| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
these data suggest that the olfactory deficits caused by depletion of the sn dopaminergic population are likely due to abnormal hyperactivity of the mitral cells in the ob. |
2020-07-06 |
2023-08-13 |
mouse |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, T Petteri Piepponen, Sari Ahola, Raimo K Tuominen, Christopher Richie, Brandon K Harvey, Mikko Airavaar. Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30548446. |
adeno-associated virus (aav) vector-mediated delivery of human α-synuclein (α-syn) gene in rat substantia nigra (sn) results in increased expression of α-syn protein in the sn and striatum which can progressively degenerate dopaminergic neurons. |
2020-07-01 |
2023-08-13 |
human |
| Huiying Liu, Hao Wu, Ning Zhu, Zijie Xu, Yue Wang, Yan Qu, Jun Wan. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. Journal of neurochemistry. vol 152. issue 3. 2020-06-30. PMID:31442326. |
its pathological features are dopaminergic neuronal death in the substantia nigra (sn), and significant reduction in dopamine (da) content in the striatum. |
2020-06-30 |
2023-08-13 |
mouse |
| Michaela E Johnson, Xin-Fu Zhou, Larisa Bobrovskay. The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: Relevance to early Parkinson's disease. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30690135. |
loss of dopaminergic neurons in the substantia nigra (sn) is one of the pathological hallmarks in parkinson's disease (pd). |
2020-06-26 |
2023-08-13 |
rat |
| Cristina Cocco, Giulia Corda, Carlo Lisci, Barbara Noli, Manolo Carta, Carla Brancia, Elias Manca, Carla Masala, Francesco Marrosu, Paolo Solla, Barbara Manconi, Paolo Bongioanni, Gian-Luca Ferr. VGF peptides as novel biomarkers in Parkinson's disease. Cell and tissue research. vol 379. issue 1. 2020-05-21. PMID:31713727. |
parkinson's disease (pd) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2020-05-21 |
2023-08-13 |
human |
| Liping Zhang, LingYu Zhang, Lin Li, Christian Hölsche. Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 1. 2020-05-20. PMID:30741689. |
in addition, both drugs rescued the decrease of tyrosine hydroxylase (th) levels, reduced the accumulation of α-syn, alleviated the chronic inflammation response in the brain, reduced lipid peroxidation, and inhibited the mitochondrial mitophagy signaling pathway, and furthermore increased expression of the key growth factor gdnf that protects dopaminergic neurons in the substantia nigra (sn) and striatum. |
2020-05-20 |
2023-08-13 |
mouse |
| Hye Ryeong Lim, Mai-Tram Vo, Dong Jun Kim, Unn Hwa Lee, Jong Hyuk Yoon, Hyung-Jun Kim, Jeongah Kim, Sang Ryong Kim, Jun Yeon Lee, Chae Ha Yang, Hee Young Kim, June-Seek Choi, Kijeong Kim, Esther Yang, Hyun Kim, Seongsoo Lee, Byung Ju Lee, Kyungjin Kim, Jeong Woo Park, Chang Man H. DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release. International journal of molecular sciences. vol 21. issue 1. 2020-05-15. PMID:31861806. |
drg2 was strongly expressed in the neurons of the dopaminergic system such as those in the striatum (str), ventral tegmental area (vta), and substantia nigra (sn), and on neuronal cell bodies in high-density regions such as the hippocampus (hip), cerebellum, and cerebral cortex in the mouse brain. |
2020-05-15 |
2023-08-13 |
mouse |
| Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang, Xiaojun W. Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice. Toxicology. vol 426. 2020-05-14. PMID:31381935. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by the degeneration of dopaminergic neurons in substantia nigra (sn). |
2020-05-14 |
2023-08-13 |
mouse |
| Rachael H Earls, Kelly B Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G Hazim, Jae-Kyung Le. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. Journal of neuroinflammation. vol 16. issue 1. 2020-05-14. PMID:31796095. |
), preceding the degeneration of dopaminergic neurons in substantia nigra (sn). |
2020-05-14 |
2023-08-13 |
mouse |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
tyrosine hydroxylase staining showed that the hfd resulted in fewer dopaminergic neurons in the substantia nigra (sn), but not the striatum. |
2020-05-14 |
2023-08-13 |
mouse |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
dendritic spine density in the sn of hfd-exposed mice decreased, which suggested that prolonged hfd altered dopaminergic neuroplasticity. |
2020-05-14 |
2023-08-13 |
mouse |
| Katarzyna Z Kuter, Łukasz Olech, Norbert A Denche. Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. Mitochondrion. vol 47. 2020-04-27. PMID:30578987. |
partial degeneration of dopaminergic neurons in the substantia nigra (sn), induces locomotor disability in animals but with time it is spontaneously compensated for by neurons surviving in the tissue by increasing their functional efficiency. |
2020-04-27 |
2023-08-13 |
rat |
| Katarzyna Z Kuter, Łukasz Olech, Norbert A Denche. Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. Mitochondrion. vol 47. 2020-04-27. PMID:30578987. |
we studied the effect of degeneration of dopaminergic neurons induced by the selective toxin 6-hydroxydopamine and/or death of 30% of astrocytes induced by chronic infusion of the glial toxin fluorocitrate on functioning of the mitochondrial electron transfer chain (etc) complexes (cxs) i, ii, iv and their higher assembled forms, supercomplexes in the rat sn. |
2020-04-27 |
2023-08-13 |
rat |
| Katarzyna Z Kuter, Łukasz Olech, Norbert A Denche. Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. Mitochondrion. vol 47. 2020-04-27. PMID:30578987. |
after death of 50% of dopaminergic neurons in the sn, we observed increased mitochondrial cxs performing, especially cx i and iv in the remaining cells. |
2020-04-27 |
2023-08-13 |
rat |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2020-04-14. PMID:32002951. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2020-04-14 |
2023-08-13 |
Not clear |
| Ankita Ravi Vaswani, Beatrice Weykopf, Cathleen Hagemann, Hans-Ulrich Fried, Oliver Brüstle, Sandra Blaes. Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons. eLife. vol 8. 2020-04-10. PMID:30689541. |
midbrain dopaminergic (mda) neurons migrate to form the laterally-located substantia nigra pars compacta (sn) and medially-located ventral tegmental area (vta), but little is known about the underlying cellular and molecular processes. |
2020-04-10 |
2023-08-13 |
Not clear |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the reduction of dopamine levels in the striatum. |
2020-04-07 |
2023-08-13 |
mouse |
| Meena Kishore Sakharkar, Sarinder Kaur Kashmir Singh, Karthic Rajamanickam, Musthafa Mohamed Essa, Jian Yang, Saravana Babu Chidambara. A systems biology approach towards the identification of candidate therapeutic genes and potential biomarkers for Parkinson's disease. PloS one. vol 14. issue 9. 2020-03-11. PMID:31487305. |
it involves progressive loss of mid brain dopaminergic neurons in the substantia nigra pars compacta (sn). |
2020-03-11 |
2023-08-13 |
Not clear |
| Shun Zhang, Rui Wang, Guanghui Wan. Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30592597. |
the characteristic feature of pd is the progressive degeneration of the dopaminergic (daergic) neurons in the substantia nigra (sn). |
2020-02-26 |
2023-08-13 |
mouse |
| Mehmet Bülbül, Osman Sinen, Ayşe Özkan, Mutay Aydın Aslan, Aysel Ağa. Central neuropeptide-S treatment improves neurofunctions of 6-OHDA-induced Parkinsonian rats. Experimental neurology. vol 317. 2020-02-26. PMID:30825442. |
parkinson's disease (pd) is characterized by degeneration of the dopaminergic neurons in substantia nigra (sn). |
2020-02-26 |
2023-08-13 |
rat |