| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Craig Hughes, Minee L Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerma. Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32071389. |
aβ aggregates caused long term potentiation (ltp) deficit in hippocampal slices and predominantly neuronal cell death in co-cultures of astrocytes and neurons, which was blocked by tlr4 antagonists. |
2021-06-17 |
2023-08-13 |
rat |
| Shuwei Hu, Yiwen Yi, Tao Jiang, Zhexiao Jiao, Shiyun Dai, Xiaohan Gong, Ke Li, Hui Wang, Dan X. Intrauterine RAS programming alteration-mediated susceptibility and heritability of temporal lobe epilepsy in male offspring rats induced by prenatal dexamethasone exposure. Archives of toxicology. vol 94. issue 9. 2021-06-16. PMID:32494933. |
expression of hippocampal glucocorticoid receptor (gr), ccaat enhancer-binding protein α (c/ebpα), intrauterine renin-angiotensin system (ras) classical pathway related genes, the h3k27ac level in angiotensin-converting enzyme (ace) promoter, as well as high mobility group box 1 (hmgb1) and toll-like receptor 4 (tlr4) were increased, but glutamate dehydrogenase (glud) 1/2 expression were decreased, accompanied by increased glutamate levels in pde fetal and adult rats, as well as in f1 and f2 offspring of the pde + lipc group. |
2021-06-16 |
2023-08-13 |
rat |
| Esther T Menze, Hager Ezzat, Salma Shawky, Marwa Sami, Eman H Selim, Samar Ahmed, Nouran Maged, Nancy Nadeem, Shorouk Eldash, Haidy E Miche. Simvastatin mitigates depressive-like behavior in ovariectomized rats: Possible role of NLRP3 inflammasome and estrogen receptors' modulation. International immunopharmacology. vol 95. 2021-06-04. PMID:33774267. |
moreover, sim prohibited hippocampal microglial activation, abrogated p2x7 receptor, tlr2 and tlr4 expression, inhibited nlrp3 inflammasome activation, with subsequent reduction in the levels of pro-inflammatory mediators; il-1β and il-18. |
2021-06-04 |
2023-08-13 |
rat |
| Andrea R Vasconcelos, Amanda G da Paixão, Paula F Kinoshita, Ana M Orellana, Cristoforo Scavone, Elisa M Kawamot. Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain. Neuroscience. vol 465. 2021-06-04. PMID:33957205. |
the results suggest that tlr4 participates in the modulatory effects of if on oxidative stress levels, on the transcription factors creb and nrf2, and on bdnf and hsp90 expressions in hippocampus. |
2021-06-04 |
2023-08-13 |
mouse |
| A M Hamieh, G Mallaret, M Meleine, A Lashermes, S Roumeau, L Boudieu, J Barbier, Y Aissouni, D Ardid, A T Gewirtz, F A Carvalho, F Marchan. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, behavior, and immunity. vol 93. 2021-05-27. PMID:33516921. |
nor there were significant changes in the expression of some cytokines (il-6, il-10 and tnf-α) and other tlrs (tlr2, tlr3 and tlr4) in the prefrontal cortex, amygdala and hippocampus of tlr5 ko mice compared to wt mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Rabi Atabaki, Ali Roohbakhsh, Ali Moghimi, Soghra Mehr. Protective effects of maternal administration of curcumin and hesperidin in the rat offspring following repeated febrile seizure: Role of inflammation and TLR4. International immunopharmacology. vol 86. 2021-05-17. PMID:32585605. |
we used enzyme-linked immunosorbent assay, western blotting, malondialdehyde (mda), and glutathione (gsh) assessment for evaluation of inflammatory cytokine levels, tlr4 protein expression, and oxidative responses in the hippocampal tissues. |
2021-05-17 |
2023-08-13 |
rat |
| Carollina Da Ré, Jéssica Maria Souza, Fernanda Fróes, Jéssica Taday, João Paulo Dos Santos, Letícia Rodrigues, Patrícia Sesterheim, Carlos Alberto Gonçalves, Marina Concli Leit. Neuroinflammation induced by lipopolysaccharide leads to memory impairment and alterations in hippocampal leptin signaling. Behavioural brain research. vol 379. 2021-05-03. PMID:31734263. |
neuroinflammation was characterized in the lps group by an increase in concentration of il-1β, cox-2 and tlr4 in the hippocampus as well as glial fibrillary acidic protein (gfap), indicating an astrocyte commitment. |
2021-05-03 |
2023-08-13 |
rat |
| Shima Mehrabadi, Elahe Motevaseli, Seyed Shahabeddin Sadr, Khadijeh Moradbeyg. Hypoxic-conditioned medium from adipose tissue mesenchymal stem cells improved neuroinflammation through alternation of toll like receptor (TLR) 2 and TLR4 expression in model of Alzheimer's disease rats. Behavioural brain research. vol 379. 2021-05-03. PMID:31739000. |
expression of tlr2 and tlr4 was measured by real-time pcr, and finally, to assess inflammation markers (il-1β and tnf-α) in the hippocampus, elisa kits were used. |
2021-05-03 |
2023-08-13 |
rat |
| Lijun Jiang, Zhenxing Xu, Hui Li, Mingfu Wu, Fudong Wang, Shunying Liu, Jianlan Tao, Xing Fen. TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model. Molecular medicine reports. vol 22. issue 2. 2021-05-03. PMID:32627010. |
furthermore, tak‑242 decreased the protein expression levels of tlr4, myd88, tir‑domain‑containing adapter‑inducing interferon‑β (trif), nf‑κb, tumor necrosis factor α (tnf‑α) and interleukin‑1β in the hippocampus. |
2021-05-03 |
2023-08-13 |
rat |
| Hualei Bai, Shize Chen, Tiezheng Yuan, Dongyuan Xu, Songbiao Cui, Xiangdan L. Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 25. issue 3. 2021-05-02. PMID:33859062. |
in this study, we aimed to investigate the effects of paeoniflorin (pf) on np-induced depression-like behaviors by targeting the hippocampal neuroinflammation through the toll-like receptor 4 (tlr4)/nuclear factor-kappa b (nf-κb) signaling pathway. |
2021-05-02 |
2023-08-13 |
mouse |
| Bruno Chausse, Andrea Lewen, Gernot Poschet, Oliver Kan. Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32446944. |
employing postnatal organotypic hippocampal slice cultures, we describe that microglia transformed into a mild reactive phenotype by single tlr4 stimulation with lipopolysaccharide (lps), which was boosted into a severe neurotoxic phenotype by ifn-γ (lps + inf-γ). |
2021-04-06 |
2023-08-13 |
Not clear |
| Wenjun Wang, Liudi Yang, Tianlong Liu, Jingwen Wang, Aidong Wen, Yi Din. Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2. Aging. vol 12. issue 11. 2021-03-08. PMID:32433038. |
in addition, ea significantly reduced the mortality and ros levels in glutamate (glu)-induced hippocampal neuron injury, and these effects of ea were enhanced in tlr4 sirna-transfected neurons. |
2021-03-08 |
2023-08-13 |
mouse |
| Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen, Zongze Zhan. Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32059688. |
wild-type (wt) c57bl/6, tlr4 knockout (tlr4 -ko) mice and hippocampal neurons from the two type mice were respectively divided into two groups: (1) veh group; (2) b2m-treated group. |
2021-02-12 |
2023-08-13 |
mouse |
| Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen, Zongze Zhan. Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32059688. |
the results showed that wt mice received b2m in the dg exhibited age-related cognitive declines, increased tlr4 mrna expression and high levels of interleukin-1β (il-1β), tumor necrosis factor-alpha (tnf-α) and apoptotic neuronal death in the hippocampus, which were partially attenuated in tlr4-ko mice. |
2021-02-12 |
2023-08-13 |
mouse |
| Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen, Zongze Zhan. Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32059688. |
moreover, in absence of tlr4, b2m treatment improved hippocampus neurogenesis and increased synaptic related proteins. |
2021-02-12 |
2023-08-13 |
mouse |
| Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen, Zongze Zhan. Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32059688. |
in summary, our results support the tlr4 contributes to b2m-induced age-related cognitive decline due to neuroinflammation and apoptosis through tlr4/myd88/nf-κb signaling pathway via a modulation of hippocampal neurogenesis and synaptic function. |
2021-02-12 |
2023-08-13 |
mouse |
| Xiaolong Wang, Hao Yu, Changliang Wang, Yang Liu, Jiabin You, Pengfei Wang, Guohui Xu, Hui Shen, Hui Yao, Xinze Lan, Rui Zhao, Xu Wu, Guohua Zhan. Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice. Toxicology. vol 446. 2021-01-14. PMID:33161052. |
western blotting was used to detect the expression of tlr3, tlr4, nf-κb, il-1β, il-6, and tnf-α in the mouse hippocampus and h4 cells. |
2021-01-14 |
2023-08-13 |
mouse |
| Xiaolong Wang, Hao Yu, Changliang Wang, Yang Liu, Jiabin You, Pengfei Wang, Guohui Xu, Hui Shen, Hui Yao, Xinze Lan, Rui Zhao, Xu Wu, Guohua Zhan. Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-κB pathway and anxiety-like behavior in male C57BL/6 mice. Toxicology. vol 446. 2021-01-14. PMID:33161052. |
the expression levels of tlr3, tlr4, nf-κb, il-1β, il-6, and tnf-α increased after ethanol exposure in both the hippocampus of mice and h4 cells. |
2021-01-14 |
2023-08-13 |
mouse |
| Jing Yang, Rongjun Liu, Fan Lu, Fang Xu, Jinwei Zheng, Zhao Li, Wei Cui, Chuang Wang, Junfang Zhang, Shujun Xu, Wenhua Zhou, Qinwen Wang, Junping Chen, Xiaowei Che. Fast Green FCF Attenuates Lipopolysaccharide-Induced Depressive-Like Behavior and Downregulates TLR4/Myd88/NF-κB Signal Pathway in the Mouse Hippocampus. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31139084. |
fast green fcf decreased the mrna and protein levels of toll-like receptor 4 (tlr4) and myeloid differentiation primary response 88 (myd88) and suppressed the phosphorylation of nuclear factor-κb (nf-κb) in the hippocampus of lps-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Fulin Gao, Yuhong Jing, Peixi Zang, Xiaojuan Hu, Cheng Gu, Ruipeng Wu, Bingyan Chai, Yi Zhan. Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease Is Associated with the TLR4 in the Hippocampus. Journal of Alzheimer's disease : JAD. vol 70. issue 2. 2020-10-01. PMID:31256136. |
vascular cognitive impairment caused by cerebral small vessel disease is associated with the tlr4 in the hippocampus. |
2020-10-01 |
2023-08-13 |
Not clear |