| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoen Cai, Fabin Lin, Dihang Wu, Chenxin Lin, Huiyun Chen, Yicong Wei, Huidan Weng, Zhiting Chen, Minxia Wu, En Huang, Zucheng Ye, Qinyong Y. Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response. Frontiers in pharmacology. vol 13. 2022-06-02. PMID:35652041. |
pretreatment with ra reduced motor impairments and dopaminergic neuronal degeneration in the sn of a mouse model injected with mptp. |
2022-06-02 |
2023-08-13 |
mouse |
| Sangeun Han, Sabina Lim, Sujung Ye. Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628462. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn), reducing dopaminergic levels in the striatum and affecting motor control. |
2022-05-28 |
2023-08-13 |
mouse |
| Qing Liu, Qiyao Li, Runjiao Zhang, Hongfang Wang, Yibo Li, Ziyu Liu, Wenmeng Xie, Dandan Geng, Lei Wan. circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease. Cell death & disease. vol 13. issue 5. 2022-05-19. PMID:35589691. |
circ-pank1 is highly expressed in the substantia nigra (sn) of pd model mice treated with rotenone and in the mn9d cell model of dopaminergic neurons. |
2022-05-19 |
2023-08-13 |
mouse |
| Seyed Zanyar Athari, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Daryoush Mohajeri, Mir Alireza Nourazar, Gisou Mohadde. Hydroxychloroquine attenuated motor impairment and oxidative stress in a rat 6-hydroxydopamine model of Parkinson's disease. The International journal of neuroscience. 2022-05-16. PMID:35522252. |
parkinson's disease (pd) is associated with the destruction of dopaminergic neurons in the substantia nigra (sn). |
2022-05-16 |
2023-08-16 |
rat |
| Frank Bearoff, Dhruva Dhavale, Paul Kotzbauer, Sandhya Kortager. Aggregated Alpha-Synuclein Activates Pro-Inflammatory NFKB Signaling Pathways Through TLR-Dependent and Independent Mechanisms in Peripheral Monocytic Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556652. |
prolonged neuroinflammation in the substantia nigra (sn) leading to accumulation of alpha-synuclein fibril (α-syn) containing lewy-bodies (lbs) and ultimately death of dopaminergic neurons is a pathological hallmark of parkinson's disease (pd) and is thought to be a major mechanism driving disease progression. |
2022-05-13 |
2023-08-13 |
Not clear |
| Cheng Chen, Yaohua Chen, Tingting Liu, Dan Song, Di Ma, Oumei Chen. Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK. Oxidative medicine and cellular longevity. vol 2022. 2022-05-09. PMID:35528513. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-05-09 |
2023-08-13 |
mouse |
| Jian Zhang, Meng Wang, Yuan Zhao, Yidan Zhang, Ya Gao, Xiangjian Zhang, Guofeng Yan. Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord. Neuroscience letters. 2022-05-01. PMID:35490905. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder, resulting in dopaminergic (da) neuronal loss in the substantia nigra (sn) and injury of extranigral spinal cord neurons. |
2022-05-01 |
2023-08-13 |
mouse |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
in the midbrain, dopaminergic neurons are mainly situated in the substantia nigra (sn) and the ventral tegmental area (vta). |
2022-04-22 |
2023-08-13 |
Not clear |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
thus, we selected sn and vta as regions of interest and performed a seed-based global correlation to evaluate the altered functional connectivity throughout the dopaminergic system post-tbi. |
2022-04-22 |
2023-08-13 |
Not clear |
| Olivier Uwishema, Helen Onyeaka, Rawa Badri, Ayşe Nazlı Yücel, Ahmet Kayhan Korkusuz, Abayomi Oyeyemi Ajagbe, Amro Abuleil, Céline Chaaya, Baraa H M Alhendawi, Elie Chalhou. The understanding of Parkinson's disease through genetics and new therapies. Brain and behavior. 2022-04-22. PMID:35451243. |
the mechanism of this disease is associated with a decrease in the number of dopaminergic neurons in the substantia nigra (sn) while lewy bodies are still present. |
2022-04-22 |
2023-08-13 |
Not clear |
| Hui-Ming Yang, Yong-Ling Wang, Chong-Yue Liu, Yu-Ting Zhou, Xiao-Feng Zhan. A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-04-17. PMID:35430334. |
the results showed that motor retardation, coordination disorders and limb stiffness occurred four weeks after pq exposure, as well as the degeneration and loss of dopaminergic neurons in the sn. |
2022-04-17 |
2023-08-13 |
mouse |
| Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Ji. Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology. 2022-03-31. PMID:35358621. |
parkinson's disease (pd) is the second most devastating age-related neurodegenerative diseases after alzheimer diseases (ad) and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and aggregation of α-synuclein (α-syn). |
2022-03-31 |
2023-08-13 |
zebrafish |
| Colleen S Stein, Jared M McLendon, Nathan H Witmer, Ryan L Boudrea. Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease. Molecular therapy. Nucleic acids. vol 28. 2022-03-14. PMID:35280925. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-03-14 |
2023-08-13 |
mouse |
| Ian M O'Shea, Haroon S Popal, Ingrid R Olson, Vishnu P Murty, David V Smit. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-03-01. PMID:35228561. |
in parkinson's disease (pd), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (sn), while leaving the ventral tegmental area (vta) relatively spared in early phases of the disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-Hong Chen, Yu-He Yua. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical research. 2022-03-01. PMID:35229270. |
progressive loss of dopaminergic neurons in the substantia nigra (sn) is one of the major pathological changes. |
2022-03-01 |
2023-08-13 |
mouse |
| Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-Hong Chen, Yu-He Yua. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical research. 2022-03-01. PMID:35229270. |
dopaminergic neurons in the sn are susceptible to oxidative stress, which is closely associated with iron dyshomeostasis in the brain. |
2022-03-01 |
2023-08-13 |
mouse |
| Cheng-Peng Sun, Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang, Christophe Morisseau, Bruce D Hammock, Xiao-Chi M. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 9. 2022-02-26. PMID:35217618. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn), causing bradykinesia and rest tremors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Jannik Prasuhn, Robert Strautz, Felicitas Lemmer, Shalida Dreischmeier, Meike Kasten, Henrike Hanssen, Marcus Heldmann, Norbert Brüggeman. Neuroimaging Correlates of Substantia Nigra Hyperechogenicity in Parkinson's Disease. Journal of Parkinson's disease. 2022-02-18. PMID:35180131. |
degeneration of dopaminergic neurons within the brainstem substantia nigra (sn) is both a pathological hallmark of parkinson's disease (pd) and a major contributor to symptom expression. |
2022-02-18 |
2023-08-13 |
Not clear |
| Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. Molecular neurobiology. 2022-02-17. PMID:35175558. |
parkinson's disease (pd) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the substantia nigra (sn), and accumulation and spread of inclusions of aggregated α-synuclein (α-syn). |
2022-02-17 |
2023-08-13 |
human |
| Tzu-Feng Wang, Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yu-Min Ku. Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits. Cells. vol 11. issue 3. 2022-02-15. PMID:35159290. |
parkinson's disease (pd) is an age-related neurodegenerative disease caused by a selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-02-15 |
2023-08-13 |
mouse |