| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justyna Barut, Katarzyna Rafa-Zabłocka, Agnieszka M Jurga, Monika Bagińska, Irena Nalepa, Rosanna Parlato, Grzegorz Kreine. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain. Neurochemistry international. 2022-02-12. PMID:35150790. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor deficits caused by the loss of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta). |
2022-02-12 |
2023-08-13 |
mouse |
| Andrew Gao, Hannah M McCoy, Vandana Zaman, Donald C Shields, Naren L Banik, Azizul Haqu. Calpain activation and progression of inflammatory cycles in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 27. issue 1. 2022-01-29. PMID:35090325. |
all three agents work through similar mechanisms and lead to degeneration of dopaminergic neurons in the substantia nigra (sn) and more recently discovered in motor neurons of the spinal cord (sc). |
2022-01-29 |
2023-08-13 |
Not clear |
| Victor Blokhin, Maria Shupik, Ulyana Gutner, Ekaterina Pavlova, Albert T Lebedev, Olga Maloshitskaya, Vsevolod Bogdanov, Sergey Sokolov, Alice Alessenko, Michael Ugrumo. The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson's Disease. Biomolecules. vol 12. issue 1. 2022-01-21. PMID:35053241. |
it has been shown that in pd models, the expression of five of the nine studied genes (cers1, cers5, asah1, asah2, and gba1) increases but only in the substantia nigra (sn) containing dopaminergic cell bodies. |
2022-01-21 |
2023-08-13 |
mouse |
| Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi She. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. Molecular medicine reports. vol 25. issue 3. 2022-01-18. PMID:35039876. |
in the mptp group, the loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta, the reduction of the tyrosine hydroxylase content in the sn and striatum and the astrocyte proliferation and microglial activation in the sn were more significant compared with the rotenone group. |
2022-01-18 |
2023-08-13 |
mouse |
| Hanjiang Luo, Caixia Peng, Xiaofeng Xu, Yuntao Peng, Fang Shi, Qinghua Li, Jianghui Dong, Min Che. The Protective Effects of Mogroside V Against Neuronal Damages by Attenuating Mitochondrial Dysfunction via Upregulating Sirtuin3. Molecular neurobiology. 2022-01-18. PMID:35040040. |
motor impairments and dopaminergic neuronal injury in the sn were alleviated with the oral administration of mv in rot-treated pd mice, indicating a relationship between protection against defective motility and preservation of dopaminergic neurons. |
2022-01-18 |
2023-08-13 |
mouse |
| Rahul, Yasir Hasan Siddiqu. Drosophila: A Model to Study the Pathogenesis of Parkinson's Disease. CNS & neurological disorders drug targets. vol 21. issue 3. 2022-01-18. PMID:35040399. |
the pathological hallmarks of pd are loss of dopaminergic neurons in the substantianigra (sn) pars compacta (snpc) and accumulation of misfolded α-synuclein, in intra-cytoplasmic inclusions called lewy bodies (lbs). |
2022-01-18 |
2023-08-13 |
human |
| Qingyu Ren, Xin Jiang, Shanshan Zhang, Xin Gao, Yam Nath Paudel, Pengyu Zhang, Rongchun Wang, Kechun Liu, Meng Ji. Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 147. 2022-01-14. PMID:35030435. |
parkinson's disease (pd) is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and aggregation of α-synuclein (α-syn). |
2022-01-14 |
2023-08-13 |
cat |
| Min Hyung Seo, Sabina Lim, Sujung Ye. Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model. BMC neuroscience. vol 22. issue 1. 2021-12-11. PMID:34736417. |
parkinson's disease (pd) represent a loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain. |
2021-12-11 |
2023-08-13 |
mouse |
| Meiqiu Liu, Qian Jiao, Xixun Du, Mingxia Bi, Xi Chen, Hong Jian. Potential Crosstalk Between Parkinson's Disease and Energy Metabolism. Aging and disease. vol 12. issue 8. 2021-12-11. PMID:34881082. |
parkinson's disease (pd) is characterized by the accumulation of alpha-synuclein (α-syn) in the substantia nigra (sn) and the degeneration of nigrostriatal dopaminergic (daergic) neurons. |
2021-12-11 |
2023-08-13 |
Not clear |
| Min Hyung Seo, Bo-Ram Jin, Hyo-Jung Kim, Hyo-Jin An, Sujung Ye. Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. Neuroscience letters. 2021-12-07. PMID:34875351. |
parkinson's disease (pd) occurs when dopaminergic cells in the substantia nigra (sn) region are destroyed; however, the cause of the destruction of dopamine cells has not yet been determined. |
2021-12-07 |
2023-08-13 |
rat |
| Min Hyung Seo, Bo-Ram Jin, Hyo-Jung Kim, Hyo-Jin An, Sujung Ye. Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. Neuroscience letters. 2021-12-07. PMID:34875351. |
th expression, expressed in dopaminergic cells and used as a dopaminergic cell detection marker, decreased, whereas α-syn expression increased at the sn site. |
2021-12-07 |
2023-08-13 |
rat |
| Sheelu Monga, Nunzio Denora, Valentino Laquintana, Rami Yashaev, Abraham Weizman, Moshe Gavis. The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson's Disease. Biology. vol 10. issue 11. 2021-11-30. PMID:34827176. |
parkinson's disease (pd) is a progressive neurodegenerative disorder which is characterized by the degeneration of dopaminergic neurons in substantia nigra (sn). |
2021-11-30 |
2023-08-13 |
Not clear |
| Hannah V Oakes, David McWethy, Shannon Ketchem, Lily Tran, Kaitlyn Phillips, Laura Oakley, Richard J Smeyne, Brooks B Pon. Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33666887. |
interestingly, proestrus females exhibited greater sensitivity to mptp, with significantly reduced dopaminergic neurons in the sn and significant increases in da quinone production. |
2021-11-29 |
2023-08-13 |
mouse |
| Monika Sharma, Jaswinder Kaur, Siddhi Rakshe, Nishant Sharma, Dignesh Khunt, Amit Khairna. Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons. Neurotoxicity research. 2021-11-24. PMID:34817799. |
pd models targeting olfactory bulb (ob) have demonstrated the dopaminergic (daergic) neurodegeneration in both ob and substantia nigra (sn). |
2021-11-24 |
2023-08-13 |
mouse |
| Tony Oosterveen, Pedro Garção, Emma Moles-Garcia, Clement Soleilhavoup, Marco Travaglio, Shahida Sheraz, Rosa Peltrini, Kieran Patrick, Valerie Labas, Lucie Combes-Soia, Ulrika Marklund, Peter Hohenstein, Lia Panma. Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem cell reports. vol 16. issue 11. 2021-11-20. PMID:34678205. |
in parkinson's disease (pd), substantia nigra (sn) dopaminergic (da) neurons degenerate, while related ventral tegmental area (vta) da neurons remain relatively unaffected. |
2021-11-20 |
2023-08-13 |
mouse |
| Brent J Ryan, Nora Bengoa-Vergniory, Matthew Williamson, Ecem Kirkiz, Rosalind Roberts, Gabriele Corda, Maximilian Sloan, Saba Saqlain, Marta Cherubini, Josse Poppinga, Helle Bogtofte, Milena Cioroch, Svenja Hester, Richard Wade-Martin. REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 16. 2021-11-19. PMID:33563726. |
alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (sn) of parkinson's patients. |
2021-11-19 |
2023-08-13 |
mouse |
| Brent J Ryan, Nora Bengoa-Vergniory, Matthew Williamson, Ecem Kirkiz, Rosalind Roberts, Gabriele Corda, Maximilian Sloan, Saba Saqlain, Marta Cherubini, Josse Poppinga, Helle Bogtofte, Milena Cioroch, Svenja Hester, Richard Wade-Martin. REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 16. 2021-11-19. PMID:33563726. |
vulnerable sn dopaminergic neurons displayed low rest levels compared with neighboring protected sn gabaergic neurons, which correlated with the accumulation of α-synuclein oligomers and disrupted mitochondrial morphology. |
2021-11-19 |
2023-08-13 |
mouse |
| I Friedrich, K Reimann, S Jankuhn, E Kirilina, J Stieler, M Sonntag, J Meijer, N Weiskopf, T Reinert, T Arendt, M Morawsk. Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33752749. |
particularly in parkinson's disease (pd) changes in iron concentrations in the substantia nigra (sn) was suggested to play a key role in degeneration of dopaminergic neurons in nigrosome 1. |
2021-11-18 |
2023-08-13 |
Not clear |
| I Friedrich, K Reimann, S Jankuhn, E Kirilina, J Stieler, M Sonntag, J Meijer, N Weiskopf, T Reinert, T Arendt, M Morawsk. Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33752749. |
here, we quantified cellular iron concentrations and subcellular iron distributions in dopaminergic neurons and different types of glial cells in the sn both in brains of pd patients and in non-neurodegenerative control brains (co). |
2021-11-18 |
2023-08-13 |
Not clear |
| Amit Khairnar, Jana Ruda-Kucerova, Anas Arab, Constantinos Hadjistyllis, Alzbeta Sejnoha Minsterova, Qi Shang, Alexandra Chovsepian, Eva Drazanova, Nikoletta Szabó, Zenon Starcuk, Irena Rektorova, Francisco Pan-Montoj. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. Journal of neurochemistry. vol 158. issue 3. 2021-11-16. PMID:34107061. |
clinical diagnosis of parkinson's disease (pd) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (sn) already died, and the first motor symptoms appear. |
2021-11-16 |
2023-08-13 |
mouse |