| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaming Liu, Fangyan Wang, Suzhi Liu, Jimei Du, Xuezhen Hu, Jiaojiao Xiong, Renchi Fang, Wenqian Chen, Jing Su. Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1. Journal of the neurological sciences. vol 381. 2018-06-11. PMID:28991675. |
dopaminergic degeneration was evaluated by western blot and immunohistochemistry of tyrosine hydroxylase (th) in the sn. |
2018-06-11 |
2023-08-13 |
mouse |
| Poonam Thakur, Ludivine S Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C Luk, Virginia M Y Lee, John Q Trojanowski, Anders Björklun. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 39. 2018-06-05. PMID:28900002. |
this synucleinopathy was fully developed already 10 days after fibril injection, accompanied by progressive degeneration of dopaminergic neurons in sn, neuritic swelling, reduced striatal da release, and impaired motor behavior. |
2018-06-05 |
2023-08-13 |
human |
| Antonio Martin-Bastida, Sara Pietracupa, Paola Piccin. Neuromelanin in parkinsonian disorders: an update. The International journal of neuroscience. vol 127. issue 12. 2018-06-04. PMID:28460588. |
the melanized dopaminergic neurons in sn and lc seem to have special vulnerability to neurodegeneration in parkinson's disease (pd). |
2018-06-04 |
2023-08-13 |
Not clear |
| Sujung Yeo, Backil Sung, Yeon-Mi Hong, Maurits van den Noort, Peggy Bosch, Sook-Hyun Lee, Jongbeom Song, Sang-Kyun Park, Sabina Li. Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. Gene. vol 661. 2018-05-30. PMID:29604467. |
parkinson's disease (pd) is a chronically progressive neurodegenerative disease, with its main pathological hallmarks being a dramatic loss of dopaminergic neurons predominantly in the substantia nigra (sn), and the formations of intracytoplasmic lewy bodies and dystrophic neurites. |
2018-05-30 |
2023-08-13 |
mouse |
| Sujung Yeo, Backil Sung, Yeon-Mi Hong, Maurits van den Noort, Peggy Bosch, Sook-Hyun Lee, Jongbeom Song, Sang-Kyun Park, Sabina Li. Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. Gene. vol 661. 2018-05-30. PMID:29604467. |
to examine what causes α-syn expression to increase, we analyzed the pattern of gene expression in the sn of mice intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), where down-regulation of dopaminergic cells occurred. |
2018-05-30 |
2023-08-13 |
mouse |
| Sujung Yeo, Backil Sung, Yeon-Mi Hong, Maurits van den Noort, Peggy Bosch, Sook-Hyun Lee, Jongbeom Song, Sang-Kyun Park, Sabina Li. Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. Gene. vol 661. 2018-05-30. PMID:29604467. |
the results of western blot analyses showed that, together with the down-regulation of dopaminergic cells, the decrease in sgk1 expression increased α-syn expression in the sn in a chronic mptp-induced parkinsonism mouse. |
2018-05-30 |
2023-08-13 |
mouse |
| Sujung Yeo, Backil Sung, Yeon-Mi Hong, Maurits van den Noort, Peggy Bosch, Sook-Hyun Lee, Jongbeom Song, Sang-Kyun Park, Sabina Li. Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. Gene. vol 661. 2018-05-30. PMID:29604467. |
these results suggest that decreased expression of sgk1 may play a critical role in increasing the expression of α-syn, which is related with dopaminergic cell death in the sn of chronic mptp-induced parkinsonism mice and in sh-sy5y cells. |
2018-05-30 |
2023-08-13 |
mouse |
| Wei-Lan Yin, Wei-Guo Yin, Bai-Sheng Huang, Li-Xiang W. Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats. Neuroscience letters. vol 657. 2018-05-28. PMID:28764908. |
parkinson's disease (pd) is age-related neurodegenerative disorder by a progressive loss of dopaminergic(da) neurons in the substantia nigra (sn) and striatum, which is at least partly associated with α-synuclein protein accumulation in these neurons. |
2018-05-28 |
2023-08-13 |
rat |
| XiaoLong Hu, Qi Song, Xin Li, DanDan Li, Qiao Zhang, WeiHong Meng, QingChun Zha. Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson's model through apoptosis inhibition and autophagy enhancement. Neuropharmacology. vol 117. 2018-05-03. PMID:28238714. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in substantia nigra (sn). |
2018-05-03 |
2023-08-13 |
Not clear |
| Jaung-Geng Lin, Chao-Jung Chen, Han-Bin Yang, Yi-Hung Chen, Shih-Ya Hun. Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28837077. |
the pathological hallmark of pd is a progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta in the brain, ultimately resulting in severe striatal dopamine deficiency and the development of primary motor symptoms (e.g., resting tremor, bradykinesia) in pd. |
2018-05-03 |
2023-08-13 |
mouse |
| Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shi. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28611284. |
the widely prescribed anti-diabetic medicine metformin is effective in preventing neurodegeneration in animal models; however, despite the significant potential of metformin for treating pd, the therapeutic effects and molecular mechanisms underlying dopaminergic neuroprotection by metformin are largely unknown.in this study, we found that metformin induced substantial proteomic changes, especially in metabolic and mitochondrial pathways in the substantia nigra (sn). |
2018-04-23 |
2023-08-13 |
Not clear |
| Yoon-Mi Oh, Fuyuki Karube, Susumu Takahashi, Kenta Kobayashi, Masahiko Takada, Motokazu Uchigashima, Masahiko Watanabe, Kayo Nishizawa, Kazuto Kobayashi, Fumino Fujiyam. Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations. Brain structure & function. vol 222. issue 5. 2018-04-17. PMID:27995326. |
the present study aimed to identify the characteristic projection patterns of pv neurons in the gp (pv-gp neurons) and determine whether these neurons target dopaminergic or gabaergic neurons in sn pars compacta (snc) or reticulata (snr), respectively. |
2018-04-17 |
2023-08-13 |
rat |
| Xingzhi Guo, Tingting Liu, Diandian Zhao, Xiaofeng Wang, Dongmei Liu, Yang He, Chang Shan, Yingying Kong, Weiwei Hu, Bei Tao, Lihao Sun, Hongyan Zhao, Shengtian Li, Jianmin Li. FGF18 protects against 6-hydroxydopamine-induced nigrostriatal damage in a rat model of Parkinson's disease. Neuroscience. vol 356. 2018-04-12. PMID:28504195. |
dopaminergic neuronal injury in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd). |
2018-04-12 |
2023-08-13 |
rat |
| Xingzhi Guo, Tingting Liu, Diandian Zhao, Xiaofeng Wang, Dongmei Liu, Yang He, Chang Shan, Yingying Kong, Weiwei Hu, Bei Tao, Lihao Sun, Hongyan Zhao, Shengtian Li, Jianmin Li. FGF18 protects against 6-hydroxydopamine-induced nigrostriatal damage in a rat model of Parkinson's disease. Neuroscience. vol 356. 2018-04-12. PMID:28504195. |
since fibroblast growth factor 18 (fgf18) is involved in midbrain development and has been reported to protect neurons from ischemic injury, we investigated whether fgf18 exerted a protective effect on dopaminergic neurons in the sn. |
2018-04-12 |
2023-08-13 |
rat |
| Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Christopher Simon, Quan Fu Gan, Vui King Vincent-Chong, Vasudevan Mani, Kesavanarayanan Krishnan Selvarajan, Vellayan Subramaniam, Sabri Musa, Noor Hayaty Abu Kasi. Effect of dental pulp stem cells in MPTP-induced old-aged mice model. European journal of clinical investigation. vol 47. issue 6. 2018-03-26. PMID:28369799. |
parkinson's disease (pd) is a neurodegenerative disease caused by the loss of dopaminergic (da-ergic) neurons in the substantia nigra (sn) and represented as a huge threat to the geriatric population. |
2018-03-26 |
2023-08-13 |
mouse |
| Nadya Pyatigorskaya, Rahul Gaurav, Dario Arnaldi, Smaranda Leu-Semenescu, Lydia Yahia-Cherif, Romain Valabregue, Marie Vidailhet, Isabelle Arnulf, Stephane Lehéric. Magnetic Resonance Imaging Biomarkers to Assess Substantia Nigra Damage in Idiopathic Rapid Eye Movement Sleep Behavior Disorder. Sleep. vol 40. issue 11. 2018-03-26. PMID:28958075. |
at pd onset, 40 to 70% of the dopaminergic neurons in the substantia nigra (sn) are already lost. |
2018-03-26 |
2023-08-13 |
human |
| M Q Xie, Z C Chen, P Zhang, H J Huang, T T Wang, Y-Q Ding, S S Qi, C Zhang, S X Chen, P Zhou, C C Shao, M Liao, C Y Su. Newborn dopaminergic neurons are associated with the migration and differentiation of SVZ-derived neural progenitors in a 6-hydroxydopamin-injected mouse model. Neuroscience. vol 352. 2018-03-05. PMID:28385636. |
to assess the regenerative/neurogenic capacity of npcs following an intranigral injection of 6-hydroxydopamine (6-ohda), the proliferation and differentiation of subventricular zone (svz)- and midbrain-derived npcs were investigated, and the origin of sn newborn dopaminergic neurons was traced by using nestin-creer |
2018-03-05 |
2023-08-13 |
mouse |
| Qing Gao, Zhou Ou, Teng Jiang, You-Yong Tian, Jun-Shan Zhou, Liang Wu, Jian-Quan Shi, Ying-Dong Zhan. Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson's disease. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28445961. |
loss of dopaminergic neurons within the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd), which leads to the onset of motor symptoms. |
2018-03-05 |
2023-08-13 |
rat |
| Qing Gao, Zhou Ou, Teng Jiang, You-Yong Tian, Jun-Shan Zhou, Liang Wu, Jian-Quan Shi, Ying-Dong Zhan. Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson's disease. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28445961. |
furthermore, we provided in vivo evidence that ang ii directly elicited apoptosis of dopaminergic neurons via activation of at1r in the sn of rats. |
2018-03-05 |
2023-08-13 |
rat |
| Xiaofei Zhao, Jun Wang, Song Hu, Renping Wang, Yongjun Mao, Junxia Xi. Neuroprotective effect of resveratrol on rotenone-treated C57BL/6 mice. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28471847. |
the aim of the present study was to investigate whether resveratrol could reduce nigral iron levels to prevent the degeneration of dopaminergic neurons in the substantia nigra (sn) of c57bl/6 mice induced by rotenone. |
2018-03-05 |
2023-08-13 |
mouse |