| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabeth G Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz, Barbara Steine. Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29803225. |
parkinson's disease (pd) is characterized by dopaminergic cell loss and inflammation in the substantia nigra (sn) leading to motor deficits but also to hippocampus-associated non-motor symptoms such as spatial learning and memory deficits. |
2019-04-08 |
2023-08-13 |
mouse |
| Fangfang Dou, Xinkun Chu, Bei Zhang, Liang Liang, Guoqiang Lu, Jianqing Ding, Shengdi Che. EriB targeted inhibition of microglia activity attenuates MPP Molecular brain. vol 11. issue 1. 2019-04-01. PMID:30563578. |
with the progressive and selective degeneration of dopaminergic (da) neurons, proinflammatory cytokines are elevated in the substantia nigra (sn) of pd patients. |
2019-04-01 |
2023-08-13 |
mouse |
| Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Denche. Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26844379. |
in parkinson's disease (pd) motor symptoms are not observed until loss of 70% of dopaminergic neurons in substantia nigra (sn), preventing early diagnosis. |
2019-03-28 |
2023-08-13 |
rat |
| Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Denche. Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26844379. |
we observed loss of dopaminergic phenotype in sn and decreased dopamine level in striatum (str) before actual death of neurons in sn. |
2019-03-28 |
2023-08-13 |
rat |
| Baihui Huang, Shihao Wu, Zhengbo Wang, Longjiao Ge, Joshua D Rizak, Jing Wu, Jiali Li, Lin Xu, Longbao Lv, Yong Yin, Xintian Hu, Hao L. Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. Neuroscience. vol 379. 2019-03-18. PMID:29592843. |
double-labeling immunofluorescence found some th-positive neurons to be co-localized with p-ser129 α-syn in the sn, suggesting the inverse correlation between p-ser 129 α-syn aggregations and dopaminergic cell loss in the sn may represent an interactive association related to the progression of the pd symptoms in the model. |
2019-03-18 |
2023-08-13 |
monkey |
| Juciano Gasparotto, Camila Tiefensee Ribeiro, Rafael Calixto Bortolin, Nauana Somensi, Thallita Kelly Rabelo, Alice Kunzler, Natália Cabral Souza, Matheus Augusto de Bittencourt Pasquali, José Claudio Fonseca Moreira, Daniel Pens Gelai. Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28821831. |
our results demonstrate that rage is an essential component in the neuroinflammation and dopaminergic denervation induced by 6-ohda in the sn. |
2019-03-15 |
2023-08-13 |
rat |
| Mohammad Raziya Banu, Muhammed Ibrahim, K Prabhu, Srinivasagam Rajasanka. Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat. Pharmacology. vol 103. issue 3-4. 2019-03-14. PMID:30544122. |
this study is the first report that evidently determines the neuro-protective efficacy of wa on dopaminergic system of sn and st in aged rats. |
2019-03-14 |
2023-08-13 |
rat |
| Ziyi Wang, Ping Kuang, Yuying Lin, Weitang Liu, Wenwen Lao, Yonghua Ji, Hongyan Zh. Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. Neuroscience letters. vol 687. 2019-03-07. PMID:30267849. |
furthermore, nav1.3 was not only expressed in th-positive dopaminergic neurons of the ipsilateral and contralateral sn, but also in nestin-positive neural progenitor cells surrounding the ipsilateral sn and the midline region adjacent to the ipsilateral sn in the midbrain at 49 days postlesion. |
2019-03-07 |
2023-08-13 |
rat |
| Ziyi Wang, Ping Kuang, Yuying Lin, Weitang Liu, Wenwen Lao, Yonghua Ji, Hongyan Zh. Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. Neuroscience letters. vol 687. 2019-03-07. PMID:30267849. |
these results suggested that the re-expression of nav1.3 may influence the electrical activity of dopaminergic neurons in the sn in 6-ohda lesioned rats. |
2019-03-07 |
2023-08-13 |
rat |
| Qian Zhang, Chengwu Li, Ting Zhang, Yaping Ge, Xiaojuan Han, Sifan Sun, Jianhua Ding, Ming Lu, Gang H. Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD. Molecular and cellular neurosciences. vol 92. 2019-03-05. PMID:30171894. |
k-atp channels in mature substantia nigra (sn) dopaminergic (da) neurons are composed of inwardly rectifying potassium channel (kir) subunit 6.2 and sulfonylurea receptor 1 (sur1). |
2019-03-05 |
2023-08-13 |
mouse |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowack. Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28466266. |
progressive degeneration of dopaminergic neurons in the substantia nigra (sn) is the underlying cause of parkinson's disease (pd). |
2019-02-26 |
2023-08-13 |
rat |
| Eugene L Boshoff, Edward J R Fletcher, Susan Dut. Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner. Neuropharmacology. vol 137. 2019-02-20. PMID:29698669. |
we set out to examine whether manipulation of the fgf20 system affected nigrostriatal tract integrity in rats, to identify which fibroblast growth factor receptors (fgfrs) might reside on dopaminergic neurons and to discover the source of endogenous fgf20 in the substantia nigra (sn). |
2019-02-20 |
2023-08-13 |
human |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
following 8 months of tce treatment, there was a progressive and selective loss of 50% of the dopaminergic neurons in mouse substantia nigra (sn) and about 50% loss of dopamine and 72% loss of 3,4-dihydroxyphenylacetic acid in the striatum, respectively. |
2019-02-04 |
2023-08-13 |
mouse |
| Won Sik Eum, Min Jea Shin, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Duk-Soo Kim, Oh Shin Kwon, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Dae Won Kim, Soo Young Cho. Neuroprotective effects of Tat-ATOX1 protein against MPP Biochimie. vol 156. 2019-01-09. PMID:30352250. |
neuroprotective effects of tat-atox1 protein against mpp parkinson's disease (pd), a neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra (sn) of the brain and it is well known that the pathogenesis of pd is related to a number of risk factors including oxidative stress. |
2019-01-09 |
2023-08-13 |
Not clear |
| Ying Jiang, Zhentang Cao, Huizi Ma, Guihong Wang, Xuemei Wang, Zhan Wang, Yaqin Yang, Huiqing Zhao, Genliang Liu, Longling Li, Tao Fen. Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson's Disease. Neurochemical research. vol 43. issue 11. 2018-12-19. PMID:30311182. |
the aim of this study was to evaluate the effects of auricular vagus nerve stimulation (avns) on substantia nigra (sn) dopaminergic neurodegeneration and the associated neuroinflammation and immune responses in a rat pd model. |
2018-12-19 |
2023-08-13 |
rat |
| Yan Zhou, Jialei Zhu, Yang Lv, Chenghuan Song, Jianhua Ding, Ming Xiao, Ming Lu, Gang H. Kir6.2 Deficiency Promotes Mesencephalic Neural Precursor Cell Differentiation via Regulating miR-133b/GDNF in a Parkinson's Disease Mouse Model. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29564810. |
the loss of dopaminergic (da) neurons in the substantia nigra (sn) is a major feature in the pathology of parkinson's disease (pd). |
2018-12-17 |
2023-08-13 |
mouse |
| Jeongah Kim, Sangwon Jang, Mijung Choi, Sooyoung Chung, Youngshik Choe, Han Kyoung Choe, Gi Hoon Son, Kunsoo Rhee, Kyungjin Ki. Abrogation of the Circadian Nuclear Receptor REV-ERBα Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration. Molecules and cells. vol 41. issue 8. 2018-12-17. PMID:30078232. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (daergic) neurons, particularly in the substantia nigra (sn). |
2018-12-17 |
2023-08-13 |
mouse |
| Debashis Dutta, Nilufar Ali, Emili Banerjee, Raghavendra Singh, Amit Naskar, Ramesh Kumar Paidi, Kochupurackal P Mohanakuma. Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson's Disease. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28062948. |
since substantia nigra (sn) and ventral tegmental area (vta) dopaminergic neurons are, respectively, susceptible or largely unaffected in parkinson's disease (pd), we searched for protein(s) that regulates this differential sensitivity. |
2018-12-11 |
2023-08-13 |
mouse |
| Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Li. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-11-26. PMID:30157869. |
in parkinson's disease (pd), loss of striatal dopaminergic (da) terminals and degeneration of da neurons in the substantia nigra (sn) are associated with inflammation. |
2018-11-26 |
2023-08-13 |
Not clear |
| Yi-Ting Wang, Hui-Ching Lin, Wei-Zhong Zhao, Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang, Anya Maan-Yuh Li. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific reports. vol 7. 2018-11-16. PMID:28401906. |
in the present study, acrolein-induced neurotoxicity in the nigrostriatal dopaminergic system was investigated by local infusion of acrolein (15, 50, 150 nmoles/0.5 μl) in the sn of sprague-dawley rats. |
2018-11-16 |
2023-08-13 |
rat |