| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sujung Yeo, Jongbeom Song, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. Advances in experimental medicine and biology. vol 1232. 2020-01-08. PMID:31893437. |
parkinson's disease, a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2020-01-08 |
2023-08-13 |
mouse |
| Sujung Yeo, Jongbeom Song, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. Advances in experimental medicine and biology. vol 1232. 2020-01-08. PMID:31893437. |
acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the sn in parkinsonism animal models. |
2020-01-08 |
2023-08-13 |
mouse |
| Sujung Yeo, Jongbeom Song, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. Advances in experimental medicine and biology. vol 1232. 2020-01-08. PMID:31893437. |
we investigated the role of acupuncture in inhibiting the increase in α-syn expression that is related to dopaminergic cell loss in the sn in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) parkinsonism mouse model. |
2020-01-08 |
2023-08-13 |
mouse |
| Edson Bor-Seng-Shu, Fernando M Paschoal, Kelson J Almeida, Marcelo De Lima Oliveira, Ricardo C Nogueira, Manoel J Teixeira, Uwe Walte. Transcranial brain sonography for Parkinsonian syndromes. Journal of neurosurgical sciences. vol 63. issue 4. 2020-01-02. PMID:31210040. |
this echofeature is owed to increased amounts of iron in the sn region and reflects a functional impairment of the nigrostriatal dopaminergic system. |
2020-01-02 |
2023-08-13 |
human |
| Edson Bor-Seng-Shu, Fernando M Paschoal, Kelson J Almeida, Marcelo De Lima Oliveira, Ricardo C Nogueira, Manoel J Teixeira, Uwe Walte. Transcranial brain sonography for Parkinsonian syndromes. Journal of neurosurgical sciences. vol 63. issue 4. 2020-01-02. PMID:31210040. |
in asymptomatic adult subjects, sn hyperechogenicity, at least unilaterally, indicates a subclinical functional insufficiency of the nigrostriatal dopaminergic system. |
2020-01-02 |
2023-08-13 |
human |
| Sanford Pc Hsu, Dao-Yuan Wang, Ming-Yuan Min, Yu-Show F. Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats. Neurochemistry international. vol 122. 2019-12-26. PMID:30423424. |
the number of dopaminergic neurons in the substantia nigra (sn), the serotonergic neurons in the dorsal raphe nucleus, and the cholinergic neurons in the tegmental nucleus significantly decreased as compared with normal group, whereas the noradrenergic neurons in the locus coeruleus substantially increased. |
2019-12-26 |
2023-08-13 |
rat |
| Sanford Pc Hsu, Dao-Yuan Wang, Ming-Yuan Min, Yu-Show F. Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats. Neurochemistry international. vol 122. 2019-12-26. PMID:30423424. |
the whole-cell recording was made from dopaminergic neurons residing in the sn for examination of their firing activity. |
2019-12-26 |
2023-08-13 |
rat |
| Sanford Pc Hsu, Dao-Yuan Wang, Ming-Yuan Min, Yu-Show F. Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats. Neurochemistry international. vol 122. 2019-12-26. PMID:30423424. |
the recorded dopaminergic neurons in sn were categorized into slow and fast firing using 10 hz as a classified index. |
2019-12-26 |
2023-08-13 |
rat |
| Yunseon Jang, Hyosun Choo, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Min Jeong Ryu, Eung Seok Oh, Song-Yi Choi, Woosuk Chung, Gi Ryang Kweon, Jun Young He. Auraptene Mitigates Parkinson's Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species. International journal of molecular sciences. vol 20. issue 14. 2019-12-23. PMID:31336718. |
treatment with aur significantly increased the viability of substantia nigra (sn)-derived sn4741 embryonic dopaminergic neuronal cells and reduced rotenone-induced mitochondrial ros production. |
2019-12-23 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Tomoko Kanzaki, Yoshimi Kotani, Mako Katoh, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. Journal of nutritional science and vitaminology. vol 65. issue 2. 2019-12-19. PMID:31061292. |
our previous study showed that the subcutaneous administration of auraptene (aur) suppresses inflammatory responses including the hyperactivation of microglia in the substantia nigra (sn) of the midbrain of lipopolysaccharide-induced parkinson's disease (pd)-like mice, as well as inhibits dopaminergic neuronal cell death in this region. |
2019-12-19 |
2023-08-13 |
mouse |
| Satoshi Okuyama, Tomoko Kanzaki, Yoshimi Kotani, Mako Katoh, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. Journal of nutritional science and vitaminology. vol 65. issue 2. 2019-12-19. PMID:31061292. |
in the present study we showed that the oral administration of this dried peel powder successfully suppressed microglial activation and protected against dopaminergic neuronal cell death in the sn, suggesting its potential as a neuroprotective agent for the treatment of patients with pd. |
2019-12-19 |
2023-08-13 |
mouse |
| Sandra Franco-Iborra, Thais Cuadros, Annabelle Parent, Jordi Romero-Gimenez, Miquel Vila, Celine Perie. Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30405116. |
however, in vivo, while tom20 overexpression exacerbated neurodegeneration in both substantia nigra (sn) pars compacta (pc) and striatum, overexpression of tim23 partially protected dopaminergic neurons in the snpc. |
2019-12-10 |
2023-08-13 |
Not clear |
| Jan Kamiński, Adam N Mamelak, Kurtis Birch, Clayton P Mosher, Michele Tagliati, Ueli Rutishause. Novelty-Sensitive Dopaminergic Neurons in the Human Substantia Nigra Predict Success of Declarative Memory Formation. Current biology : CB. vol 28. issue 9. 2019-11-25. PMID:29657115. |
these data reveal that dopaminergic neurons in the human sn are modulated by memory signals and demonstrate a progression of information flow in the hippocampal-basal ganglia-frontal cortex loop for memory encoding. |
2019-11-25 |
2023-08-13 |
human |
| Xiao-Yan Feng, Jingting Yang, Xiaoli Zhang, Jinxia Zh. Gastrointestinal non-motor dysfunction in Parkinson's disease model rats with 6-hydroxydopamine. Physiological research. vol 68. issue 2. 2019-11-25. PMID:30628835. |
parkinson's disease (pd) is a neurodegenerative disease with a progressive loss of mesencephalic dopaminergic neurons of the substantia nigra (sn). |
2019-11-25 |
2023-08-13 |
rat |
| Xiao-Yan Feng, Jingting Yang, Xiaoli Zhang, Jinxia Zh. Gastrointestinal non-motor dysfunction in Parkinson's disease model rats with 6-hydroxydopamine. Physiological research. vol 68. issue 2. 2019-11-25. PMID:30628835. |
the results indicated that the dopaminergic neurons in sn and fibres in the striatum were markedly reduced in 6-ohda rats. |
2019-11-25 |
2023-08-13 |
rat |
| M. Angela Cenci, Kenneth Campbell, Klas Wictorin, Anders Björklun. Striatal c-fos Induction by Cocaine or Apomorphine Occurs Preferentially in Output Neurons Projecting to the Substantia Nigra in the Rat. The European journal of neuroscience. vol 4. issue 4. 2019-11-20. PMID:12106364. |
the present findings are consistent with the idea that striatal c-fos induction by dopaminergic agents is primarily mediated by an interaction with d1-receptors, which are thought to be selectively localized on neurons projecting to sn. |
2019-11-20 |
2023-08-12 |
rat |
| Zhibin Wang, Xiao-Guang Luo, Chao Ga. Utility of susceptibility-weighted imaging in Parkinson's disease and atypical Parkinsonian disorders. Translational neurodegeneration. vol 5. 2019-11-20. PMID:27761236. |
when the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (sn) have been lost. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ayse Ozkan, Hande Parlak, Gamze Tanriover, Sayra Dilmac, Seher Nasircilar Ulker, Ilknur Birsen, Aysel Aga. The protective mechanism of docosahexaenoic acid in mouse model of Parkinson: The role of hemeoxygenase. Neurochemistry international. 2019-11-20. PMID:27984168. |
parkinson's disease (pd) is characterized by degeneration of the dopaminergic neurons in substantia nigra (sn). |
2019-11-20 |
2023-08-13 |
mouse |
| Hilary A Marusak, Joshua R B Hatfield, Moriah E Thomason, Christine A Rabina. Reduced Ventral Tegmental Area-Hippocampal Connectivity in Children and Adolescents Exposed to Early Threat. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2019-11-20. PMID:28740870. |
here, we evaluate the impact of early threat exposure (violence, abuse) on functional connectivity of putative dopaminergic midbrain regions, the ventral tegmental area (vta) and substantia nigra (sn), giving rise to mesocorticolimbic and nigrostriatal pathways, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He, Ping-Yi X. Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo. Translational neurodegeneration. vol 7. 2019-11-20. PMID:30128145. |
abnormal expression of major histocompatibility complex class i (mhc-i) is increased in dopaminergic (da) neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |