| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopass. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042097. |
parkinson's disease (pd) is a neurodegenerative condition caused by age-related death of dopaminergic (da) neurons in the substantia nigra (sn). |
2018-02-22 |
2023-08-13 |
mouse |
| Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopass. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042097. |
these double-mutant 'twinkpark' mice had 1, the highest mtdna deletion concentration in sn; 2, the lowest mitochondrial function and membrane potential; 3, the most severe neurobehavioral deficits at 19months; 4, the least dopaminergic neurons in the sn and lowest dopamine levels, i.e. |
2018-02-22 |
2023-08-13 |
mouse |
| A D Surowka, M Töpperwien, M Bernhardt, J D Nicolas, M Osterhoff, T Salditt, D Adamek, M Szczerbowska-Boruchowsk. Combined in-situ imaging of structural organization and elemental composition of substantia nigra neurons in the elderly. Talanta. vol 161. 2018-02-07. PMID:27769419. |
human dopaminergic system in general, and substantia nigra (sn) neurons, in particular, are implicated in the pathologies underlying the human brain aging. |
2018-02-07 |
2023-08-13 |
human |
| Megan E Straley, Wesley Van Oeffelen, Sarah Theze, Aideen M Sullivan, Siobhain M O'Mahony, John F Cryan, Gerard W O'Keeff. Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:27266391. |
mesodiencephalic dopaminergic neurons in the ventral tegmental area (vta) regulate motivation and reward, whereas those in the substantia nigra (sn) are essential for motor control. |
2018-01-30 |
2023-08-13 |
rat |
| Megan E Straley, Wesley Van Oeffelen, Sarah Theze, Aideen M Sullivan, Siobhain M O'Mahony, John F Cryan, Gerard W O'Keeff. Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:27266391. |
defective vta dopaminergic transmission has been implicated in schizophrenia, drug addiction and depression whereas dopaminergic neurons in the sn are lost in parkinson's disease. |
2018-01-30 |
2023-08-13 |
rat |
| Linde Boekhoudt, Azar Omrani, Mieneke C M Luijendijk, Inge G Wolterink-Donselaar, Ellen C Wijbrans, Geoffrey van der Plasse, Roger A H Ada. Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 11. 2018-01-26. PMID:27712862. |
these results show a clear functional difference between neuronal subpopulations in the vta and sn with regards to inducing locomotor hyperactivity, and suggest that the dopaminergic pathway from vta to nac may be a promising target for the treatment of hyperactivity disorders. |
2018-01-26 |
2023-08-13 |
rat |
| Yannick Vermeiren, Peter P De Dey. Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story. Neurochemistry international. vol 102. 2018-01-25. PMID:27899296. |
for almost half a century, the motor aspects have been attributed to lewy pathology (lp) predominantly in the substantia nigra (sn), causing a major loss of dopaminergic neurons. |
2018-01-25 |
2023-08-13 |
Not clear |
| Yannick Vermeiren, Peter P De Dey. Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story. Neurochemistry international. vol 102. 2018-01-25. PMID:27899296. |
moreover, norepinephrinergic neurons directly innervate the sn, and, lc lesioning causes more severe dopaminergic cell loss and supplementary motor manifestations, as shown in preclinical research. |
2018-01-25 |
2023-08-13 |
Not clear |
| Sean L Hammond, Ashley N Leek, Evan H Richman, Ronald B Tjalken. Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. PloS one. vol 12. issue 12. 2018-01-08. PMID:29244806. |
because aav-mediated transgene expression is of interest in neurodegenerative diseases such as parkinson's disease, we examined the sn with microscopy techniques, such as clarity tissue transmutation, to identify aav serotypes that resulted in optimal transgene expression in either astrocytes or dopaminergic neurons. |
2018-01-08 |
2023-08-13 |
mouse |
| Kirsten E Schoonover, Lesley A McCollum, Rosalinda C Robert. Protein Markers of Neurotransmitter Synthesis and Release in Postmortem Schizophrenia Substantia Nigra. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550734. |
the substantia nigra (sn) provides the largest dopaminergic input to the brain, projects to the striatum (the primary locus of action for antipsychotic medication), and receives gabaergic and glutamatergic inputs. |
2018-01-05 |
2023-08-13 |
human |
| Ping-Yue Pan, Xianting Li, Jing Wang, James Powell, Qian Wang, Yuanxi Zhang, Zhaoyu Chen, Bridget Wicinski, Patrick Hof, Timothy A Ryan, Zhenyu Yu. Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 47. 2017-12-04. PMID:29054882. |
parkinson's disease (pd) is characterized pathologically by the selective loss of substantia nigra (sn) dopaminergic (daergic) neurons. |
2017-12-04 |
2023-08-13 |
Not clear |
| Inga B Fricke, Thomas Viel, Maik M Worlitzer, Franziska M Collmann, Alexis Vrachimis, Andreas Faust, Lydia Wachsmuth, Cornelius Faber, Frédéric Dollé, Michael T Kuhlmann, Klaus Schäfers, Sven Hermann, Jens C Schwamborn, Andreas H Jacob. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. The European journal of neuroscience. vol 43. issue 10. 2017-11-16. PMID:26950181. |
parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (sn), leading to severe impairment in motor and non-motor functions. |
2017-11-16 |
2023-08-13 |
mouse |
| Inga B Fricke, Thomas Viel, Maik M Worlitzer, Franziska M Collmann, Alexis Vrachimis, Andreas Faust, Lydia Wachsmuth, Cornelius Faber, Frédéric Dollé, Michael T Kuhlmann, Klaus Schäfers, Sven Hermann, Jens C Schwamborn, Andreas H Jacob. 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. The European journal of neuroscience. vol 43. issue 10. 2017-11-16. PMID:26950181. |
we found that activation of microglia in the sn is an acute process accompanying the degeneration of dopaminergic cell bodies in the sn. |
2017-11-16 |
2023-08-13 |
mouse |
| Kyung Moon Lee, Yujeong Lee, Hye Jeong Chun, Ah Hyun Kim, Ju Yeon Kim, Joo Yeon Lee, Akihito Ishigami, Jaewon Le. Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27265894. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn). |
2017-11-03 |
2023-08-13 |
mouse |
| Kyung Moon Lee, Yujeong Lee, Hye Jeong Chun, Ah Hyun Kim, Ju Yeon Kim, Joo Yeon Lee, Akihito Ishigami, Jaewon Le. Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27265894. |
in the mouse model, morin pretreatment ameliorated motor dysfunction, protected against dopaminergic neuronal losses in sn and striatum, and alleviated mptp-induced astrocyte activation. |
2017-11-03 |
2023-08-13 |
mouse |
| J Gao, X-Y Kang, S Sun, L Li, B-L Zhang, Y-Q Li, D-S Ga. Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression. Cell death & disease. vol 7. 2017-10-31. PMID:27148690. |
glial cell line-derived neurotrophic factor (gdnf) has strong neuroprotective and neurorestorative effects on dopaminergic (da) neurons in the substantia nigra (sn); however, the underlying molecular mechanisms remain to be fully elucidated. |
2017-10-31 |
2023-08-13 |
Not clear |
| Merja H Voutilainen, Francesca De Lorenzo, Polina Stepanova, Susanne Bäck, Li-Ying Yu, Päivi Lindholm, Eeva Pörsti, Mart Saarma, Pekka T Männistö, Raimo K Tuomine. Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action. eNeuro. vol 4. issue 1. 2017-10-31. PMID:28303260. |
parkinson's disease (pd) is a neurodegenerative disorder associated with a progressive loss of dopaminergic (daergic) neurons of the substantia nigra (sn) and the accumulation of intracellular inclusions containing α-synuclein. |
2017-10-31 |
2023-08-13 |
rat |
| Ting-Ting Huang, Dong-Lin Hao, Bo-Na Wu, Lun-Lin Mao, Jin Zhan. Uric acid demonstrates neuroprotective effect on Parkinson's disease mice through Nrf2-ARE signaling pathway. Biochemical and biophysical research communications. vol 493. issue 4. 2017-10-30. PMID:28986252. |
we showed that uric acid improved behavioral performances and cognition of pd mice, increased th-positive dopaminergic neurons and decreased gfap-positive astrocytes in substantia nigra (sn). |
2017-10-30 |
2023-08-13 |
mouse |
| Chi Wang Ip, Laura-Christin Klaus, Akua A Karikari, Naomi P Visanji, Jonathan M Brotchie, Anthony E Lang, Jens Volkmann, James B Kopric. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28143577. |
aav1/2-driven overexpression of human mutated a53t-α-synuclein in rat and monkey substantia nigra (sn) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (th). |
2017-10-25 |
2023-08-13 |
mouse |
| Hyein Kim, Hojin Kang, Yunjong Lee, Chi-Hu Park, Areum Jo, Rin Khang, Joo-Ho Shi. Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and biophysical research communications. vol 493. issue 2. 2017-10-23. PMID:28939041. |
the overexpression of paris selectively leads to the loss of dopaminergic neurons (dn) and mitochondrial abnormalities in the substantia nigra (sn) of parkinson's disease (pd) models. |
2017-10-23 |
2023-08-13 |
mouse |