| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Ting Wang, Hui-Ching Lin, Wei-Zhong Zhao, Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang, Anya Maan-Yuh Li. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific reports. vol 7. 2018-11-16. PMID:28401906. |
acrolein-induced neurodegeneration of nigrostriatal dopaminergic system was delineated by reductions in tyrosine hydroxylase (th) levels, dopamine transporter levels and th-positive neurons in the infused sn as well as in striatal dopamine content. |
2018-11-16 |
2023-08-13 |
rat |
| Yi-Ting Wang, Hui-Ching Lin, Wei-Zhong Zhao, Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang, Anya Maan-Yuh Li. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific reports. vol 7. 2018-11-16. PMID:28401906. |
compared with well-known parkinsonian neurotoxins, including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and rotenone which do not exist in the sn of pd patients, our in vivo study shows that acrolein acts as a parkinsonian neurotoxin in the nigrostriatal dopaminergic system of rat brain. |
2018-11-16 |
2023-08-13 |
rat |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30138818. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2018-11-16 |
2023-08-13 |
Not clear |
| Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Che. Abnormal ventral tegmental area-anterior cingulate cortex connectivity in Parkinson's disease with depression. Behavioural brain research. vol 347. 2018-11-05. PMID:29530489. |
the present study used resting-state fmri and seed-based functional connectivity of putative dopaminergic midbrain regions (i.e., substantia nigra (sn) and ventral tegmental area (vta)) to investigate the circuit-related abnormalities in pd with depression. |
2018-11-05 |
2023-08-13 |
Not clear |
| Yuyan Tan, Elaine Delvaux, Jennifer Nolz, Paul D Coleman, Shengdi Chen, Diego Mastroen. Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease. Neurobiology of aging. vol 68. 2018-10-16. PMID:29803514. |
these data provide evidence that selective inhibition of hdac2 in pd sn microglia could be a promising approach to treat microglial-initiated nigral dopaminergic neuronal cell loss in pd. |
2018-10-16 |
2023-08-13 |
human |
| Mohammed Abdel-Rahman, Rania A Galhom, Wael Amin Nasr El-Din, Mona H Mohammed Ali, Alaa El-Din Saad Abdel-Hami. Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29864896. |
rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (sn) of midbrain producing parkinsonism. |
2018-10-15 |
2023-08-13 |
rat |
| Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng F. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences. vol 19. issue 1. 2018-08-20. PMID:29267220. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn). |
2018-08-20 |
2023-08-13 |
rat |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (sn) and may in fact initiate the loss of dopaminergic neurons within the sn. |
2018-08-16 |
2023-08-13 |
mouse |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
we demonstrated that chronic stress was associated with a clear loss of dopaminergic neurons within the sn. |
2018-08-16 |
2023-08-13 |
mouse |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
collectively, these results reinforce the negative effects of chronic stress on the viability of dopaminergic cells within the sn. |
2018-08-16 |
2023-08-13 |
mouse |
| Sara Pietracupa, Antonio Martin-Bastida, Paola Piccin. Iron metabolism and its detection through MRI in parkinsonian disorders: a systematic review. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue 12. 2018-08-07. PMID:28866787. |
whether iron overload leads to dopaminergic neuronal death in the sn of pd patients or is instead simply a by-product of the neurodegenerative progression is still yet to be ascertained. |
2018-08-07 |
2023-08-13 |
Not clear |
| Vedad Delic, Jeddidiah W D Griffin, Sandra Zivkovic, Yumeng Zhang, Tam-Anh Phan, Henry Gong, Dale Chaput, Christian Reynes, Vinh B Dinh, Josean Cruz, Eni Cvitkovic, Devon Placides, Ernide Frederic, Hamed Mirzaei, Stanley M Stevens, Umesh Jinwal, Daniel C Lee, Patrick C Bradsha. Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28620826. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2018-08-06 |
2023-08-13 |
human |
| Qing Ye, Xiaolei Yuan, Jie Zhou, Canxing Yuan, Xuming Yan. Effect of Zishenpingchan granule prepared from Chinese medicinal substances on the c-Jun N-terminal protein kinase pathway in micewith Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 37. issue 2. 2018-07-31. PMID:29960635. |
to investigate the regulatory mechanism of the c-jun n-terminal protein kinase (jnk)signaling pathway in substantia nigra (sn) dopaminergic neurons inflammation and apoptosis, andthe neuroprotective effect of zishenpingchan granules in mice with parkinson's disease (pd) inducedby 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2018-07-31 |
2023-08-13 |
mouse |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
furthermore, after chronic agonist treatment, we observed reduced cb1r binding and mrna levels in sn and striatum, providing evidence for a possible regulatory role of the endocannabinoid system on dopaminergic function. |
2018-07-27 |
2023-08-13 |
rat |
| Ori J Lieberman, Se Joon Choi, Ellen Kanter, Anastasia Saverchenko, Micah D Frier, Giulia M Fiore, Min Wu, Jyothisri Kondapalli, Enrico Zampese, D James Surmeier, David Sulzer, Eugene V Mosharo. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. vol 4. issue 6. 2018-07-25. PMID:29177188. |
α-synuclein-dependent calcium entry underlies differential sensitivity of cultured sn and vta dopaminergic neurons to a parkinsonian neurotoxin. |
2018-07-25 |
2023-08-13 |
mouse |
| Ori J Lieberman, Se Joon Choi, Ellen Kanter, Anastasia Saverchenko, Micah D Frier, Giulia M Fiore, Min Wu, Jyothisri Kondapalli, Enrico Zampese, D James Surmeier, David Sulzer, Eugene V Mosharo. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. vol 4. issue 6. 2018-07-25. PMID:29177188. |
parkinson's disease (pd) is a debilitating neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra (sn). |
2018-07-25 |
2023-08-13 |
mouse |
| Ori J Lieberman, Se Joon Choi, Ellen Kanter, Anastasia Saverchenko, Micah D Frier, Giulia M Fiore, Min Wu, Jyothisri Kondapalli, Enrico Zampese, D James Surmeier, David Sulzer, Eugene V Mosharo. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. vol 4. issue 6. 2018-07-25. PMID:29177188. |
although mitochondrial dysfunction and dysregulated α-synuclein (asyn) expression are postulated to play a role in pd pathogenesis, it is still debated why neurons of the sn are targeted while neighboring dopaminergic neurons of the ventral tegmental area (vta) are spared. |
2018-07-25 |
2023-08-13 |
mouse |
| Caroline Cristiano Real, Priscila Crespo Garcia, Luiz R G Britt. Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson's Disease Model. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28801819. |
parkinson's disease (pd) involves loss of dopaminergic neurons in the substantia nigra (sn), which can be correlated to neuroinflammatory changes with the aging of the nervous system. |
2018-06-27 |
2023-08-13 |
rat |
| Caroline Cristiano Real, Priscila Crespo Garcia, Luiz R G Britt. Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson's Disease Model. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28801819. |
seven and 30 days after surgery, brains were collected for immunohistochemistry and immunoblotting for dopaminergic and neuroinflammatory markers into sn and striatum. |
2018-06-27 |
2023-08-13 |
rat |
| Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P Manfredsson, Matthew J Benskey, Xuebing Cao, Jun Xu, Yi E Sun, Keqiang Y. TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 40. 2018-06-26. PMID:28923922. |
bdnf/trkb neurotrophic signaling is essential for dopaminergic neuronal survival, and the activities are reduced in the substantial nigra (sn) of parkinson's disease (pd). |
2018-06-26 |
2023-08-13 |
Not clear |