| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amit Khairnar, Jana Ruda-Kucerova, Anas Arab, Constantinos Hadjistyllis, Alzbeta Sejnoha Minsterova, Qi Shang, Alexandra Chovsepian, Eva Drazanova, Nikoletta Szabó, Zenon Starcuk, Irena Rektorova, Francisco Pan-Montoj. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. Journal of neurochemistry. vol 158. issue 3. 2021-11-16. PMID:34107061. |
increases in mean kurtosis were first observed in the dorsal motor nucleus of the vagus (dmv) after 2 months of exposure to rotenone and before the loss of dopaminergic neurons in the sn occurred. |
2021-11-16 |
2023-08-13 |
mouse |
| Rachel Underwood, Mary Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A Yacoubia. 14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33413679. |
14-3-3θ overexpression by aav in the substantia nigra (sn) also delayed αsyn aggregation in the sn and partially rescued pff-induced reduction in tyrosine hydroxylase (th)-positive dopaminergic cells in the sn. |
2021-11-15 |
2023-08-13 |
Not clear |
| Rachel Underwood, Mary Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A Yacoubia. 14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33413679. |
14-3-3 inhibition in the sn accelerated nigral αsyn aggregation and enhanced pff-induced reduction in th-positive dopaminergic cells. |
2021-11-15 |
2023-08-13 |
Not clear |
| Aqilah M McCane, Meredyth A Wegener, Mojdeh Faraji, Maria T Rivera-Garcia, Kathryn G Wallin-Miller, Vincent D Costa, Bita Moghadda. Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-14. PMID:34611024. |
static characteristics of dopamine neurons, such as dopamine cell number and size, were similar in the vta and sn of both ages, but there were age-related differences in stimulated dopamine release and correlated spike activity, suggesting that differences in reward responsiveness by adolescent dopamine neurons are not because of differences in intrinsic properties of these neurons but engagement of different dopaminergic networks. |
2021-11-14 |
2023-08-13 |
rat |
| Md Shahidul Islam, Fazli Azim, Hedaeytullah Saju, Arman Zargaran, Meysam Shirzad, Mostofa Kamal, Kaniz Fatema, Sumbul Rehman, M A Momith Azad, Somayeh Ebrahimi-Baroug. Pesticides and Parkinson's disease: Current and future perspective. Journal of chemical neuroanatomy. vol 115. 2021-11-04. PMID:33991619. |
pesticides strongly inhibit mitochondrial complex-i, causing mitochondrial dysfunction and death of dopaminergic neurons in the substantia nigra (sn), thus leading to pathophysiologic implications of pd. |
2021-11-04 |
2023-08-13 |
Not clear |
| Md Shahidul Islam, Fazli Azim, Hedaeytullah Saju, Arman Zargaran, Meysam Shirzad, Mostofa Kamal, Kaniz Fatema, Sumbul Rehman, M A Momith Azad, Somayeh Ebrahimi-Baroug. Pesticides and Parkinson's disease: Current and future perspective. Journal of chemical neuroanatomy. vol 115. 2021-11-04. PMID:33991619. |
their main aim is to replace and/or support the lost and dying dopaminergic neurons in the sn. |
2021-11-04 |
2023-08-13 |
Not clear |
| Yan Teng, Zhihao Liu, Xingmin Chen, Yanzhuo Liu, Fan Geng, Weidong Le, Haisong Jiang, Lu Yan. Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34288397. |
to evaluate the necessity of m6a in dopaminergic neuron functions, we conditionally deleted mettl14, one of the most important part of m6a methyltransferase complexes, in the substantia nigra (sn) region enriched with dopaminergic neurons. |
2021-11-04 |
2023-08-13 |
mouse |
| Yan Teng, Zhihao Liu, Xingmin Chen, Yanzhuo Liu, Fan Geng, Weidong Le, Haisong Jiang, Lu Yan. Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34288397. |
our finding first confirmed the significance of m6a in maintaining normal dopaminergic function in the sn of adult mouse. |
2021-11-04 |
2023-08-13 |
mouse |
| Jui-Chih Chang, Yi-Chun Chao, Huei-Shin Chang, Yu-Ling Wu, Hui-Ju Chang, Yong-Shiou Lin, Wen-Ling Cheng, Ta-Tsung Lin, Chin-San Li. Intranasal delivery of mitochondria for treatment of Parkinson's Disease model rats lesioned with 6-hydroxydopamine. Scientific reports. vol 11. issue 1. 2021-10-28. PMID:34011937. |
dopaminergic (da) neuron survival and recovery > 60% occurred in lesions of the substantia nigra (sn) and striatum in mito and p-mito rats. |
2021-10-28 |
2023-08-13 |
rat |
| Fatema Currim, Jyoti Singh, Anjali Shinde, Dhruv Gohel, Milton Roy, Kritarth Singh, Shatakshi Shukla, Minal Mane, Hitesh Vasiyani, Rajesh Sing. Exosome Release Is Modulated by the Mitochondrial-Lysosomal Crosstalk in Parkinson's Disease Stress Conditions. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33404982. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta region of the brain. |
2021-10-27 |
2023-08-13 |
Not clear |
| Abhishek Kumar Mishra, Anubhuti Dixi. Dopaminergic Axons: Key Recitalists in Parkinson's Disease. Neurochemical research. 2021-10-12. PMID:34637100. |
the dopamine level in the striatum is preserved because of the innervation of the substantia nigra (sn) dopaminergic neurons into it. |
2021-10-12 |
2023-08-13 |
Not clear |
| Weitang Liu, Wenwen Lao, Renxing Zhang, Hongyan Zh. Altered expression of voltage gated sodium channel Nav1.1 is involved in motor ability in MPTP-treated mice. Brain research bulletin. vol 170. 2021-10-07. PMID:33610724. |
parkinson's disease (pd) is a motor disabling disorder owing to the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2021-10-07 |
2023-08-13 |
mouse |
| Weitang Liu, Wenwen Lao, Renxing Zhang, Hongyan Zh. Altered expression of voltage gated sodium channel Nav1.1 is involved in motor ability in MPTP-treated mice. Brain research bulletin. vol 170. 2021-10-07. PMID:33610724. |
the results showed that nav1.1 was significantly reduced in tyrosine hydroxylase (th) positive dopaminergic neurons of the sn. |
2021-10-07 |
2023-08-13 |
mouse |
| Haichen Niu, Qian Wang, Weiguang Zhao, Jianxin Liu, Deguang Wang, Bilal Muhammad, Xiaoyu Liu, Ning Quan, Haoyu Zhang, Fang Zhang, Yong Wang, Haiying Li, Rongli Yan. IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32678959. |
moreover, 6 weeks after the lps treatment, mice showed reduced sn tyrosine hydroxylase, decreased striatal dopaminergic metabolites and pd-like behaviors. |
2021-10-06 |
2023-08-13 |
mouse |
| Zhe Zhong, Weijie Chen, Huan Gao, Ningning Che, Min Xu, Lanqing Yang, Yingfang Zhang, Min Y. Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein. Neurochemical research. vol 46. issue 11. 2021-10-04. PMID:34347266. |
dopaminergic neurons and microglial activation in the sn were analyzed by immunohistochemistry (ihc) and immunofluorescence (if) staining. |
2021-10-04 |
2023-08-13 |
mouse |
| Min Hyung Seo, Sujung Ye. Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 162. 2021-09-29. PMID:32485229. |
parkinson's disease (pd) is a progressive neurodegenerative disease, which shows distinct manifestations such as significant loss of dopaminergic neurons in the substantia nigra (sn). |
2021-09-29 |
2023-08-13 |
mouse |
| Min Hyung Seo, Sujung Ye. Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 162. 2021-09-29. PMID:32485229. |
gene expression was analyzed in the sn of mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), wherein downregulation of dopaminergic neurons occurred to examine the possible causes leading to the loss of dopaminergic neurons. |
2021-09-29 |
2023-08-13 |
mouse |
| Min Hyung Seo, Sujung Ye. Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 162. 2021-09-29. PMID:32485229. |
western blot analysis showed that, concomitant to the downregulation of dopaminergic cells, there was a substantial increase in serping1 expression within the sn of the mptp-induced pd mouse model. |
2021-09-29 |
2023-08-13 |
mouse |
| Min Hyung Seo, Sujung Ye. Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 162. 2021-09-29. PMID:32485229. |
these results show that increased expression of serping1 may play a critical role in dopaminergic cell death in the sn of chronic mptp-induced pd mouse model and in sh-sy5y cells. |
2021-09-29 |
2023-08-13 |
mouse |
| Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH. vol 65. issue s1. 2021-09-23. PMID:34468106. |
it is present in various areas of the human brain, most often in the substantia nigra (sn) pars compacta and the locus coeruleus, the main centers of dopaminergic and noradrenergic innervation, respectively. |
2021-09-23 |
2023-08-13 |
human |