| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung Hwa Kim, Seung Young Lee, Jaekwon Shin, Jae-Taeg Hwang, Hat Nim Jeon, Hyunsu Ba. Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31024294. |
dose-dependent neuroprotective effect of standardized bee venom phospholipase a parkinson's disease (pd) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of dopaminergic neurons within the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
bee |
| Hendrik Schöneborn, Fabian Raudzus, Emilie Secret, Nils Otten, Aude Michel, Jérome Fresnais, Christine Ménager, Jean-Michel Siaugue, Holm Zaehres, Irmgard D Dietzel, Rolf Heuman. Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins. Journal of functional biomaterials. vol 10. issue 3. 2020-10-01. PMID:31315182. |
parkinson's disease (pd) is a neurodegenerative disease associated with loss or dysfunction of dopaminergic neurons located in the substantia nigra (sn), and there is no cure available. |
2020-10-01 |
2023-08-13 |
human |
| Li Zhou, Xue-Rui Ran, Feng Hong, Guang-Wen Li, Jin-Xia Zh. Downregulated Dopamine Receptor 2 and Upregulated Corticotrophin Releasing Hormone in the Paraventricular Nucleus Are Correlated With Decreased Glucose Tolerance in Rats With Bilateral Substantia Nigra Lesions. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31396037. |
we hypothesize that damage to dopaminergic neurons in the sn might influence the blood glucose level through the hpa system. |
2020-10-01 |
2023-08-13 |
mouse |
| Li Zhou, Xue-Rui Ran, Feng Hong, Guang-Wen Li, Jin-Xia Zh. Downregulated Dopamine Receptor 2 and Upregulated Corticotrophin Releasing Hormone in the Paraventricular Nucleus Are Correlated With Decreased Glucose Tolerance in Rats With Bilateral Substantia Nigra Lesions. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31396037. |
in summary, the present study suggests that the dopaminergic neurons in the sn are involved in the regulation of body glucose metabolism through crh neurons that express d2 in the hypothalamic pvn. |
2020-10-01 |
2023-08-13 |
mouse |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Rou-Shayn Chen, Hua-Chien Chen, Ying-Zu Huang, Yi-Hsin Weng, Yi-Chuan Cheng, Yu-Chuan Liu, Ann-Joy Cheng, Ya-Ching Lu, Yu-Jie Chen, Yan-Wei Lin, Chia-Chen Hsu, Ying-Ling Chen, Chin-Song Lu, Hung-Li Wan. Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31572127. |
the mrna and protein levels of dyrk1a were increased in sh-sy5y dopaminergic cells expressing mir-204-5p and sn of mptp-induced pd mouse model. |
2020-10-01 |
2023-08-13 |
mouse |
| Shiqing Zhang, Peng Sun, Kaili Lin, Florence Hiu Ling Chan, Qi Gao, Wai Fung Lau, Vellaisamy A L Roy, Hongqi Zhang, King Wai Chiu Lai, Zhifeng Huang, Ken Kin Lam Yun. Extracellular Nanomatrix-Induced Self-Organization of Neural Stem Cells into Miniature Substantia Nigra-Like Structures with Therapeutic Effects on Parkinsonian Rats. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871862. |
substantia nigra (sn) is a complex and critical region of the brain wherein parkinson's disease (pd) arises from the degeneration of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
rat |
| Renrong Wei, Cuiping Rong, Qingfeng Xie, Shouhai Wu, Yuchao Feng, Ruihua Wang, Zhenhui Dai, Tongxiang Li. Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson's Disease through the Inflammation Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-10-01. PMID:31929812. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (sn)-striatum circuit, which is associated with glial activation and consequent chronic neuroinflammation. |
2020-10-01 |
2023-08-13 |
mouse |
| Renrong Wei, Cuiping Rong, Qingfeng Xie, Shouhai Wu, Yuchao Feng, Ruihua Wang, Zhenhui Dai, Tongxiang Li. Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson's Disease through the Inflammation Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-10-01. PMID:31929812. |
to confirm the effect of oyf on dopaminergic neurons and glia activation in this model, we analyzed the expression of tyrosine hydroxylase (th) and glia markers, ionized calcium-binding adapter molecule 1 (iba-1), and glial fibrillary acidic protein (gfap) in the sn region of the rat pd model. |
2020-10-01 |
2023-08-13 |
mouse |
| Tineke K Steiger, Nico Bunzec. Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28174533. |
importantly, analyses of structural mri data revealed that individual reward-related differences in the elderlies' response time could be predicted by the structural integrity of the dopaminergic substantia nigra (sn; as measured by magnetization transfer (mt)). |
2020-09-30 |
2023-08-13 |
human |
| Ashwin G Ramayya, Isaac Pedisich, Deborah Levy, Anastasia Lyalenko, Paul Wanda, Daniel Rizzuto, Gordon H Baltuch, Michael J Kahan. Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning. Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:28536513. |
we obtained microelectrode recordings to assess the proximity of the electrode tip to putative dopaminergic and gabaergic sn neurons and applied stimulation to assess the functional importance of these neuronal populations for learning. |
2020-09-30 |
2023-08-13 |
human |
| Juan M Viveros-Paredes, Rocio E González-Castañeda, Juerg Gertsch, Veronica Chaparro-Huerta, Rocio I López-Roa, Eduardo Vázquez-Valls, Carlos Beas-Zarate, Antoni Camins-Espuny, Mario E Flores-Sot. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP. Pharmaceuticals (Basel, Switzerland). vol 10. issue 3. 2020-09-30. PMID:28684694. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
Not clear |
| Juan M Viveros-Paredes, Rocio E González-Castañeda, Juerg Gertsch, Veronica Chaparro-Huerta, Rocio I López-Roa, Eduardo Vázquez-Valls, Carlos Beas-Zarate, Antoni Camins-Espuny, Mario E Flores-Sot. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP. Pharmaceuticals (Basel, Switzerland). vol 10. issue 3. 2020-09-30. PMID:28684694. |
in the murine model, bcp pretreatment ameliorated motor dysfunction, protected against dopaminergic neuronal losses in the sn and striatum, and alleviated mptp-induced glia activation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Qingqing Wang, Nan Ren, Zhipeng Cai, Qingxia Lin, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan L. Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29071302. |
exposure to 10 mg/kg pq or 30 mg/kg mptp caused damage to nerve cells in the substantia nigra (sn) in both nrf2 (+/+) and nrf2 (-/-) icr mice, which included cell morphological changes, detectable apoptosis and a significant reduction in the number of dopaminergic (da) neurons. |
2020-09-30 |
2023-08-13 |
mouse |
| Guo-Qing Wang, Dai-Di Li, Chun Huang, Di-Sheng Lu, Chao Zhang, Shao-Yu Zhou, Jie Liu, Feng Zhan. Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29375304. |
icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation parkinson's disease (pd) is one of the most common neurodegenerative diseases characterized with a gradual loss of midbrain substantia nigra (sn) dopamine (da) neurons. |
2020-09-30 |
2023-08-13 |
rat |
| Margabandhu Gopi, Arambakkam Janardhanam Vanisre. Attenuated levels of phospholipids in the striatum of rats infused with rotenone causing hemiparkinsonism as detected by simple dye-lipid complex. IBRO reports. vol 3. 2020-09-30. PMID:30135937. |
parkinson's disease (pd), a progressive neurodegeneration, is characterized by loss of dopaminergic neurons in the substantia nigra (sn) and loss of motor co-ordination. |
2020-09-30 |
2023-08-13 |
rat |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
considering that the ventral tegmental area (vta) and substantia nigra (sn) in the midbrain are the primary dopamine producers, creating reliable anatomical templates of the vta and sn through neuroimaging studies would be useful for achieving a detailed understanding of this dopaminergic system. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xing-Zhi Guo, Chang Shan, Yan-Fang Hou, Geng Zhu, Bei Tao, Li-Hao Sun, Hong-Yan Zhao, Guang Ning, Sheng-Tian Li, Jian-Min Li. Osteocalcin Ameliorates Motor Dysfunction in a 6-Hydroxydopamine-Induced Parkinson's Disease Rat Model Through AKT/GSK3β Signaling. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30319352. |
as dopaminergic neuronal injury in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd), we investigated whether ocn could exert protective effects on 6-hydroxydopamine (6-ohda)-induced pd rat model. |
2020-09-30 |
2023-08-13 |
rat |
| Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
the overall goal of our research is to establish a preformed molecular guidance pathway to direct the growth of dopaminergic axons from embryonic ventral mesencephalon (vm), tissue placed within the substantia nigra (sn), into the striatum to reconstruct the nigrostriatal pathway in a hemi-parkinson's disease rat model. |
2020-09-30 |
2023-08-13 |
rat |
| Sora Ahn, Quan Feng Liu, Jae-Hwan Jang, Jeonghun Park, Ha Jin Jeong, Youngman Kim, Dong-Hee Kim, Guwon Jeong, Seung Tack Oh, Seong-Uk Park, Seung-Yeon Cho, Hi-Joon Park, Songhee Jeo. Gami-Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson's Disease Mouse Model Though DJ-1 and BDNF Expression. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31555122. |
moreover, gcf inhibited the reduction of dopaminergic neurons in the substantia nigra (sn) and fibers in the striatum (st) against mptp/p challenge. |
2020-09-30 |
2023-08-13 |
mouse |
| David Sulzer, Clifford Cassidy, Guillermo Horga, Un Jung Kang, Stanley Fahn, Luigi Casella, Gianni Pezzoli, Jason Langley, Xiaoping P Hu, Fabio A Zucca, Ioannis U Isaias, Luigi Zecc. Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease. NPJ Parkinson's disease. vol 4. 2020-09-29. PMID:29644335. |
recent studies suggest this can be accomplished by magnetic resonance imaging (mri) detection of neuromelanin (nm), the characteristic pigment of sn dopaminergic, and locus coeruleus (lc) noradrenergic neurons. |
2020-09-29 |
2023-08-13 |
human |