| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Zampese, D James Surmeie. Calcium, Bioenergetics, and Parkinson's Disease. Cells. vol 9. issue 9. 2021-04-27. PMID:32911641. |
degeneration of substantia nigra (sn) dopaminergic (daergic) neurons is responsible for the core motor deficits of parkinson's disease (pd). |
2021-04-27 |
2023-08-13 |
Not clear |
| P A Dionísio, J D Amaral, C M P Rodrigue. Oxidative stress and regulated cell death in Parkinson's disease. Ageing research reviews. vol 67. 2021-04-19. PMID:33540042. |
motor deficits usually associated with pd correlate with dopaminergic axonal neurodegeneration starting at the striatum, which is then followed by dopaminergic neuronal death in the substantia nigra pars compacta (sn), with both events occurring already at the prodromal stage. |
2021-04-19 |
2023-08-13 |
Not clear |
| Helena Xicoy, Jos F Brouwers, Bé Wieringa, Gerard J M Marten. Explorative Combined Lipid and Transcriptomic Profiling of Substantia Nigra and Putamen in Parkinson's Disease. Cells. vol 9. issue 9. 2021-04-12. PMID:32858884. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons from the substantia nigra (sn) that project to the dorsal striatum (caudate-putamen). |
2021-04-12 |
2023-08-13 |
Not clear |
| Tingting Du, Le Wang, Weijin Liu, Guanyu Zhu, Yingchuan Chen, Jianguo Zhan. Biomarkers and the Role of α-Synuclein in Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-04-10. PMID:33833675. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the presence of α-synuclein (α-syn)-rich lewy bodies (lbs) and the preferential loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta (snpc). |
2021-04-10 |
2023-08-13 |
Not clear |
| Abbas Mohammadipour, Hossein Haghir, Alireza Ebrahimzadeh Bideska. A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful? Reviews on environmental health. vol 35. issue 4. 2021-03-30. PMID:32681785. |
they can damage neurons, in particular dopaminergic neurons in the substantia nigra (sn) and striatal neurons which their lesion is associated with parkinson's disease (pd). |
2021-03-30 |
2023-08-13 |
Not clear |
| Yong Wang, Qian Wang, Ruobing Yu, Qi Zhang, Zhonghai Zhang, Haiying Li, Chao Ren, Rongli Yang, Haichen Ni. Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression. Aging. vol 12. issue 14. 2021-03-24. PMID:32706757. |
the mαsyn expression leads to the loss of dopaminergic neurons in the substantia nigra (sn) and consequent motor dysfunctions. |
2021-03-24 |
2023-08-13 |
human |
| Yong Wang, Qian Wang, Ruobing Yu, Qi Zhang, Zhonghai Zhang, Haiying Li, Chao Ren, Rongli Yang, Haichen Ni. Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression. Aging. vol 12. issue 14. 2021-03-24. PMID:32706757. |
the data demonstrated that inhibiting microglial activation or hindering il-1r1 reversed the persistent motor deficits, neurodegeneration of the nigrostriatal dopaminergic system, and development of lewy body pathology caused by human mαsyn overexpression in the sn. |
2021-03-24 |
2023-08-13 |
human |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Violina Kakoty, Sarathlal K C, Ruei-Dun Tang, Chih Hao Yang, Sunil Kumar Dubey, Rajeev Taliya. Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-03-11. PMID:32361164. |
the predominant pathological hallmark is progressive loss of dopaminergic (da) neurones in the substantia nigra (sn) complicated by aggregation of misfolded forms of alpha-synuclein (α-syn). |
2021-03-11 |
2023-08-13 |
Not clear |
| Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zh. miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in International journal of molecular medicine. vol 47. issue 4. 2021-03-10. PMID:33649797. |
mir‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-10 |
2023-08-13 |
Not clear |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
parkinson's disease (pd), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-08 |
2023-08-13 |
Not clear |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
dopamine (da) metabolism is a cardinal physiological process in dopaminergic neurons, which is closely related to the loss of dopaminergic neurons in the sn. |
2021-03-08 |
2023-08-13 |
Not clear |
| Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen, Ming-Tsan Su, Kuo-Hsuan Chan. Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability. Cells. vol 9. issue 5. 2021-02-24. PMID:32429337. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective dopaminergic (daergic) neuronal degeneration in the substantia nigra (sn) and proteinaceous α-synuclein-positive lewy bodies and lewy neuritis. |
2021-02-24 |
2023-08-13 |
mouse |
| Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, Dong-Kug Choi, In-Su Ki. GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell. International journal of molecular sciences. vol 21. issue 20. 2021-02-24. PMID:33053856. |
in parkinson's disease, mitochondrial oxidative stress-mediated apoptosis is a major cause of dopaminergic neuronal loss in the substantia nigra (sn). |
2021-02-24 |
2023-08-13 |
Not clear |
| Simone Mesman, Marten P Smid. Acquisition of the Midbrain Dopaminergic Neuronal Identity. International journal of molecular sciences. vol 21. issue 13. 2021-02-16. PMID:32629812. |
the mesodiencephalic dopaminergic (mdda) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (sn) and ventral tegmental area (vta) are the best known, due to the selective degeneration of the sn during parkinson's disease. |
2021-02-16 |
2023-08-13 |
Not clear |
| Fábio G Teixeira, Helena Vilaça-Faria, Ana V Domingues, Jonas Campos, António J Salgad. Preclinical Comparison of Stem Cells Secretome and Levodopa Application in a 6-Hydroxydopamine Rat Model of Parkinson's Disease. Cells. vol 9. issue 2. 2021-02-12. PMID:32012897. |
results revealed that hbm-mscs secretome per se appears to be a modulator of the dopaminergic system, enhancing th-positive cells expression (e.g., dopaminergic neurons) and terminals both in the sn and str when compared to the untreated group 6-ohda. |
2021-02-12 |
2023-08-13 |
human |
| K D Chaprov, E V Teterina, A Yu Roman, T A Ivanova, V V Goloborshcheva, V G Kucheryanu, S G Morozov, E A Lysikova, O A Lytkina, I V Koroleva, N Ia Popova, A I Antohin, R K Ovchinnikov, M S Kukharsk. [Comparative Analysis of MPTP Neurotoxicity in Mice with a Constitutive Knockout of the α-Synuclein Gene]. Molekuliarnaia biologiia. vol 55. issue 1. 2021-02-12. PMID:33566034. |
the role of α-synuclein in selective loss of sn dopaminergic neurons (dns) in pd is studied in mice knocked out in the α-synuclein gene. |
2021-02-12 |
2023-08-13 |
mouse |
| Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeon. Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. Stem cells international. vol 2021. 2021-02-10. PMID:33552161. |
pd is a chronic age-related neurodegenerative disease (ndd) characterized by loss of dopaminergic neurons in the substantia nigra (sn) and abnormal accumulation of |
2021-02-10 |
2023-08-13 |
human |
| Azizul Haque, Supriti Samantaray, Varduhi H Knaryan, Mollie Capone, Azim Hossain, Denise Matzelle, Raghavendar Chandran, Donald C Shields, Ariana Q Farrand, Heather A Boger, Naren L Bani. Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease. Experimental neurology. vol 330. 2021-02-01. PMID:32302678. |
parkinson's disease (pd), a debilitating progressive degenerative movement disorder associated with loss of dopaminergic (da) neurons in the substantia nigra (sn), afflicts approximately one million people in the u.s., including a significant number of veterans. |
2021-02-01 |
2023-08-13 |
mouse |
| Kecheng Lei, Yijue Shen, Yijing He, Liwen Zhang, Jingxing Zhang, Weifang Tong, Yichun Xu, Lingjing Ji. Baicalin Represses C/EBP Oxidative medicine and cellular longevity. vol 2020. 2021-01-27. PMID:32566108. |
baicalin represses c/ebp parkinson's disease (pd) is a neurodegenerative disease characterized by the gradual loss of dopaminergic (da) neurons in the substantia nigra (sn) and the formation of intracellular lewy bodies (lb) in the brain, which aggregates |
2021-01-27 |
2023-08-13 |
Not clear |