| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianqi Liu, Lanqi Zhou, Rui Dong, Yizhe Qu, Yuan Liu, Wei Song, Jiayao Lv, Shan Wu, Wen Peng, Lin Sh. Isomalto-Oligosaccharide Potentiates Alleviating Effects of Intermittent Fasting on Obesity-Related Cognitive Impairment during Weight Loss and the Rebound Weight Gain. Journal of agricultural and food chemistry. 2024-10-21. PMID:39431286. |
transcriptomic analysis of the hippocampus revealed that the protective effects on cognition might be attributed to the suppression of toll-like receptor 4 (tlr4)/nfκb signaling, oxidative phosphorylation, and neuroinflammation. |
2024-10-21 |
2024-10-23 |
mouse |
| Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-Na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-En Deng, Yuanyuan Zhang, Yimeng Feng, Junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Gen. Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. European journal of pharmacology. 2024-10-19. PMID:39426465. |
pathological changes in the hippocampal regions were identified through nissl staining, and western blotting was used to quantify the protein levels of bdnf, trkb, creb, tlr4, myd88, and nf-κb. |
2024-10-19 |
2024-10-22 |
rat |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
the protein expressions of cd300f, tlr4, synaptophysin(syn), and postsynaptic density protein 95(psd-95) in microglial cells of the hippocampus were detected by immunofluorescence and western blot. |
2024-09-22 |
2024-09-26 |
rat |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
in addition, the cd300f expression was down-regulated in microglial cells of the hippocampus, and the tlr4 expression was up-regulated. |
2024-09-22 |
2024-09-26 |
rat |
| Qian-Qian Li, Qi Yu, Zhi-Yi Liu, Qin Zhang, Meng-Yuan Li, Yan H. Sevoflurane anesthesia during late gestation induces cognitive disorder in rat offspring via the TLR4/BDNF/TrkB/CREB pathway. Journal of neuropathology and experimental neurology. 2024-09-13. PMID:39271176. |
sevo upregulated tlr4 and impeded bdnf/trkb/creb signaling transduction in the hippocampus of rat offspring; tak-242 administration reversed these effects. |
2024-09-13 |
2024-09-16 |
rat |
| Negar Hajheidari, Zahra Lorigooini, Rohollah Mohseni, Hossein Amini-Khoe. Umbelliprenin attenuates comorbid behavioral disorders in acetic acid-induced colitis in mice: mechanistic insights into hippocampal oxidative stress and neuroinflammation. Naunyn-Schmiedeberg's archives of pharmacology. 2024-09-04. PMID:39230587. |
histopathological changes in the colon were evaluated, and total antioxidant capacity (tac), malondialdehyde (mda) levels, and the expression of inflammatory genes (tnfα, il1β, and tlr4) were measured in the hippocampus. |
2024-09-04 |
2024-09-06 |
mouse |
| Macarena González-Portilla, Sandra Montagud-Romero, Susana Mellado, Fernando Rodríguez de Fonseca, María Pascual, Marta Rodríguez-Aria. Region-Specific Gene Expression Changes Associated with Oleoylethanolamide-Induced Attenuation of Alcohol Self-Administration. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201687. |
in addition, we measured gene expression changes in the striatum and hippocampus of relevant receptors for alcohol consumption (drd1, drd2, cnr1, oprm) as well as immune-related proteins (il-6, il-1β, tlr4) and the brain-derived neurotrophic factor (bdnf). |
2024-08-29 |
2024-09-04 |
Not clear |
| Lixia Luo, Shitong Lin, Guoli Hu, Jiahui Wu, Yulin Hu, Fengjing Nong, Cheng Lu, Rongbin Chen, Jin Li. Molecular mechanism of Rolupram reducing neuroinflammation in noise induced tinnitus mice through TLR4/NF kB/NLRP3 protein/caspase-1/IL-1 β signaling pathway. International journal of biological macromolecules. 2024-08-24. PMID:39181359. |
finally, qpcr and western blot were used to detect the expression of tlr4, nf kb, nlrp3, caspase-1, and il-1 β in the hippocampus of each group of mice. |
2024-08-24 |
2024-08-28 |
mouse |
| Masoud Kaboutari, Masoumeh Asle-Rousta, Sanaz Mahmaz. Protective effect of menthol against thioacetamide-induced hepatic encephalopathy by suppressing oxidative stress and inflammation, augmenting expression of BDNF and α7-nACh receptor, and improving spatial memory. European journal of pharmacology. 2024-08-18. PMID:39154831. |
likewise, this monoterpene reduced the expression of tlr4, myd88, and nf-κb in the hippocampus while increasing the expression of bdnf and α7-nach receptor. |
2024-08-18 |
2024-08-21 |
rat |
| Qinghe Li, Zhicui Ouyang, Yunqiao Zhang, Zhen Li, Xing Zhu, Zhen Tan. Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage. Molecular neurobiology. 2024-07-02. PMID:38954251. |
however, the effect of toll-like receptor 4 (tlr4) activation on hippocampal plasticity after neonatal hypoxic-ischaemic brain damage (hibd) remains unclear. |
2024-07-02 |
2024-07-06 |
rat |
| Qinghe Li, Zhicui Ouyang, Yunqiao Zhang, Zhen Li, Xing Zhu, Zhen Tan. Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage. Molecular neurobiology. 2024-07-02. PMID:38954251. |
the pups were ligated in the left common carotid artery and then subjected to hypoxia to establish the neonatal hibd model.the expression of the tlr4 in the left hippocampus of the hi group was increased compared to the control group, while tak-242 reduced the expression level at 3 days after hibd. |
2024-07-02 |
2024-07-06 |
rat |
| Qinghe Li, Zhicui Ouyang, Yunqiao Zhang, Zhen Li, Xing Zhu, Zhen Tan. Effect of Early Inhibition of Toll-Like Receptor 4 on Hippocampal Plasticity in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage. Molecular neurobiology. 2024-07-02. PMID:38954251. |
finally,tak-242 increased the percentage of third-grade dendritic mushroom spines processes in the basal and apical segments of neurons in the hippocampal ca1 region at 21 days after hibd.therefore, we conclude that preinhibition of tlr4 prior to neonatal hibd improved the plasticity of the hippocampus. |
2024-07-02 |
2024-07-06 |
rat |
| Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tan. Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-11. PMID:38860393. |
pde4 inhibitors play a role in depression; autism spectrum and huntington's disease by inhibiting the advanced glycation end product receptor (rage), tlr4 and nlrp3 pathways in the hippocampus, reducing the activation of microglia and the production of interleukin-1β, down-regulating hmgb1/rage signaling pathway and inhibiting inflammatory factors and increase the nociception threshold. |
2024-06-11 |
2024-06-14 |
Not clear |
| Maziar Mahmoudian, Zahra Lorigooini, Mohammad Rahimi-Madiseh, Sahreh Shabani, Hossein Amini-Khoe. Protective effects of rosmarinic acid against autistic-like behaviors in a mouse model of maternal separation stress: behavioral and molecular amendments. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-10. PMID:38730077. |
nitrite level and gene expression of inflammatory cytokines including tnf-α, il-1β, tlr4, and inos were assessed in the hippocampus. |
2024-05-10 |
2024-05-27 |
mouse |
| Yiqin Lin, Zhenming Kang, Changsheng Su, Shunyuan Li, Wenqin Xi. Extracellular vesicles ameliorates sleep deprivation induced anxiety-like behavior and cognitive impairment in mice. Molecular therapy. Methods & clinical development. vol 32. issue 1. 2024-03-04. PMID:38435131. |
western blotting analysis also revealed that ev treatment reduced the levels of tlr4 and p65 in the hippocampus. |
2024-03-04 |
2024-03-06 |
mouse |
| Yuan Chen, Yi Zhou, Jinhan Cai, Jiayi Xu, Chenwei Hu, Huiyue Chen, Yirui Hong, Nanyi Pan, Yujie Jiang, Chenhui Zhou, Hua Wei, Zhipeng Xu, Lin Liu, Xiang Wu, Wei Cu. The activation of RARα prevents surgery-induced cognitive impairments via the inhibition of neuroinflammation and the restoration of synaptic proteins in elderly mice. International immunopharmacology. vol 130. 2024-03-03. PMID:38432148. |
both agonists inhibited the expression of toll-like receptor 4 (tlr4), myeloid differentiation factor 88 (myd88) and the phosphorylation of nuclear factorkappa-b (nf-κb), leading to the prevention of microglial over-activation and pro-inflammatory cytokines secretion in the hippocampal regions of elderly mice after surgery. |
2024-03-03 |
2024-03-06 |
mouse |
| Guang-Jun Hu, Xiao-Yang Jiang, Si-Yu Du, Kun Zhang, Zhuo Che. miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB(NF-κB) pathway. The Kaohsiung journal of medical sciences. vol 40. issue 2. 2024-02-02. PMID:38305705. |
mir-107-5p expression, along with tlr4, apoe, and trem2 in hippocampal tissue homogenate, and nf-κb p65 protein expression in the nucleus and cytoplasm were assessed via rt-qpcr and western blot. |
2024-02-02 |
2024-02-04 |
mouse |
| Lulu Ren, Huazheng Liang, Li Zhu, Xiao Yang, Hong Zhang, Nianyi Sun, Dunbing Huang, Jing Feng, Yufeng Wu, Lize Xiong, Xiaohua Ke, Min Li, Anren Zhan. Dietary restriction improves perioperative neurocognitive disorders by inhibiting neuroinflammation and gut microbial dysbiosis. Neuroscience. 2024-01-25. PMID:38272300. |
the western blot technique was utilized to assess expression levels of hippocampal psd 95, synaptophysin, tlr4, myd88, and nf-kb p65. |
2024-01-25 |
2024-01-28 |
mouse |
| Vahid Reisi-Vanani, Zahra Lorigooini, Elham Bijad, Hossein Amini-Khoe. Maternal separation stress through triggering of the neuro-immune response in the hippocampus induces autistic-like behaviors in male mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-12-18. PMID:38110192. |
then, hippocampi were dissected out, and the gene expression of inflammatory mediators including tnf-α, il-1β, tlr4, hmgb1, and nlrp3 was assessed in the hippocampus using rt-pcr. |
2023-12-18 |
2023-12-21 |
mouse |
| Huili Jiang, Xianqi Long, Yu Wang, Xuhui Zhang, Lu Chen, Xinjing Yang, Bingcong Zhao, Ye Zhang, Yemao Chai, Tuya Ba. Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress. Molecular neurobiology. 2023-11-02. PMID:37917302. |
the expression of key proteins on tlr4 signaling pathway of tlr4, myd88, traf6, nf-κb p65, tnf-α, and mrna of tlr4 in the hippocampus was detected by western blot and real-time quantitative polymerase chain reaction to investigate the effect of acupuncture on stress-induced activation of neuroinflammation. |
2023-11-02 |
2023-11-08 |
rat |