho-1). |
2017-02-21 |
2023-08-13 |
rat |
| Yan Feng, Junling Gao, Ying Cui, Minghang Li, Ran Li, Changmeng Cui, Jianzhong Cu. Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26961544. |
double immunolabeling demonstrated that lc3 dots co-localized with the hippocampus pyramidal neurons, and tlr4 was localized with the hippocampus neurons and astrocytes. |
2017-02-13 |
2023-08-13 |
rat |
| Yan Feng, Junling Gao, Ying Cui, Minghang Li, Ran Li, Changmeng Cui, Jianzhong Cu. Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26961544. |
in addition, the expression of tlr4 downstream signaling molecules, including myd88, trif, nf-κb, tnf-α, and il-1β, was significantly downregulated in hippocampus tissue by western blot analysis. |
2017-02-13 |
2023-08-13 |
rat |
| Li Pang, Nan Zhang, Ning Dong, Da-Wei Wang, Da-Hai Xu, Ping Zhang, Xiang-Wei Men. Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses. Inflammation. vol 39. issue 2. 2017-01-06. PMID:26521252. |
at 48 h after treatment, the expression levels of tlr4 and nf-κb as well as the levels of inflammatory cytokines in the hippocampal tissues were measured. |
2017-01-06 |
2023-08-13 |
rat |
| Li Pang, Nan Zhang, Ning Dong, Da-Wei Wang, Da-Hai Xu, Ping Zhang, Xiang-Wei Men. Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses. Inflammation. vol 39. issue 2. 2017-01-06. PMID:26521252. |
our results showed that co poisoning induced a significant upregulation of tlr4, nf-κb, and inflammatory cytokines in the injured rat hippocampal tissues. |
2017-01-06 |
2023-08-13 |
rat |
| Li Pang, Nan Zhang, Ning Dong, Da-Wei Wang, Da-Hai Xu, Ping Zhang, Xiang-Wei Men. Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses. Inflammation. vol 39. issue 2. 2017-01-06. PMID:26521252. |
treatment with epo remarkably suppressed the gene and protein expression levels of tlr4 and nf-κb, as well as the concentrations of tnf-α, il-1β, and il-6 in the hippocampal tissues. |
2017-01-06 |
2023-08-13 |
rat |
| Yuyan Cheng, Marta Pardo, Rubia de Souza Armini, Ana Martinez, Hadley Mouhsine, Jean-Francois Zagury, Richard S Jope, Eleonore Beure. Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain, behavior, and immunity. vol 53. 2017-01-03. PMID:26772151. |
toll-like receptor 4 (tlr4) was involved in this response because most stress-induced hippocampal cytokines and chemokines were attenuated in tlr4 knockout mice. |
2017-01-03 |
2023-08-13 |
mouse |
| Yuyan Cheng, Marta Pardo, Rubia de Souza Armini, Ana Martinez, Hadley Mouhsine, Jean-Francois Zagury, Richard S Jope, Eleonore Beure. Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain, behavior, and immunity. vol 53. 2017-01-03. PMID:26772151. |
stress activated glycogen synthase kinase-3 (gsk3) in wild-type mouse hippocampus, but not in tlr4 knockout mice. |
2017-01-03 |
2023-08-13 |
mouse |
| Yuyan Cheng, Marta Pardo, Rubia de Souza Armini, Ana Martinez, Hadley Mouhsine, Jean-Francois Zagury, Richard S Jope, Eleonore Beure. Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain, behavior, and immunity. vol 53. 2017-01-03. PMID:26772151. |
thus, stress-induces a broad inflammatory response in mouse hippocampus that involves tlr4, gsk3, and downstream inflammatory signaling, and these stress responses contribute to susceptibility to depression-like behavior in mice. |
2017-01-03 |
2023-08-13 |
mouse |
| M J Eimerbrink, D Kranjac, C St Laurent, J D White, M K Weintraub, R J Pendry, R Madigan, S L Hodges, L N Sadler, M J Chumley, G W Boeh. Pre-treatment of C57BL6/J mice with the TLR4 agonist monophosphoryl lipid A prevents LPS-induced sickness behaviors and elevations in dorsal hippocampus interleukin-1β, independent of interleukin-4 expression. Behavioural brain research. vol 302. 2016-12-13. PMID:26778788. |
pre-treatment of c57bl6/j mice with the tlr4 agonist monophosphoryl lipid a prevents lps-induced sickness behaviors and elevations in dorsal hippocampus interleukin-1β, independent of interleukin-4 expression. |
2016-12-13 |
2023-08-13 |
mouse |
| Yan Deng, Xiao Yuan, Xue-ling Guo, Die Zhu, Yue-ying Pan, Hui-guo Li. Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: Involving TLR4 and its downstream signaling pathway. Respiratory physiology & neurobiology. vol 218. 2016-07-13. PMID:26200444. |
efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: involving tlr4 and its downstream signaling pathway. |
2016-07-13 |
2023-08-13 |
mouse |
| Yan Deng, Xiao Yuan, Xue-ling Guo, Die Zhu, Yue-ying Pan, Hui-guo Li. Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: Involving TLR4 and its downstream signaling pathway. Respiratory physiology & neurobiology. vol 218. 2016-07-13. PMID:26200444. |
our study suggests that atorvastatin may attenuate cih induced hippocampal neuronal damage partially via tlr4 and its downstream signaling pathway. |
2016-07-13 |
2023-08-13 |
mouse |