| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei-Pei Feng, Pu Deng, Li-Hua Liu, Qi Ai, Jie Yin, Zhe Liu, Gai-Mei Wan. Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28684969. |
the aim of this study was to examine whether ea improves cognitive dysfunction caused by surgery and to investigate the pathological mechanism of tlr2 and tlr4 in the hippocampus of aged rats. |
2020-09-30 |
2023-08-13 |
rat |
| Yuqin Ye, Yongxiang Yang, Chen Chen, Ze Li, Yanfeng Jia, Xinhong Su, Chaoxian Wang, Xiaosheng H. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem cells international. vol 2017. 2020-09-29. PMID:28848607. |
electroacupuncture improved hippocampal neurogenesis following traumatic brain injury in mice through inhibition of tlr4 signaling pathway. |
2020-09-29 |
2023-08-13 |
mouse |
| Yuqin Ye, Yongxiang Yang, Chen Chen, Ze Li, Yanfeng Jia, Xinhong Su, Chaoxian Wang, Xiaosheng H. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem cells international. vol 2017. 2020-09-29. PMID:28848607. |
this study aims to investigate the effect of ea on hippocampal neurogenesis and neurological functions, as well as its underlying association with toll-like receptor 4 (tlr4) signaling in tbi mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Yuqin Ye, Yongxiang Yang, Chen Chen, Ze Li, Yanfeng Jia, Xinhong Su, Chaoxian Wang, Xiaosheng H. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem cells international. vol 2017. 2020-09-29. PMID:28848607. |
the hippocampal level of tlr4 and downstream molecules and inflammatory cytokines were, respectively, detected by western blot and enzyme-linked immunosorbent assay. |
2020-09-29 |
2023-08-13 |
mouse |
| Yuqin Ye, Yongxiang Yang, Chen Chen, Ze Li, Yanfeng Jia, Xinhong Su, Chaoxian Wang, Xiaosheng H. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem cells international. vol 2017. 2020-09-29. PMID:28848607. |
ea enhanced hippocampal neurogenesis and inhibited tlr4 expression at 21, 28, and 35 days after tbi, but the beneficial effects of ea on posttraumatic neurogenesis and neurological functions were attenuated by lipopolysaccharide-induced tlr4 activation. |
2020-09-29 |
2023-08-13 |
mouse |
| Li-Jun Jiang, Zhen-Xing Xu, Ming-Fu Wu, Gai-Qin Dong, Li-Li Zhang, Jun-Yan Gao, Chen-Xi Feng, Xing Fen. Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960818. |
our results indicate that administering tak-242 to neonatal rats after hibd could significantly reduce the infarct volume and the extent of cerebral edema, alleviate neuronal damage and neurobehavioral impairment, and decrease the expression levels of tlr4, phospho-nf-κb p65, beclin-1, microtubule-associated protein l light chain 3, tumor necrosis factor-α, and interleukin-1β in the hippocampus. |
2020-09-28 |
2023-08-13 |
rat |
| Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Pen. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway. Stem cells international. vol 2020. 2020-09-28. PMID:32300366. |
furthermore, amsc-derived exosomes were found to reduce hippocampal neuronal apoptosis and the expression of tlr2, tlr4, myd88, and nf- |
2020-09-28 |
2023-08-13 |
rat |
| Giorgia Moschetti, Giada Amodeo, Maria Serena Paladini, Raffaella Molteni, Gianfranco Balboni, Alberto Panerai, Paola Sacerdote, Silvia Franch. Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31525509. |
pk2, pk-rs, cytokines, neuroinflammatory markers (cd68, cd11b, gfap, tlr4) and atf3 were evaluated in drg, spinal cord, prefrontal cortex and hippocampus. |
2020-09-16 |
2023-08-13 |
mouse |
| Min Yu, He Huang, Shiyang Dong, Huanhuan Sha, Wei Wei, Cunming Li. High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31430517. |
the hippocampal inflammatory responses were enhanced in the hfhfd-induced obesity, including the activation of tlr4 and nf-κb, the production of il-1β, tnf-α and il-6, as well as the activation of microglia and astrocytes. |
2020-08-25 |
2023-08-13 |
rat |
| Qing Li, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus. Neural plasticity. vol 2019. 2020-07-27. PMID:31781182. |
ethanol exposure induces microglia activation and neuroinflammation through tlr4 activation and senp6 modulation in the adolescent rat hippocampus. |
2020-07-27 |
2023-08-13 |
rat |
| Akshata A Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakuma. Toll-like Receptor 4 Signaling in Neurons Enhances Calcium-Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Currents and Drives Post-Traumatic Epileptogenesis. Annals of neurology. vol 87. issue 4. 2020-07-27. PMID:32031699. |
here we examined the effect of innate immune receptor toll-like receptor 4 (tlr4) on excitability of the hippocampal dentate gyrus and epileptogenesis after brain injury. |
2020-07-27 |
2023-08-13 |
Not clear |
| Sreemathi Logan, Gordon H Royce, Daniel Owen, Julie Farley, Michelle Ranjo-Bishop, William E Sonntag, Sathyaseelan S Deep. Accelerated decline in cognition in a mouse model of increased oxidative stress. GeroScience. vol 41. issue 5. 2020-05-21. PMID:31641924. |
markers of oxidative stress (4-hydroxynonenal, 4-hne) and neuroinflammation [proinflammatory cytokines (il6 and il-1β) and neuroinflammatory markers (cd68, tlr4, and mcp1)] were significantly elevated in the hippocampus of male and female sod1ko compared to wt mice. |
2020-05-21 |
2023-08-13 |
mouse |
| Dalibor Stajic, Dragica Selakovic, Nemanja Jovicic, Jovana Joksimovic, Nebojsa Arsenijevic, Miodrag L Lukic, Gvozden Rosi. The role of galectin-3 in modulation of anxiety state level in mice. Brain, behavior, and immunity. vol 78. 2020-04-13. PMID:30682502. |
this was accompanied with lower interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α) relative gene expression and hippocampal content, with no effect on tlr4 expression. |
2020-04-13 |
2023-08-13 |
mouse |
| Dalibor Stajic, Dragica Selakovic, Nemanja Jovicic, Jovana Joksimovic, Nebojsa Arsenijevic, Miodrag L Lukic, Gvozden Rosi. The role of galectin-3 in modulation of anxiety state level in mice. Brain, behavior, and immunity. vol 78. 2020-04-13. PMID:30682502. |
the anxiogenic effect of acute neuroinflammation was accompanied with increased hippocampal il-6, tnf-α and tlr4 gene expression, as well as decreased gene and immunohistochemical bdnf expression in hippocampus, with significant decline in gaba-ar2s in wild type (wt) mice in comparison to basal conditions. |
2020-04-13 |
2023-08-13 |
mouse |
| Opal V Potter, Megan E Giedraitis, Charles D Johnson, Mackenzie N Cox, Rachel A Kohma. Young and aged TLR4 deficient mice show sex-dependent enhancements in spatial memory and alterations in interleukin-1 related genes. Brain, behavior, and immunity. vol 76. 2020-02-28. PMID:30394314. |
collectively, these data provide the initial evidence that tlr4 deficiency enhances cognitive function and modulates the inflammatory profile of the hippocampus in a sex- and age-dependent manner. |
2020-02-28 |
2023-08-13 |
mouse |
| Zhen Tang, Shaowu Cheng, Yanyan Sun, Yunqiao Zhang, Xiying Xiang, Zhicui Ouyang, Xing Zhu, Bo Wang, Mingyan He. Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity. Experimental neurology. vol 321. 2020-02-28. PMID:31442443. |
early tlr4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity. |
2020-02-28 |
2023-08-13 |
rat |
| L H Khedr, N N Nassar, Laila Rashed, E D El-Denshary, A M Abdel-Tawa. TLR4 signaling modulation of PGC1-α mediated mitochondrial biogenesis in the LPS-Chronic mild stress model: Effect of fluoxetine and pentoxiyfylline. Life sciences. vol 239. 2020-02-13. PMID:31678277. |
given that cms-induced depressive behavior was previously related to impaired hippocampal energy metabolism and mitochondrial dysfunction, our current study aimed to investigate the interplay between toll-like receptor 4 (tlr4) signaling and peroxisome proliferator-activated receptor gamma coactivators-1-alpha (pgc1-α) as a physiological regulator of energy metabolism and mitochondrial biogenesis in the combined lps/cms model. |
2020-02-13 |
2023-08-13 |
Not clear |
| Mahshid Hosseinzadeh, Hamid Gholami Pourbadie, Fariba Khodagholi, Mahtab Daftari, Nima Naderi, Fereshteh Motamed. Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy. Neuroscience. vol 408. 2020-01-09. PMID:31026566. |
in conclusion, early activation of tlr4 and tlr2, probably through preserving normal hippocampal cytokine profile and neuronal function attenuates seizure severity in the rat model of tle. |
2020-01-09 |
2023-08-13 |
rat |
| Peng Wang, Bo-Ya Liu, Ming-Mei Wu, Xiao-Yan Wei, Sen Sheng, Si-Wei You, Li-Xin Shang, Fang Kuan. Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats. Neuroscience letters. vol 699. 2019-12-17. PMID:30710662. |
lps treatment dramatically up-regulated the expressions of tlr4 and its downstream molecules in the hippocampus of paired-food and control groups. |
2019-12-17 |
2023-08-13 |
rat |
| Ewa Trojan, Katarzyna Chamera, Natalia Bryniarska, Katarzyna Kotarska, Monika Leśkiewicz, Magdalena Regulska, Agnieszka Basta-Kai. Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway. Molecular neurobiology. vol 56. issue 8. 2019-12-12. PMID:30610610. |
next, we observed that in the hippocampus, tianeptine and fluoxetine suppressed upregulation of tlr4. |
2019-12-12 |
2023-08-13 |
rat |