| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thalita Mázala-de-Oliveira, Bruna Teixeira Silva, Paula Campello-Costa, Vinicius Frias Carvalh. The Role of the Adrenal-Gut-Brain Axis on Comorbid Depressive Disorder Development in Diabetes. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892186. |
diabetes also induces an increase in the permeability of the blood-brain barrier (bbb) and toll-like receptor 4 (tlr4) expression in the hippocampus. |
2023-10-30 |
2023-11-08 |
mouse |
| Annette Brandt, Franziska Kromm, Angélica Hernández-Arriaga, Inés Martínez Sánchez, Haktan Övül Bozkir, Raphaela Staltner, Anja Baumann, Amélia Camarinha-Silva, Rochellys Diaz Heijtz, Ina Berghei. Cognitive Alterations in Old Mice Are Associated with Intestinal Barrier Dysfunction and Induced Toll-like Receptor 2 and 4 Signaling in Different Brain Regions. Cells. vol 12. issue 17. 2023-09-08. PMID:37681885. |
furthermore, levels of tlr2 and tlr4 ligands, and downstream markers of tlr signaling were higher in the hippocampal and prefrontal cortex of old mice compared to young animals. |
2023-09-08 |
2023-10-07 |
mouse |
| Fang Qiu, Changchun Zeng, Yuqiang Liu, Haobo Pan, Changneng K. J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway. Journal of molecular histology. 2023-09-07. PMID:37676534. |
we investigated the effects of j147 on lipopolysaccharide (lps)-induced neuroinflammatory, depressive-like behaviors, and the toll-like receptor 4 (tlr4)/nuclear factor-κb (nf-κb) signal pathway in the mouse hippocampus and microglia (bv2 cells). |
2023-09-07 |
2023-10-07 |
mouse |
| Liu Ruilian, Zhou Hao, Qu Honglin, Chen Yilin, Bai Qingyun, Guo Fuqiang, Wang Liang, Jiang Xiaobo, Mao Haifen. Effects of aerobic exercise on depression-like behavior and TLR4/NLRP3 pathway in hippocampus CA1 region of CUMS-depressed mice. Journal of affective disorders. 2023-08-27. PMID:37634821. |
the paper observes regulation of the expression levels of nlrp3 and tlr4 in hippocampal ca1 neurons in cums mice by aerobic exercise with constructing cums depression mouse model, in order to explore the neuroprotective mechanism of aerobic exercise on the hippocampus of depressed mice. |
2023-08-27 |
2023-09-07 |
mouse |
| Yujie Hu, Chong Hu, Jierong Yin, Jialing Zhong, Yuan Deng, Guoshuai Yan. MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway. Anais da Academia Brasileira de Ciencias. vol 95. issue suppl 1. 2023-07-19. PMID:37466537. |
moreover, the expression levels of hmgb1, tlr4 and p-nf-κb in the hippocampus of overexpressed mir-181c-5p mice were reduced. |
2023-07-19 |
2023-08-14 |
mouse |
| Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhan. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267300. |
the expression levels of tlr4, myd88, nf-κb p65, tnf-α, inos, occludin and zo-1 in hippocampal and colonic tissues were detected by western-blot method. |
2023-06-02 |
2023-08-14 |
mouse |
| Yunfang Su, Dahui Wang, Ningning Liu, Jiajia Yang, Ruiqin Sun, Zhenqiang Zhan. Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PloS one. vol 18. issue 6. 2023-06-02. PMID:37267300. |
the results showed that cb improved the cognitive dysfunction of icv-stz mice, restored the structure and cell number of hippocampal and cortical neurons, decreased the protein levels of pser404-tau protein in hippocampal tissues and tlr4, myd88, nf-κb p65 and inos in hippocampal and colonic tissues, and increased the protein levels of occludin and zo-1 in colonic tissues. |
2023-06-02 |
2023-08-14 |
mouse |
| Yu Gao, Haoxin Liu, Jiejie Zhou, Min Guo, Jie Sun, Manlin Dua. THE PROTECTIVE EFFECT OF C23 IN A RAT MODEL OF CARDIAC ARREST AND RESUSCITATION. Shock (Augusta, Ga.). vol 59. issue 6. 2023-05-25. PMID:36930651. |
besides, it can decrease the expressions of tlr4, tnf-α, il-6, and il-1β in the cortex and hippocampus and inhibit the colocalization of cirp and tlr4 ( p < 0.05). |
2023-05-25 |
2023-09-07 |
rat |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Yuechi Fu, Jiaying Hu, Heng-Wei Chen. Research Note: Probiotic, Bacillus subtilis, alleviates neuroinflammation in the hippocampus via the gut microbiota-brain axis in heat-stressed chickens. Poultry science. vol 102. issue 6. 2023-04-03. PMID:37011470. |
within the hs groups, compared to the hs-rd broilers, the hs-pd broilers had lower levels of il-6, il-8, hsp70, and tlr4 (p < 0.05) in the hippocampus. |
2023-04-03 |
2023-08-14 |
Not clear |
| Yuechi Fu, Jiaying Hu, Heng-Wei Chen. Research Note: Probiotic, Bacillus subtilis, alleviates neuroinflammation in the hippocampus via the gut microbiota-brain axis in heat-stressed chickens. Poultry science. vol 102. issue 6. 2023-04-03. PMID:37011470. |
within the tn groups, the tn-pd broilers had lower il-8 at both mrna expressions and protein levels (p < 0.05) but higher tlr4 protein levels (p < 0.05) in the hippocampus as compared to the tn-rd broilers. |
2023-04-03 |
2023-08-14 |
Not clear |
| Bo Wu, Anna Gan, Ruixuan Wang, Fei Lin, Tingxu Yan, Ying Ji. Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway. Journal of chemical neuroanatomy. 2023-03-31. PMID:37001682. |
moreover, aovo was found to inhibit the hippocampal damage, decrease inflammatory cytokines (reduced il-1β, il-6, and tnf-α by 19.97%, 22.87%, and 24.13%, respectively), and downregulate the expression of tlr4/myd88/nf-κb signaling pathway-related proteins in the hippocampus of cums-exposed mice (reduced tlr4, myd88, and nf-κb by 46.14%, 42.48%, and 38.08%, respectively). |
2023-03-31 |
2023-08-14 |
mouse |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
the levels of il-1β, tnf-α, and il-6 in the hippocampus of the model control group increased significantly, and the expression levels of tlr4, p-nf-κb p65/nf-κb p65, p-iκbα/iκbα, and nlrp3 proteins in the hippocampus increased significantly. |
2023-03-05 |
2023-08-14 |
rat |
| Li-Ping Huang, Long-Hui Lu, Xi-Yang Yang, Yong-Yan Xie, Zi-Wei Xu, Xu-Dong Zhu, Jing-Jing Wang, Zhi-Xin Wu, Jian-Fu Tang, Yi Wu, Yao-Hui Che. [Effect of Erjing Pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872241. |
compared with the model control group, the erjing pill groups enhanced the new object recognition index of rats, decreased the deposition of aβ_(1-42) and the expression of p-tau~(404) positive protein in the hippocampus, inhibited the activation of microglia in the dentate gyrus, reduced the levels of inflammatory factors il-1β, tnf-α, and il-6 in the hippocampus, and down-regulated the expression levels of tlr4, p-nf-κb p65/nf-κb p65, p-iκbα/iκbα, and nlrp3 proteins in the hippocampus. |
2023-03-05 |
2023-08-14 |
rat |
| M I Airapetov, S O Eresko, D V Kochkin, A M Nosov, E R Bychkov, A A Lebedev, P D Shabano. [Ginsenosides affect the system of Toll-like receptors in the brain of rats under conditions of long-term alcohol withdrawal]. Biomeditsinskaia khimiia. vol 68. issue 6. 2022-12-27. PMID:36573411. |
a significant effect of ginsenosides on the level of tlr3 and tlr4 mrna in the nucleus accumbens was found, while in the hippocampus, ginsenosides significantly affected the level of tlr7 mrna. |
2022-12-27 |
2023-08-14 |
rat |
| Adriana Fernanda K Vizuete, Miriara B Leal, Ana Paula Moreira, Marina Seady, Jéssica Taday, Carlos-Alberto Gonçalve. Arundic acid (ONO-2506) downregulates neuroinflammation and astrocyte dysfunction after status epilepticus in young rats induced by Li-pilocarpine. Progress in neuro-psychopharmacology & biological psychiatry. 2022-12-24. PMID:36565981. |
in se animals, arundic acid was able to prevent the damage induced by li-pilocarpine in the hippocampus, decreasing neuroinflammatory signaling (reducing il-1β, cox2, tlr4 and rage contents), astrogliosis (decreasing gfap and s100b) and astrocytic dysfunction (recovering levels of gsh, glutamine synthetase and connexin-43). |
2022-12-24 |
2023-08-14 |
rat |
| Yao Lin, Man Ding, Qiaoyu Gong, Zheman Xia. Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway. Brain sciences. vol 12. issue 11. 2022-11-11. PMID:36358363. |
western blot and immunofluorescence staining were used to detect the protein expression levels of tlr4 and gabaarα1 in the temporal cortex, hippocampus, trigeminal ganglion, and medullary dorsal horn. |
2022-11-11 |
2023-08-14 |
rat |
| Yao Lin, Man Ding, Qiaoyu Gong, Zheman Xia. Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway. Brain sciences. vol 12. issue 11. 2022-11-11. PMID:36358363. |
western blot was used to detect the protein expression levels of tlr4 and gabaarα1 in the temporal cortex, hippocampus, trigeminal ganglion, and medullary dorsal horn. |
2022-11-11 |
2023-08-14 |
rat |
| Li Hu, Xianxiang Zeng, Kai Yang, Hongli Peng, Jinhong Che. n-3 polyunsaturated fatty acids improve depression-like behavior by inhibiting hippocampal neuroinflammation in mice via reducing TLR4 expression. Immunity, inflammation and disease. vol 10. issue 11. 2022-10-27. PMID:36301036. |
n-3 polyunsaturated fatty acids improve depression-like behavior by inhibiting hippocampal neuroinflammation in mice via reducing tlr4 expression. |
2022-10-27 |
2023-08-14 |
mouse |
| Dong An, Xiuting Qi, Kunpeng Li, Weixing Xu, Yue Wang, Xi Chen, Sha Sha, Chunfeng Wu, Yimei Du, Lei Che. Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. Cellular and molecular neurobiology. 2022-07-15. PMID:35840809. |
application of a trpv4 antagonist markedly attenuated the pise-induced increase in hippocampal hmgb1, tlr4, phospho (p)-iκk (p-iκk), and p-iκbα protein levels, as well as those of cytoplasmic p-nf-κb p65 (p-p65) and nuclear nf-κb p65 and p50; in contrast, the application of gsk1016790a, a trpv4 agonist, showed similar changes to pise mice. |
2022-07-15 |
2023-08-14 |
mouse |