| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong An, Xiuting Qi, Kunpeng Li, Weixing Xu, Yue Wang, Xi Chen, Sha Sha, Chunfeng Wu, Yimei Du, Lei Che. Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. Cellular and molecular neurobiology. 2022-07-15. PMID:35840809. |
administration of the tlr4 antagonist tak-242 or the nf-κb pathway inhibitor bay 11-7082 led to a noticeable reduction in the hippocampal protein levels of cleaved il-1β, il-6 and tnf, as well as those of cytoplasmic p-p65 and nuclear p65 and p50 in gsk1016790a-injected mice. |
2022-07-15 |
2023-08-14 |
mouse |
| Muhammed A Saad, Muhammad Y Al-Shorbagy, Hany H Ara. Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats. Molecular neurobiology. 2022-05-16. PMID:35578102. |
after rat killing, tlr4, caspase-8, and nlrp mrna expression and protein levels of asc, aim2, caspase-1, nlrp1, and pkr were measured in hippocampus. |
2022-05-16 |
2023-08-13 |
rat |
| Mahsa Tashakori-Miyanroudi, Samira Ramazi, Paria Hashemi, Morteza Nazari-Serenjeh, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy. Journal of molecular neuroscience : MN. 2022-03-23. PMID:35320462. |
as well, obtained findings showed that alc can partially reverse hippocampal levels of mda, ros, sod, tnfa, nf-kb, tlr4, gfap, and caspase 1. |
2022-03-23 |
2023-08-13 |
rat |
| Changliang Zhu, Tao Hong, Hailiang Li, Shucai Jiang, Baorui Guo, Lei Wang, Jiangwei Ding, Caibin Gao, Yu Sun, Tao Sun, Feng Wang, Yangyang Wang, Din Wa. Glucagon-Like Peptide-1 Agonist Exendin-4 Facilitates the Extinction of Cocaine-Induced Condition Place Preference. Frontiers in systems neuroscience. vol 15. 2022-01-13. PMID:35024034. |
to explore the possible impacts of ex4 and neuroinflammation on cocaine, the expression levels of tlr4 within the hippocampus was detected using western blotting. |
2022-01-13 |
2023-08-13 |
mouse |
| Nosaibeh Riahi Zaniani, Ali Roohbakhsh, Ali Moghimi, Soghra Mehr. Protective effect of Toll-like receptor 4 antagonist on inflammation, EEG, and memory changes following febrile seizure in Wistar rats. Behavioural brain research. 2021-12-19. PMID:34923024. |
the levels of inflammatory cytokines, tlr4 protein expression, and oxidative stress markers were detected by enzyme-linked immunosorbent assay, western blotting, malondialdehyde (mda), catalase (cat), and superoxide dismutase (sod) assessments in the cortex and hippocampus. |
2021-12-19 |
2023-08-13 |
rat |
| Nosaibeh Riahi Zaniani, Ali Roohbakhsh, Ali Moghimi, Soghra Mehr. Protective effect of Toll-like receptor 4 antagonist on inflammation, EEG, and memory changes following febrile seizure in Wistar rats. Behavioural brain research. 2021-12-19. PMID:34923024. |
pretreatment with tak-242 reduced the inflammatory cytokines and tlr4 protein expression in the cortex and hippocampus of neonate rats and improvement in memory deficit in nort and double y-maze tasks. |
2021-12-19 |
2023-08-13 |
rat |
| Yu Bu, Wen-Shuang Li, Ji Lin, Yu-Wei Wei, Qiu-Ying Sun, Shi-Jie Zhu, Zhong-Sheng Tan. Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway. Chinese journal of integrative medicine. 2021-12-16. PMID:34913150. |
to investigate whether electroacupuncture (ea) alleviates cognitive impairment by suppressing the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88) signaling pathway, which triggers immune-inflammatory responses in the hippocampus of rats with vascular dementia (vad). |
2021-12-16 |
2023-08-13 |
rat |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
s1 increased and/or modulated neuroimmune gene expression (iba1, cd11b, mhciiα, cd200r1, gfap, tlr2, tlr4, nlrp3, il1b, hmgb1) and protein levels (ifnγ, il-1β, tnf, cxcl1, il-2, il-10), which varied across brain regions (hypothalamus, hippocampus, and frontal cortex) and time (24h and 7d) post-s1 treatment. |
2021-12-16 |
2023-08-13 |
human |
| Meghan G Connolly, Oriana L Yost, Opal V Potter, Megan E Giedraitis, Rachel A Kohma. Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. Hippocampus. vol 30. issue 9. 2021-11-26. PMID:32343455. |
however, tlr4 is also expressed on neural progenitor cells and has been reported to regulate hippocampal neurogenesis as young male tlr4 knockout mice show increases in cell proliferation and doublecortin positive cells. |
2021-11-26 |
2023-08-13 |
mouse |
| Meghan G Connolly, Oriana L Yost, Opal V Potter, Megan E Giedraitis, Rachel A Kohma. Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. Hippocampus. vol 30. issue 9. 2021-11-26. PMID:32343455. |
the present study evaluated whether tlr4 deficiency alters adult hippocampal neurogenesis in young (3-4 months) and aged (18-20 months), male and female, tlr4 deficient (tlr4-/-; b6.b10scn-tlr4lps-del/jthj) and wild type (wt) mice. |
2021-11-26 |
2023-08-13 |
mouse |
| Meghan G Connolly, Oriana L Yost, Opal V Potter, Megan E Giedraitis, Rachel A Kohma. Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. Hippocampus. vol 30. issue 9. 2021-11-26. PMID:32343455. |
additionally, neurogenesis within the dorsal and the ventral hippocampal subdivisions was evaluated to determine if tlr4 has differential effects across the hippocampus. |
2021-11-26 |
2023-08-13 |
mouse |
| Meghan G Connolly, Oriana L Yost, Opal V Potter, Megan E Giedraitis, Rachel A Kohma. Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. Hippocampus. vol 30. issue 9. 2021-11-26. PMID:32343455. |
the data collectively indicate that tlr4 regulates hippocampal neurogenesis in young adults, but that these effects are region-specific in males and that females show broader changes in neurogenesis throughout the hippocampus. |
2021-11-26 |
2023-08-13 |
mouse |
| Wei Wei, Zhentao Sun, Shifeng He, Wanyue Zhang, Sai Che. Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 92. 2021-11-24. PMID:34509269. |
the levels of tlr4 and nf-κb p65 in hippocampus and cortex were measured. |
2021-11-24 |
2023-08-13 |
rat |
| Huei Gau Chuang, NurNaznee Hirni Abd Aziz, Jia Hui Wong, Muzaimi Mustapha, Jafri Malin Abdullah, Zamzuri Idris, Zuraidah Abdullah, Aziza Alrafiah, Sangu Muthuraj. Role of toll-like receptor 4 antagonist Lipopolysaccharide-Rhodobacter sphaeroides on acute stress-induced voluntary ethanol preference and drinking behaviour: In vivo Swiss Albino mouse model. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 45. 2021-11-22. PMID:32014377. |
morphological analysis showed no significant change in the prefrontal cortex and hippocampus among all groups, while immunoreactivity analysis showed higher expression of c-fos in prefrontal cortex and hippocampus, higher tlr4 expression in the prefrontal cortex and glial fibrillary acidic protein (gfap) in hippocampus among stressed-animals. |
2021-11-22 |
2023-08-13 |
mouse |
| Yunchang Mo, Lu Wang, Miao Ren, Wenjing Xie, Xiaoxiao Ye, Bingbing Zhou, Anqi Zhang, Qinxue Dai, Junlu Wan. Electroacupuncture prevents LPS- induced neuroinflammation via upregulation of PICK-TLR4 complexes in the microglia of hippocampus. Brain research bulletin. vol 177. 2021-11-18. PMID:34673136. |
behavioral tests; microglial activity of hippocampus; neuron survival and the inflammatory factors pick1 and tlr4, as well as tlr4-related proteins, such as erk, jnk, and p38, were assessed after ea treatment. |
2021-11-18 |
2023-08-13 |
mouse |
| Yuan Han, Rui Chen, Qicheng Lin, Yu Liu, Wenwei Ge, Hong Cao, Jun L. Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus. Journal of cellular and molecular medicine. vol 25. issue 18. 2021-11-10. PMID:34405526. |
additionally, curcumin treatment could effectively decrease hmgb1 protein expression, advanced glycosylation end product-specific receptor (rage), toll-like receptors-4 (tlr4) and nuclear factor kappa b (nf-κb) in transgenic mice hippocampus. |
2021-11-10 |
2023-08-13 |
mouse |
| Andrew J Kwilasz, Laurel S Todd, Julissa C Duran-Malle, Anouk E W Schrama, Eric H Mitten, Tracey A Larson, Madison A Clements, Kevin M Harris, Scott T Litwiler, Xiaohui Wang, Anne-Marie Van Dam, Steven F Maier, Kenner C Rice, Linda R Watkins, Ruth M Barriento. Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone. Behavioural brain research. vol 396. 2021-11-09. PMID:32905811. |
this was associated with increased mrna for hippocampal interleukin-1β (il-1β), tlr2, tlr4, nlrp3, and il-17 and elevated expression of the microglial marker iba1 in ca1 and dg regions of the hippocampus, confirming the neuroinflammation observed in higher-dose eae models. |
2021-11-09 |
2023-08-13 |
human |
| Wei Fen. Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway. Bioscience, biotechnology, and biochemistry. vol 85. issue 7. 2021-11-09. PMID:34014269. |
cell viability and apoptosis of transfected ht22 cells and toll-like receptor-4 (tlr4)/nuclear factor-kappab (nf-κb) pathway-related factor levels in hippocampal tissue and ogd/r models were detected. |
2021-11-09 |
2023-08-13 |
mouse |
| Wei Fen. Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway. Bioscience, biotechnology, and biochemistry. vol 85. issue 7. 2021-11-09. PMID:34014269. |
cci caused cognitive impairment, hippocampal damage, and decreased myelin density in mice while promoting interleukin-1β, tumor necrosis factor-alpha, tlr4, myeloid differentiation primary response gene 88, p-p65, nlrp3, and asc levels. |
2021-11-09 |
2023-08-13 |
mouse |
| Pinku Mani Talukdar, Fazal Abdul, Michael Maes, Michael Berk, Ganesan Venkatasubramanian, Bindu M Kutty, Monojit Debnat. A proof-of-concept study of maternal immune activation mediated induction of Toll-like receptor (TLR) and inflammasome pathways leading to neuroprogressive changes and schizophrenia-like behaviours in offspring. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 52. 2021-11-01. PMID:34261013. |
the hippocampus of offspring rats showed increased expression of tlr3, tlr4, nlrp3, il1b, and il18 of poly (i:c) and tlr4, nlrp3, cas1, il1b, and il18 of lps-treated dams. |
2021-11-01 |
2023-08-13 |
rat |