| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Silva-Gotay, Jillian Davis, Elizabeth R Tavares, Heather N Richardso. Alcohol drinking during early adolescence activates microglial cells and increases frontolimbic Interleukin-1 beta and Toll-like receptor 4 gene expression, with heightened sensitivity in male rats compared to females. Neuropharmacology. vol 197. 2021-10-29. PMID:34252404. |
il1b mrna changes were not observed in the hippocampus, but alcohol elevated tlr4 mrna in both sexes, highlighting regional specificity in inflammatory responses to alcohol. |
2021-10-29 |
2023-08-13 |
rat |
| Tian Tang, Yujie Guo, Xiaoyan Xu, Libo Zhao, Xia Shen, Lin Sun, Peng Xi. BoDV-1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats. Journal of medical virology. vol 93. issue 11. 2021-10-29. PMID:34260072. |
the expression of tlr4, myd88, and irf5 in the hippocampus was significantly changed in the bodv-1 group. our results indicate that bodv-1 infection stimulates tlr4/myd88/irf5 pathway activation, causing the release of downstream inflammatory factors, which leads to neuroinflammation in rats. |
2021-10-29 |
2023-08-13 |
rat |
| Giada Amodeo, Benedetta Verduci, Patrizia Sartori, Patrizia Procacci, Vincenzo Conte, Gianfranco Balboni, Paola Sacerdote, Silvia Franch. The Antagonism of the Prokineticin System Counteracts Bortezomib Induced Side Effects: Focus on Mood Alterations. International journal of molecular sciences. vol 22. issue 19. 2021-10-28. PMID:34638592. |
the presence of mood alterations is related to the presence of neuroinflammation and pk system activation in prefrontal cortex, hippocampus and hypothalamus with high levels of pk2 and pkr2 receptor, il-6 and tnf-α, tlr4 and an upregulation of glial markers. |
2021-10-28 |
2023-08-13 |
mouse |
| Jesús Aranda, María Del Mar Fernández-Arjona, Francisco Alén, Patricia Rivera, Leticia Rubio, Inés Smith-Fernández, Francisco Javier Pavón, Antonia Serrano, Pedro J Serrano-Castro, Fernando Rodríguez de Fonseca, Juan Suáre. Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain. Brain structure & function. vol 226. issue 7. 2021-10-26. PMID:34236532. |
we also found that microglial cell area correlated with changes in mrna expression of chemokines (cx3cl1/fractalkine, cxcl12/sdf1α, ccl2/mcp1), cytokines (il1β, il6, il10) and the innate immune toll-like receptor 4 (tlr4) in dorsal hippocampus. |
2021-10-26 |
2023-08-13 |
rat |
| Walaa Yehia Abdelzaher, Hanaa H Mohammed, Nermeen N Welson, Gaber El-Saber Batiha, Roua S Baty, Asmaa Mohamed Abdel-Azi. Rivaroxaban Modulates TLR4/Myd88/NF-Kβ Signaling Pathway in a Dose-Dependent Manner With Suppression of Oxidative Stress and Inflammation in an Experimental Model of Depression. Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630092. |
cums showed a significant decrease in hypothalamic neurotransmitters, hippocampal gsh, sod, bndf, and vegf-a with a significant increase in hippocampal mda, nox, nf-kβ, myd88, tlr4, tnf-α, and gfap immunoexpression. |
2021-10-12 |
2023-08-13 |
rat |
| Shuang Zhao, Wen-Jie Cheng, Xin Liu, Zhao Li, Hui-Zhou Li, Na Shi, Xiu-Li Wan. Effects of Dexmedetomidine and Oxycodone on Neurocognitive and Inflammatory Response After Tourniquet-Induced Ischemia-Reperfusion Injury. Neurochemical research. 2021-10-09. PMID:34625874. |
the expression of nf-κb, tlr4, nr2b, m1 (cd68 and tnf-α) and m2 (cd206 and il-10) polarization markers in mice hippocampus were detected by western blot or immunofluorescent staining. |
2021-10-09 |
2023-08-13 |
mouse |
| Chen Qiu, Min Wang, Wen Yu, Zheng Rong, He-Sheng Zheng, Ting Sun, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34278533. |
we revealed that sd resulted in lxrβ reduction in the hippocampus, which was associated with upregulated expression of high mobility group box 1 (hmgb1)/toll-like receptor 4 (tlr4)/nf-κb p65, and knockdown of hippocampal lxrβ by shrna (shlxrβ) led to cognitive impairment. |
2021-10-08 |
2023-08-13 |
mouse |
| Donya Nazarinia, Mojtaba Dolatshahi, Masoumeh Faezi, Solmaz Nasseri Maleki, Nahid Aboutale. TLR4 /NF-ĸB and JAK2/STAT3 signaling pathways: Cellular signaling pathways targeted by cell-conditioned medium therapy in protection against ischemic stroke. Journal of chemical neuroanatomy. vol 113. 2021-10-01. PMID:33636320. |
immunohistochemistry of hippocampus and western blot assay were performed to evaluate the expression of tlr4 /nf-ĸb and jak2/stat3, respectively. |
2021-10-01 |
2023-08-13 |
human |
| Donya Nazarinia, Mojtaba Dolatshahi, Masoumeh Faezi, Solmaz Nasseri Maleki, Nahid Aboutale. TLR4 /NF-ĸB and JAK2/STAT3 signaling pathways: Cellular signaling pathways targeted by cell-conditioned medium therapy in protection against ischemic stroke. Journal of chemical neuroanatomy. vol 113. 2021-10-01. PMID:33636320. |
intravenous injection of hamsc-cm after reperfusion markedly reduced levels of tlr4 /nf-ĸb and jak2/stat3 in hippocampus region (p < 0.05). |
2021-10-01 |
2023-08-13 |
human |
| Meghan G Connolly, Opal V Potter, Ashley R Sexton, Rachel A Kohma. Effects of Toll-like receptor 4 inhibition on spatial memory and cell proliferation in male and female adult and aged mice. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343615. |
knockout of the toll-like receptor 4 (tlr4) subtype enhances spatial memory and adult hippocampal neurogenesis through increasing proliferation and neuronal differentiation. |
2021-09-22 |
2023-08-13 |
mouse |
| Meghan G Connolly, Opal V Potter, Ashley R Sexton, Rachel A Kohma. Effects of Toll-like receptor 4 inhibition on spatial memory and cell proliferation in male and female adult and aged mice. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343615. |
the present study evaluated water maze performance, cytokine expression, and cell proliferation in the hippocampus of young and aged male and female c57bl6/j mice following treatment with the tlr4 antagonist, tak-242. |
2021-09-22 |
2023-08-13 |
mouse |
| Stephanie M Muscat, Nicholas P Deems, Heather D'Angelo, Meagan M Kitt, Peter M Grace, Nathan D Andersen, Shaelyn N Silverman, Kenner C Rice, Linda R Watkins, Steven F Maier, Ruth M Barriento. Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats. Neurobiology of aging. vol 98. 2021-09-20. PMID:33341652. |
in support of this, aged, laparotomized, and morphine-treated rats exhibited increased gene expression of various proinflammatory markers (il-1β, il-6, tnfα, nlrp3, hmgb1, tlr2, and tlr4) in the hippocampus at the 2-week time point. |
2021-09-20 |
2023-08-13 |
rat |
| Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan He. Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. Experimental neurology. vol 345. 2021-09-07. PMID:34343528. |
inhibition of tlr4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. |
2021-09-07 |
2023-08-13 |
rat |
| Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan He. Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. Experimental neurology. vol 345. 2021-09-07. PMID:34343528. |
a tak-242 inhibitor and a p38 inhibitor (sb203580) were administered to ht22 hippocampal neurons to explore the association between tlr4 in inflammation and ferroptosis in vitro. |
2021-09-07 |
2023-08-13 |
rat |
| Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan He. Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. Experimental neurology. vol 345. 2021-09-07. PMID:34343528. |
hi insult significantly upregulated the tlr4, increased the p53 level, reduced the slc7a11 and gpx4 levels, and caused mitochondrial damage, thereby inducing neuronal ferroptosis in the hippocampus. |
2021-09-07 |
2023-08-13 |
rat |
| Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan He. Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. Experimental neurology. vol 345. 2021-09-07. PMID:34343528. |
inhibition of tlr4 inhibited the expression of ferroptosis-related proteins, decreased the expression of ferroptosis-related genes and the proinflammatory milieu, attenuated oxidative stress and mitochondrial injury and, finally, ameliorated the activation of hippocampal neuronal ferroptosis following hibd. |
2021-09-07 |
2023-08-13 |
rat |
| Yang Zhang, Hailin Liu, Zixuan Chen, Min Yu, Jiaxin Li, Hongquan Dong, Nana Li, Xiahao Ding, Yahe Ge, Cunming Liu, Tengfei Ma, Bo Gu. TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice. Neurochemistry international. vol 140. 2021-09-02. PMID:32758588. |
the surgery also increased protein levels of tlr4, tumor necrosis factor (tnf)-α, interleukin (il)-1β, albumin, matrix metalloproteinase (mmp)-2, and mmp-9, and decreased protein levels of claudin-5, occludin, tissue inhibitor of matrix metalloproteinase (timp)-1, and timp-2 in the hippocampus of db/db and db/m mice. |
2021-09-02 |
2023-08-13 |
mouse |
| Yang Zhang, Hailin Liu, Zixuan Chen, Min Yu, Jiaxin Li, Hongquan Dong, Nana Li, Xiahao Ding, Yahe Ge, Cunming Liu, Tengfei Ma, Bo Gu. TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice. Neurochemistry international. vol 140. 2021-09-02. PMID:32758588. |
at last, compared with those in post-operative db/m mice, the surgery increased protein levels of tlr4, tnf-α, and il-1β, decreased protein levels of claudin-5 and occludin, and sustained the mmp/timp imbalance in the hippocampus of db/db mice on pod 3. |
2021-09-02 |
2023-08-13 |
mouse |
| Changliang Zhu, Hong Tao, Shikuo Rong, Lifei Xiao, Xinxiao Li, Shucai Jiang, Baorui Guo, Lei Wang, Jiangwei Ding, Caibing Gao, Haigang Chang, Tao Sun, Feng Wan. Glucagon-Like Peptide-1 Analog Exendin-4 Ameliorates Cocaine-Mediated Behavior by Inhibiting Toll-Like Receptor 4 Signaling in Mice. Frontiers in pharmacology. vol 12. 2021-08-06. PMID:34349653. |
to elucidate the molecular mechanism underlying the potential effects of ex4 on maladaptive behaviors of cocaine, the tlr4-related inflammation within the hippocampus was observed by immunofluorescence staining, and the expression levels of toll-like receptor 4 (tlr4), tumor necrosis factor (tnf)-α, and interleukin (il)-1β were detected by western blotting. |
2021-08-06 |
2023-08-13 |
mouse |
| Xinfei Ma, Zhenhua Zhu, Sheng Guo, Jinao Dua. The effect of deoxyschizandrin on chronic unpredictable mild stress-induced depression. Biotechnology and applied biochemistry. vol 68. issue 1. 2021-07-06. PMID:31985079. |
additionally, the expressions of tlr4, myd88, traf6, p-nf-κbp65, nlrp3, cleaved caspase-1, cleaved il-1β, glur, and psd95 in hippocampus were detected by western blot. |
2021-07-06 |
2023-08-13 |
mouse |